The People's Perspective on Medicine

FDA Follow-Up Finds Another Generic Bupropion Fails Bioequivalence Test

The Food and Drug Administration has issued a long-awaited report on the quality of a generic antidepressant. Last October the FDA reported that one generic form of the drug Wellbutrin did not meet its bioequivalence standards. This long-acting form of bupropion was unceremoniously pulled off the market. This was the first time in recent memory that a generic medication approved by the FDA was later determined to be inadequate.

At that time the FDA required all generic forms of the long-acting 300 mg formulation to be tested to see if they were identical to the brand name Wellbutrin. While products from Mylan, Actavis and Par were acceptable, the Watson form was deemed not therapeutically equivalent to Wellbutrin XL 300. The drug will be voluntarily withdrawn. 

[FDA, Oct. 10, 2013]

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About the Author
Terry Graedon, PhD, is a medical anthropologist and co-host of The People’s Pharmacy radio show, co-author of The People’s Pharmacy syndicated newspaper columns and numerous books, and co-founder of The People’s Pharmacy website. Terry taught in the Duke University School of Nursing and was an adjunct assistant professor in the Department of Anthropology. She is a Fellow of the Society of Applied Anthropology. Terry is one of the country's leading authorities on the science behind folk remedies. .
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I have lived with major depression for the last 25 years of my life. I have always been able to maintain my illness without having to be hospitalized. In 2014 I took a vacation out of state and accidentally didn’t remember my meds: synthroid, paroxetine hcl 30mg and bupropion xl 300mg. My primary doctor called in a prescription to the pharmacy. When I picked up the medicine the bupropion xl was a different pill than I usually took. I mentioned to the pharmacist that it looked different from what I usually take. He assured me not to worry. It was exactly the same.

I took the meds, and after having three doses of Teva/ActAVIS bupropion xl 300mg, I experienced a major panic attack. Never having had one before I had no idea what was happening to me or why. I ended up in the emergency room. At that time I did not realize that it was a reaction to the bupropion xl. Here I am three years later. I changed companies I work for and with that I get my prescriptions filled by a different mail-order pharmacy. They send me bupropion xl 300mg manufactured by ActAVIS. Again, I noticed the different look of the pill but like everyone has told me “all generic medicine is exactly the same as the brand name.” I didn’t think much of it.

After taking the pill for three days, for the second time in my life I experienced a major panic attack, again sending me to the emergency room. This is my confirmation that the only two panic attacks and two trips to the emergency room I’ve ever had in my life were caused by the Teva/ActAVIS manufactured bupropion xl 300mg tablets. After querying the internet about this medication I came to find out that the bupropion xl 300mg tablet were “voluntarily” taken off the market by Teva. I find it very interesting that Teva acquired ActAVIS, which is the manufacturer of the bupropion xl that caused me to have a panic attack.

My wife has been taking many anti depressants for 15+ years. Many of them with with one brand or another of bupropion. What we know to be true is that the biggest difference between generic brands is their delivery system. ie, what prolongs the distribution into the blood system.

The original manufactures patents ran out way before the distribution apparatus and hence the difference. I have been told that to meet equivalence criteria, a brand only requires to be within 80%. which is fine if you end up with the right dose.

Switch to another brand, and you also change dosage. Remember with these drugs that more is not always more effective, and that with all drugs, you can build a tolerance and efficacy is not always resolved with larger doses.

I have been taking the Watson brand generic bupropion sr 150 for years.It has been a lifesaver for me. In the last couple of months I have been experiencing a return of my depression and some side effects that I normally don,t experience I.e. Slight tremors and anxiousness. I am in a quandary as to why this is happening. The only change I have noticed is the appearance of the bottle the pills come in.I have read there were problems with the Watson bupropion XL. Is anyone noticing a difference in the Watson SR version?

Over the years I have taken several different versions/brands of generic wellbutrin xl, none of them was ever 100%. It generally changed when the pharmacy just switched with out letting me know. However I have never had any real issues until about a year ago when I was switched to a white pill apparently made by watson.

I began having severe heart issues, high blood pressure, serious anxiety, etc. I didn’t put the two together until 6 months after I had been to the cardiologist several times. I never had any issues and previously wasn’t aware of the “allowances to generic makeup”. After stoping the medicine I felt 80 % better within a week and did some research only to find that there are 13 additional inactive ingredients in the current watson version than there are in brand name, 7 additional inactive ingredients than the previous version of watson and 9 additional ingredients than the Teva/Par version!!!

