Do You Want a Natural Thyroid Treatment?

Thyroid problems are far more common than you might guess. Pharmacists dispense approximately 120 million prescriptions each year for levothyroxine (Levoxyl, Synthroid, Tirosint, Unithroid). People whose thyroid glands do not work well need to take this hormone to provide what their own bodies do not. However, not everyone thrives on a synthetic hormone. Some people find that a natural thyroid treatment is better for them. But many worry, for good reason, that the FDA might make it harder to get natural thyroid medication.

What Will the FDA Do About Armour Thyroid and Other Natural Thyroid Products?

This reader points out that the FDA is making some worrisome noises:

Q. I read recently that the FDA is changing the classification of natural desiccated thyroid extracts. They will now be considered “biologics.” I fear that this will increase the price a lot, even though these medicines are not expensive to produce.

The company that makes Armour Thyroid is not objecting to this change. To my mind, that could mean they stand to benefit financially. Can you enlighten your readers about what is going on?

A. The FDA appears to be skeptical about the value of desiccated thyroid extract (DTE). Even though a major pharmaceutical company (AbbVie) makes both synthetic levothyroxine (Synthroid) and Armour Thyroid, the FDA cites safety, effectiveness and quality issues with natural thyroid extract.

The FDA has classified DTE as a “biological product.” That means the agency could require a special license for these medicines. The agency has announced that it will take action against animal-derived natural thyroid products. The precise timetable is still a mystery.

Trying Both Synthetic and Natural Thyroid Treatments:

Q. My body does not convert T4 (levothyroxine) to T3 (triiodothyronine). I started taking NDT (natural desiccated thyroid with both T3 and T4) about nine months ago, and it has given me my life back. I have no more headaches, nausea or foggy head, fatigue, depression or hair loss. The list is much longer. I am awake when I get out of bed in the morning and feel rested for the first time since my diagnosis. I’ve even lost a few pounds, though that was not the reason at all for my taking it. It is a welcome surprise. Why do many doctors seem reluctant to prescribe this medicine?

A. We suspect that doctors find it easy to prescribe levothyroxine, which effectively controls TSH (thyroid-stimulating hormone) levels in 70 to 80 percent of patients. But what are the other 20 to 30 percent of patients supposed to do if they still feel terrible despite taking levothyroxine?

Your experience with natural desiccated thyroid extract is not unusual. We have heard from many readers who have found it reduces or eliminates their symptoms of hypothyroidism (fatigue, weakness, constipation, hair loss, etc.). Research confirms that many patients prefer NDT or combination therapy with both T3 and T4 to levothyroxine alone (Journal of Clinical Endocrinology and Metabolism, Feb. 18, 2025).

People unfamiliar with this treatment can learn more in our eGuide to Thyroid Hormones, in which we discuss the treatment of both under- and overactive thyroid glands. We also explain how to interpret blood tests for thyroid disease.

Are You Looking for a Natural Thyroid Treatment?

Q. I have been taking Synthroid since my thyroid was removed two decades ago. I’m not happy with it and have been hoping to lower the dose. But my last test showed an elevated TSH so my doctor wants to increase the dose. I would prefer a natural treatment. Is that possible?

A. With no thyroid gland of your own to produce thyroid hormone, you have to take it in pill form. Doctors usually prescribe synthetic levothyroxine (T4). However, some are willing to prescribe desiccated pig thyroid (Armour Thyroid, Nature-Throid). This dried gland provides T3 as well as T4.

The Story on a Natural Thyroid Treatment:

Many people prefer desiccated thyroid gland (Journal of Clinical Endocrinology and Metabolism, May 2013).  However, your doctor may not be familiar with its use. Investigators reviewed records for 100 patients of a Pennsylvania endocrinology clinic for more than two years. They found that people do equally well on synthetic and natural therapies (Southern Medical Journal, June 2018). Some people do appear to have fewer symptoms when they are taking a combination T3 and T4 treatment, whether it is synthetic or natural.

On the other hand, a recent review (International Journal of Clinical Practice, Feb. 2018) of several studies concluded that

“Current clinical evidence is not sufficiently strong to support LT4/LT3 combination therapy in patients with hypothyroidism.”

What Readers Say About Natural Thyroid Treatment:

As you might expect, some people do extremely well on this treatment, while others experience side effects. Here are a few comments we have received:

Cindy reported:

“There are a huge number of us that benefit from natural desiccated thyroid (NDT) like Armour, NP Thyroid,etc. I was on T4 only medications for over a decade and kept telling my doctor I still had the symptoms of hypothyroidism despite their testing results that read out normal. Many doctors don’t listen and treat your lab results and not you! Finally I found a doctor who would listen–ran the right lab tests and prescribed NDT. I am feeling so much better now. I also had to educate myself so I could speak fluently about this topic and insist on what is good for me and not the stockholders of levothyroxine!”

Jen had a similar experience:

“I have been on Armour for most of twenty years prescribed by my family doctor. Several years ago went endocrinologist, and she put me on Synthroid immediately. It was horrible. All kinds of symptoms. Most endo doctors are Synthroid only. I found a new family doctor (DO), as my old one had moved. Back to Armour. Endo doctors like whatever Big Pharma likes. Big Pharma can’t make $$ off of NDT as it’s all natural.”

Aya cautioned:

“Armour Thyroid does not work for everyone, however. It made my heart race. There might be other options such as adding some low-dose T3 to the Synthroid treatment.”

Learn More:

You can learn more about Armour or other desiccated thyroid in our online Guide to Thyroid Hormones. Endocrinologists may be more willing to prescribe desiccated thyroid as they become aware that people taking this natural thyroid treatment are, in general, more satisfied with their medication and their physician than those on levothyroxine alone (Thyroid, June 2018). You may also want to consult Mary Shomon’s blog, www.mary-shomon.com. She is an extremely well-informed patient who offers information from the patient perspective.

We interviewed Mary Shomon and Dr. Antonio Bianco for our podcast on this topic. It is Show 1452: Why Is the FDA Planning to Ban Natural Desiccated Thyroid?