The People's Perspective on Medicine


Metoprolol is a beta blocker used to treat heart disease and high blood pressure and to prevent migraine headaches.

Metoprolol is available as immediate-release metoprolol tartrate (Lopressor) or extended release metoprolol succinate (Toprol-XL). It is also found combined with hydrochlorothiazide (as Dutoprol in the metoprolol succinate form and Lopressor HCT in the metoprolol tartrate form).


Metoprolol belongs to the group of heart/blood pressure drugs known as beta-blockers. That means they work partly by blunting the action of adrenaline, the body’s natural fight-or-flight chemical. People normally respond to stressful situations with a rapid pulse, a pounding heart and an increase in blood pressure. Metoprolol helps block such reactions by slowing the heart rate and relaxing the blood vessels so the heart does not have to pump as hard.

This medication is usually prescribed for high blood pressure, chest pain, heart attacks, and prevention of a second heart attack. The extended release metoprolol is also used in combination with other medications to treat heart failure. Although the FDA has not specifically approved its use for other purposes, doctors sometimes prescribe it to treat irregular heart rhythms or tremors and to prevent migraine headaches.

People’s Pharmacy Perspective

Beta blockers have been around a long time and generally have low cost generics available. One word of caution, however: We have heard from a significant number of people that not all generic Toprol XL (metoprolol succinate) is created equal. Some people have seen their blood pressure skyrocket while others have developed irregular heart rhythms. See their stories.

Beta blockers such as metoprolol should probably not be considered as first-line treatments for high blood pressure (1,2). British hypertension experts reserve beta blockers almost as a last resort, when other blood pressure medicines don’t work (3). Since beta blockers have the potential to cause numerous side effects (and negatively impact blood fats), we agree that they should be used cautiously.

Beta blockers are valuable for managing chest pain and preventing another heart attack after someone has already had one. They may also be valuable when adequate blood pressure control is not achieved with other classes of drugs. You and your physician will need to decide if the benefits outweigh the risks. The information provided here is not a substitute for the medical advice or care of a physician or other health care professional.

Special Precautions

DO NOT stop taking metoprolol (Lopressor, Toprol-XL) suddenly without first talking to your doctor. Stopping abruptly may trigger potentially fatal heart problems.


Consult your doctor if you are pregnant or planning a pregnancy, or will be breastfeeding while taking this medication.

Who Should Avoid Metoprolol

Metoprolol is not recommended for some people: People who have had an allergic reaction to beta-blockers, metoprolol and people with certain serious heart problems, such as heart rates less than 45 beats per minute (for heart attack patients) or abnormal heart rhythms. The medication could occasionally lead to serious cardiac complications for these individuals. Note that only metoprolol succinate, the extended release tablet, is indicated for heart failure. Metoprolol tartrate is not recommended for people with heart failure.

Some people must be very carefully monitored if they take beta-blockers such as metoprolol. In general, people with heart failure must be extremely cautious if prescribed beta blockers because the medicine could lead to cardiac complications. Those prescribed metoprolol succinate are no exception; other medications they are on may need to be adjusted, and most importantly, they must be closely monitored for worsening of their heart condition.

Asthmatics and patients with other respiratory problems are especially vulnerable, as these drugs can make breathing worse. Metoprolol may be a little better than other beta-blockers in this regard, but monitor breathing carefully.

Diabetics should inform their physicians if they are taking metoprolol, since the medication may mask the signs of low blood sugar levels.

People with a history of depression should inform their doctors to ensure both their depression and beta-blocker therapy is well managed. Metoprolol is more likely to affect the nervous system than others in its class and may contribute to depression. People with a thyroid disorder should also be carefully monitored as metoprolol may mask signs of an overly active thyroid. Lastly, people with liver impairments may also need to be very carefully monitored.

Be certain to inform your doctor of any other conditions you may have. This information may affect your dose, whether you should even take this medication, or require you to take special tests during treatment.

Taking the Medicine

Metoprolol is best absorbed when taken with or right after meals. Food may reduce the risk of digestive tract upset and taking the drug at roughly the same time each day allows your body to maintain a constant level of the medication in your blood stream. This medication should be taken with a full glass of water. Avoid alcohol while on metoprolol because it could increase drowsiness or dizziness. Do not take calcium supplements or antacids within two hours of metoprolol because they may reduce absorption.

If surgery is scheduled, ask your surgeon and anesthesiologist to see if your beta blocker dose will need to be adjusted. Never stop taking metoprolol suddenly. Your doctor must reduce your dose gradually to prevent serious heart problems.

Adverse Effects and Interactions

Common Side Effects

  • anxiety, nervousness
  • dizziness or vertigo
  • sleep problems (daytime drowsiness or insomnia)
  • tired feeling
  • abdominal pain or diarrhea
  • decreased sex drive, impotence, or difficulty having an orgasm
  • arthritis or gout pain
  • elevated triglycerides and lower HDL cholesterol; a lipid test before treatment and periodically thereafter would be prudent.

Serious Side Effects

Obtain emergency medical care if you experience these signs of a potential allergic reaction:

  • breathing difficulties
  • swelling in your face, lips, tongue, or throat

Call your doctor promptly if you experience any of these serious side effects:

  • feeling light-headed, fainting
  • worsening depression, memory loss or mood swings
  • wheezing, worsening asthma
  • feeling short of breath, even with mild exertion
  • extra-slow or uneven heartbeats
  • stomach upset, low fever, lack of appetite, dark urine, pale-colored stools, jaundice (yellowing of the skin or eyes)
  • swelling of your ankles or feet
  • cold feeling in your hands and feet
  • hives, itchiness, rash, increased susceptibility to sunburn

There may be other side effects not listed here. Talk to your doctor if your condition worsens and ask about any side effect that seems unusual or is especially bothersome. Never stop taking any beta blocker medication abruptly unless you are under very close medical supervision. Angina or a heart attack could occur.

Drug Interactions

  • celecoxib (Celebrex): This NSAID could reduce the effectiveness of metoprolol and make you retain sodium and fluid.
  • cimetidine (Tagamet): The combination could slow heart rate.
  • clonidine (Catapres): If you are on both blood pressure medications, do not suddenly discontinue either medicine, as the increase in blood pressure could be life threatening.
  • diclofenac (Cataflam, Voltaren): This NSAID could reduce the effectiveness of metoprolol and make you retain sodium and fluid.
  • dolasetron (Anzemet): The combination increases the risk of heart rhythm disturbances.
  • etodolac (Lodine): This NSAID could reduce the effectiveness of metoprolol and make you retain sodium and fluid.
  • fenoprofen (Nalfon): This NSAID could reduce the effectiveness of metoprolol and make you retain sodium and fluid.
  • flurbiprofen (Ansaid): This NSAID could reduce the effectiveness of metoprolol and make you retain sodium and fluid.
  • hydralazine (Apresoline), propafenone (Rythmol), quinidine, and calcium channel blockers (verapamil (Calan), diltiazem (Cardizem CD)): These are also heart/blood pressure medications, which would have increased effects if given together with metoprolol. Taking beta-blockers with calcium channel blockers is generally not advised since the combined effects may lead to serious heart problems. If they must be taken together, the dose of one or both medications may need to be reduced and cardiac function should be carefully monitored.
  • ibuprofen (Advil, Motrin): This NSAID could reduce the effectiveness of metoprolol and make you retain sodium and fluid.
  • indomethacin (Indocin): This NSAID could reduce the effectiveness of metoprolol and make you retain sodium and fluid.
  • insulin: Adding a beta-blocker such as metoprolol to the diabetes injection insulin can increase the risk of low blood sugar and make it harder to detect.
  • ketorolac (Toradol): This NSAID could reduce the effectiveness of metoprolol and make you retain sodium and fluid.
  • meloxicam (Mobic): This NSAID could reduce the effectiveness of metoprolol and make you retain sodium and fluid.
  • naproxen (Aleve, Naprosyn): This NSAID could reduce the effectiveness of metoprolol and make you retain sodium and fluid.
  • propylthiouracil or methimazole (Tapazole): Beta-blockers may make treatment of thyroid disorders more complicated. Your physician will need to monitor such conditions closely.
  • saquinavir (Invirase): The combination can increase the risk of irregular heart rhythms.
  • sulindac (Clinoril): This NSAID could reduce the effectiveness of metoprolol and make you retain sodium and fluid.

Not every drug interaction could be listed here. Do not start any new medications or make changes to your treatment without first consulting your prescribing physician.


1. Lindholm, L. H., et al. “Should Beta-Blockers Remain First Choice in the Treatment of Primary Hypertension? A Meta-Analysis.” Lancet 2005; 366:1545-1553.

2. Kaplan, N.M., and Opie, L.H. “Controversies in Hypertension.” Lancet 2006; 367:168-176.

3. Beevers, D.G. “The End of Beta-Blockers for Uncomplicated Hypertension?” Lancet 2005; 366:1510-1512.

Be certain to consult a physician about your health, especially with regard to any signs or symptoms that may require diagnosis or medical attention. Information provided is not a substitute for the medical advice or care of a physician or other health care professional.