I was never aware that companies were able to add whatever they felt regardless the effect. This is leading to all the symptoms that i had. I am currently fighting my insurance company to have them cover the brand name that I need, but because of all these issues the company is able to charge over the moon cost for brand.

It is a very sad, continuous cycle that appears to be several years long and doesn’t look to be stopping. It shouldn’t be ok for these companies to create half way drugs with potentially lethal effects at the cost of consumers, that have little to no choice. Take meds to help emotionally, hope that you are taking something that won’t be equally as bad for you physically.

Did you ever figure out what the difference was?

Last November I had a seemingly functional friend commit suicide. He was taking prednizone and had been switched over to Wellbutrin. He became agitated and depressed and when left alone shot himself. Was the faulty generic Wellbutrin still out there? And what might the combination of Wellbutrin and prednizone have done to his state of mind?

I do believe that the antidepressants are responsible for the suicides. I had this happen to me taking Wellbutrin. I was taking Watson 100 SR . I began being sick at my stomach becoming very very scared and fearful. I didn’t realize at first what was happening . The more I took and the longer I took it the more depressed and suicidal I got. Then I got the 75 milligram Apotex brand in the first day I took it I knew something wasn’t right. I was almost hysterical, crying, wanting to die. I finally had it compounded thinking that would be better and the same thing happened. When I went to increase the dose thinking that I wasn’t taking enough that I became much worse. Too scared to leave the house and very very suicidal. Until it happens to you it’s hard to understand. When it is caused from the medication the feelings are so strong. It’s because the medicine changes your brain you become very depressed with no reason to live. These drugs are very very dangerous! That was two months ago and I’m still dealing with the anxiety which I never had before taking these meds and suicidal thoughts. It did something that changed me. This was three different generic brands of Wellbutrin !!! If consumer labs can test these then why can’t the FDA? Every one of the generic wellbutrin should be pulled from the market until the FDA test each one instead of letting the company test them and submit the report.

I say yes definitely this is what contributed to your friends suicide. When I told the pharmacy they didn’t even care let alone report it. Actually the one Pharmacy argued with me that the generic and brand name was the same and that the FDA would back that. Do they not see these reports?

Where can I find comparisons of the various generic meds? I once saw a chart of the bioavailability of about 10 generic versions of Wellbutrin. The info was from a study testing the blood levels found in patients after various numbers of hours. It was great info. I need it again and am unable to find it. I used the brands Wellbutrin and Prozac with good results for years. Tried generic Wellbutrin and quickly became very depressed again. Resolved to pay for the brand name for the rest of my life. Insurance changed and I stopped taking Prozac. Found myself depressed, unable to get out of bed, unable to go to work most days and not doing a very good job when I could go in. Tried generic Prozac and felt as if there was a small electric current running through my chest and remembered having the same experience 10 plus years ago. Stopped taking the generic and found a mail order company which offered brand Prozac for about $30 less for a 90 day supply. Now resolved to paying about $100 each month for these brand meds until retirement.

After retirement our health care insurance will pay only what they would pay for the generic. They also use only one supplier for all meds. Retirement is in another year or so. I’ll contact the med supply company to find out the final cost. In the mean time I’m looking for the best quality generic Prozac and Wellbutrin. Would like to give them a try. If they work I’m hoping that they’ll be available through the supplier used by our retirement insurance. Thanks for all of the great info here.

I was bumped up from Bupropion 150XL (Global) to 300XL (Anchen). After three miserable months and getting worse, I decided to write a letter to my doc asking if I can take two 150’s instead. Then I did a Google search and found what most have seen. Only some brands work for you and that according to the comments is subject to change as these suppliers continue to merge and who knows what we are getting.

I’ve been on antidepressants most of my adult life. When I was 21 I had ovarian cancer and my body was thrown into menopause after a total hysterectomy – 50 years ago. Most recently I was taking Bupropion 150 and it wasn’t helping so my doctor bumped up the RX to 300mg HCL made by Anchen. It didn’t help and slowly made my depression much worse, to a point where I considered suicide. I had no energy, spent most of my days in bed sleeping and watching TV and wanted no contact with anyone.

