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Problems with Generic Wellbutrin (Bupropion)? Not Again!

We had hoped that problems with generic Wellbutrin (bupropion) were behind us. That may no longer be the case. The brand name price is astronomical!
Wellbutrin generic antidepressant

A decade ago we received a message from J. in Danville, New York. She said:

“I have been taking Budeprion XL 300 mg for three months instead of Wellbutrin XL 300 mg. I find that I am easily upset and cry very easily. Sometimes I feel aggressive. I also have short, stabbing pains in my head. Taking the brand-name drug (Wellbutrin) helped me feel the best I have felt in twenty years–not depressed and able to enjoy being with my family and friends.”

That letter started a saga of woe and intrigue with the Food and Drug administration. When we published J’s message in our syndicated newspaper column, we started hearing from other people with similar stories. At first it was dozens of letters. Then scores. Eventually hundreds of people wrote to say that Budeprion XL 300 and some other generic bupropion products were not working as well as Wellbutrin.

We sent these messages on to the FDA. The answer from executives at the agency was that this was all a tempest in a tea pot. These were psychosomatic reactions (headache, anxiety, irritability, nausea, dizziness, insomnia, tremor, mood swings, panic attacks, depression, suicidal thoughts, etc). A highly-placed FDA staffer insisted that such side effects could not be brought on by the generic drug. Budeprion and Wellbutrin were supposed to be identical.

After five years of arm-wrestling the FDA, we learned that the agency would request removal of Budeprion XL 300 and some other generic bupropion products. At long last the FDA admitted that there were problems with the absorption of these generics. They were not considered “bioequivalent.” Here is a post we wrote nearly five years ago.

Patients Vindicated! Generic Wellbutrin Withdrawn

Fast Forward to Bupropion 2017:

We had hoped that the problems with generic Wellbutrin (bupropion) were behind us. Officials at the FDA seemed more vigilant about approving this generic product. Sadly, we are starting to hear from readers again that they are experiencing problems. Here is the latest story:

Q. I believe you helped reveal the generic Wellbutrin (bupropion) failures several years ago. Is there any chance that there are still problems with some generic pills?

I have chronic fatigue, for which I take bupropion. About eight months ago, I started having bad nausea every single day. I tried everything, but the only thing that helped was Dramamine, which made me too drowsy to function. I even tried lowering my dose of bupropion, but the nausea didn’t go away. (My morning dose stayed the same.)

I read a recent news article (Bloomberg) about the differences between generic and brand-name drugs. I realized the release mechanism of my morning pills might be the problem. I take two bupropion in the morning, get nauseated and crash around midday.

I’m convinced that the pills are dumping the active ingredient in my system far too quickly, causing that rollercoaster side effect profile. It started when I got a new job and thus, a new online pharmacy that sent a different generic.

After that insight, I switched to a longer-acting version and I haven’t been nauseous since. Does the FDA do testing for this type of problem?

A. We alerted the FDA to problems with generic Wellbutrin (bupropion) back in 2007. It took five years for the agency to acknowledge there was a serious problem with some slow-release bupropion formulations. Although these drugs were removed from the market, we have continued to receive complaints about certain generic products. The FDA doesn’t test samples submitted by individuals.

Other Readers Complaining about Generic Wellbutrin (bupropion)

Inez in Preston, MD:

“I have been taking Wellbutrin for years. Of course insurance required a change to generic bupropion. I tried it and it DID work. My pharmacy changed to a different manufacturer. The pills even looked different.

“It was bupropion XL. After a week of headaches, nausea, vivid dreams, etc. (felt like withdrawal; like I wasn’t even taking it) I realized that is the only change and symptoms started a day after the change.”

Carolyn in Colorado:

“I had been on Wellbutrin for 20 years or so. Bupropion or what ever that pill is had an horrible effect on me. It took a year or so to find the right one in the first place. I have tried what they call bupropion and had a horrible time. It also smells like sulfur which I am allergic to.

“Tried another which did not work. Horrible. I am having a terrible time not wanting to end it all. I feel that I can not make it and just want to leave. Why mess with something that works?”

John in Texas reports a similar situation:

“Reading these entries is rather alarming. I have been taking the round small bupropion XL for 2 years. I experienced a drastic improvement in my bipolar 2 depressive symptoms.

“Within the last 2-3 weeks of taking the same dosage, but a new manufacturer, I am having suicidal ideations. These thoughts are persistent. I have never considered thoughts such as these…ever! This manufacturer was just approved. It’s an oblong, white pill. Anyone else out there going through anything similar?”

Laura in Arkansas feels blindsided:

“I feel like I’ve been blindsided by the manufacturers of name brand Wellbutrin. I used to take it and it was affordable. Now, I have no option. It’s too expensive to use. The drug companies get you used to using it then jack up the price so high nobody can afford to pay for it. Thanks manufacturer of name-brand Wellbutrin XL.”

Can You Believe the Price?

We just checked with our local chain pharmacy. The cost for one month’s supply (30 days) of brand name Wellbutrin XL 300 was $1,836. Yup, you read that right. That means each pill costs over $60. Put another way, a year’s supply of brand-name Wellbutrin XL 300 could cost a depressed patient over $20,000.

The original developer of Wellbutrin was Burroughs Wellcome. When that company was acquired, the drug became the property of GlaxoSmith Kline, now known as GSK. More recently, the drug was acquired by Valeant, a Canadian drug company.