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About the Author
Joe Graedon is a pharmacologist who has dedicated his career to making drug information understandable to consumers. His best-selling book, The People’s Pharmacy, was published in 1976 and led to a syndicated newspaper column, syndicated public radio show and web site. In 2006, Long Island University awarded him an honorary doctorate as “one of the country's leading drug experts for the consumer.” .
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its been 12 days since my last dose of the metoprolol. I refuse to endure another single day of lack of energy, the headaches etc. It’s been 5 month’s since my 100% left artery blockage. My other meds are doing just fine. That crap will not be missed. Big pharma likes to scare us into buying that crap. Live on your own terms, not theirs.

Did anybody experience hair loss?

So my doctor I went to see after being on Metoprolol Succinate ER 25 mg for several years said that I can come off of them. I was told to monitor my progress and at first not told that I should wean off the medication. I knew that I should be weaned off of it based on what I’ve researched. I went to see him but ended up speaking with the Physican Assistant. I told her about how cold my hands and feet were and also of a drop in overall body temp. I wanted to tell her that I thought it could be an adverse side effect of the Metoprolol. She agreed but wanted to check with the Dr since my blood pressure reading was good. He basically said I should come off. He told her I was on so little that it I could just stop. I pretty told her that was not right and she said to try 1 every other day for a week and then half every other day for the following week. I did my own research and just been taking half for about a week now. I didn’t think I should skip days but wondering where to go next. Should I be halfing the half and take that for a week and stop? I was wondering if anyone could offer advise, the dr’s and a pharmacist I also spoke with, didn’t really give me a proper direction to take.

Just to balance these comments, I’ve been taking Metoprolol Succinate at 100mg / day for about two years and have not suffered any ill-effects at all, so it doesn’t affect everyone badly. I was put on Metoprolol as a preventative measure after years of hypertension and a Myocardial Infarction (heart attack), and it’s controlling my blood pressure perfectly.

One day recently I missed a single dose, and late that same day I had quite severe angina (the first in over a year) and had to use my GTN (Nitrolingual) spray twice to ease it off. So, I won’t be stopping my Metoprolol anytime soon.

So, just because the people who report problems with a drug seem to be in the majority here doesn’t mean that it causes problems for everyone.

Metoprolol makes me sluggish, sleepy and depressed.

I had been on Metoprolol for a while and started having orthostatic hypotension. My doctor changed me to a different drug combination. I started having extreme muscle weakness. I checked with 3 doctors: it is a group setting, and they all said it was not my meds.

After 18+ months with this major problem, I did my research on my meds. Of the 12 I was on, for hypertension, depression, fluid retention, and high cholesterol, 8 caused muscle fatigue. I dropped the 8 drugs. Within 4 days the muscle fatigue disappeared. I refused to take these 8, and the doctor had to replace the hypertension drugs. I am now doing serious research on all the drugs I take and have serious input on what I take. I print out info and recommendations on my anti-hypertension drugs. We as patients have rights, and one is to refuse our meds if they are doing us more harm than good, and if the side effects are worse or more detrimental than the doctor alludes to. Have the doctor prescribe something else. If he refuses, then change doctors. They are working for you, the patient.

I had the same problem after taking for almost one year, and I ended up tearing my acl in my knee when I climbed on my ladder because my legs had gotten so weak. I also had issues with very cold hands and feet. Now for some reason my BP has gone crazy again, and they handed me the same meds after telling them I did not do well on them. I can’t take this again, and it was very hard to wean off of them.

I am reading about the experiences with metropolol. My husband has been on high doses of bisoprolol and of metropolol over the past 8 months. The doctor prescribes extended release form and then tell him to take it twice a day. An 80-yer old man does not clear the drugs efficiently from his system, one pharmacist said that for him a 12-hour half-life could well be 18 hours. And yet, he gets another dose fed to him before the first dose is even half-way cleared from his body, on and on, every day, day after day — the drug builds up and up in his body.

He first got confused, then constipation one day, diarrhea the next day, his belly put on flab, then the rash started, a horrible bright red supporating rash, with broken blisters, the palms of his hands became like leather, his finger tips lost all feeling, and split open, then he developed tremors of his hands and feet/lower legs, then most recent thing to happen, swelling. At first his right hand was swollen, that extended to his forearm, then that subsided, then his feet, then his lower legs. Along the way, I read Dr. Sinatra’s The Sinatra Solution, and I began giving him some l-carnitine, and some ubiquinol — had been giving him some magnesium in the powder drink form for several years. Meanwhile, the doctor who prescribed this stuff to an eighty year old — who I might add is also a polio survivor who ought not be given sedating drugs — did not seem to “get it” that these drugs at these ridiculous doses were destroying our lives.

All this because the man had atrial fibrillation, which led to a lower ejection fraction. And yet, why start at the highest possible dose even for a man half his age? And why ignore the clinical literature that shows good results for both atrial fibrillation and for heart failure from nutriceuticals like ubiquinol, l-carnitine, d-ribose and adequate intra cellular magnesium — the latter well known since the 1940’s? Joyce’s comment that the doctors do not know anything about the drugs is accurate — my daughter who went to vet school to become a horse doctor had several semesters of pharmacology, and had to learn the mechanism of action of every drug they were likely to utilize for the animals. Her sister, who went to medical school and became a family physician, said — “we did not have to learn the mechanism of action, only when to give the drug.” The pharmaceuticalization of our so-called medical “care” system is criminal, in my opinion. But who am I? However why don’t the powers that be pay attention to the physicians with decades of experience and good credentials like Marcia Angell, John Abramson, Jerome Kassirer, and Jay S. Cohen who have written extensively on exactly this topic?

I’m not even sure why my doctor chose metoprolol as my only problem was moderate BP and a somewhat fast heartbeat (which I’ve had as long as I can remember) . He put me on 100mg of the extended release one a day–Why such a high dose to start? I recently found out this drug can affect cholesterol and blood glucose levels and does not mix well with thyroid meds. I told my new doctor I was concerned and she prescribed Bystolic 5mg. This med costs over $123.00– per month! It is also a beta-blocker with many of the same side effects. I can’t afford it and I certainly don’t want the same side effects I’m trying to get away from. Doctors don’t seem to know much about the drugs they give us. I’m losing confidence in our medical care system. I’m a 71 yr. old female.

I am having diarrhea issues and also bladder infections and bladder urgency issues with no infection as well as urine retention and incontinence if I bend over. I do have aches and pains and a feeling of fullness when I eat as well as sometimes feeling nauseaus and having trouble sleeping. Loss of appetite and gained 5 pounds in 2 months. Going to a urologist Monday to see if I have an inflamed bladder but really thinking it may be the metoprolol. This is my last hope to take BP meds as I have had issues with every other ones I have taken. But, I cannot put up with these issues anymore. I will speak with my doc to let him know that I am going to wean myself off this med. I have been on it about 6 months and been very tired and no energy and that’s not me.

I have been taking metoprolol ER for 3 weeks. The side effects were awful. My doctor originally wanted me to start of with a day and then changed to 1/2 2x a day. I also take Amiodarone. The side effects were still too much to bear, esp. the headaches.

So I have just began taking 12.5 mg 1/2 hour after I take my Amiodarone. Is this working for anyone? I was afraid to reduce it but I have. Feel better in the morning but this is day one.

This is one BP med I will never take again metaproplo is horrible
I had weakness in my legs after about 7 months on this drug.
I tore my ACL in my knee I really think that this drug weakened my leg muscles and cause my knee injury.
I started to ease off the meds slowly finally got off but it had such a drug addicted effect not good finally went away after 11 days of hell .

I take 12.5 mg ( 1/2 tablet) / day. It took me close to 4 weeks to adapt to this med- I had a very hard time with nausea, fatigue, dizziness, pretty extreme, I barely left the house. Then after about 3- 4 weeks all those side effects went away. It works very well for me- blood pressure averages 107/ 67, heart rate 60. I think it’s key to drink lots of water- a full glass when you take it & plenty more throughout the day.

My best friend was prescribed the metoprolol and he went from an active 77yo person to a totally inactive person in a matter of weeks. Granted it lowered his blood pressure but now he has no desire to do anything and sleeps all the time and is depressed over the whole situation. The side effects are not worth it. I’m seeing online that Bystolic has a lot fewer side effects and people say it changed their lives after being stuck on metoprolol. It’s not generic and is more expensive but the reviews say it’s worth it. We’re waiting for his nephrologist to make the change in his meds so he can start to enjoy life again. Metoprolol is bad news!