I called my physician and told her I couldn’t take the Bupropion any longer and we discussed options. I’d taken Prozac (among others) many years ago and did well on it for a long time. Eventually the depression arose again and I was moved to another antidepressant. So my doctor suggested I try the Prozac again. So started Fluoxetine HCL 20 mg made by Sandoz.

On the second day, I broke out in hives, took it one more day and quit! I’m currently not taking any antidepressant at all and hoping for the best.

With so many problems with prescription drugs for so many people, shame on the FDA for not doing a better job in monitoring what the pharmaceutical manufacturers are putting in their products!

The FDA is run by Wall Street, and Wall Street only knows profit. Sorry to hear about your story.

I have been on Generic Wellbutrin for past 4 months. At first I had this pretty circle pill from Anchen and it worked like a miracle… I was really happy with the results and all that. Throughout increasing my dosage and refilling my pills, I somehow got the pill that is oval and not as shiny and has 142 on (yes, the one from Actavis) Both myself and my spouse know- I have been acting like I do not take any pills and almost felt like I was completely withdrawn. I just re-filled my pills last night and accidentally (?) got my circle pill again – it got me curious and I have been searching this morning to see what the differences are between 142 and 102… and now I see it. I am not the only one who suffered from 142 pills as it does not do a thing for me. I am back on 102 from Anchen and I hope it works as it did four months ago.

I received the Actavis 142 generic yesterday and I knew within hours it wasn’t working at all. Today is even worse. I called the pharmacy, and was assured that it’s the same; I thought perhaps I was succumbing to my own fears regarding the switch. Last night I came home cranky and exhausted. Today was worse: can’t concentrate, foggy head, unproductive and desperate for bedtime at 4 p.m. Thanks to others sharing their experiences, I told the pharmacist that this medication was NOT working and insisted on returning it. I told him I knew for a FACT that Actavis had merged with the company (Watson) responsible for recent recalls on their generic, and that they were the SAME company who dragged their feet for months when the FDA requested bioequivalence test results only about a year ago.

My previous generic was Par, and I had no issues with it. The pharmacist promised he’d have the Par in tomorrow at 10:30 a.m. Otherwise, I told him, I’m paying extra for brand. I can’t imagine continuing like this another day. My body feels like it’s underwater. I don’t think the FDA should consider itself done with this mess!

Jen, I had the same problem recently. I was on the Watson 3332 pill for a month, felt great towards the end, then got switched to the Actavis 142. Two days after switching I began feeling worse. I checked my food diary, mood charts, everything; I concluded there was nothing to throw off my mood except for the pill. That was a month ago and I’ve felt “meh” this whole month. Now I have the Anchen 102 pill, which looks very similar and has mostly the same inactive ingredients as the Watson pill I liked. We’ll see how this switch goes… Hopefully the circle pill is the magic one!!

valeant is the name brand and has a program,i would look into that program it can save you lots of money….

Here in Canada I pay $8.00 for 3 months worth of 300mg valeant wellbutrin and I love the brand, but my wife swears by mylan brand over my valeant, she ran out of hers and tried mine and didn’t feel anything with it. I myself think if you start on one brand and you can still find that, brand you should stick with that brand. I just think name brand is made the exactly the way it was tested- thats just my thought.

This is my first time getting help with my lifelong depression. I am 23 years old. I have been taking Bupropion (apparently produced by Zydus) for just over three months now. The first week or so I was taking it I saw a huge improvement. From there, not much has changed. My doctor upped my dosage from 150mg to 300mg (Bupropion XL 300mg once per day) and I literally saw no changes whatsoever in this past month. Like others, I have been clenching my jaw lately and had no idea why.

Two days in a row this past week I lost my temper over the most trivial things; things I never would have reacted so insanely over before taking the meds (and trust me, I’ve always had a temper). Not only that, in times where I’m feeling seriously depressed (which is still occurring on every couple days on this drug) I’ve had thoughts like “I wonder if the world really would be better without me” or “If I never change I don’t know if I’ll want to go through my whole life like this.” I’ve never had such serious thoughts along the lines of taking myself away from this life; and I’ve been seriously depressed for a very long time. Additionally, since switching to the 300 mg, I have been very jittery. I can’t even hold my hand out without it shaking, and it feels like I can feel my insides just rattling all day.

