The People's Perspective on Medicine

Stopping Antihistamine Leads to Unbelievable Itching

Abruptly stopping the antihistamine cetirizine (Zyrtec) led to unbelievable itching. The doctor who reported this had not seen it in the medical literature.

Every so often, doctors discover something from their own experience as patients that they didn’t learn in medical school and haven’t heard from their colleagues. Often, the symptoms of withdrawal from common medications may fit this description. Who knew that suddenly quitting an OTC antihistamine could result in unbelievable itching?

Stopping Cetirizine Produces Unbelievable Itching:

Q. As a doctor with 35 years in practice, I did not realize withdrawal from the antihistamine cetirizine caused severe itching until I had the problem myself.

I have been taking cetirizine for more than three years. Like many others, I experienced severe itching and hives all over my body when I stopped taking it.

One tablet would cover 36 hours free of symptoms. However, if I missed taking it right before the time limit, my skin started itching and hives would develop. I tried to wean off it three times, but failed due to unbelievable itching. My lips and eyelids swelled too. I am afraid my epiglottis or throat might swell some day so that I could not breathe.

I checked the medical literature and found, to my surprise, there are no reports of cetirizine withdrawal symptoms. Doctors should know about this.

No Information on This Withdrawal Symptom:

A. We have received hundreds of reports of unbearable itching resulting from sudden discontinuation of the allergy drug cetirizine (Zyrtec). We have alerted the FDA about this reaction, but as far as we know no such warnings have been issued.

The main source of information for doctors is the FDA-approved Prescribing Information (PI, which could also stand for package insert). These are published in the Physicians Desk Reference, and they are also available online at

We were never able to find mention of a withdrawal syndrome in the prescribing information when Zyrtec was still a prescription product. As an OTC drug, it carries very limited safety information. People rarely anticipate difficulty stopping a nonprescription pill.

Many People Suffer Unbelievable Itching When They Stop Cetirizine:

Nonetheless, so many visitors to this site have reported similar problems that there is little doubt cetirizine withdrawal itch is a common problem. Some who have stuck it out have reported that the itching fades after six to eight weeks. That is a long time to endure severe itching and hives, but it may be worth consideration.

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About the Author
Terry Graedon, PhD, is a medical anthropologist and co-host of The People’s Pharmacy radio show, co-author of The People’s Pharmacy syndicated newspaper columns and numerous books, and co-founder of The People’s Pharmacy website. Terry taught in the Duke University School of Nursing and was an adjunct assistant professor in the Department of Anthropology. She is a Fellow of the Society of Applied Anthropology. Terry is one of the country's leading authorities on the science behind folk remedies. .
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I am 70 years old and have been on antihistamines since forever. I try to alternate Claritin & Zyrtec so I don’t become immune. I have severe environmental allergies and have been taking 2 allergy shots monthly for 10 years. Recently I have had severe allergy problems, so my doctor recommended we redo allergy test. In order to do testing, I had to stop Zyrtec for 2 weeks prior to testing. I have been itching terribly with bumps, pimples, hives etc. I have to use cortisone cream to live with the discomfort. I need the antihistamines but sure don’t want to start back on them after this episode.

I was on Zyrtec and Xyzal for severe allergies, and when I quit taking them I experienced severe antihistamine withdrawal with hives and itching. I believe tapering off is the best approach.

I have had this as well with Zyrtec in the past. Had extremely difficult time weaning off of it due to severe itching. I stopped taking antihistamines for 2 years but then tried Allegra recently. I started getting bad itching while on it. No I’m taking Benadryl to see if I can get it to stop and then will stop using them again.

I have this. And I don’t care what it is: Benadryl, Alavert, you name it. If I don’t take an antihistamine for a day my hands and feet itch, and I scratch til I draw blood! I recently cut the alavert in half and take it in the morning. By 4pm I’m itching like my feet are in a fire-ant bed!
If anyone finds relief or a way to wean off better, please share!