For whoever might find this relevant, I was diagnosed with chronic lone atrial fibrillation more than a decade ago and have been on metoprolol tartrate and a blood thinner (now Pradax) ever since. Everything under control – my pulse reads 61 according to my Fitbit – and I diligently take my meds (I’m 72). However, if I forget to take the metoprolol in the morning, anxiety, irritability, and even expressions of anger show through by early afternoon (at 25mg. twice a day) and my wife quickly sees it. On the other hand, I have more physical and mental energy when I forget my meds. The cardiologist had me back on the holter monitor for a couple of days and we meet again in a couple of weeks to discuss the result and a more optimal calibration of the metoprolol dosage.
Oh, Chantix and metoprolol did not mix well.

I’ve been on it about three weeks now after ablation for tachycardia and ICD placement. I’ve had two or three episodes while on the medication I used to tach at high as 260 but the last previous episodes were no higher than 126 so I guess it’s working either that or the ablation. However I believe the ablation make the episodes more frequent the. Prior to the ablation. But I feel a lot of palpitations now. Other forums say that’s normal after any heart surgery for at least three months so time will tell right !!!

I was put on monitor box and it recorded some heart blips. I do not have high blood pressure or feel the blips. I passed the stress test but there was some irregularity on one side of the heart. Cardiologist put me on metropolol tartrate 25mg .
I got vertigo was changed to one pill in half twice day. Do not have high blood pressure. I am 78. Very active person. I want off this med. Now I feel dizzy, off balance, constipated can’t sleep gained 5 lb in 3 months. How do I get off it? I am afraid to stop it. This generic med cost $1.65 for 30 days. I wonder where it is coming from. My insurance does not cover it at all. It is my body and I don’t want to take this. Am I being stupid?

No you are not stupid I’m on this after heart surgery. I’m like you to many side effects I just want to feel normal I’m asking to get off them too

Please talk with your doctor about discontinuing. It should not be done suddenly.

which is good? propranolol or metoral?

thanks for your data

how long does side effects last when just getting on metropolol?

I take metoprolol er succinate 25mgs. twice a heart rate is in a normal range sometimes and other times anywhere between not know what to do about this,doctor will not adjust my meds.

I was prescribed metoprolol 50mg for my supraventricular tachycardia and it makes me SOOOO sleepy. I am so exhausted and tired all of the time. I can’t even think straight because I’m so tired and my brain is just so fuzzy from the meds. It does help my heart flutters quite a bit but the side effects are just too much to handle.

I know your post is from a few years back but if you see this reply can you let me know if you were put on an alternative medication. I am having the exact experience now. Was diagnosed with SVT and prescribed this med but the side effects are horrible. I am in college and it’s really interfering with my studies and life in general. If you could share from your experience I would appreciate it. Thank you

I’ve been having panic attacks and anxiety. Went to the doctor and he prescribed me Prozac and that made it worse. I stopped taking it after 2 weeks! Was sent to cardiologists and had a sonogram and stress test. He said my heart is good but my heartbeat is too high. He prescribed me motpolol tratrat 25mg take half in morning and half in evening. It’s been almost 2 weeks on it and I can barely breath and my chest hurts. The last 2 days I have cut them in quarters and take one quarter in morning and one at night. Hoping the side effects wouldn’t Be so bad. Has not helped! Called the dr and waiting on him to call me back. Can I just stop taking them after only being 2 weeks on them? I can’t go everyday not catching my breath and my chest hurting.

I forgot to mention, this is the best article I was able to find that really told me everything I was asking about metoprolol. Thank you SO much!

I meant metoprolol

My dr put me on Metoprolol, low dose, for atrial fib. I have a bovine aortic valve & pacemaker, & one blockage. I had extreme fatigue to the point I would cry because I had to get out of bed. I finally just stayed in bed for about 3 weeks & could not function because I was so tired. I came off and still have fatigue but not like /w the toporol. It did my 90 yr old Mother the same way.

I’m 77 and this was 3 yrs ago. My valve will be 11 yrs old in July 2015 & functions well. There are just some meds we have to say NO to! We know our bodies better than the Dr’s & just have to let them know what’s going on.

My drs also try to make me take cholesterol lowering drugs but after one day, my legs & muscles ache & I can’t take… My cholesterol has been 240 since I was 22 yrs old!!

When I first started Metoprolol and Lisinopril, I was not told to take them separately. I took them together at night. As a result, my heartbeat was so loud that I could not lie on my side to sleep. On my own, I decided to separate the two – one in the A.M. and one in the P.M. (Lisinopril in the P.M.) and the loud beating STOPPED. Be your own advocate.

I was prescribed metoporol extended release following heart bypass surgery several months ago. The cardiologist said that despite some problems from propanorol taken long ago for migraines, it would be safe. I asked for the lowest dose possible and got it reduced from 50mg to 25mgXL.

Disclaimer – As I also take a half dose of plavix (37.5mg), aspirin 81mg, atorvastatin 10mg, and so forth, I could not attribute any side effects from metoporol with certainty.

I do have somewhat of a runny nose, cold extremities, and a low pulse, none of which impede my daily activities. And like I said, for myself or anyone else on multiple substances, we react in individual ways. But after over 6 months on this stuff, I don’t have any side effects that reduce the quality of my life.

Just returned from 5.5 mile jog, trim and fit with lots of energy. In fact, I have been trying without success to gain weight, but no matter what I do, the needle is stuck.

My plan is to get off the metoporol and atorvastatin by the 2nd year post surgery. I was already told I could stop taking plavix. Male in early 60s in excellent health.

Was taking moexpril and metoprolol from 2005 to 2012. Started gaining weight in 2008. Had a major hemorrhage stroke in 2012; they all are major. When I started in 2000 on zesteril, my starting BP was 131 over 90. No telling what BP was when I had the stroke. Took half a maxifed with the BP medicine and woke up a month later more dead than alive.
I was a very strong person also as in power and strength. All of that is gone with a lot more now. Still take metoprolol and lispronil with ampoldine bysilate. The key information to remember is that the doctors may know less than the patients or the internet. Beware or suffer my fate. The only benefit of the stroke was the incredibly strange trip that went on for about six or seven weeks. Beyond imagination or belief.

I am having trouble with constipation since going on METOPROLOL ER SUCCINATE 25MG . What do you suggest?

Nancy.. try something natural.. prune juice it works

The doctor put me on this med in the hospital and was taking 2 months after. I stopped my meds as I got a back back ache and constipation which I think were from Lipitor and Plavix. Somewhere along the line I stopped the Metoprolol too. I called the doctor about the back ache and had to wait 2 months to see him. All this time I was not on any of the meds. When I finally saw the doc, he had a fit we argued about it and finally he refused to be my doctor.

My new doctor put me on Metoprolol 50 mg and after 1 day I was dizzy and had breathing problems. Now I also have bad insomnia. All the nurse would say is keep taking the med and drink lots of water, then call back in a week. Frankly I have no inkling to take the med anymore. Somewhere somehow I also developed driving phobias.

Whats frustrating is neither doctor was willing to try a different med. They seem to be adamant that metoprolol is the right one and too bad so sad for me. Looks like the second doctor is going to be dropped too.

Hi I’ve been experiencing the same thing. I recently got off metoprolol and ever since then I’ve been super anxious. It’s been about 5 days. And I can’t stand it. How long do you have the anxiousness?

How did you stop? I was on 25 mg, I have cut down 1/2, then again to 6.25 mg,/day extended release. After 2weeks, still have elevated press/ pulse at times… I started taking metoprolol 5 months ago…thks

Two to three months to getback to normal.

Doctors give you meds based on which big pharma is giving them money or some type of perks…..that is why they do it…find another doctor until you get one who listens and will either put you on a med that works for you and you are happy with or seeks a doctor to help you lower your pressure without. Sometimes this means going to a naturepath….who is not a MD. Don’t give up. you have a right to your health…the doctor is paid the bigs buck to take great care of you …don’t accept one who does not…

I’m recently taking 150 MG Metroprolol succinate every day. It doesn’t work effectively. My heart rate is good in 60 but sometimes my BP get high with no reason. I started with 25 MG then to 50 mg then to 100 and now 150 mg. It’s early in the morning (4:30 am) I woke up with pounding heart beat my Bp is 182/105 heart rate 92. I have no side effect with this medication, and I’ve been taking it for around 2 months. I can’t wait to make appointment with my doctor this morning and change to another medication.

I think you may be on too much at 150mg. I was on 100, then 50 then 25 then 12.5…. Now off and just on Lisiniprol and feel great. Been very anxious and up tight since getting off the metroprolol. Takes two or three months to get right when getting off. Body not use to normal heartrate I think.

I was on 25mg of Metoprolol twice a day for about 2 months. My doctor told me to stop them cold turkey, as I wasn’t on them for very long in the first place. I decided to do a short wean process (about five days) and have been off them mostly for about two weeks now. I have been incredibly anxious since then, and have had at least two episodes of tachycardia (once at about 120 bpm, another nearing 140). I am curious how long these effects will last, and if I should just go back on the pill? I’ve been reading that getting off of these pills can be dangerous, and I don’t know if I have passed that window of danger or not.

