The People's Perspective on Medicine

Will a Keto Diet Help Eliminate Your Knee Pain?

One reader reports that following a keto diet eliminated her knee pain. Researchers have confirmed that a low-carbohydrate diet can reduce pain.

Americans are continually searching for the one best diet that will make it easy to maintain a healthy weight, keep blood pressure and blood fats under control and help people feel vigorous. Over the last decade or so, a ketogenic diet has captured a great deal of attention and publicity. People following a keto diet stay away from carb calories in an effort to get the body to burn fat. Could such an eating plan have unexpected benefits?

 Could a Keto Diet Affect Joint Pain?

Q. Last year I went on the keto diet to lose a few pounds. After three weeks I was shocked at how my knees felt almost no pain. After six weeks they felt better than they had in years. I told my husband I had forgotten how it felt to have no knee pain. I was really amazed and thankful.

A. A small study confirms your experience (Pain Medicine, online, March 13, 2019). A low-carbohydrate diet reduced pain intensity and improved mobility. We don’t know if it was low enough to qualify as a keto diet, but the low-carb regimen reduced oxidative stress as well as pain intensity in a comparison with a low-fat diet. 

The Research Supporting a Keto Diet for Knee Pain:

Researchers at the University of Alabama in Birmingham studied the effects of a low-carbohydrate diet on joint pain.

Twenty-one arthritis sufferers between 65 and 75 years old were randomly assigned to follow a low-carb diet, a low-fat diet or their usual diet for three months (Strath et al, Pain Medicine, online, March 13, 2019). The investigators assessed the participants’ pain and quality of life every three weeks during that time. 

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Did a Low-Carbohydrate Diet Help Ease Knee Pain?

People who followed a low-carbohydrate diet had less pain and were better able to walk for a distance and stand up from sitting. The researchers noted that the improvement could not be attributed to weight loss alone. (A low-carb diet is frequently used to achieve weight loss.)

Diet quality was paramount. A healthful low-carbohydrate diet with lots of leafy vegetables and healthful fats such as nuts and olive oil can be helpful. It may not be quite as effective for relieving knee pain as NSAIDs or opioids. On the other hand, such a diet is less likely to have unpleasant side effects than the drugs.

Controversy Over the Keto Diet:

For decades, nutrition experts have been claiming that a calorie is a calorie, no matter what food provides it. A well-done study in the BMJ (Nov. 14, 2018) threw the dogma that all calories are equal into question. When we wrote about it, we heard from plenty of readers who think a low-carbohydrate or keto diet is anathema.

The researchers recruited 164 overweight individuals from Framingham, Massachusetts, who had just lost 12 percent of their body weight on a low-calorie diet supplied by the researchers. They provided these volunteers with their meals, with the calories adjusted to maintain that weight loss.

A Randomized Trial:

Participants were randomly assigned to take meals with 60 percent, 40 percent or 20 percent of their calories from carbohydrate sources. Protein was held constant at 20 percent of calories in all three experimental diets. Fat varied depending upon carb intake. If someone was getting 20 percent of calories from carbohydrates (the low-carb diet) fat had to be 60 percent. Conversely, if a volunteer was on the high-carb diet, fat intake would be 20 percent.

Where the Food Came From:

The investigators arranged for all the meals to be provided, thus bypassing individual variations that occur when people fend for themselves. They assessed energy expenditure very accurately using radioactive labeled water.

The Envelope Please!

By the end of the five-month trial, people in the low-carb diet group were using significantly more energy than those in the high-carb diet group. The difference came out to approximately 250 calories a day. If a person used 250 calories more than they ate every day, they could potentially lose more than 20 pounds in three years.

The researchers report that the energy expenditure on the low-carb diet was highest for those who had high insulin levels when the study began. The hormones ghrelin and leptin, which regulate hunger and fat storage, were also lower among the individuals on the low-carb regimen.

One of the principal investigators, David Ludwig, MD, PhD, explained the team’s research in the L.A. Times (Nov.14, 2018).