I take piriton, and I’m finding the itching so unbearable whenever I haven’t had a tablet. I’m currently writing this at 3:45 a.m., as I can’t sleep due to the crazy itching. It gets so bad that I have to get in a cold bath to take away the itching. Otherwise I will be in a bad way. Is there anything that can help it except taking another piriton tablet? LOL.

I have been taking Aller-Tec for over 5 years. I stopped taking Aller-Tec for 2 days now for upcoming allergy test, and I feel like I am dying. Itching got so bad, I cried in front of my 7-year old. Withdrawal is real.

My 14 y/o son has been on Zyrtec, then Xyzal, since age 3 or 4. He has asthma and eczema. He had to stop antihistamines 1 week prior to an allergy test, and he had a hellacious worsening of the eczema, even involving his face and trunk which never were affected before. He is still having a bad flare even after being back on the antihistamines for over a month. Antihistamine withdrawal is a real thing. One of my older children had a similar experience going off of Zyrtec. My advice is to taper slowly over weeks.

Taking Telfast (fexofenadine) daily for past 3 months, more or less. Worse decision ever! I am now itching more than ever once the meds wore off. In the midst of weaning off.

Absolutely unbearable itching. I had no idea antihistamine withdrawal was to to blame at first. I though it was just allergies. I’ve been taking Zyrtec D for over TEN YEARS DAILY! The itching is unbelievable. I’ve given myself bruises, open sores, and it wakes me at night. I stopped taking Zyrtec D in early October. It is now nearly the end of December. I’ve taken only a very small (5-8) number of doses of antihistamines to help get off of the stuff. It’s absolutly maddening.

Of my goodness! I’ve been thinking I’m crazy for over eighteen months! I started taking benadryl for seasonal allergies in spring of 2017. Then in the summer we were swarmed by hornets, and I’m allergic so was taking benadryl for the reaction. About a week or two later I was off the meds and noticed I had hives on my arm. I thought it was strange, but ignored it. It got gradually worse, and I took an antihistamine, thinking I was just have been having a reaction to something. It’s now been over 18 months. I take allegra every day and itch like crazy until the itch wears off. Quitting today. Wish me luck.

Yes! I’ve experienced this too! I’ve been on daily Claritin for years. This year, I decided I wanted to see if I could do without the Claritin. Three days off, and WOW, the itching was insane! I went back on and tried stopping every other day, but after about a week and a half my body decided that the reduced dosage was no good, and the itching started again. So now I’m going to try a long-term weaning plan. I’m going to skip 1 pill every 4 days for a month, then skip 1 pill every 3 days, for another month, etc. I’m hoping that at the very least I can reduce the dosage my body depends on. I’m curious to see if anyone else has been successful at a long, slow wean without the horrible itching.

I’m having the exact same symptoms while trying to get rid of ebastine (an antihistamine as well). I’ll try my best to keep off it now and will never go back!!!

I asked my doctor about this and she never heard of such a thing. I tried googling it and didn’t come up with anything a few years ago. I thought, “What the heck I am going to try again,” and BAM I found this. Thank you so much for validating my symptoms when I go off of Zyrtec. I feel so stuck. Now I am trying to wean off by taking one every other day then go to 1 every 2 days and then 1 ever 3 days, etc. We shall see what happens. WISH ME LUCK!!!!!

I am so happy to find this site when I google ‘if I stop antihistomin my hive comes bcak’. I realize my itch will getting worse if I develop the medicine dependence. I will try my best to ween off this medicine.

Going through this right now with hydroxyzine! Doctor basically just did nothing and said “there has been no record of withdrawal from this drug” my ass! I’ve noticed that the itching only gets completely unbearable after I take a bath, so I’m hoping to wait it out for a couple of weeks before taking a bath or shower (I know, it’s gross, but I have to get through this)

I am so glad I found this. I decided to try not taking generic Zyrtec 3 days ago and I had no clue where the itching was coming from and couldn’t figure it out. It clicked this morning that was the only changed I made to my daily regimen! I guess I will have to try to ween myself off as this itching is horrible and everywhere!

