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High Cost of Spravato (Esketamine) For Depression!

Ketamine has been in the headlines for its unusual antidepressant effect. Now esketamine is approved. Will the high cost of Spravato make it hard to access?
High Cost of Spravato (Esketamine) For Depression!
Young Teen holding Head with a Case of Depression

The first really new antidepressant in decades recently won FDA approval for treatment-resistant depression. Esketamine nasal spray will be sold under the brand name Spravato. Physicians and patients have been eagerly awaiting the arrival of this new type of antidepressant. That’s largely because there has been a lot of hype around the new drug. Perhaps another reason is that traditional antidepressants take weeks to go to work. This nasal spray should start working within hours or days. But at what cost? Will the high cost of Spravato prevent patient access?

The High Cost of Spravato Could Be a Deterrent:

Patients may be shocked by the high cost of Spravato. People starting on this medication will need twice-a-week dosing for the first month. The list price is roughly $600 to nearly $900 per dose. That means the initial month could cost as much as $6,800.

After that, people will require once weekly or twice monthly nasal spray administration. Those costs would range from $2300 to $3500. At the end of a year, Spravato could end up costing $45,000. Some insurance companies may balk at that expense.

What’s the Story on Spravato?

Is the high cost of Spravato worth it? Most people never find out the actual effectiveness of a drug their doctor prescribes. They may also miss out on the side effects. 

Here is a link to a recent article we have written on this topic:

What Should You Know about New Antidepressant Spravato?

If you take the time to read the article above you will learn that two clinical trials with esketamine did not demonstrate that it was better than placebo. The FDA apparently ignored those studies. 

What About Ketamine Nasal Spray?

What the FDA is not talking about is the generic drug ketamine. It has been on the market since 1970. Here are some articles we have written about ketamine and depression:

Could Suicide Be Prevented with Better Access to Ketamine?

You can get an insider’s view of the history of ketamine at this link:

Some physicians are prescribing ketamine as a nasal spray. It is prepared by compounding pharmacies. This is completely off label. We suspect that the FDA would frown at such use. Although we have done no real cost comparison we suspect that such products are far less expensive than the high cost of Spravato. 

Share your own experience with depression below in the comment section. Has your doctor prescribed ketamine? How well did it work? What about side effects? If your doctor has prescribed Spravato, did your insurance company pay for it without objection? 

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About the Author
Joe Graedon is a pharmacologist who has dedicated his career to making drug information understandable to consumers. His best-selling book, The People’s Pharmacy, was published in 1976 and led to a syndicated newspaper column, syndicated public radio show and web site. In 2006, Long Island University awarded him an honorary doctorate as “one of the country's leading drug experts for the consumer.” .
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