I was given metoprolol when I went into the ER 3 weeks ago with heart rate bouncing between 130-190, arrythmia, etc. due to thyroiditis. The drug seemed to do next to nothing as they pumped it into me for six hours. They changed to some other beta blocker after that and it went right down to 105, very steady, then 84 by the next morning. I’m now taking carvedilol but don’t like ANY drugs so I’m taking it less often and in half-tablets rather than what they have prescribed. I feel better when I take less.
People’s Pharmacy response: Make sure your doctor knows exactly what you are doing and why.

My Doc started me on Metoprolol Succinate ER to treat premature ventricular contractions. I’ve had these for 20-30 years and he said that if they became troublesome then we would do something. Well, in Feb. of this year I started experiencing 10-12 episodes a day and he put a Holter Monitor on me which showed in 24 hrs. that I had 12 episodes.
He started me @ 25 mg a day. After a few days I was having about 30 episodes a day so he increased the dose to 50 mg a day. After a couple of days I had to go see him as I was now getting about 60-80 episodes a day and while he was taking my pulse he felt three episodes in a matter of a few minutes. So he then said to continue the 50 mg in the AM and take another 25 mg in the PM.
After a few days I began having continuous episodes a day and when I called him he seemed to either not believe me or thought this was impossible. Today I saw a cardiologist and he seemed to not believe this was possible, yet while I was there I had over a dozen episodes. The unbelievable part was that he suggested I increase the dose!!
I told him I was going to decrease the dose and he said OK and see what happens. If I had known about the possibility of sudden death from quitting this med I would never had started on it, but there was nothing with the med and the doc said nothing. The last few months have been pure misery.

Metprolol Tartrate 50mg [Generic} prescribed for abdominal aortic aneurism in April, 2014 dosing is one 50mg tablet BID [twice per day]. This medication causes various side effects but most concerning was the scalp itching and hair loss never before experienced with any other medications though none for High Blood Pressure. Hair loss or medical term is “ALOPECIA”.
Hair loss became evident about one week of being on the medication and leaving short hair strands everywhere and major loss upon combing with wide tooth comb. Although this is considered as less severe, to those who have fine hair this can be catastrophic for a woman. Beware always of medications prescribed and always look up the side effects so you are aware of what to look for in you medications and how to address the problem you are experiencing.

@FDK you made some excellent points about generics!!!
We know generics can be very different from the main drug in how they react in out body…mostly from experience.
But one little molecule difference can make all the difference and that can make it literally a DIFFERENT drug that should be tested as well.
Why are Generics ANY different from the original? What standards do they use to get it exactly like the original?
I had this experience years ago getting some dental work done and got prescribed Lortab for pain. It was expensive so they switched me to a generic and the difference was substantial. I have experienced it with BP meds and with Lorazepam generics…several that all worked different. All from different drug stores.
To me it would seem that any change needs to be tested as the effects could be life threatening.
UPDATE. I finally finished getting off Metpoprolol last week and am finally starting to feel bits of my old self come back. What a two month journey of hell getting off of them. Anxiety and panic…and lots of heart Palpitations!!! Now a week later they are almost gone…Thanks God!
I went to my Dr. a few days ago and told him and he almost let me go as a patient….he said in 25 years he never had anyone have side effects or withdrawals besides being tired. He basically said it was all in my head and supplements cause heavy metal poisoning. Amazing that he can discount my experience and others here who are having almost identical symptoms.

I have been reading with interest all the comments on side effects from generics. My personal experience has been with generics of LOPRESSOR. The generic of Lopressor is metoprolol tartrate. My insurance company also pushed me into generics. Some worked, some did not. The big problem is that when you run out of your prescription (one that worked) and go to refill it, you most likely will get a different generic by another company. Every time you refill your prescription, you worry if you are going to have bad side effects. After a few years of generics of Lopressor and many trips to the doctor and hospital, my physician put me on LOPRESSOR (no substitutions). Since that time I have not had any problems with side effects. I take this medication mainly for atrial fibrillation and blood pressure. I, like many others, tried other medications (since 1995)e.g. calcium channel blockers, anti-arrhythmia drugs, etc. The only one that has worked and improved my condition is LOPRESSOR (name brand).
The Company that used to manufacture LOPRESSOR was Novartis. They sold off the rights to LOPRESSOR a couple of years ago. The Company that bought the rights is Validus Pharmaceutical located in Parsippany, New Jersey. They are ready to release LOPRESSOR again after a much delayed start-up of production because of strict regulations in manufacturing. I personally have had a very difficult time in filling my prescriptions in the last year because there is so little, if any, remaining inventory of LOPRESSOR. I am counting the days when I will be able to have my prescription filled with no worries. I will not take a generic for LOPRESSOR because of past history of ineffective or even dangerous substitutions. I can buy a 90 day supply of the generic for about $10. However, I gladly pay $120 with my prescription plan for the NAME BRAND LOPRESSOR.
When you have a medication like LOPRESSOR that treats a myriad of serious conditions, generic drugs should NOT be substituted. If quality control is so important with a name brand medicine, why are companies allowed to make the generic drug without the strict guidelines? The heart and lungs are nothing to fool around with. Insurance companies pressure you to take the generics and make it difficult to take a name brand (Doctor must fill out a form and answer questions as to why you should take the name brand. The doctor must fill out this form every year or you will not be ALLOWED to get your name brand medicine. Then the form goes to someone at the insurance company for review.) This is outrageous! Who are they to tell your doctor what medicine is best for your treatment?
By the way, Toprol XL, is the same medicine as LOPRESSOR but it is a time released version. Anyone having problems with Toprol XL may be having an issue with the ingredients that make it an extended release product.

Get another doctor…your doctor is a quack and has disrespected you to boot…you are paying his bill. Find a doctor who cares about your opinion and what you are feeling….never allow a doctor to care for you that does not! This is horrible medicine. Recent recall in 2014.

Hey JR !
I will say it is funny how Dr. will NOT talk about this. That includes the two Dr.s I presently have and two personal friends that are Dr.s. One is one of the best Dr.s in the country in his area… but I have one heck of a time getting him to talk about getting off these meds…. and trust me we talk about much deeper stuff that I would be more worried about with no issue. So there is something they are afraid of.
I have gone.
Next I have gone from 100 mg (50mg x2) down to 12.5 mg once a day in the AM. It has been a scary trip with lots of anxiety and panic..mainly based on the palpitations. They seem to trigger all kinds of other worries in me.
I would recommend you read about palpitations… it did ease my mind a bit.
I notice a lorazepam can settle them down… but watch on taking too many of these or for too long as you can become dependent quickly. Talk to your Dr. about it if you can.
Breathing and meditation can for sure help if you can settle down enough to do it.
And keep your nutrition clean!!! I noticed the side effects and palpitations became much worse when I ate junk foods with lots of bad oil fats. Try to juice and eat veggies as much as possible over your withdrawal time. Your heart will appreciate it especially in withdrawals.
At 12.5 I am feeling comfortable enough to jump off completely soon. I may try 6mg for a few days then get off it. It has taken me 6 weeks+ to get to this point. So those on a higher dose please take it slow even though you may want to go fast. The fast way is very unpleasant …and from what I have read under certain circumstances it can kill. So please be careful and good luck.
The biggest reward for me so far is that recently I have got my thinking back to a level I can produce again. I do creative work and the whole 7 months I have been on these drugs I have been a zombie when it comes to creating and work. Time to build our savings up again as I have no insurance…nor my wife and kids anymore since Obama-care had tripled our rates in a time of need and we had to give it up to pay the bills.
Good luck!

After one year taking 12.5mg of Toprol XL once a day as a preventive medication, there are other factors, but I’m going to be one of the people who stop it cold because none of my doctors will address the problems. Not when first taking it, and not now. Wish me luck, and better doctors for all who need them.

After 5 years of taking metoprolol for HP I didn’t have any problems, then suddenly I was had severe leg and back pain and other serious issues, this all took place after I had changed over to mail order after my HMO suggested I do that. Not all generic brands are good, and some are dangerous. I stopped the mail order pharmaceuticals and stopped metorprolol, and I recovered. It may be safer to take the brand name and stay away from generic brands. There is no government oversight for labs that produce these generic products. The brand names are expensive, however may be the better method. Your doctors could prescribe a different type of med. There are others.

I was prescribed metoprolol succinate for irregular heart rhythm (pvc’s every 30 seconds or so for the past 6 months). Only 25mg extended release. Took two weeks to work, but then pvcs reduced by more than 90%. Worked great for me! I’m back to normal with no side effects. What a relief!