I also thought I would just discontinue the generic Zyrtec (ceterizine hydrochloride) and would have no problems. I was wrong. I am itchy everywhere. I’m glad I ran across this forum and learned that it is not uncommon. I will now try to wean myself off gradually.

I’ve had some of the same crazy itching on days I’ve forgotten to take my Allegra….which I’d really like to stop taking…

Add me to the list! I have been taking Claritin since mid-April for seasonal allergies. It’s been a rough allergy season for all, and since I have both spring and fall allergies I decided to take one tablet every day out of precaution. I noticed I was getting sore throats and had a dry mouth towards the beginning of July, and my dentist recommended trying to wean off any allergy medications since it can lead to these issues.

I started taking it only when the pollen count was high, and now not at all. I noticed I was extremely itchy starting a week or two ago on my thighs, scalp, chest, neck and shoulders in the late afternoon and into evening, and couldn’t figure out what was wrong!

This makes total sense to me now that I have read about it, and I was shocked to have such a reaction to something that was supposed to help me with allergies, not hurt me. The sore throat and dry mouth have gone away (yay!) but the itching is awful. I’ve been using lotion to soothe my skin, but the red, itchy late afternoon spots just aren’t going away. Ugh.

Well, add me to the list too! I have been taking Zrytec for as long as it has been on the market I think. First as a prescription drug then as an OTC later. Last week I thought,” Why am I taking this everyday, that doesn’t seem right”. as I am trying to clean up my life styles and habits.

I figured it would be no big deal but Boy was I wrong! We need to get someone to admit to the unbelievable itching that occurs when you stop. I thought my eyelids were going to bleed I have scratched them so hard. My whole face has itched, along with my body but the eyelid and face itching is insane!

I broke down and took a pill this morning because I couldn’t take it anymore but I will be attempting to wean off them now, instead of cold turkey. This needs to be in the literature for sure!!!

YES! Thank goodness this is here for people to confirm they’re not crazy. I’ll be honest, one of the first things I thought was how grateful I am I’m only trying to kick an antihistamine and I took back any bad thought I’ve ever had about an addict of any other drug trying to kick the habit. One of my doctors recommended first cutting the pill in half but continuing to take it daily. After a couple of weeks, move to 1/2 pill and take 2 days, off 1, take 2 days off 1, etc. After a couple more weeks, move to 1/2 pill every other day until you just stop. I tried cold turkey and the itching was far more severe. I’m doing the weaning method now and it’s better but definitely still there.

I am on 8 different medications for differing health problems. Most of them I have been on for 20 years or more. I have been on antihistamines since I was a little kid. Now that I am in my 40s, they don’t seem to be very effective. I am also starting to notice some serious memory/processing issues…which is a big deal to me because I consider myself to have been an intelligent person at some point. I would ask my doctors and was always told that “it’s just a part of aging,” “you’re depressed,” “you’re under a lot of stress.” After talking with my dad, a former nurse practitioner, about my list of rxs and side effects, I was alarmed that it was most likely my medications. He told me about something called a Beers List and after looking at it, most of the meds I take are on there. Not once has anyone taken my complaints/concerns seriously. Anyway, as a result, I have tried to come off of Xyzal (a cousin of Zyrtec). I’ve had to come off before for allergy testing and experienced the insane itching about 3 days in. This time, I’m trying to come off of it for good…I didn’t realize it could be 2 months before this stops…it’s only been 2 weeks and I’m scratching like a bear!

I’m not sure that these side effects are widely known. I was a pharmacy tech for 20 years and not once did anyone tell me that my medicines should be reevaluated. If you think something is off, talk to your doctor and stick up for yourself. I really wish I had.

My experience is similar to yours. I have been on allergy meds since I was a child. I am now 37 years old, and I know that my allergy meds are no longer working whatsoever. I would switch brands every three months or so but I have now decided to end them for good. I would really like to find an alternative to the meds. No luck. For years I knew my allergy meds would cause severe itching, to the point that I would bruise my legs or arms or torso because they itched so badly. I would tell doctors, and they would look at me like I had lost my mind. I am so thankful that this has finally been proven!!

