The People's Perspective on Medicine

Can Magnesium Help Your Restless Legs Syndrome?

Although doctors can prescribe drugs for RLS, many people would prefer nonpharmacologic approaches. Do you take magnesium for your restless legs syndrome?
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“Restless legs” hardly sounds like medical terminology, but it describes a neurological condition first described in the late 17th century. People with the condition describe sensations similar to something crawling over the legs. The legs might also throb, ache or itch. Sufferers relieve this unpleasant feeling by moving their legs, often getting out of bed and walking around. Needless to say, restless legs syndrome can disrupt sleep. Most North American doctors had little to offer patients with this problem until a few decades ago. Then the FDA approved medications specifically to treat this condition. However, people have been swapping home remedies for a long time. Could magnesium supplements help ease your restless legs syndrome?

How Can You Alleviate Your Restless Legs Syndrome?

Q. I have restless legs syndrome that keeps me awake at night unless I take a magnesium supplement at bedtime. This gives me excellent results.

On the rare occasion that I get that creepy crawly feeling anyway, I rub magnesium oil on my lower legs. This helps almost immediately, and I am able to go back to sleep.

A. Restless legs syndrome (RLS) was first described in 1944 by a Swedish neurologist, Dr. Karl-Axel Ekbom. People with this condition describe an unpleasant creeping or crawling sensation in the legs that is relieved by moving them. RLS mostly happens when the person is resting, and it frequently interferes with sleep. Doctors do not know the cause of RLS, although people with kidney disease and those with iron deficiency appear to be more susceptible to the condition (Sleep Medicine, March 2017).

Magnesium for RLS:

Many people report that magnesium supplements can help with insomnia, RLS and leg cramps. Unfortunately, we found only one uncontrolled study on magnesium therapy for RLS (Sleep, Aug. 1998). In this “open” study, people with RLS or a related problem, periodic limb movement during sleep, took magnesium supplements and found them beneficial. We wish that scientists had followed up on this approach to see how well magnesium might work for your restless legs syndrome. 

Magnesium Caution:

One minor note and one important warning: First, magnesium can cause diarrhea, so be careful with the dose of your bedtime supplement. Most people can take 300 mg without problems, but you may need less.

Most importantly, people with limited kidney function must not take supplemental magnesium. It could overwhelm the kidneys and build up to dangerous levels. It isn’t clear whether topical magnesium oil would provide enough magnesium to be dangerous, but it wouldn’t make sense to push the envelope. As we noted, people with kidney disease are susceptible to RLS, but they should avoid this possible remedy.

Other Nondrug Approaches for Your Restless Legs Syndrome:

Many readers have shared their experience with RLS. Some people report that certain medications make the condition worse. Others have found helpful remedies, such as soap under the bottom sheet or a cup of chamomile tea at bedtime. Here are a few other non-pharmacological options you might consider.

Experts often recommend strictly avoiding caffeine, nicotine and alcohol, because these may make RLS symptoms worse (Sleep Medicine Clinics, Dec. 1, 2009). In addition, they suggest regular exercise during the day and/or a brief walk before bedtime. Restless legs syndrome, known in medicalese as Willis-Ekbom disease or simply Ekbom disease after the Swedish doctor who first described it, may respond to exercise, massage, infrared-light therapy or pneumatic compression devices that squeeze the legs to maintain good circulation (Neuropsychiatric Disease and Treatment, May 6, 2011). We don’t know how well these approaches may work, so if you have tried them, let us know whether they were helpful for you.

Selenium Supplements:

Another mineral that might be helpful for treating RLS is selenium. Swedish scientists reported on a handful of cases in which people with severe RLS took 100 micrograms of selenium daily and experienced noticeable improvement (Iranian Journal of Neurology, Oct. 7, 2016). 

Acupuncture for RLS:

Q. I suffered from restless legs syndrome for many years and took ropinirole (Requip) to treat it. The medication worked, but it caused me many worrying symptoms on a regular basis: dizziness, nausea, feeling like I was going to pass out, even vomiting at times. However, if I didn’t take the drug, I couldn’t sleep because my legs started acting up the minute I laid down in bed.

