logoThe People's Perspective on Medicine

Does Cytotec Ease Acid Reflux?

For people who must take NSAID pain relievers such as aspirin or naproxen, Cytotec can help protect the digestive tract from damage and ease discomfort.
Does Cytotec Ease Acid Reflux?
Cardiac pain. Mature woman holds her heart

Proton pump inhibitors such as esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec) or pantoprazole (Protonix) have become such staples of treating heartburn and digestive distress that doctors may not think beyond this toolbox. But they are not appropriate for everyone.

This reader found a physician willing to consider a different approach to her acid reflux. We don’t know if it would work well for other readers, but it might be worth consideration.

Prilosec Did Not Ease Symptoms of Reflux:

Q. I am a 72-year-old woman. About nine months ago, I suddenly came down with a bad case of acid reflux. My doctor prescribed Prilosec, which had awful side effects and did not help much.

With the help of your booklet on digestive disorders, I tapered off the medicine, modified my diet drastically and drank a lot of ginger tea. I finally consulted a gastroenterologist who prescribed Cytotec.

I took this drug for four weeks. It worked without too many side effects and I am keeping my fingers crossed. Apparently, it can cause miscarriage, but that is not a problem for me.

How does Cytotec ease acid reflux? What can you tell me about it?

Controlling NSAID-Related Damage:

A. Misoprostol (Cytotec) protects the stomach from damage caused by aspirin and other pain meds like diclofenac, ibuprofen and naproxen.These NSAIDs (nonsteroidal anti-inflammatory drugs) block a natural compound called prostaglandin E1 (PGE1), which protects the stomach lining.

Misoprostol supplies synthetic PGE1 to the digestive tract and helps ulcers heal.Back when it was first introduced in the mid to late 1980s, doctors were excited about its protective potential (Postgraduate Medicine Journal, 1988: Suppl. 1). By the late 1990s, research was showing that omeprazole worked just as well for healing ulcers and many people seemed to like omeprazole better (New England Journal of Medicine, Mar. 12, 1998).

PPI Side Effects:

That was, however, before the many side effects of the PPIs had surfaced. We now know that they can deplete the body of vitamin B12 or magnesium (PLoS One, Nov. 13, 2014), increase the risk of bone fractures (Bone, Aug. 28, 2015), boost the chance of developing diarrhea from a C diff infection or pneumonia (Expert Review of Clinical Pharmacology, July, 2013) and raise the possibility of a heart attack (Circulation, online July 3, 2013).

Even more alarming, the use of proton pump inhibitors together with NSAID pain relievers can intensify the damage caused to the small intestines (Clinical Gastroenterology and Hepatology, Oct. 29, 2015). Misoprostol, on the other hand, protects against such damage, at least in rats (Journal of Pharmacology and Experimental Therapeutics, Feb., 2014).

Misoprostol Side Effects:

In addition to the miscarriage that you mentioned, misoprostol can cause severe changes in blood pressure and heart rhythm, blood clots (thromboembolism) and even heart attacks. So it is not a purely benign drug.

Common side effects include diarrhea, stomachache, nausea, gas and headache.

We don’t know if your doctor selected Cytotec for you because you take aspirin or ibuprofen for joint pain, as you didn’t mention that. It certainly has its own side effects, some of them serious, but as a way of protecting your gut from NSAID damage, it has advantages.

Rate this article
4.5- 19 ratings
About the Author
Terry Graedon, PhD, is a medical anthropologist and co-host of The People’s Pharmacy radio show, co-author of The People’s Pharmacy syndicated newspaper columns and numerous books, and co-founder of The People’s Pharmacy website. Terry taught in the Duke University School of Nursing and was an adjunct assistant professor in the Department of Anthropology. She is a Fellow of the Society of Applied Anthropology. Terry is one of the country's leading authorities on the science behind folk remedies. .
Digestive Disorders

Download this guide to getting off heartburn medicine. Preventing ulcers. Effective treatments for constipation and diarrhea. Foods and drugs that cause gas.

Digestive Disorders
Join over 150,000 Subscribers at The People's Pharmacy

We're empowering you to make wise decisions about your own health, by providing you with essential health information about both medical and alternative treatment options.