I thought I was having some severe health issues until I came onto this page and discovered it has to be a side effect of this medication. I just discovered that UHC does not cover brand name Wellbutrin so I’m expected to pay $400 for a 30 day supply for it. This is absurd to me for so many reasons. I did come across the Valeant program but just left my appointment yesterday and am not due back for 3 months. I can schedule another appointment before then but each one costs me $150 (of course none of my psychiatric services are covered by UHC either despite having one of the best plans) and it’s very sad to me that I’m going to have to suffer with this generic medicine for the time being because I don’t have infinite money to shell out for this.

I’m not sure how much traffic this page gets but I feel much better knowing these side effects likely aren’t a result of some larger health issue and can be attributed to the Bupropion. If anyone is reading this who has used the Valeant program (to pay $50 for 30 days of brand name Wellbutrin) can you please chime in and let me know if the brand name has worked better for you? Was it difficult to get your doctor to agree to it? Mine already wrote me the Rx for brand name Wellbutrin and thats how I just discovered UHC won’t cover it. Please help, I cannot afford to spend $400 and would like to hear from others if the Valeant plan is legitimate. Thank you.

I have been struggling to find an okay generic for Wellbutrin 200SR. I found the Medschat site in April after having a miserable experience with Sun Pharma’s generic – made in India – that is distributed by Caraco pharmaceutical Co in the US. I filed a report with the FDA, and encourage you to do the same if you have had a negative experience with generic Wellbutrin. Follow this link to file a report…

Only if enough of us report to the FDA, is there any chance that they will address this problem appropriately. They ought not to permit an ineffective drug prescribed for depression to be given to people when there is such a high risk for debilitating or worse results!
http://www.fda.gov/ForConsumers/ConsumerUpdates/ucm354560.htm#Submit

Last weekend, after yet one more restless night with heavy sweating and hot flashes, I got online to see if I could solve that mystery.
I was astonished when I found just about every symptom I’ve been going through most if this year (the YEAR!!) while taking generic bupropion made by Mylan.
I’d had good results from bupropion in the past so I was surprised when it wasn’t helping last winter. My doctor said I could take up to 425 mg. I’d never needed more than 150, one 75 mg twice a day.
Not this year.
I finally gave up in the spring, concluding that my life is just a mess and it’s not really Depression, hence the bupropion did not help.
I started back on it again, as things in my life escalated. Same dosage, same generic (Mylan).
For the last three months I have had what I would call debilitating Depression, suicidal ideations, daily sobbing fits, frequent hot flashes and profuse sweating, headaches and sleep disturbances. I had attributed everything to Depression except for the hot flashes. I’m through with menopause and should not be having them (or at least not every night and during the day too).
I don’t care that the FDA has only pulled the 300 mg XL version of generic bupropion. This is not a placebo or psychosomatic effect because I’ve been going through this all year and only found out on Sunday morning about the decision to remove the 300 mg XL from the market.
I do not trust any generic bupropion after what I have read. I have never had any qualm using generics, but something is very very wrong with the generic bupropion. I feel I have been poisoned and that I’m also lucky to be alive after this horrifying experience.
Please put pressure on the FDA to look into all of the generic bupropion. I suspect with the number of people reporting suicidal ideations, some users have succumbed to suicide due to the generic bupropion. That is a chilling thought. Depression can be deadly and any drug that makes it worse is a very serious threat to public health.
I’m glad I found this information and I remain convinced that most of my agony this whole year has been due to bupropion made my by Mylan.

Just curious, are you on brand name Wellbutrin now? If so, is it helping? Or have you stopped taking Bupropion and Wellbutrin altogether? I’m trying to decide if making the switch to brand name Wellbutrin is worth it or not because Bupropion is giving me horrible side effects as well.

I have been taking a generic wellbutrin for almost a year. I noticed that made me crazy when I was taking too high of a dose. Once I lowered the dose I was better off than before I started the medication. I would recommend this to anyone I wasn’t even trying to quit smoking and it made me quit, I started to forget about the cigarette and I was a 20 year smoker. I continue taking Wellbutrin to better my daily events.