I accepted this until I happened to speak to someone who recommended that I see an acupuncturist. This woman cured me after only one visit. I’ll never forget that day, three years ago, when she needled my body and left the room. I felt strong movements of energy throughout my body and was so tired after that initial treatment that I went to bed as soon as I got home. I never took Requip again.

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For quite a while, I saw the acupuncturist every month. Then over time I visited less frequently, though I still  go back for a “tune up” several times a year. I am extremely grateful that I no longer need to take Requip.

A. Many people would prefer to use some method other than medication to control their restless legs syndrome. A review of non-pharmacological interventions found that acupuncture reduces RLS symptoms (Harrison et al, Disability and Rehabilitation, March 21, 2018).  Your results are surprising in that you got such long-lasting relief from acupuncture to calm your restless legs. Other people may find that they need to continue with acupuncture to maintain freedom from RLS symptoms.


One randomized study found that massage, specifically massage with lavender oil, could ease RLS symptoms in people on hemodialysis (Hashemi et al, Nursing and Midwifery Studies, Dec. 2015). People with kidney disease often suffer from restless legs syndrome.


Placing the legs on a vibrating pad (Relaxis) for a 35-minute therapy cycle appears to be as effective as the drugs FDA has approved for treating RLS (Mitchell, Therapeutics and Clinical Risk Management, Dec. 3, 2015). Users have not reported adverse effects from using the pad, other than to the wallet–it can cost around $1,000. 

Folic Acid:

Q. You’ve discussed treatments for restless legs syndrome (RLS) in your column but you have not mentioned folic acid.

Decades ago, I was renting a room from a medical student. She observed my distress and pointed out a page in a textbook. That was the first time I had ever heard of “restless legs syndrome.” The book said that it was caused by folic acid deficiency.

I started taking folic acid, and it worked like gangbusters. It’s cheap and readily available, and it has never stopped working for me.

A. Your report is fascinating. Restless legs syndrome has been attributed to vitamin D deficiency (Neuropsychiatric Diseases and Treatment, online May 21, 2014) as well as lack of iron. Although folic acid deficiency is considered less often, it too seems to be linked to RLS (Alternative Medicine Review, June, 2007). We are disappointed not to find reports of controlled trials of this common B vitamin for treating restless legs syndrome.

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About the Author
Terry Graedon, PhD, is a medical anthropologist and co-host of The People’s Pharmacy radio show, co-author of The People’s Pharmacy syndicated newspaper columns and numerous books, and co-founder of The People’s Pharmacy website. Terry taught in the Duke University School of Nursing and was an adjunct assistant professor in the Department of Anthropology. She is a Fellow of the Society of Applied Anthropology. Terry is one of the country's leading authorities on the science behind folk remedies. .
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  • Connor JR et al, "Iron and restless legs syndrome: Treatment, genetics and pathophysiology." Sleep Medicine, March 2017. DOI: 10.1016/j.sleep.2016.07.028
  • Hornyak M et al, "Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome: An open pilot study." Sleep, Aug. 1998. DOI: 10.1093/sleep/21.5.501
  • Ulfberg J et al, "Treatment of restless legs syndrome/Willis-Ekbom disease with selenium." Iranian Journal of Neurology, Oct. 7, 2016.
  • Pigeon WR & Yurcheshen M, "Behavioral sleep medicine interventions for restless legs syndrome and periodic limb movement disorder." Sleep Medicine Clinics, Dec. 1, 2009. doi: 10.1016/j.jsmc.2009.07.008
  • Mitchell UH, "Nondrug-related aspect of treating Ekbom disease, formerly known as restless legs syndrome." Neuropsychiatric Disease and Treatment, May 6, 2011. DOI: 10.2147/NDT.S19177
  • Harrison EG et al, "Non-pharmacological interventions for restless legs syndrome: a systematic review of randomised controlled trials." Disability and Rehabilitation, March 21, 2018. DOI: 10.1080/09638288.2018.1453875
  • Hashemi SH et al, "The effect of massage with lavender oil on restless leg syndrome in hemodialysis patients: A randomized controlled trial." Nursing and Midwifery Studies, Dec. 2015. DOI: 10.17795/nmsjournal29617
  • Mitchell UH, "Medical devices for restless legs syndrome – clinical utility of the Relaxis pad." Therapeutics and Clinical Risk Management, Dec. 3, 2015. doi: 10.2147/TCRM.S87208
  • Oran M et al, "Possible association between vitamin D deficiency and restless legs syndrome." Neuropsychiatric Diseases and Treatment, online May 21, 2014. DOI: 10.2147/NDT.S63599
  • Patrick LR, "Restless legs syndrome: pathophysiology and the role of iron and folate." Alternative Medicine Review, June, 2007.
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Never worked for me. I got some Quinine from Canada that works every time.

