Young woman's back with allergy skin problem, stopping cetirizine

Every so often, doctors discover something from their own experience as patients that they didn’t learn in medical school and haven’t heard from their colleagues. Often, the symptoms of withdrawal from common medications may fit this description. Who knew that suddenly quitting an OTC antihistamine could result in unbelievable itching?

Stopping Cetirizine Produces Unbelievable Itching:

Q. As a doctor with 35 years in practice, I did not realize withdrawal from the antihistamine cetirizine caused severe itching until I had the problem myself.

I have been taking cetirizine for more than three years. Like many others, I experienced severe itching and hives all over my body when I stopped taking it.

One tablet would cover 36 hours free of symptoms. However, if I missed taking it right before the time limit, my skin started itching and hives would develop. I tried to wean off it three times, but failed due to unbelievable itching. My lips and eyelids swelled too. I am afraid my epiglottis or throat might swell some day so that I could not breathe.

I checked the medical literature and found, to my surprise, there are no reports of cetirizine withdrawal symptoms. Doctors should know about this.

No Information on This Withdrawal Symptom:

A. We have received hundreds of reports of unbearable itching resulting from sudden discontinuation of the allergy drug cetirizine (Zyrtec). We have alerted the FDA about this reaction, but as far as we know no such warnings have been issued.

The main source of information for doctors is the FDA-approved Prescribing Information (PI, which could also stand for package insert). These are published in the Physicians Desk Reference, and they are also available online at

We were never able to find mention of a withdrawal syndrome in the prescribing information when Zyrtec was still a prescription product. As an OTC drug, it carries very limited safety information. People rarely anticipate difficulty stopping a nonprescription pill.

Many People Suffer Unbelievable Itching When They Stop Cetirizine:

Nonetheless, so many visitors to this site have reported similar problems that there is little doubt cetirizine withdrawal itch is a common problem. Some who have stuck it out have reported that the itching fades after six to eight weeks. That is a long time to endure severe itching and hives, but it may be worth consideration.

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  1. Karin
    CA - California

    I was on Zyrtec and Xyzal for severe allergies, and when I quit taking them I experienced severe antihistamine withdrawal with hives and itching. I believe tapering off is the best approach.

  2. Jaime

    I have had this as well with Zyrtec in the past. Had extremely difficult time weaning off of it due to severe itching. I stopped taking antihistamines for 2 years but then tried Allegra recently. I started getting bad itching while on it. No I’m taking Benadryl to see if I can get it to stop and then will stop using them again.

  3. Tanya W.

    I have this. And I don’t care what it is: Benadryl, Alavert, you name it. If I don’t take an antihistamine for a day my hands and feet itch, and I scratch til I draw blood! I recently cut the alavert in half and take it in the morning. By 4pm I’m itching like my feet are in a fire-ant bed!
    If anyone finds relief or a way to wean off better, please share!

  4. Michael L.
    Hampshire, UK

    I take piriton, and I’m finding the itching so unbearable whenever I haven’t had a tablet. I’m currently writing this at 3:45 a.m., as I can’t sleep due to the crazy itching. It gets so bad that I have to get in a cold bath to take away the itching. Otherwise I will be in a bad way. Is there anything that can help it except taking another piriton tablet? LOL.

  5. sharon

    I have been taking Aller-Tec for over 5 years. I stopped taking Aller-Tec for 2 days now for upcoming allergy test, and I feel like I am dying. Itching got so bad, I cried in front of my 7-year old. Withdrawal is real.

  6. M

    My 14 y/o son has been on Zyrtec, then Xyzal, since age 3 or 4. He has asthma and eczema. He had to stop antihistamines 1 week prior to an allergy test, and he had a hellacious worsening of the eczema, even involving his face and trunk which never were affected before. He is still having a bad flare even after being back on the antihistamines for over a month. Antihistamine withdrawal is a real thing. One of my older children had a similar experience going off of Zyrtec. My advice is to taper slowly over weeks.

  7. Veron

    Taking Telfast (fexofenadine) daily for past 3 months, more or less. Worse decision ever! I am now itching more than ever once the meds wore off. In the midst of weaning off.

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