“Participants in the low (20%) carbohydrate group burned on average about 250 calories a day more than those in the high (60%) carbohydrate group, just as predicted by the carbohydrate-insulin model. Without intervention (that is, if we hadn’t adjusted the amount of food to prevent weight change), that difference would produce substantial weight loss — about 20 pounds after a few years. If a low-carbohydrate diet also curbs hunger and food intake (as other studies suggest it can), the effect could be even greater.”

These results offer hope that a strict low-carb or keto diet could help increase energy expenditure and potentially help people trying to lose weight.

Reader Response:

We were a bit surprised at the reader reaction to this study. After all, this was well-conducted research. Such a feeding study is a rarity.

Here is how Dr. Ludwig explains the protocol:

“For our clinical trial — one of the largest feeding studies ever conducted — we collaborated with Framingham State University and the company that manages its food service. We recruited 164 students, faculty, staff and community members who agreed to eat only what the study dictated for a full academic year.”

As we described in our original summary of the research, this kind of feeding study is unusual. Many of the other studies that are so frequently quoted in books and the media are epidemiological or observational studies. They are far less reliable than an actual feeding study where food intake is carefully controlled and energy expenditure carefully monitored.

Readers Offer Their Perspective:

William R. is a low-carb diet skeptic:

“The study did NOT show that a low-carb diet helps you lose weight; It showed that low carb diets increase your metabolic rate. The weight loss implications are only speculative, not proven.

“In fact, most studies have shown that a low-carb diet does little to help you lose weight, unless the diet also makes you eat less. By the way , the authors state that their study suggests, but does not prove that the diet could help you lose 20 pounds ‘in a few years.’ So let’s say the few years is 6 years. That means you would lose 20/6 or 3.3 pounds a year. If you think this is the answer to obesity, you need to think again.

“Losing weight requires eating fewer calories or exercising more. If a low-carb diet enables you to eat fewer calories, then go for it.”

We have heard from many low-fat advocates. They are enthusiastic followers of Dean Ornish and T. Colin Campbell.

Mary in Washington shares her perspective:

“The diet that has worked for me for many, many years is a vegan whole foods, plant based diet with small amounts of fat and sugar. It is essentially the diet recommended in the film and book, “Forks Over Knives,” by Drs. Dean Ornish, Caldwell Esselstyn, John and McDougall, and by T. Colin Campbell, Ph.D., author of the China Study. This diet helps me stay healthy and active at 70+, and it’s been documented to reverse obesity, heart disease, Type 2 diabetes, and other lifestyle diseases.”

Jane eats “tons of carbs” and doesn’t get the new research:

“Before I had open heart surgery I had a test to see how my arteries were and they were wide open. My problem was a valve problem. The cardiologists doing the test said to me, ‘we can tell that you have watched your fats over the years because you have no blockages and will not need any by-passes during the surgery. We will only deal with the valve issue.”

“I eat tons of carbohydrates. I read all food labels. When I see there is a fat content of more than just a few grams, I don’t purchase that product.”

“So, what’s the story? Now I’m to eat fat and skip carbohydrates? By the way, my weight is low and became low when I began eating low-fat foods. I don’t understand.”

The Other Side of the Low-Carb Diet Story:

Jade has a different story regarding the low-carb diet approach:

“I was introduced to a low-carb diet by a friend who had lost 40 pounds in 6 months. It was a plan provided through her health provider. Basically it was a keto diet approach that provided a list of ‘allowed’ foods – lots of veggies, and proteins (emphasizing eggs and fish over meats). That appealed to me because I didn’t have to keep track of anything and it fit with my ‘on and off again vegetarian’ philosophy.

“So far I’ve lost 13 pounds and 3-4 inches off thighs, midriff and belly. It feels weird at first to emphasize even good fats. It’s amazing how ‘programmed’ we all are against a high-fat diet! I’ve been following the latest research which concurs that sugar, not fat, is the true enemy here.”

