Another Indian generic drug company is recalling an important heart medicine called metoprolol. Dr. Reddy’s Laboratories determined that their 25 mg metoprolol tablets did not dissolve as expected. Over a million pills are affected by the voluntary recall, although it may be difficult for patients to tell if their metoprolol is one of the two lots affected. This action comes on the heels of a recall by another Indian drug company, Wockhardt. In May, Wockhardt removed over 100,000 bottles of its metoprolol because it too had dissolution problems.

This beta blocker heart medicine is prescribed to patients with irregular heart rhythms, angina and high blood pressure. Shortly after the brand name Toprol-XL lost its patent in 2006, some patients have complained that the long-acting generic metoprolol did not seem to work as well as the brand name. The quality control problems that have surfaced over the intervening years seem to vindicate the patients’ reports of their experience.  

We have been concerned about this issue for years, so it is good that quality control problems with this long-acting medication are finally being brought to light. Cleveland Clinic cardiologist Harry Lever, MD, has been paying attention to how faulty pills affect his patients, and The New York Times wrote about it earlier this week.  

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  1. Yhtak

    Been using Metoprolol for one year. Used Coreg for 15 years loved it. First put on Carvedilol because Medicaid wouldn’t pay for Coreg. The generic instantly showed it didn’t work. Dr then prescribed Metoprolol. It wasn’t much better. I’ve complained for a year. Both meds have similar side effects for me.

    My insurance company has refused to agree with Dr to give me back Coreg. Today. I’ve been told to try at least one more generic for Coreg. There’s not another generic just another distributor. The generics come from India.

    Anyway tomorrow starts a new generic. Hopefully the bad results show quickly and I can demand that I get my Coreg back. These insurance companies are slick. Even on Medicaid I thought choosing a provider would solve these problems. Ha, 64 and still learning!

  2. Lisa

    I have just been given an Rx for topronol xl but cvs gave me the generic and I called them about the previous recalls and they told me to stay off the internet. Can someone tell me is it safe now?

  3. Jeanne M.

    Have been using metoprolol tartrate 50mg for many years…so is that the same as the generic mentioned in the article? I never see the word tartrate in any writing about metoprolol.

  4. MW

    I am HIV+, and one of my generic NRTI is manufacturered in India. I am terrified of that something like this will occur with devastating and expensive consequences to thousands of people.

  5. DCC

    Is there a difference between metropolol succinate and metropolol tartrate?

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