Hi – I too was on WATSON 300 XL for years when Wellbutrin went generic & it really worked for me – when this was pulled by the FDA (& on another occasion prior to this, I was switched), & spiraled horribly into a deep depression… finding out it was the binding/inactive ingredients that were preventing it from working on me. Then I switched to WATSON 150 XL 2x daily & now that is no longer available… I am very concerned. The Dr.s & pharmacists really DO NOT GET IT… I can’t take Activis or Par & am now comparing the inactive ingredients of the Watson to others available with no luck… Has anyone switched from XL to SR? Or any other suggestions, PLEASE? Needing your feedback…

Actavis DID NOT work for my last 2 refills! The Actavis oval pill bupropion 300mg with number 142 on it.
I was on Brand name Wellbutrin 300mg XL or Anchen generic, all good for last 9 years. I switched from my hospital pharmacy to CVS pharmacy in June. CVS gave me Actavis brand and the first three refills went ok.

Starting 5 weeks ago on Actavis, my second most current refill, I started experiencing restless sleep, extreme body aches, increased irritability, stinky mucus in nasal, some increased tinnitus (ringing in ears), a brand new low roaring noise in ears (like furnace running).
Last week, after 6 days on most current Actavis refill, FULL BLOWN WITHDRAWAL, I was angry, frustrated, I had more increased hearing loss and body aches. I called my old pharmacy and got a refill of Anchen, 1st day back on “Normal” meds, I slept the best I have in a month. Today, 4th day on normal meds, my sense of well being is back, mood greatly improved.

I went and saw a Audiologist today, I have reverse slope hearing loss from inner ear and she referred me to a ENT specialist in two weeks. Reverse slope hearing loss is very uncommon, often medication induced. New hearing loss is likely permanent. (From Generic Actavis!?)

I see my family doctor in 3 days, my pharmacy says I can insist on name-brand Wellbutrin only.
From what I have learned recently, Actavis was purchased by Watson, and Watson bupropion 300mg XL was removed by FDA. Any relationship issues here or did Actavis put out a crap batch of pills?

love actavis. not a huge fan of mylan. makes me extremely anxious and paranoid, especially if I take any caffeine.

I recently started taking Bupropion HCI XL, 150 mg. I have been reluctant to take it every day or build up to a 300mg dose. So I have been taking it every other day. I seem to be better, but am not sure if this generic is the best thing to take. Should I be asking my doctor to prescribe the brand name? I note that I had difficulty in obtaining this, as the pharmacist said it was on back order. Now I see why! Everything but this one was taken off the market. I am also concerned that getting off this drug one day will present problems. I will be curious to hear what people think about this. Thanks.

Just wondering if you were able to try the Mylan version of Bupropion xl 300 mg. I just started this medication today and am having a hard time finding any reviews on this specific drug. please let me know. thanks

I was googling about withdrawals from Wellbutrin HCL XL 300 mg and I decided to google to find out more about Actavis — that’s how I found this post on the People’s Pharmacy website. I can’t believe someone else was recently having the same problem that I am currently having with generic Wellbutrin HCL XL!!!
For years I had been taking the generic brand made by other companies- I think Mylan & Teva. I was getting them from a small independent pharmacy.
I just started getting prescriptions filled at Wegman’s and I was given a different generic Bupropion HCL XL made by Actavis. I thought all was fine. But after a week of taking it I’m in full withdrawals. I’m taking the medicine like I always do- nothing has changed except the different brand of generic pills- these are big oval pills– not my normal generic Wellbutrin. I feel awful & sick.
I was reading that most of the medicines we use in this country are made over-seas with little to no oversight. If two people are having this same reaction- there must be a lot more people! Can anything be done about this generic Wellbutrin which must not be bio- equivalent!

I have been taking one generic Wellbrutrin 300XL by Mylar for years. I was switched to generic Activis 300XL upon my last refill. I’ve taken it for 7 days and I am having an extreme reaction. It feels like I have just stopped taking wellbrutrin entirely. I went to my pharmacy and was told that the Mylar generic “Is nowhere to be found”. I called several other pharmacy’s to try to find the Mylar brand. No place has it. I’m becoming concerned as my reaction to the Activis is quite uncomfortable and includes jitters, depression, irritability and throat constriction. I also find myself clenching my jaw. This is awful. Has anyone had a similar reaction and how did you resolve it? Any advice is appreciated. Also, does anyone know what happened to Mylar 300XL?

Just refilled Wellbutrin generic at Walgreens. Was given Mylan brand. Last time they gave me Watson which worked well. Actavis did nothing for my depression.