My mother went to her Primary Care Physician back in January and he discovered her pulse was skipping, so he sent her to a cardiologist, who then did a stress test (came back normal), tests for CHF (also came back normal), but he put her on Metoprolol anyway to get her heart rhythm back to normal.
Since then, her legs and feet have swollen to 3-4 times their size, to the point where she can barely walk or get her shoes on, and is in pain from the tissues in her legs being so swollen. She also developed a mucus-producing, constant cough (her PCP has ruled out every respiratory condition and has no answer), and also has wheezing and shortness of breath. About a month and a half after starting Metoprolol, she ended up in the ER with a rash on her swollen legs, and on her back – the ER had no answers for that, either. When she brought up all of this to her PCP, and the cardiologist, both of them refused to believe it was the Metoprolol, despite it being her only new/different medication, and will not let her stop taking it or switch it to something else.
Two weeks ago, she stopped taking it (without my knowledge – I know it’s dangerous), and told me that after a week, all of her symptoms started to go away. She started taking it again when I told her how dangerous it was to stop, and the side effects all returned. Now we’re convinced it’s the Metoprolol, but don’t know what to do since her doctors refused to let her stop taking it. She’s exhausted and depressed from the pain, swelling, constant coughing and shortness of breath and has basically just given up.

I feel better taking half (25 mg once a day)–but asked my doctor first. Also, taking it at night when I’m home. I don’t know how that will feel when I go out somewhere at night. I also take .250 mg digoxin for heart failure and systolic atrial fibrillation.

I have been on Metoprolol-l25 mg x2 daily for two years always have had some diarrhea, lately it has gotten bad has any one else had this problem.

I have diarrhea on metoprolol 25mg twice a day. Going to wean myself off it as I also have bladder issues, dizziness at times and my stomach hurts. I started taking it 6 months ago.

Ask your doctor about the brand name Toprol XL. You may get less side effects.
The Mfg is AstraZeneca. Good Luck

My Dr took me off of 50 mg of metroplol ER to 25mg twice a day tart rate and i feel bad. Is it safe to half the night dose of tart rate ? Has anyone successfully stopped this medication? I was doing good for years on the succinate until i had parathyroid surgery in March and now my meds stopped working. i am also on 10 mg lisonopril and recently hydrochlrothiazide was added because of spikes in my bp.

I recently was diagnosed with Hasimoto’s after 5 months on this drug. Just crossed over the line. Not sure if this drug caused it but it has been hell since I have been on it.
I asked my NEW Dr. if I should get off the BP meds to determine what I am like without them since I have so many side effects. I want to know the difference between what is side effect and what is really wrong with me. He said stay on it while I get off of gluten as he thought it might be gluten causing symptoms.
Been off of gluten for 3 weeks now and anxiety is worse. I think most of my issues beside high BP is from side effects from Metoprolol.

What a horror story to try and lower my Blood Pressure!
Had really high BP last November 2013. Dr. immediately put me on three BP drugs and thank goodness Lorazepam of which I am not sure I would have survived without
Metaprolol, Benazepril, Amlodapine and I was a zombie for the last 6 months. Couldn’t work and ate our savings up as I had no insurance and because of this we have lost out kids and my wife’s Insurance as well as we can no longer afford it along with our business insurance amongst other things.
A little over a month ago I decided to get off the amlodapine fist as it seemed to have the worst side effects. Found a site in UK that confirmed this with over 800 patient comments, some saying it was the devil’s drug. I took two weeks to wean off of it and had some minor heart palpitations.
Part of my thinking came back. So a week later I decided to get off Benazapril over two weeks. No issues here… but a month later I was having severe anxiety. A kind I have never had before and boy was it scary. numb face…eyes burning…internal shakes bad but rarely manifested externally. I couldn’t believe as bad as I shake inside it wasn’t showing outside..weird. I would feel frozen and like I couldn’t move or speak. I would take a lorazepam and in an hour or so I would smooth out and usually be ok for the rest of the day. But I was constantly worried as I never knew when these attacks would hit …and hit hard they did.
I was doing some research on something and saw a article attached that said something about ACE inhibitors(Benazipril) helping with the anxiety from metaprolol. Reading that was like a holy grail. It said something to the effect that when Metaprolol slows things down the adrenals then send a signal to adrenals to pump it way up… and it can cause overwhelming anxiety…and the ACE inhibitor sends a signal to the adrenals not to pump it up.
So now I know why when I was weaning off of metaprolol (2x50mg)to (2×37.5mg) ( yes I cut the pill into a half and 1/4)the anxiety got worse after metaprolol started to wear off
So I started Benazapril again at half a dose first thing in the morning (as the night metaprolol pill had worn off) and before the morning metaprolol pill two hours later. It seemed to help. Also taking the Lorazepam with it in AM seems to be getting me through the day for now until I can get off these horrible pills. This morning the heart would startle me awake several times and I would feel the internal shaking on my right side and it would go across my body to my left side like it was passing through me from side to side. When I was at the dentist’s office in February getting a filling done…the numbing agent wore off really fast. The dentist couldn’t believe it so he put really strong stuff all over in my mouth (big needle) it too wore off fast and I could feel the drill on the nerve as I wasn’t numb at all. My body started shaking horribly from my feet to my shoulders and then back to my feet. He was really worried and so was I.
Funny thing was my head was fairly level but my body was trembling unbelievably. My rear end hurt for days after from the trembling. I wonder if that was from the meds as I didn’t take the morning pill and was still going on the pill the night before. I wonder if it screwed something up with the meds after that experience because the anxiety got worse with other symptoms. The visual disturbances are particularly frightening.
Wondering if anyone has any ideas on how quick I CAN get off the 2x 37.5 at a safe rate. I figured a quarter a pill a week???
I want my life back…a.any help is well appreciated
PS I have had most of these symptoms by other posters. The anxiety and zombie brain fog are the worst. I am 54 years old

Hi there, I realise your post is a few years old, but many people have success getting of their meds by adhering to a whole-food, plant-based diet.

Yes, I do know what causes your hair loss. This drug directly interferes with thyroid hormones. Low thyroid hormones make you lose hair. Free-T4 thyroid hormone does not convert correctly into free-T3 thyroid hormone with this drug. Your doctor may say you are in the range for TSH test. Tell your doctor you want to be in the top 1/3 of the range on the Free-T4 and Free-T3 tests. Most doctors are clueless about these tests. So maybe an easier way would be to tell your doctor “Get me another heart drug that is not in the beta-blocker category. Beta-blockers commonly cause these problems.

I am a 22 year old female, been taking Metoprolol (25mg, 2x/day) for about a month. My doctor prescribed this because I have a very fast heart rate. My blood pressure is normal (sometimes even low) and I am not overweight. Since taking the medication I have been noticing a lot of random side effects- my left arm feels weaker, often goes numb at night, more muscle pains, lethargy, still get a lot of chest pains and irregular heartbeats. It seems that the medication is not helping anything other than the fast heart rate, although I feel “better” (due to slower heart) at the same time I feel worse because of all the other new symptoms. I don’t want to be stuck on this medication, I would be so happy if I could find something that could control my heart rate without the other side effects that often make me feel miserable.

can you develop an allergic reaction in the form of raised swollen bumps ranging in size clusters to size of a quarter on your body and can include your face, such as lower eye lid, lips, cheek, torso from metoprol er succinate 50mg tabs after taking it successfully for a couple of years? WHAT should you do?

you should not take any medications with grapefruit.
People’s Pharmacy response: There are a number of medications that can interact with grapefruit, but in most cases there are alternatives that do not interact.

I’ve been on metoprolol 25mg 1x daily for a little over a week now. The only side effects I’m having is itchy skin and short of breath sometimes. On the plus side though, my BP is 130/80-85 and it has helped with my anxiety. My question to Peoples Pharmacy is, are itchy skin and short of breath a common side effect? I went and seen the Doc after taking it 5 days and told him about the shortness of breath, but he didn’t seem to worried about it, so should I be?

II have been taking mmetopolol for years, and 5 months ago I broke out all over my body in the raised rash as you decribed. It was very itchy. A dermatologist finally took a plug from my skin and found I was allergic to both metopolol and the diuretics. I was taking. In the last week ,I have tried 2 new bp meds and both make me feel like a zombie and the one I’m on now brings my pressure too low. I’ll be be glad to find something to work.

Metoprolol should generally not be given to people with asthma or COPD. While metoprolol may dilate the blood vessels and lower blood pressure, it causes the bronchial tubes to constrict, leading to shortness of breath and aggravation of asthma and COPD.
I got serious troubled breathing, anxiety, fast heart beat, throbbing, insomnia, crying only 4 days after starting for palpitations at 12.5mg 2x/day. I quit cold turkey after day 6. Did not have any worse effects after stopping than I did while taking it.

Some people get a reaction to Metoprolol which is the generic form of Toprol XL. Toprol XL is the brand name and costs a little more but it may be worth it. AstraZeneca is the mfg. of Toprol XL. See if he will switch her and try it for a few weeks. You may see some improvement. It’s great that you are taking care of your mom. She is fortunate to have someone like you.