Judy shares a somewhat similar experience:

“I’ve followed a low-carb diet with varying amounts of fruit (depending on if I’m trying to lose weight) since the Atkins diet came out in the 1970s. My primary care physician (an internist) stated that “a low-carb diet will cure type 2 diabetes.” He emphasized the word cure. At 70, I’m active, still working, and take no prescription medications (but quite a few supplements.) This study is consistent with my experience.”

Melanie in North Carolina adds this story:

“I am so glad the research continues and shows positive results. I am a believer.

“Four years ago, my blood sugar tested high and I got the ‘speech’ from my doctor. He wanted to put me on metformin then, but I said no – – what could I do to change my blood sugar levels?

“That’s when I began to thoroughly study the low-carb diet way of life and how it could help. I am proud to say, that I’ve lost 30 pounds and am on no medication. My blood sugar is very stable and my A1C is awesome!

“YEAH ME! Keep spreading the word.”

Harvey in Ohio notes that the intermittent fasting approach of Dr. Jason Fung also helps:

“I am pleased to see The Peoples Pharmacy so quickly covered this new research. It is elegant.

“I am also extremely happy to see that Jason Fung is a featured guest on your radio show this week. All this ties together.

“Dr. Fung’s Intermittent fasting results in ketosis. A low-carb, high-fat diet (LCHF) also results in ketosis. When combined, the effect is magnified. There is rapid weight loss. I have been doing both for three months with rapid weight loss. I am feeling fabulous. It reduces inflammation drastically. That helps many conditions including arthritis and autoimmune disorders. I have no soreness after heavy workouts!”

You can listen to our interview with Dr. Jason Fung at this link.

We are agnostic on the best dietary pattern for any given individual. We had the opportunity to interview Dr. Christopher Gardner about his DIETFITS study  published in JAMA on February 20, 2018. Dr. Gardner points out that some people do really well on the low-carb diet while others do really well on the low-fat diet. We think you will find this interview equally informative.

Todd in Missouri offered this opinion:

“When it comes to the low carbohydrate lifestyle, you have to go to the leading expert in the field, Dr. Stephen Phinney. His book with Jeff Volek is the research backed, biochemistry packed education America needs. He is a Stanford MD, MIT PhD, and had been doing research on high fat eating since the 80’s. Read The Art and Science of Low Carbohydrate Living and you will see this style of eating fits hand in glove with the biochemistry processes of our bodies.”

Dr. Eric Westerman has also collaborated with Dr. Phinney and Dr. Volek. We interviewed him several years ago, and you may want to listen to what he has to say. 

Learn More: 

If you would like advice on how to follow a healthful low-carb diet, you may want to consult our book, The People’s Pharmacy Quick & Handy Home Remedies. In it, we discuss the low-carb diet, DASH diet and Mediterranean diet patterns. You might also be interested in listening to a few interviews we have done with diet experts. We spoke with Dr. David Ludwig a few times, in Show 1020: How to Lose Weight Without Feeling Hungry, and in Show 1149: Is Cutting Carbs More Important Than Cutting Calories? We also interviewed Dr. Jason Fung on intermittent fasting to control blood sugar and protect the kidneys. It is Show 1143: Can You Control Your Blood Sugar by Fasting? You may also be interested in a different perspective, from Dr. Christopher Gardner of Stanford, who led the DIETFITS study. You’ll find it in Show 1126: Can You Find Your Best Diet?

Our book, The Graedons’ Guide to Alternatives for Arthritis, may also interest you.

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About the Author
Terry Graedon, PhD, is a medical anthropologist and co-host of The People’s Pharmacy radio show, co-author of The People’s Pharmacy syndicated newspaper columns and numerous books, and co-founder of The People’s Pharmacy website. Terry taught in the Duke University School of Nursing and was an adjunct assistant professor in the Department of Anthropology. She is a Fellow of the Society of Applied Anthropology. Terry is one of the country's leading authorities on the science behind folk remedies. .
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People with diabetes are often told to follow a very strict low-fat diet to reduce their risk of heart disease. Could a low-carb, high-fat diet really be a healthier way to eat to control blood sugar and fats?

