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Will Fish Oil Reduce Your Risk of Heart Disease?

British data suggest that fish oil reduces your risk of heart disease modestly. These supplements have other health benefits as well.
Healthy fish oil nutritional supplements pills / close-up macro

Could fish oil reduce your risk of heart disease? This question has been puzzling scientists for decades. Some studies have shown benefit, while others have been inconclusive (Circulation, April 11, 2017). 

Does Fish Oil Reduce Your Risk of Heart Disease?

This week The BMJ published a study analyzing data from the UK Biobank (The BMJ, March 4, 2020). The results should help clarify how well fish oil could reduce your risk of heart disease.

What Did the Scientists Find Out About Fish Oil and the Risk of Heart Disease?

Approximately 427,000 men and women between 40 and 69 years old filled out questionnaires between 2006 and 2010. About a third of them reported taking fish oil supplements on a regular basis.

Those who took the supplements were 13 percent less likely to die during the follow-up period. They were also 7 percent less likely to have heart attacks and 16 percent less likely to die from cardiovascular causes.

Other Benefits from Fish Oil Supplements:

This is far from the first study to indicate that fish oil may reduce your risk of heart disease. We heard earlier from a reader wondering about supplements.

Q. I’ve taken fish oil successfully for years for lupus, osteoarthritis, dry eye, and cardiovascular benefits. Three different specialists recommended it. Even if they changed their minds about it tomorrow, their updated opinion wouldn’t alter my opinion on the benefits of fish oil.

I’ve found that quality matters for fish oil, as it does in many things in life. The amount and ratio of EPA and DHA are also important.

How Do Quality Fish Oil Supplements Affect Health?

A. A recent review of three large randomized controlled trials concluded that marine omega-3 fats (fish oil) can reduce the risk of cardiac complications and death from cardiovascular causes (Mayo Clinic Proceedings, Oct. 15, 2019).  One of these trials (REDUCE-IT) used a prescription pharmaceutical EPA product, Vascepa.

To summarize, the authors of this analysis concluded that 

“Marine omega-3s should be used in high doses for patients with CHD on statins who have elevated triglycerides and at about 1 gram/day for primary prevention for individuals who do not consume at least 1.5 fish or seafood meals per week.”

iMedical Consensus Advisory

Supplements of prescription-strength omega-3 fatty acids derived from fish oil (Lovaza, Vascepa) show that these can benefit people with heart disease and those at high risk for heart disease. Doctors have been uncertain whether such pills help people with no heart disease stay healthy. In the US, health care professionals justifiably question the quality of fish oil supplements their patients may take. These are not regulated by the FDA or other agencies.

A different meta-analysis published in the Journal of the American Heart Association (Oct. 1, 2019) also concluded that fish oil supplements can reduce the risk of heart attacks and death from cardiovascular disease. In the thirteen trials analyzed here, higher doses of quality fish oil were linked to more protection.

Autoimmune Conditions Like Lupus or Rheumatoid Arthritis:

In addition, there is evidence that omega 3 fats have potential in treating autoimmune diseases like yours (Frontiers in Immunology, Sept. 27, 2019). Although your joint pain is caused by osteoarthritis, quality fish oil has beneficial effects in rheumatoid arthritis (Nutrition, Jan. 2018). 

Dry Eye Disorder:

You mentioned that fish oil helps ease your dry eyes. A systematic review of 15 studies suggests that supplements with omega-3 fatty acids may improve symptoms of dry eyes (Acta Ophthalmologica, Dec. 2017). While the scientific evidence is not perfect, it makes sense for you to continue with something that appears to be helping you.

How Can You Find Quality Fish Oil Supplements?

A few of the studies included in these analyses used pharmaceutical-grade fish oil, including icosapent ethyl (Vascepa) as mentioned above and omega-3 acid ethyl esters (Lovaza). The downside of these prescription products is price. 

If your physician does not prescribe one of these prescription quality fish oil supplements, you will want to choose carefully at the drugstore or online. We like to consult ConsumerLab.com when we contemplate an important supplement purchase. In the latest analysis (Feb. 2020), the organization found that Kirkland Signature Fish Oil 1000 mg was a top pick. Another brand that it rated highly is Minami Garden of Life Platinum Omega-3 Fish Oil Orange Flavor. For more information on these and other fish oil supplements, you may wish to purchase the report from ConsumerLab.com. 

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About the Author
Terry Graedon, PhD, is a medical anthropologist and co-host of The People’s Pharmacy radio show, co-author of The People’s Pharmacy syndicated newspaper columns and numerous books, and co-founder of The People’s Pharmacy website. Terry taught in the Duke University School of Nursing and was an adjunct assistant professor in the Department of Anthropology. She is a Fellow of the Society of Applied Anthropology. Terry is one of the country's leading authorities on the science behind folk remedies. .
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Citations
  • Siscovick DS et al, "Omega-3 polyunsaturated fatty acid (fish oil) supplementation and the prevention of clinical cardiovascular disease: A Sscience advisory from the American Heart Association." Circulation, April 11, 2017. DOI: 10.1161/CIR.0000000000000482
  • Li ZH et al, "Associations of habitual fish oil supplementation with cardiovascular outcomes and all cause mortality: Evidence from a large population based cohort study." The BMJ, March 4, 2020. doi: https://doi.org/10.1136/bmj.m456
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Seems like the benefit of fish oil is becoming a bit more accepted among medical “professionals.” I also note this change is coming on the heels of a new prescription-strength version available which of course is MUCH more expensive. Coincidence??? I think not.

I’ve taken fish oil for over 40 years now. It was prescribed for me for adult acne. It worked like a charm for that. I also ate a lot of fish when I was a youngster. My grandparents’ house was across from the Indian River, and a big fish house was on the dock there. Plus, we fished, oystered and clammed for our dinner every week. I’m 83. The fish oil I take is from a reputable online pharmaceutical company, 10,000 i.u. per capsule. I take 4 every other day.

Have there been any studies on the benefits of krill oil ?

Krill oil may have some advantages over fish oil, though both contain EPA and DHA. This study is pretty technical: https://www.ncbi.nlm.nih.gov/pubmed/31201957

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