We checked with PharmacyChecker.com. This organization compares prices. They say that Canadian pharmacies charge roughly between $1.30 and $2.19 per pill for the branded version of Wellbutrin XL 300.

The Canadian Option:

We have created a Guide to Saving Money on Medicine with tips on how to use generic drugs wisely. There are also legitimate Canadian pharmacies where you can buy brand-name drugs at more affordable prices. Access to this online resource may be found in our Guide section:

Share your own experience with Wellbutrin (bupropion) below in the comment section. While you are at it, please let the FDA know if you have had problems with either Wellbutrin or bupropion at their MedWatch site. We told executives at the agency that we are once again hearing about problems with this antidepressant but we are not sure whether they are really paying attention.

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About the Author
Joe Graedon is a pharmacologist who has dedicated his career to making drug information understandable to consumers. His best-selling book, The People’s Pharmacy, was published in 1976 and led to a syndicated newspaper column, syndicated public radio show and web site. In 2006, Long Island University awarded him an honorary doctorate as “one of the country's leading drug experts for the consumer.” .
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comments (157 total)
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Taking Par Pharm 150 bupropion (generic wellbutrin). It is like taking a placebo and worse, depressed worse than taking it. Awful and doesn’t work. Took the name brand for years, and it was amazing.

I have had no luck with generic forms of Buproprion. The only thing that works for me is the brand. Years back when it became unaffordable, I started getting my Wellbutrin XL from Canadian pharmacies. Fortunately I had a doctor who was willing to send my script to Canada back when it wasn’t so common and has continued to do so ever since, since I need the brand to feel my best. A 90 day suply costs me about $100 out of pocket.

Actavis’s bupropion is like taking a sugar pill. It does nothing. I was taking the Lupin version. It worked quite well, and then my pharmacy just switched it without warning. I called them back and demanded Lupin, which they are ordering for me.

My pharmacy switched my XL 150 pill (which reads WPI 331) to a different brand that has a smaller pill (which reads 150 XL), and it is completely ineffective. I also get bitter metallic drainage down the back of my throat after taking it. What the hell is the FDA doing?

Yes, there is a problem with Bupropion then and now (20 years ago and now). It will cost me $1,300 a month for Wellbutrin – 30 tabs. Seriously, when will the insurance company and drug companies care about us? We are the ones taking the generic crap they are making. I would like to know – do they take the generic or name brand? The bioequivalence of generic Bupropion needs to be revisited but until then why are we not allowed to take the name brand at a reasonable price?

Yes, the problems continue. I was first prescribed 150 MG of Bupropion, then tapering up to 300 MG by taking two pills. I didn’t pay attention to the manufacturer of that one, but it sure got my attention when I was switched to the Anchen formulation of Bupropion XL 300MG. It was like I had stopped taking the drug entirely. My symptoms returned with a vengeance. After running through that 30-day supply, my pharmacy apparently switched to a different generic manufacturer for the drug (Cipla/Invagen). I wouldn’t have noticed at all if it weren’t for the difference in size, shape, and labeling of the pill. The symptoms again subsided after taking this pill, but I didn’t make the connection until once again the pharmacy switched back to the Anchen formulation. Miserable again. I’ve filed a report with the FDA, but maybe you guys can bend their ear again as well. The bioequivalence of generic Bupropion needs to be revisited AGAIN.

I have been using Bupropion SR 150 mg per day for 17 years. I use it for smoking cessation, and it has worked fine until about 3 months ago. I received a refill manufactured by a private pharmacy. Within 2 weeks I began to crave a cigarette. I don’t believe there was any active medication in the pills. I checked online and found a long history of complaints including ineffectiveness. Now I’ve learned that Mylan pharm has stopped production. This only leaves a group of Indian-based manufacturers with a list of complaints too high to number. Why does the FDA not support the consumers. These companies are growing exponentially by producing ineffective products. I am currently back on a low dose nicotine patch which is effective but has my blood pressure way up. Is this how it ends? The tobacco companies were more reputable.

I have been on Wellbutrin XL 300 mg for well over 20 years. A few years ago when I switched to a high deductible plan where we paid retail prices for prescriptions until we meet our deductible I tried a generic form (bupropion) in the face of $1800/month price for the Wellbutrin. It did not work. It didn’t even seem like the same medication. I began to spiral into the clinical depression that had been under control for so many years.

I can not understand why they are allowed to call this medication a substitution for Wellbutrin. It seems like the manufacturers of Wellbutrin have left out a key ingredient (like your Aunt Sally’s delicious cranberry sauce that you can never seem to get right).

I am a physician who has suffered from depression most of my adult life.

I can tell you from personal experience that there is definitely a difference between brand-name Wellbutrin XL compared to its generic counterparts. I have personally experienced the dramatic difference numerous times. If you share my experience, I highly advise you contact the FDA and report the dramatic difference.

I believe the difference is in the way the active ingredient gets released throughout the day. This is a huge difference for medications that work on neurotransmitter activity in the central nervous system.

The FDA should not allow marketing of products that are clearly different in their efficacy and side-effect profile.

We need to take action. This is not a joke. Peoples’ lives depend on it.

If you have similar experiences, please inform your doctors, your health insurance company, the FDA, and your representatives in Congress.

I’ve taken bupropion XL 300mg for three years. Had no problems with the Par Pharmaceutical formula. Due to insurance change, started the Blue Point Pharmaceutical formula with side effects that include vertigo, nausea, headache, fatigue, and tinnitus. I’ll be changing back to Par brand and reporting this experience to Blue Point and the FDA!!!

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