Are you still off of allergy meds or what did you do to help allergy symptoms??

I feel for all of you experiencing this horrible reaction from the withdrawal of antihistamines. I too, have experienced this when seeing a Dr. at 60 years of age for what I thought was an ongoing illness of cold, cough, sneezing, achy bones, lack of energy and at times, what I thought was a temperature. Those that do not have allergies can’t relate to how one can feel like they have the flu when affected with allergies.
He looked in my nasal passages and said ” you have allergies as your passages are red and inflamed “. He told me to take Zyrtec in the morning and Benadryl at night. From the first dosage I felt better and had NEVER slept as well than I did when taking Benadryl.
After 4 months of allergy free symptoms, I decided I did not want to keep taking this medications as I can’t imagine they are good for your body. As soon as I stopped, the itching and hives started. It was miserable so Googled this situation and found out about the Zyrtec withdrawal syndrome. There are NO warnings about this withdrawal and I spoke with my new Dr. about this and she had no clue and thought I just was allergic to Zyrtec and made note on my chart. What a joke and what a scam from this manufacturer as I called to complain, they said “oh, we’ve never heard about this ” I call BS !
I ended up using advice from all those that went before us in regards to withdrawal and started taking more C, adding a Quercetin dosage and after 6 months of itching, it finally stopped. Fast forward to the next allergy attack after many months and decided instead of taking it all the time, I would try to do it only when the symptoms hit. I took Zytec for a few days then stopped ………..and the nightmare began all over again. It took me 7 MONTHS this time to get over the unbearable itching and hives and have sworn I would never take it again.
SO, after being allergy free for over a year, here I am with allergies feeling like crap and not sure what to do ? I have continued with the extra vitamin C and Quercetin as part of a daily regime and was totally allergy free until this week. I just looked up ‘natural antihistamines and found a few options like Butterbur but not sure how effective they are.
Anyone have some new information to alleviate the suffering ?

Good luck to all that are dealing with allergies and their withdrawals from antihistamines !

Adding to the conversation, I am having the SAME problem with Benadryl!! After learning that antihistamines also contribute to DEMENTIA, I tried stopping it cold turkey, but have horrible scalp itching. So I am going to try weaning off slowly. Thank you to the commenter who suggested acupuncture. The more I learn about the true nature of the drug companies, the MORE DETERMINED I am to STOP buying what they are pedaling!!!

I quit taking Claritin a couple of weeks ago, and OH, MY HEAVENS, the itching… I can barely type this out. I was not warned of this. I am now worried about my 8 yr old daughter who is also on it. When the time comes for her to come off, I don’t want her to go through this because this is complete and utter torture!! I hope it goes away soon!!!

I have an appt next week for allergy testing and was told to stop taking my long-term antihistamine a week before. No one mentioned the effects of his abrupt withdrawal and I’m really hating it. Anything I would normally take to relieve the itching is also on the “don’t take before the testing” list. This sucks. I’m hoping not to start taking this med again but am discouraged about the 7-8 weeks people are saying this lasts. At least after the tests I can take something occasionally for relief.

I have been taking generic Zyrtec for several years daily. My doctor said I needed to stop taking it because it added to a dizziness problem I was having from dryness and it wasn’t helping. So I quit cold Turkey a little over a week ago and it’s been driving me mad. Itching all over especially under my hair on my head and under my beard. I’m determined to stick it out under shear principle at this point and hope to never start taking it again. I have horrible allergies and it was maintaining that for the most part but I don’t like being a slave to any drug. But this is miserable. Like all day itching.

How did you wean off of it? Please help me I am having the worst time of my entire life

I, too, am suffering severe itching trying to get away from this miserable drug. I am in Oregon where pot is legal and have found that smoking a bit of high CBC pot helps calm the nerve endings. Good luck to all of us at the mercy of drug corporations.