I have RLS, and lots of other nerve-involved issues. I was frequently getting the crawling, tiny muscle spasms, and minor jerking of my legs, especially late in the day and when retiring. It made me squirm, without relief, and really interfered with my sleep.

Labs tests done for other reasons showed low magnesium and B vitamin levels. So here’s what is working for me (beautifully!): Magnesium 500mg twice a day, and B50 capsules, 2 of them, twice a day. Rather than just addressing the symptoms when they start, I chose to do this routinely, in order to keep the blood levels constant. (I started with a lower dose of Magnesium and had no problems with diarrhea by increasing it slowly).

And thanks to People’s Pharmacy – I added soap beneath the sheet to my repertoire, because I had been getting weird foot and ankle cramps too. NOW all this stuff never happens any more. Yea!

I read where wearing compression stockings could help with RLS. I didn’t have compression stockings, so decided to try an Ace bandage – worked like a charm; it’s cheap; and I can adjust it to tighter or looser as needed.

Magnesium has proven to be very successful for me in treating leg cramps while sleeping. When I stopped taking it, I had a small cramp and began again. They immediately stopped.

Have experimented with many remedies for RLS with only partial relief. About 2 months ago was gifted with a prescription CBD-THC ointment, and it has been a miracle cure. I rub just a tiny bit on my upper legs about 20 minutes before bed. The only problem is that I live in a state w/o legal access so would have to depend on continued gifting. But will probably also experiment with over the counter CBD when my supply is gone.

P.S. Can confirm that, for me, all types of dairy consumption, but especially ice cream at night, makes RLS worse.

I started running in my twenties 50 years ago. I have had restless leg syndrome which I always thought was related to running and leg exercise. I take 400mg of magnesium oxide daily, and I feel it helps. I also stretch my legs every evening before bed. I take methyl folate also. The bottom line is that I have been able to sleep without RLS when I use this strategy. When I do not, I may wake up with RLS or even a knot in my hamstring or calf. I have tried the mustard therapy for that, and it has worked.

I have Charcot Marie Tooth disease. One of the early symptoms was restless legs syndrome and severe leg cramps. I started taking magnesium which relieved the leg cramps. I still have restless legs and CMT. Nothing alleviates either of those.

I have taken magnesium for many years. The only time my restless leg shows up is when I take less than my full dose of Tramadol – 2 50mg. tablets three times a day.

I got rid of restless legs by taking vitamin E 400 units daily. I started when I was about 30 and continued for many years. It works. I no longer take it now beach the RLS never came back, and I am in my 70’s. It was a terrible thing to have.

I started using a Magnesium/L-Arginine lotion on my legs before bed ~ works wonderfully!

I bend over and touch my toes every night before bed for a minute, and I hardly ever have RLS problems anymore. This has made a huge difference for me. I read about it on this website.

If I consume a product with sugar, cream, later on I will have not only RLS but whole leg cramps.
Glad to read that there is a problem with mag and kidney function. Having one kidney has put me on the alert not to use.

I am a Parkinson’s patient and have great difficulty with my lower legs. Restless legs times ten is how I used to describe it. By accident I discovered a half tablet of Tramadol (100mg) makes my legs feel normal in 20 minutes. My doctor saw the relief I was getting and allowed me to try no more than 4 half tablets a day. (2 tablets cut in half.) it eliminates my tremor on the right leg and the restless leg feelings in both legs.

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