Certain drugs, including Benadryl and Cipro, appear to trigger restless legs syndrome in susceptible people. Be aware of diphenhydramine!
Have you seen commercials for RSV vaccines Arexvy and Abrysvo? The CDC reports a connection between RSV vaccines and Guillain-Barré syndrome.
Does your skin itch? Is it red and irritated? You could have eczema or atopic dermatitis. Prescriptions work, but at a price.