According to my pharmacist last Saturday, ALL of the 150mg generics except for the “Par” brand have been pulled from the market.
I had a really bad experience in 2011 when I was changed from the Teva to the Activis. I didn’t figure out what had happened until I got my refill (90 days) and immediately felt hugely better and dropped the 13lbs I had put on. In my case, I was GREAT on a DIFFERENT BATCH of the Activis. I did some research, discussed it with my pharmacist, and for 2 years I took the Watson brand and did fine on it.
Well now the pharmacist says that the Par is the only one available, and the other ones are gone — which is unusual, as usually when a company stops making a drug for business reasons you can get remaining stock out of warehouses for months/years later.
What’s weird is that my “Par” brand pills have “A 101” stamped on them, which, according to drugs.com, means that they are made by Teva.

My generic bupropion 300 Xl was switched to Par in November 2013. I am in such terrible pain and I know it is because of this generic. I tried to get my insurance to allow me to get the non-generic one but they will not pay for it because there are generic versions available. I am very disappointed in Par’s generic Wellbutrin.

Hello, sorry this is much later than your post. just reading it and wondering if you are still on the generic 300mg Wellbutrin? If you found a generic brand that works for you as brand did? I haven’t as yet. Loriamn

Plz contact me. I was switched to generic wellutribin approx 08. Seen immediate chgs. Depressed increased jaw kept hurting had been on brand wellubtrin np. Make long story short I went got dental exam found osteomyletis. Surgeon reported to board bout my concern on the generic. He said no other reports found at that time. Went through 8wks daily central line antibiotics. Never heard anything bout this issue on generic until I went back to my same psy dr. Of 20 yrs.. last wk I complain need energy she went to prescribe wellbutrin I said oh no she recalled my issue with jaw on the generic brand. Told me it resulted law suit that she was prescribing different brand that I should have no issue with this one.. well I haven’t filled it yet. Plz contact me regarding my outcome from the generic wellbutrin. Ty

I thought it was just me. Target filled my rx at the end of December with the actavis brand after having Watson’s for years. I didn’t think much about it. Within 2 days, I was anxious, somewhat paranoid and wanted to cry. I stuck it out for 2 weeks and no changes. My Dr fit me in and gave me a new script. I got it filled elsewhere with Par brand and I’m much better.

With mergers and acquisitions, these companies in some cases produce different versions of the same drug. I know that PAR produces a round-white 102 tablet, and is also producing an large oval white 142 tablet. Does the recent FDA pronouncement of bio-equivalence apply to both? Or only the 102? I can’t seem to find this anywhere.

I had been taking name-brand Wellbutrin 150mg XL for over 10 years when my insurance company switched me to the generic form. I noticed a difference pretty quickly but my doctor didn’t believe that it was a problem with the generic. It was only after I found websites where other patients were having the same problem that my doctor told the insurance company that it didn’t work for me.
Every year I have had to jump through hoops to continue getting the name brand. Well today, I got my new prescription and it is a generic made by Global. I haven’t read that anyone has taken this company’s form of the generic. Was Global’s one of the generics tested by the FDA? If so how did it do?

Already posted this in other Wellbutrin threads but I want to add my voice again to this fiasco. Didn’t do well on the Watson (round) 300XL or the Actavis (Oval) 300XL. Just signed up and are paying $50.00 a month for name brand Valeant through the company. I checked the whole Canadian thing out. There is a version that ships from “Canadian Pharmacies” that actually seems to be manufactured in Turkey. It is a GSK product.
Overall the reviews seem to be better than the other “generics”. That said, there are still a lot of people who seem to indicate on other forums that the Canadian manufactured Valeant is superior to the Turkey manufactured GSK. I was able to find the Turkish type for about $135 for 90 days and the Canadian manufactured stuff for $170 for 90 days. Now I’m paying $150.00 for 90 days for the Valeant name brand. A lot more expensive than my $10 90-day copay for the generics but I’m feeling better already.

I had a terrible experience with generic Wellbutrin XL some years ago and have been on the name brand since then, paying full price. My new doctor convinced me to try the generic again, saying the problems had been solved. I am on third week of bupropion hcl xl 300 by Anchen, which is Par Pharmaceuticals. Feeling very low though not end-of-my-rope like the first time. I am going to switch back to name brand for a week and compare. My concerns: Mail order pharmacy will not guarantee which generic they send. Why won’t insurance cover brand name, even with a high co-pay, if generics don’t work? I have to get a waiver to even get the brand name. Any advice?

