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Army Scientists Working on a Universal Vaccine against Coronavirus

Investigators from Walter Reed Army Institute of Research are testing a universal vaccine to provide immunity against all coronaviruses.
Army Scientists Working on a Universal Vaccine against Coron...
The Rhesus Macaque Monkey in its natural habitat

The onslaught of infection attributed to the Omicron variant of SARS-CoV-2 drives home the likelihood that there will be additional changes in the coronavirus that causes COVID-19. Although pharmaceutical manufacturers like Pfizer are ready to tweak their vaccines to match new variants, that takes time. The prospect of a universal vaccine for coronavirus infections is very appealing.

Could There Be a Universal Vaccine?

Such a universal vaccine is no longer a mere fantasy. Investigators at Walter Reed Army Institute of Research are hopeful about a new vaccine they have developed against COVID and other coronaviruses. After two years of intense research, they have recently concluded animal and human trials. A trial in rhesus macaques succeeded in eliciting neutralizing antibodies against several variants of concern (Science Translational Medicine, Dec. 16, 2021).

The scientists reported

“robust and rapid reduction in replicating virus in the upper and lower airways of animals and resultant prevention of pulmonary pathology.”

Omicron showed up after the animal trials were completed, but researchers will include it as part of the coming clinical trials.

How Does the New Vaccine Work?

The Spike Ferritin Nanoparticle COVID-19 vaccine utilizes a unique soccer-ball shaped protein that attaches to spikes from a variety of coronavirus strains. These spikes trigger the immune system to recognize and respond to coronavirus with different mutations.

In addition to the SpFN universal vaccine itself, the investigators administered a special “adjuvant” developed by the Army. They designed the adjuvant to increase the immune response to vaccines. The adjuvant does not contain aluminum or mercury. Instead, it consists of liposomes of phospholipids, cholesterol and a compound from the soap bark tree.

In conclusion, researchers hope that this proposed universal vaccine will be effective against Omicron and all future SARS-CoV-2 variants. The vaccine may not be fully tested in time to prevent the spread of Omicron. On the other hand, it may help against future variants of COVID-19 or other coronaviruses.

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About the Author
Terry Graedon, PhD, is a medical anthropologist and co-host of The People’s Pharmacy radio show, co-author of The People’s Pharmacy syndicated newspaper columns and numerous books, and co-founder of The People’s Pharmacy website. Terry taught in the Duke University School of Nursing and was an adjunct assistant professor in the Department of Anthropology. She is a Fellow of the Society of Applied Anthropology. Terry is one of the country's leading authorities on the science behind folk remedies. .
Citations
  • Joyce MG et al, "A SARS-CoV-2 ferritin nanoparticle vaccine elicits protective immune responses in nonhuman primates." Science Translational Medicine, Dec. 16, 2021. DOI: 10.1126/scitranslmed.abi5735
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