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Can You Prevent Alzheimer Disease with L-Lysine?

Data linking herpes virus infections (HSV-1) with a higher risk of dementia offer hope that taking L-lysine might prevent Alzheimer disease.
Can You Prevent Alzheimer Disease with L-Lysine?
Brain decline and dementia or aging as memory loss concept for brain cancer decay or an Alzheimer’s disease with the medical icon of a old rusting mechanical gears and cog wheels of metal in the shape of a human head with rust.

Intriguing research suggests that the dementia we call Alzheimer’s disease may be triggered by a common infection: herpes virus. Although the story is not yet complete, the brain’s immune response to the viral intruder may initiate the development of amyloid beta plaques and tau tangles that are so distinctive. Yet there are hints that antiviral drugs might prevent Alzheimer disease. Could a simple supplement, L-lysine, also help?

Could L-Lysine Prevent Alzheimer Disease?

Q. Whenever I feel a cold sore coming on (the telltale “tingly feeling”), I take L-lysine tablets. When I take 1000 mg a day, often the cold sore will never develop. If it got a head start, it disappears several days sooner than it would otherwise.

I read your article about herpes and cold sores being linked to Alzheimer’s disease. Is there anything in L-lysine that could be helpful in preventing dementia? I’m going to start taking it every day, maybe 500 mg a day.

No Good Studies of L-Lysine to Prevent Alzheimer Disease:

A. There are few well-controlled long-term studies of the amino acid L-lysine to prevent or treat cold sores (HSV-1 or herpes labialis). A review in the dermatology journal Cutis (July, 2005)  concluded that L-lysine benefits against HSV-1 are unclear. It might help prevent recurrences in selected patients. That said, many readers report success like yours.

There is growing evidence to suggest a link between herpes infection and the risk of developing Alzheimer’s disease (Frontiers in Genetics, Sep. 10, 2018).  A study from Taiwan found that people taking antiviral medicines for herpes were significantly less likely to develop dementia (Neurotherapeutics, April, 2018).

Whether L-lysine would be beneficial remains to be determined. There is, however, some very technical modeling that suggests key lysine residues may help the brain clear itself of certain toxic metabolites (Interdisciplinary Sciences, Computational Life Sciences, Sep. 7, 2018). We’ll be watching for further research to see whether this translates into an ability for L-lysine supplements to prevent Alzheimer disease.

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About the Author
Terry Graedon, PhD, is a medical anthropologist and co-host of The People’s Pharmacy radio show, co-author of The People’s Pharmacy syndicated newspaper columns and numerous books, and co-founder of The People’s Pharmacy website. Terry taught in the Duke University School of Nursing and was an adjunct assistant professor in the Department of Anthropology. She is a Fellow of the Society of Applied Anthropology. Terry is one of the country's leading authorities on the science behind folk remedies. .
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