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Show 1257: The Metabolical Results of the American Diet

Dr. Robert Lustig describes how processed food is driving inflammation and subcellular pathologies that underlie chronic disease.
Show 1257: The Metabolical Results of the American Diet
Robert Lustig, MD, MSL, author of Metabolical
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The Metabolical Results of the American Diet

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Dr. Robert Lustig has been warning us all about the hazards of sugar since 2009, when his YouTube lecture “Sugar: The Bitter Truth” went viral. As a pediatric neuroendocrinologist, he spent much of his career treating the causes of obesity in children. Now, he turns his impressive expertise to helping adults as well as children. Metabolic syndrome contributes to the chronic diseases like diabetes and heart disease that kill most Americans. But what is causing the metabolic syndrome? Could it be the American diet?

Addressing the Roots of Disease:

Heart disease and diabetes kill millions of Americans. If you ask doctors why, they point to obesity. But Dr. Lustig says obesity is not actually the problem; instead, it is a symptom of the problem. The true cause is subcellular dysfunction. Eight different pathologies are difficult for doctors to diagnose and even harder to treat with medication. But the right food (real food, not processed food) can correct the pathologies and lead to good health.

Is Disease Genetic?

According to genome-wide association studies (GWAS), about 15% of the risk of chronic disease is attributable to genes. But that means the vast majority of our risk is related to how we live and particularly how we eat.

How Should We Eat?

Dr. Lustig has simple advice: Feed your gut and protect your liver. We need to eat in ways that keep insulin under control. That means avoiding added sugar and highly processed carbohydrates–crackers, cookies, pizza and other treats.

The Hateful 8:

The cellular pathologies include glycation, oxidative stress, mitochondrial dysfunction, insulin resistance, inflammation, methylation, and autophagy. These are the sources of metabolic syndrome.

While we don’t have drugs to treat these processes, we can alter them by eating foods that are minimally processed and rich in fiber, vitamins, minerals and phytonutrients. But eating a highly processed diet can lead to non-alcoholic fatty liver disease. That’s because the liver metabolizes sugar to fat that is stored in the liver, and processed food has a lot of sugar. This explains why children are now developing fatty liver disease, which was once a condition affecting older people, especially alcoholics.

Do You Have Fat in Your Liver?

Dr. Lustig describes how you can use a tape measure around your waist to see if you have fatty liver disease. He also discusses the lab values of ALT that indicate a problem. Intermittent fasting can help reduce liver fat, so long as you are not eating food full of sugar. Getting added sugar out of your diet is the most powerful way to reverse all these problems. Protecting the liver with real food is also a good way to help your body fight off COVID-19.

Is Breakfast Helping or Hurting?

You may have heard that breakfast is the most important meal of the day, but there is relatively little scientific evidence to support that statement. What’s more, many popular breakfast choices drive insulin up and aggravate the subcellular pathologies. Instead, we should strive for breakfasts of real food, low in sugar and high in fiber. According to Dr. Lustig, “Breakfast could be the most important meal of the day, if there wasn’t any sugar in it.”

The articles demonstrating that some groups at high risk for COVID-19 tend to consume more processed food are published in the British Journal of Nutrition, Feb. 26, 2021 and Public Health Nutrition, Jan. 27, 2021.

This Week’s Guest:

Robert H. Lustig, MD, MSL, is a pediatric neuroendocrinologist, an emeritus professor of pediatrics in the Division of Endocrinology, and member of the Institute for Health Policy Studies at the University of California, San Francisco. He has authored 130 peer-reviewed articles, 80 academic chapters and reviews, and dozens of op-eds for the public. He is the former chairman of the Obesity Task Force of the Pediatric Endocrine Society, a member of the Obesity Task Force of the Endocrine Society, and a member of the Pediatric Obesity Devices Committee of the U.S. Food and Drug Administration.

Dr. Lustig is also the Chief Science Officer of the nonprofit Eat REAL, dedicated to reversing childhood obesity and type 2 diabetes by bringing real food into schools. He has never taken money from the food industry, so has no conflicts of interest. His new book is Metabolical: The Lure and the Lies of Processed Food, Nutrition, and Modern Medicine. The photograph of Dr. Lustig is by Roberto Candia.

Listen to the Podcast:

The podcast of this program will be available Monday, May 10, 2021, after broadcast on May 8. In this extended podcast, Dr. Lustig discusses the pros and cons of statins as well as the addictive nature of sugar-laden foods and how dentists have turned away from warning against sugar. The show can be streamed online from this site and podcasts can be downloaded for free. CDs may be purchased at any time after broadcast for $9.99.

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About the Author
Terry Graedon, PhD, is a medical anthropologist and co-host of The People’s Pharmacy radio show, co-author of The People’s Pharmacy syndicated newspaper columns and numerous books, and co-founder of The People’s Pharmacy website. Terry taught in the Duke University School of Nursing and was an adjunct assistant professor in the Department of Anthropology. She is a Fellow of the Society of Applied Anthropology. Terry is one of the country's leading authorities on the science behind folk remedies. .
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