Show 958: Flipping the Food Pyramid Upside-Down
  • Strath et al, "The effect of low-carbohydrate and low-fat diets on pain in individuals with knee osteoarthritis." Pain Medicine, online March 13, 2019. DOI: 10.1093/pm/pnz022
  • Ebbeling et al, "Effects of a low carbohydrate diet on energy expenditure during weight loss maintenance: Randomized trial." BMJ, Nov. 14, 2018. doi:
  • Gardner et al, "Effect of low-fat vs low-carbohydrate diet on 12-month weight loss in overweight adults and the associateion with genotype pattern or insulin secretion: The DIETFITS randomized clinical trial." JAMA, Feb. 20, 2018. doi:10.1001/jama.2018.0245
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I would be interested to hear from people who have high cholesterol and have used the Keto diet. I have been on a low cholesterol/fat diet for many years with questionable results. My doctor does not recommend a Keto diet for me.

Most grains, all sugar, and all processed carbs have been shown to be pro-inflammatory, as has insulin and adenosine (of ATP). So a diet that avoids consuming or driving the production of these would be less inflammory, creating a decrese in inflammation related pain. Furthermore, healtjy fats, assosciated with a keto diet, reduce inflammation. And the gut biome responds favorably to ketosis, increasing absorbtion of nutrients and synthesis of CNS protective factors, which greatly impact how we experience pain. All help explain why keto impacts pain so effectively.

I have been doing the keto diet for 8 months; also gave up sugar. I have lost 21 pounds and I feel great. I’m 66 years old and have never had to take any prescription meds but my weight was getting out of control. I’m 5’3” and was weighing 142 lbs now I weigh 121 lbs.
I look at it as a life style change. It works for me. I do allow myself a “cheat” meal every now and then especially when I’m getting together with friends or family. I have noticed that if my increased carb intake comes from breads or pasta, my stomach becomes bloated. Not only is it noticeable but uncomfortable as well.
I’m sticking to keto, works for me and I have no problems with inflammation, especially with my lower back.

?? I’m on a Keto diet, and it hasn’t helped my knees any!

I note the lady above states she ate little fat and protein and mostly vegs and fruit. I would point out there is a vast difference between mostly carbs in those forms and the typical mostly carbs of say…pizza, chips,desserts and soda. If you eat like she does you are going to see good results.

I think a big problem with all the research in diet, drugs, etc. is precisely the striving for one-size-fits-all outcomes. People are widely different and should seek what works long term and safely to create health for themselves. Because an individual’s experience is different doesn’t mean a given theory is worthless, and they should not angrily slam other people’s results as bogus.

Since I started following the Keto way of eating, my knee pain from osteoarthritis is gone. Out the window, no longer debilitating, not even noticeable. I have lost weight, feel good, and my blood test result markers are all within normal range. I can’t say if this way of eating is right for others, but it works for me. I don’t eat grains, sugars, high carb fruits or veggies or refined carbs. What do I eat? Whole foods, including green veggies, moderate fat and proteins. I am not a butter and bacon guzzler. A typical dinner might be 5 oz of grilled salmon, asparagus with a small amount of melted lemon butter and a small salad with EVOO dressing. No potatoes, no pasta, no rice. I keep my daily carb intake under 25 grams.

I’ve been doing low carb/keto for over 2 yrs. I have lost 100 lbs & have never felt better. At 67 I am off all meds. I tried a low fat/vegetarian diet years ago & it caused more problems than it solved. I think a lot of this has to do with individual metabolism. It’s not “one size fits all”. You have to find out what works for your metabolism. For me keto has been by far the best dietary regimen. Btw I’ve lost all this weight without counting one calorie.

In 2004 I was diagnosed with type 2 diabetes. I was determined to treat it without medication. I read a lot of books and studied on-line. That is when I began the Atkins diet. I lost 60 pounds in 4 months and have kept it off ever since. My pain in every joint went away, and my blood sugar has been normal and stable ever since.

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