I am inquiring about metoprolol. My 85 year old mother is on this medication. It is 25mg daily. She went off this and was put on bisoprolol. Didn’t make much difference. The Dr. took her off both and monitored her heart rate. Her heart rate was a little ll4-117. Dr. put her back on metoprolol. She is feeling ill.
Symptoms include: nausea, spitting up after she eats, pains in stomach, wants to sleep most of the time, having trouble sleeping at night, numbness in feet, no energy. She is also taking benazepril for BP, warfarin, furosemide, potassium, and 25 mg of metoprolol. She also has been prescribed Xanax to help her sleep.
Do you have any suggestions? She can’t go on like this. My heart is aching for her. She also has copd and congestive heart failure. She had a set back and went to hospital for heart failure, that’s when they put her on the metoprolol. She says that she never felt the same since she’s been taking it. Any answers would be greatly appreciated. She is also on oxygen 24/7.

I am no a doctor but sounds to me like you are having Panic attacks. I would seek another doctor opinion. ASAP

It’s a bit scary reading some of the side effects you can get with taking metoprolol Tarta 50 mg (I’ve only been taking it for a week for a prescribed 2 week period.) I’ve been going through some episodes of rapid heart beats followed by dizziness. These episodes would happen at work more often than not, and I put in a demanding 10-12 hour day in a stressful environment… same occupation for over 30 years, and more physical than mental.
I’ve always been a bit hyper and anxious my entire life, and for me, I only feel a little lightheaded after taking it. It doesn’t slow down my physical activity throughout the day, and I feel a lot less anxious and irritated. I’m also sleeping great at night. Sometimes my heart felt like it would pound through my chest when I would get irritated, but I have since felt totally relaxed in the same environment. So far so good, but I wonder if it will last…?

My doctor put me on generic Toprol-XL 25mg last month. I was on it 3 weeks before I decided to stop taking it. It made me super tired, gave me body aches, & my bp became higher than when I was first prescribed it. My bp still hasn’t gone down, even though I’ve been using a different medication for a week now. Pre generic Toprol-XL bp was: 150/98, after my bp has been consistently around 200/119 with exercise and healthy eating habits. That stuff should be recalled.

can I take aspirin with metoprolol?

Has anyone experienced mouth sores from metoprolol or a combo of it and lisinopril?

On the Mayo Clinic website, it is advised to not drink large amounts of grapefruit juice (>/= 1 liter) while on Metoprolol.

My Doc just ordered generic Toprol-XL for me, but my mail order pharmacy, Express Scripts, supplied the brand-name drug, anyway, saying that it was competitively priced. Perhaps you don’t have to pay for it yourself after all.

JR You should not stop it abruptly. Read the black box warning regarding Metoprolol and Toprol Xl You should taper off gradually. See your doctor regarding this. You can then move on to a different type of prescription.

To DCK: Many people will agree that the Metopropol brand name is a “safer” and better way to go. There are documented issues with generic brands. I was seriously affected by a generic Metoprolol, as soon as I got off this med I improved greatly and quickly. My issue is that I don’t believe that generic brands are safe. There is no oversight on the labs that make these drugs.

Three months taking metorpolol succinate 12.5 mg once a day for some apical sluggishness, possible, but not confirmed, intermittent hypertension, and chest discomfort that was called angina, and noticeable arrhythmia that was non-pathological.
Early severe effects were dizziness, increased arrhythmias, the dramatic dreams, imbalance. Blood pressure was consistently higher.
I began experiencing lower back pain for two weeks, then, almost to the 3-month start date, severe, crippling femur and leg pain, with continued lower back pain. This is the only medication I am taking, and, I’ve stopped it as of tonight, but not without anxiety in doing so, but it is the only way I can rule out correlation between the pain and the medication.

I have been on Toprol XL 100 cut in half (50 mg per day) for about ten years. Before that I tried many other blood pressure drugs. All of these I could not tolerate the side effects mainly feeling drowsy. The side effects I have is feeling colder than normal. Winter months are hard to adjust to living in Michigan.
I have gained about ten pounds while taking this drug. I have tried the generic version of this drug and it caused me to have a bad headache, drowsy and was not as effective in lowering my blood pressure. so I`am back on the brand name drug and have my energy back. The problem is my insurance will not cover this drug. I just purchased a ninety day supply at costco for $199.00. The generic is $48.00.
My doctor said he has other patients with the same complaints and if the brand name drug works that’s what you are going to have to keep taking. So I would tell everybody that the generic metoprolol can cause a lot of side effects that do not exist when taking the brand named drug. Any thoughts on this would be appreciated.

I have been on (50 mg. daily) Metoprolol Er for almost six months. The side effects have gotten worse each month. I have severe vision problems, muscle and joint pain, and severe fatigue.I have SLE and end-stage renal disease, but not on dialysis yet. It has become painful to walk and stand for longer than 10 minutes. I think it is the Metoprolol. My doctor never told me about these side effects. I plan on weaning off this medication. I ‘m worried that weaning off will cause my blood pressure to rise again. I can’t afford this because of my renal problem. Has anyone weaned off and kept their blood pressure under control at the same time?

OMG. I have been on toprol for years after a car accident caused a problem in my heart which caused arrhythmia that eventually would not stop unless I called an ambulance and had my heart reset with another drug. I’m supposed to have ablation surgery, but like most people, am nervous about having the surgery since if they don’t get it just right I might have to have a…there…just forgot the word for it completely…the thing they insert into your body to regulate your heart…see, and that’s the first problem…my memory for words and for things that I’ve misplaced is crazy bad, and getting worse.
I’m not a big eater, and I eat organically mostly and don’t eat sugars or white breads, and yet the less I eat the more weight I put on. That’s how I got here…I just wanted to check and see if one of the side effects of the toprol is weight gain…and sure enough, there it is, damn it. Now, for me, that’s a good reason to get the surgery done. Then I read the other side effects, and lo and behold, I’m feeling faint every now and again, I feel depressed all the time, which is definitely not me.
I’m feeling anxious all the time, and that’s not me. I’m itchy in the last couple of months especially, swelling in my feet, the sex thing, and now shortness of breath with any exertion and I’m tired all the time and have insomnia. Wow…I thought I was just getting older and now find out it is this drug…I have to call my heart doctor and discuss the ablation surgery again.

I am on metoprolol tart 100mg only 2 weeks but that is why I am checking the Internet fatigue is terrible I am a very fit person usually but since having a heart attack in march and having a defibrillator implanted trying the correct formula in drugs makes me feel worse than before I had the attack so any help and advice maybe a different diet could help I’m not sure but I hope someone has advice. I am 62 years old but seem to feel a lot older now.

dp yes calcium does effect metropolol you musnt take it close together. 2 hrs apart is good. it interferes with the absorption of the metropolol and effectiveness of the drug.

To Judy Montanna, I to have had the same problem. My lopressor was changed to metropolol, and I had problems also and ended up in the hospital. I can’t take anything generic without problems. Hopefully I can get back on lopressor soon. I hear another company took over the rights so they will be resuming making it again around oct 2013. Meanwhile I am dealing with lousey generic metropolol which has side effects. like swelling in feet and fatigue. good luck jr

Has anyone had luck with Cardizem (Diltiazem). I’ve been on Metaprolol for years for atrial fib. Each episode they double my dosage and I’m now up to 200 mgs time-release pills. My panic attacks are horrible, arrhythmias and palpitations and my blood pressure is still above 130. I was put on Diltiazem during one episode and felt wonderful. I was full of energy and my blood pressure was stellar although I was still in a-fib for a week afterward. The VA doctor put me back on metaprolol and I’ve been having panic attacks ever since and my blood pressure is back up again.
I want to quit the metaprolol and go back to the Cardizem. Two nurses told me to just do it and stop the metaprolol. My doctor won’t comment but says I shouldn’t stop abruptly. I’m at a loss at what to do. Does anyone has any experience with this?

I’ve been on Metoprolol ER suc 25 mg 1x per day for a month now for pvc’s. It seemed to be working fine until the last couple days, and now I am feeling the pvc’s again. It has lowered my BP and slowed my heart rate, neither of which was really high. I do notice my hair falling out, and I am afraid once I am off my very strict wt-loss diet, I am going to gain a lot of weight like so many on her have complained of.
My question is whether calcium supplements interfere with Metoprolol absorption. I see conflicting statements about it online. I started feeling the pvc’s again when I started taking calcium late at night, right before taking my Met. I thought the calcium would help me fall asleep. Unlike most of you, I have insomnia with this drug.

I was put on Metoprolol Tarta 50mg in Feb ’13 for A-FB….my heart rate was way up before doing a stress test….121/147 …..I did not feel bad and had no chest discomfort. I was given an intravenous injection and my heart settled down in 24 hrs…no hospitalization….I was started on the tablet immediately…..but
The 1st month I gained 15 – 20 pounds…mostly blotted gut….I use to be able to get up and go and do all I want to do is sleep and lay around…no get up and go…..
My heart doctor will not discuss my dosage or this medication….
Are the Docs getting extra pay for this evil drug?
Seeems my eye sight is beginning to be affected now,,,,,I want to cut back to 25mg then get off this mess…..I would prefer taking my “healthy chances” with out this med.
Has anyone stopped taking this med on your own with no problem?