I also switched from Cetirizine to Claritin and found myself extremely itchy after stopping the Claritin. My doctor told me that I just had a condition called Dermatographia and after being told I would have to be on these drugs for the rest of my life I decided to take matters into my own hands and do some research. It is now clear to me that I have been wrongly diagnosed and actually just formed a physical dependance to my seasonal allergy meds which I should NOT be taking in the winter. My only question is why are these threads focused solely on Cetirizine? It seems that antihistamines in general are the problem.

I am having horrible itching from stopping my antihistamine that I’ve been on for 10 years. How long will this last??

Hello to A and others, thank you for your comments….. I feel for you re: “takings things into my own hands” …. I really don’t think “traditional” medicine offers us a pathway to wholeness or wellness. I took loratadine (generic Claritin) for years for seasonal allergies. Last Sept, broke out in hives perhaps from chronic stress (I was a caretaker for 4 months for mother who had a stroke).

My primary care provider wanted to put me on Prednisone !!!! I said no thank you and went to a accupuncturist. She listened more thoroughly to ALL symptoms. After 6 months of on/ off again hives I am weaning myself off loratadine and using Udos Oil( balanced Omega oils) , quercetin, nettles , high fruits/veges, whole grains , lean protein, high fiber. Basically low inflammatory diet foods.

At night when itching becomes unbearable I sponge calamine lotion all over skin, drink Yogi Bedtime tea, has valerian root and camomile etc. Do deep breathing, prayer and meditation, knitting and reading to distract and calm myself.

We are all doing a lot of work to help ourselves!!!! No easy! I wish everyone wholeness on your journey. Peace….

After several years of taking daily Zyrtec and an inability to control the withdrawal, I tried acupuncture and a Chinese herb for skin. I had 4-5 days that were rough, but I have now been off it for 3 weeks with minimal sporadic itching. I am a bit concerned about ragweed season and the need for an antihistamine. I don’t want to be hooked again.

I had been reading about how abruptly stopping Zyrtec can lead to terrible itching. As I had been taking Zyrtec for mysterious hives in the first place, I certainly did not need that. So I spent two months weaning myself off of it and that worked out all right. (Hives had gone away as mysteriously as they had arrived)

It’s amazing how little information drug manufactures actually have to provide to get approval for a drug. I am still in a quagmire with the unknown withdrawals from Lyrica, Pfizer’s so called wonder drug. So many people’s lives are being destroyed by this medication but my Doctors will not consider it. Without proper input from consumers the makers of R.X meds will never know the true effects of their drugs. This article reiterates that point. It must be considerably harder when it’s an over the counter med. I’ve reported my issues with Lyrica to my doctors, the F.D.A, pharmacist’s, MedWatch, and on & on. I suspect Pfizer’s big $$ suppresses most info. SAD.

I recently weaned myself off of generic Zyrtec and had the uncontrollable itching and hives. I was miserable to say the least. It took 7 weeks to wean off of it. I didn’t think it was a good idea to quit “cold turkey”; so took myself off of it slowly. It was an awful experience that I would not want to go thru again. I literally had itching everywhere on my body; and would wake up in the middle of the night itching and scratching. I even had bruises from the scratching.

This severe itching occurs as a withdrawal symptom with Claritin also. I have tried to wean myself off of it on three separate occasions and failed. I have resigned myself to taking this medication for the rest of my life!

After being on diuretics for “idiopathic” edema, for six to eight years, a new doctor told me to stop taking them. Along came the itchies! I was putting on lanacaine at bedtime and slept just until it stopped being effective. A dermatologist gave me a steroid cream to use twice a day; but even with that it was another few weeks until it stopped. I used to scratch my skin hard enough, in my sleep, to leave marks. I think when your system is used to anything you take long term, there are going to be rebounds and repercussions when you stop and some may be expressed as itching.

I went through this myself. Switching to another antihistamine ( I used fexofenadine a.k.a Allegra) for a few weeks after stopping the cetirizine worked pretty well; when I stopped the fexofenadine I had some mild residual itching but it went away in a few weeks.

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