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Did Cholesterol Drug Cause Man Boobs?

Q. At 65 years old, I’ve been active all my life. I’ve been a runner since returning from Vietnam in 1969 and also lifted weights. I stopped lifting weights ten years ago because I was lifting plenty on my job in construction.

I still work out several times a week, but I am plagued with man boobs! I feel like my pecs have become flabby, and it seems all the exercise I’ve done over the years was for naught.

I know some medicines can cause breast development in men, but the only thing I take is simvastatin for cholesterol. Can you help me correct this? Any explanation would be welcome.

A. Male breast enlargement goes by the medical term gynecomastia. Although many medications can cause this complication, it is not generally recognized as a side effect of statin-type cholesterol-lowering drugs.

After some sleuthing, however, we found that statins such as atorvastatin (Lipitor), rosuvastatin (Crestor) and simvastatin (Zocor) have been linked to gynecomastia (European Journal of Clinical Pharmacology, June, 2012). Statins apparently decrease testosterone levels, perhaps allowing estrogen to dominate and stimulate breast growth (Journal of Sexual Medicine, April, 2010; June, 2011). One case report centered on a man who found his golf game hampered after taking Lipitor (Pharmacotherapy, Aug., 2006).

Other men have noted sexual difficulties that may be attributed to a statin drug. One reader reported: “I am a very active Army Physical Training Instructor. I am 45 years old and have always had a great sex drive until I started taking Crestor six months ago to lower my cholesterol.

“My sex drive has totally disappeared. I am unable to maintain an erection and feel tired all the time. It has been causing me a great deal of stress and anguish. Is Crestor causing my ED and libido problems?”

Another reader complained:

“My boyfriend (age 72) never had a problem with sex, but when he was put on simvastatin to lower his cholesterol, his sex drive declined. After the doctor doubled the dose, our sex life came to a screeching halt.

“He discontinued the drug for a week and during that time, his sex drive came back. Doctors do not discuss this well-known side effect when prescribing this medication, and that is a dereliction of their medical duty.”

Not everyone agrees with her. Her comment elicited this response: “This article fails to mention the extremely important role which statins play in the reduction of cardiovascular (heart attack) and cerebrovascular (stroke) disease. In a 72 year old, although sexual pleasure and contact are very important, the statistics for the development of a major life threatening vascular event are very real. Indeed, statins (Zocor, Lipitor, Crestor, etc.) have all been proven in huge cardiovascular trials to significantly reduce the risk of a vascular events and death in such a patient.

“Although sexual dysfunction may be a side effect, it is an extremely rare side effect, occurring in less than 1% of patients taking the medication. More likely culprits are blood pressure medications, poor sugar control and age related testosterone decrease. Discouraging patients from taking statin medications based upon this rare side effect will cause many people to stop these important drugs which will be a certain detriment to their health.

“I run The Cholesterol Treatment Center in Morganville, NJ. I see and treat complex cholesterol patients to determine individualized therapy based on a complex analysis of their risk profile . My analysis, laboratory workup and conventional treatment goes way beyond “good” and “bad” cholesterol – outmoded concepts which most doctors still cling to when devising a one-size fits all approach to high cholesterol management.”

Spencer Kroll MD PhD

The Cholesterol Treatment Center, Morganville, NJ

While Dr. Kroll is correct that there are many other causes of sexual difficulties and also that some patients really benefit from a statin to prevent a repeat heart attack, we are a bit skeptical about the statistics. Because men are loath to volunteer this information spontaneously, we really know very little about the proportion of men taking statins who may experience some sexual dysfunction.

If you would like to have a much more wholistic view of how to handle cholesterol and heart health, you may find our 494-page book, Best Choices from The People’s Pharmacy of value. It has a whole chapter on the pros and cons of statin-type cholesterol-lowering drugs and offers a variety of non-drug options to lower a variety of risk factors for heart disease. Here is a link to our books.

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About the Author
Joe Graedon is a pharmacologist who has dedicated his career to making drug information understandable to consumers. His best-selling book, The People’s Pharmacy, was published in 1976 and led to a syndicated newspaper column, syndicated public radio show and web site. In 2006, Long Island University awarded him an honorary doctorate as “one of the country's leading drug experts for the consumer.”.
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