Check with your doctor to see if the brand name would be a better choice for you. He may want you to wean yourself off of the Metoprolol and switch over gradually to the Toprol XL (Mfg. by AstraZeneca). Try to do it over a two week period. For instance take one half of the metoprolol and one half of the Toprol for two weeks. But it is important to see your doctor because some people have different medical situations. Depression or nervousness is a symptom of metoprolol also.
God bless and best of luck to you.

The first day I took Metoprolol tarta 50mg I found I couldn’t stand up getting out of my car. It wasn’t painful just an odd feeling across the back of my knees. This has continued- having difficulty standing. Now that I’ve been on it a year I can barely get around, I have shortness of breath, weakness, joint pain, back ache & can barely walk my dog, it takes my bp down, but I’m wondering if it’s worth it.
I am on an anti-depressant, but I barely find it’s working. I have taken an anti-anxiety since on this drug as I’ve found less and less wanting to go out of house to parties and mingle.

Linda, I started experiencing every single serious side effect with no exceptions last fall after being put on a very low dose of 12.5 mg. for a slightly fast pulse against my better judgment. Then early this year in February I was sent to a Hematologist-Oncologist who was very astute and kept running tests from the bone marrow because my test showed very-low risk Multiple Myeloma, but everyone has some of these cells and he thought it too low. He diagnosed me with Primary AMyloidosis and Four weeks ago I went to Mayo Clinic for confirmation of this diagnosis which was right and started treatment locally three weeks ago with CYBORD which is a predisnone, Cy(chemo) and Velcade (chemo)right under the skin.
This is a very rare disease and there is an AMblydosis Support Group on the internet which helps to learn about this. Mayo and Boston are the two centers which specialize in this with about three hundred doctors at Mayo studying just this. It is rough and affects different organs. I was so convinced that all of my problems were caused by the Metoprolol that I was ready to file a class action suit with some others. I am still not convinced that it did not have something to do with it. I wish you well and hope you have a better result than I did.
Sincerely, Judy P.

Does anyone know if you can still have a heart attack while on metoprolol 100? Or will taking it, daily, as prescribed, will prevent a heart attack?

Metoprolol aka Lopressor, keeps me fatigued, headache everyday, etc., I stopped taking it several years ago after maintaining regular exercise and weight loss I was able to keep my BP in check without BP drugs and felt great. Now my BP has risen along with my weight and I’m back on Lopressor. I’m completely fatigued by 3PM and have a headaches everyday. This isn’t the drug for me. What else is available? I’ve tried Bistolis for 6 weeks as a sample from my Doc, but it’s 3x the $ of Metoprolol, however the side effects seem less severe.

I am a US Veteran and get all my health care from the VA. all of the side effects I have read on this site have been made known to me by my VA doctor. If ANY of you are vets, I suggest you go to your nearest VA hospital. I am on metoprplol tartrate 25mg for high bp and arrhythmia. I am doing well and having NO side effects. I will be having heart surgery later this month to replace a faulty heart valve which my doctors have determined is the initial cause of my high bp and arrhythmia.
As far as your insurance companies wanting you to switch to generic meds, its because they want to make more MONEY and spend less on your health care. Find a doctor with some guts to stand up to the insurance companies.

I can’t understand why the cardiologists still prescribe this unless they want repeat business. I weaned myself off it my daughter who works at a internists office and others warned me not taking it could cause a ht attack. I was just on it to lower heart rate. It caused me to gain weight 40 lbs. I swelled up worse in legs. So tired couldn’t move. Had severe itching and psoriasis in the last weeks I took it.
I went to natural stuff and breathing.. my blood pressure has gotten a little high this week since I have had a tooth abscess and a major family problem that wont resolve. But I will be drinking plenty of water and raw undistilled apple cider vinegar along with coenzyme 1000 mg and vit e hawthorn berries and horse tail I will take this 5 days on 2 off and it will help. I slacked off with all the antibiotics I have had to take. I am 62 and don’t smoke or drink but live with a chain smoker who smokes in the house. My stress from having too many kids and too many problems owning too many businesses and a couple of horrid ex husbands has been worse on me than being a roaring drunk. I think if it weren’t for all the years of supplements I would be dead.

Metoprolol made me really tired. The Dr changed it to night time and it seemed to help. I stopped taking it as I think it caused some issues with my eyes and it seems to have a lot of side effects.

My husband had a heart attack in October 2012 and they placed a stent. He is on Metoprolol ER 25 mg a day. He has started having chest pains again and in the last 2 months has been extremely fatigued. EXTREMELY!! I mean this man used to be the energizer bunny. Granted he is 54 but he can hardly function at work, comes home totally spent and most days has to sleep for an hour or two before he can do anything else.
He just discussed this with his cardio at his appointment and she gave him samples of another medication. He decided to just cut his Metoprolol in half and try but isn’t feeling any better. After reading these posts I am feeling strongly that the Metoprolol ER is the cause of his problems. Did anyone else feel OK when they first started Metoprolol and then developed extreme fatigue after several months?
PEOPLE’S PHARMACY RESPONSE: The metoprolol could certainly be responsible for his fatigue, although it is possible there is something else going on with his health that is contributing. His cardiologist needs to work with him to get to the bottom of this. It’s no way for him to live, and we know plenty of 54-year-old people who don’t need a nap after work!

J B P – So sorry you feel “exactly as I”. Hope you are getting better – and good health will return.
The advice I wish I had know, before my Pulmonary Embolism (PE) /many blood clots in both lungs caused by prescribed medications (and don’t get too focused on any one medication – although this site is about metoprolol) go to this site and check for yourself.
Use their drug-drug interaction checker. It is available to registered users only. It’s FREE to register and you’ll get instant access. My Doctors know my blood clots did not come from my legs because there are none in my legs. They (3 doctors) took me off the two medications I had been on, for years – put me on Coumadin and sent me home from the hospital after 5 days, to recover. When and if you have other illnesses, take that into consideration, because most people are on a page full of medications and drugs do interact … some in a bad way.
I tell everyone about checking for drug-drug interaction. Google it and you will find many sites, on-line. I use this one because a doctor friend recommended it and helped me understand that we must be our best doctor. The site I post calls for a fee – but you can use the drug interaction for Free. Good health to all. Get well soon.

Linda; wish someone had scared me! I have commented a couple of times about my predicament, going from perfectly normal to an upside down no-life with all the major side effects; had perfect stats before, now all are out of whack and was sent to hematologist-oncologist for a bone marrow because of spike in one of my blood tests.
They say I now have very Low Risk MDS-has anyone else on this RX been diagnosed with this? I know Metopolol can sometimes cause RX induced Lupus, but what about MDS-if someone has had this diagnosis, please let me know. My breathlessness and shortness of breath is still terrible also. Just want it all to go away so I can be a normal person again.

Ok. So I’m seeing lots of the same problems I started experiencing around the same time as others which apparently had to do with a recall. The symptoms I experienced were a really fast heart rate, shortness of breath, and dizziness. I thought I was having a heart attack one night but didn’t go to the ER and after a hour and a half the pain subsided. I’m 28 and have been on metoprolol for 5months after sudden high blood pressure and raised heart rate. The medicine worked great for months and then like I said recently started causing complications.
I was diagnosed with chronic myelogenous leukemia about a month ago. After the new complications I abruptly stopped taking it 4 days ago and now my feet, legs, and hands are swollen, I keep feeling faint, blurred vision extreme fatigue, and shortness of breath. I called my Dr but am unable to reach them. I am wondering if I should go to the ER or a clinic?! Any opinions?

Chris, So sorry you feel I’m unnecessarily scaring people off the fast acting Metroprolo by being reactionary. Mt post on this site, was made because I have blood clots in my lungs, because I was left on two medications, and I wanted to hear from others to help myself understand. Knowledge is gold – take it or leave it. No two people are alike. If the meds work for you, fine and dandy – I’m happy for you.
Since I only knew my experience with the drugs, I’m just a wee bit sad that you feel I unnecessarily scared people. My comment states what happened to me because two medications prescribed, for a heart problem I did not have, nor brittle bones, which I do not have, has totally stopped me in my tracks. My energy level is back to about 75% of what I use to be – hope over a years time – without any other health problems, I will return to a full days of strength. My suggestion to each and every one that has contacted me is to Google a site for medications interactions, type in all the medications prescribed to you + over the counter drugs,and read the results. Print it out and take it with you to your doctor.
I repeat, I am sorry I unnecessarily scared people. I have received enormous help/suggestions & advice, thru my eMail, that my heart/lung and Internal Medicine Doctors have used, & I’m alive & on my way to returned health. I’ll try and remove my above post, so there will be no further harm done to others.
Linda P. C.