Further to my comment…it appears the Par brand of Buproprion generic 300mg XL was originally approved in 2006, the Mylan brand in 2010. Each of these Buproprion generic manufacturer submitted a supplemental application (sANDA) to the FDA after the bioequivalency retest. As per your article, the FDA approved Par and Mylan.
But why did they approve Actavis? That company just merged with Watson, and Watson’s generic was disapproved. Plus, I believe that Actavis has had recent recalls of this product.

This is very concerning.

My pharmacist said I can no longer get the Watson brand of 300mg Buproprion XL. I went online and googled — surprise, the FDA said it is not the same as Wellbutrin 300XL (as the article above reports). No wonder I have been feeling crappy and agitated for so long. So yet another generic brand of Wellbutrin is being pulled, this time by Watson. And again, my pharmacist is not telling me why.
So, what does work for depression, insofar as Wellbutrin generics? Not the Impax/Teva brand (Budeproprion), as that was pulled a year ago. Not the Watson brand (Buproprion). Not the Actavis brand (see the FDA website — recent batches were bad and were recalled). And probably not even the Par brand (it is brand new, and if you look at the warnings page, you will see they only tested the Buproprion SR for depression, and are extrapolating that the Buproprion XL is safe and works just as well. Poor conclusion).
So now, all that is left for me to check out (and hopefully try) is the Mylan brand. The FDA should be ashamed of their irresponsibility and lack of oversight.

I was taking the Watson generic for years with no problems. I had been prescribed the Teva version years ago and was extremely agitated and depressed. CVS pharmacist thought I was nuts when I complained. It took over a year before they pulled the Teva version off the market. I am now having the same problems with the Actavis generic. Off to CVS I go. Thank God for this website. It is nice to be validated when others have the same complaints. FDA should be ashamed of themselves for allowing substandard drugs on the market.

I have been taking the Watson generic bupropion xl 300mg for several years, and it works fine for me, but the Mylan and Activis versions don’t work at all & leave me extremely depressed.
It’s strange that the version that has now been yanked off the market by the FDA is the only one that works for me – and the ones that don’t work for me have been given the FDA’s blessing.
I have been on the Activis version for a month now & feel miserable. I’m sure it’s not psychosomatic because at first I couldn’t figure out why I was so depressed — then suddenly it dawned on me that must be the new generic I’m taking, since nothing else has changed.
I am going to try the Par version and hope for the best. If that doesn’t work I guess I will look into buying brand-name Wellbutrin XL from Canada.

Concerning your responses to two inquiries today about Watson, you did not distinguish between 150 XL and 150SR (which is what I take.). Also, Watson is now Actavis Pharmaceuticals with headquarters in NJ/Switzerland, I learned when I Googled Watson to learn of other Watson products that I might be taking.
People’s Pharmacy response: The bioequivalence test applies only to 300 XL.

I am currently taking 3 Bupropion 150 a day, and for a while I have noticed that I have been worse, now I am wondering if my pharmacy switched to another generic. Thanks for the heads up, I will definitely be looking into this!

I have been on generic Wellbutrin for years, and found that the EON / Sandoz Bupropion 150 SR is the only one that works for me, even better than the name brand.
Unfortunately most pharmacies stock the Watson generic, assuring me that it is just as effective. I had to make a lot of phone calls to find one that was willing to special order the Sandoz.

Is Teva acceptable I have been supplied that also by Caremark.
People’s Pharmacy response: Teva makes Budeprion. Budeprion XL 300 was removed from the market last year. Budeprion XL 150 is still on the market. You may be interested in the curve, though. https://www.peoplespharmacy.com/2013/04/16/firm-faked-generic-drug-data–fda-mum/

What about the Watson 150mg Bupropion? I have been using this for awhile and doesn’t seem to work?
PEOPLE’S PHARMACY RESPONSE:
We only wish we could say. From the bioequivalence curves the FDA has posted between Budeprion XL 150 and Wellbutrin XL 150 we have some concerns about generic 150 bupropions.

There is a claim that Bupropion also helps people stop smoking. My patient took a generic form, and it made him so nervous that he DOUBLED the number of cigarettes he smoked.

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