As we all know, we’re taking this medicine for a condition. Whether it be a hearth arrhythmia or hypertension. Our bodies are unwell in some way and there are side effects for every medicine. This is a Metroprolol Tartrate thread and you are unnecessarily scaring people off of the fast acting tartrate version by being reactionary. I am not saying you are not having side effects. But please post these concerns in a pertinent forum. I have atrial fibrillation and my dosage of 50 mg a day spread out over the day is working well. Yes, I am tired somewhat. Yes I am itchy. But I don’t have a pounding heart and my BP is as stable as it has been in years.

I have been on Metoprolol Succ Er 25mg for about 3years. I live and work on a farm. I spend almost 8/10 hours a day in the garden in full sun. Yesterday I broke out in a bad rash everywhere I got a little sun burned. It itches very bad and is very painful. What should I do?

I am recovering from PE – blood clots in both lungs {over the years had no major health problems to run back and forth to doctors just yearly physicals} During those yearly visits I was given two medications that cause blood clots. Evista was prescribed,by my regular family practice doctor, MD – as what I thought to be a hormone replacement. It is a medication for osteoporosis.
A heart doctor prescribed in 2009 (because I had what was thought to be “heart problems” – (NO high blood pressure, actually always ran low) Metoprolol. I have no doubt I was given Metoprolol for a condition I did not have (NO high blood pressure) and Evista for a problem I never had (my bones were never “weak’ with the results of two bone density test I have had) … And now, Feb 2013, I almost died with blood clots in both lungs, Misdiagnosed in the emergency room, on the evening I was taken by ambulance to our local hospital as a heart attack. My failure to breath, talk, or walk more than 4 steps, looked like a heart attack, waited till the next day to do a heart cauterization.
Heart had no blockage – so I was sent back to my room, with the good news my heart was fine. I was so struggling for oxygen to get to my lungs. Thank God, my daughter could read the monitors and see something was wrong, besides an old woman struggling in her bed that could not even think sensible to make a statement that sounded intelligent …. she insisted an ultrasound – low and behold, they FINALLY saw the clots.
The medications caused my PE (pulmonary embolism) blood clots in my lungs. (Leg ultra sound show NO clots in my legs)
Terrible condition!! And it’s damaged my heart and has left me weak as a kitten. A cardiologist that is now treating me only said “I should have never been left on these drugs that long.”
There is a site on internet for drug interactions – should take you there – or just Google drug interactions and several sites will appear. I recommend using your computer to be your best doctor. My family doctor changed three times, over the years – same practice, and it is VERY hard – next to impossible to see her without being half dead – well, actually I was and her office was too full to work me in – so I came home and 911 had to be called, the evening I went into our local hospital – for a 5 day stay – that was a nightmare straight out of hell!! I should have never been left on either/neither of the medications since 2009. Be your best doctor!!

I have been on Metoprolol tartrate since the middle 1980’s when I was in my 40’s. I have gotten used to the side-effects, i.e., feeling of having to urinate all the time, tired, etc. I am on 25mg twice a day. Last year, my doctor put me on 5mg Norvasc because my BP would go up every time I went into the doctor (white coat), and these 2 medications have kept my BP under control except when I go to the doctor. I have been running good at home. They raised my Norvasc to 10mg in January this year 2013 because it was still going up in the office, but I myself went back to 5mg because my BP went too low 98/58.
On Metoprolol, my pulse goes into the high 50’s to low 60’s and then starts going up before that second Metoprolol dose of 25mg is due. What bothers me, and this has been going on for many years, about 2 hours before my evening dose of Metoprolol is due, I start feeling anxious, nervous,flushed and a bit out of breath. This stops about an hour after I take the 25mg evening pill. Is being on this medication for over 30 years bad? I had had anxiety/panic disorder way before I was put on Metoprolol and technically had been over this before being put on Metoprolol.
Is there another good alternative medication I could suggest to my doctor instead of Metoprolol?. I have been tried on Toprol XL, Lotensin, Lisinopril, all of which had terrible consequences for me, only to go back to Metoprolol, which side-effects are tolerable. Can this medicine hurt my heart after so many years? Norvasc and Metoprolol seem to get along well for me, but again, when this Metoprolol wears off, I get those symptoms as above. The Norvasc does make my hands a bit puffy, but not my ankles, so I do not worry. My blood work is good. I feel my anxiety causes my elevated BP, but getting off Metoprolol does not seem to be an option. If you have any information, I would appreciate it.

I have not seen any posts since March 1st 2013 so I don’t know if this thread is still active. However, I agree with most of the comments on side effects of metoprolol. Some of the ones I have experienced are, Foggy sensation from time to time or memory loss, cold hands, feeling anxious. I also have a few questions that others on this blog might of had also. Sorry for repeating some of the same questions but maybe there are some people who have different responses that have not answered.
1. Do the majority of those who have had both metoprolol generic and the Brand Toprol XL, found that Toprol XL is the better one with less side effects?
2. Has anyone come of either one with no effects?
3. What is the best or better replacement alternative for Toprol or Meto?
4. Has anyone been on this drug longer than 10 years and if so what if any side effects do they think they have.
Thanks for any questions you may answer and good health to all.

Can you eat grapefruit while taking metoprol Tar 25mg?

This drug has not been good for my Mom. She has passed out three times since she has been on it. Two times taken by ambulance to the hospital where each time they lessened the mg. Yesterday was another episode. Passed out in church and taken by ambulance again. Finally they are taking her off of this drug. She has many of the other symptoms like shortness of breath with minimal exertion. She had a stress test which came out very well. Please monitor carefully when taking this med. It isn’t for everyone.

I never had high BP, but was prescribed metoprolol for what was thought to be fast heartbeat – but last week I had a horrible time with Pulmonary Embolism. After ultrasound of legs, the clots did not come from legs. The doctor took me off metoprolol – and I have been searching for an answer, “could the Pulmonary Embolism been caused by being on metoprolol too long? Please answer, on this site or eMail. Thanks.

I have been taking 50mg metoprolol succ(toprolol)er since nov 12. Have had allergic reactions to diovan (broken veins on face), lisynopril (severe swelling of the tongue), tetanus shot(redness, swelling, fever of arm), and pneumonia shots (same as tetanus). The right side of my neck is very stiff and the left shoulder, elbow and wrist (previously injured) have been painful.
The oddest thing is pricking feeling (like veins breaking) that is happening at different times all over my body. This could be on a finger, a cheek, a toe, my stomach, my back, my privates, etc. I have checked and there are no broken veins. This feels almost like an electrical shock and like it is about 1/2 inch long. These are very quick and sporadic. I think it is allergy to the medicine, but cannot take any of the previous classes of bp medications. I also take amlodipin. Is it safe to half the dosage or should I try to get the brand in place of the generic?

Have you had any anxiety or breathing problems? I note that you are going to try breathing exercises while coming off-is this because you have experienced either anxiety or breathing difficulty or is it just a precautionary measure?

I am still searching for people who have quit taking Metoprolol, how long they weaned off and how long before all symptoms were gone and did all symptoms disappear such as shortness of breath, anxiety? Also, how long were they on it. I was on for about 6-8 months or more and stopped two weeks ago this Wednesday after taking 1/2 of 12.5 for five days and then 1/2 every other day for five days. I was told to quit cold turkey by my Dr. ,but did not think that best and my sister said her Dr said you should wean off over a period of six weeks. My ?-IS ANYBODY OUT THERE BACK TO NORMAL LIFE AND HOW LONG DID IT TAKE?

I did fine on this for 8 months then hives bug bite like whelts itching then eyelids started to peel psoriasis on head forehead eyes back hip. Cold hands feet numb lips occasional vertigo a rump a dump thump in chest every so often. I am weaning my self off this also severe edema in feet I am going to try breathing exercises.

On Metoprolol for several years. First, Succinate ER 25mg, 2x daily, then Tartrate Lopressor 50 mg, 2x daily after ER visit. About 1-1/2 years ago, also took Digoxin with the Lopressor. Started having symptoms thought to be dehydration cause, but milder form of the now existent severe nausea attacks. Got off Digoxin in hospital stay. Nausea continued for several days, then stopped some, but still returns, some days with vengeance like today. After reading these comments, I am now convinced that I have gone through year and better of nausea linked to medication. Ruled out many other causes with lab tests. Cardiologist said Digoxin would not cause, even though others I knew were experiencing same. GI doc suspected the Digoxin for cause.
From these posts appears beta blockers in general can cause persistent nausea, shortness of breath, neuropathy of extremities, constipation, insomnia, anxiety, jitteriness, bloat, runny nose and dry, itchy eyes, which I’ve suffered all. Again, thought G. I. problems were separate issue. For several weeks, also have had right shoulder blade pain and stiffness – now it appears others have had this too and I blamed something else, ready to go to PT. What next?
Doc will have a persistent patient here soon at upcoming visit. Now, what is next alternate solution? They keep pushing Ablation, or Pacemaker, but they are not the ultimate solution either. Have many of you gone to Calcium Channel Blockers in similar situation, and if so, which one?

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