garlic and garlic cloves, vampires

A few weeks ago we got a fascinating email from a doctor. He wants to remain anonymous, for reasons you’ll soon see. However, his theory on how tales about vampires may have gained ground really intrigued us. Perhaps you will find it interesting, too.

He wrote:

I am a 67 year old physician, and 8 years ago discovered I have a novel mutation for a rare disease called variegate porphyria. For 3-4 years before this, I was chronically ill with recurrent episodes of severe abdominal pain, syncope (fainting), pain in the right buttock area and sometimes down the thigh. These attacks were often so severe that hospitalization was required, at which time I was found to also have high blood pressure (otherwise normal in between attacks). This is an unusually late time in life for the disease, a metabolic disorder, to initially present. Once the diagnosis was made, I hoped to prevent subsequent attacks by avoiding exposure to the trigger agents described in textbooks and the medical literature: most commonly, alcohol and various drugs. Despite avoiding these known triggers, I felt no better.

Of course, when the diagnosis was established, I was referred to experts in the porphyrias (there are several varieties corresponding to different locations in the metabolic pathway) but we could not achieve symptomatic improvement. I should also say that some experts were skeptical that the novel mutation was the certain root cause of my symptoms. Efforts at symptom improvement included my keeping a detailed diary of dietary intake for every meal over several weeks. No patterns seemed to emerge. Determined to reverse what appeared to me an ominous trend of declining function, I searched via Google for possible insight beyond current accepted medical knowledge.

Did Vampires Have Porphyria?

One day, I came across an online posting by someone who conjectured that the legendary vampires of Eastern Europe might have had porphyria. The porphyrin synthetic pathway in the liver produces a key component of hemoglobin for red blood cells. If there is a problem with precursor substances moving down the synthetic chain because of a less than fully functional intermediary reaction, such as occurs in variegate porphyria, then the substances that would ordinarily proceed past that point in the chain begin to accumulate in relation to how much precursor is fed into the chain. Current medical therapy for a porphyria attack entails intravenous administration of hemin, a substance closely related to hemoglobin, which down-regulates the porphyrin synthetic pathway. By “turning down the tap” controlling the pathway, the accumulation of intermediary products is mitigated and the symptoms of the attack improve. The author of the conjecture had proposed that those who had a strong desire to drink blood might have done so because it made them feel good; because actually, they had porphyria and the ingested blood down-regulated their porphyrin synthetic pathway.

Why Do Vampires Avoid Garlic?

Since nothing I had tried to date had helped me feel better, I gave this idea some thought, quickly realizing that those so-called vampires also avoided garlic. If indeed those “vampires” had porphyria, might there have been a genuine reason they avoided exposure to garlic? I decided to begin a two week trial of avoiding items in the allium plant family, which includes garlic, onion, shallots, chives, and leeks. By the end of the trial, I felt like a new person, better than I had felt in years! Still, this whole idea did seem bizarre, so I then had a meal containing garlic and onion. Hours later, I had another porphyria attack.

Soon after gaining this understanding, I found an article in the Scandinavian pharmacology literature describing how sulfonated compounds in plants of the allium family up-regulate a metabolic pathway in the liver related to porphyrin synthesis.

I’ve shared my experience with medical experts involved in the NIH rare disease program. It’s unclear whether information associated with my novel mutation is applicable to others with porphyria.

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  1. Kathryn
    Los Angeles

    I thought digestive problems after consuming foods high in sulfur are related to a Molybdenum deficiency.

  2. ebm

    wonder why dogs cannot eat foods with garlic and onions!?

  3. John

    Just about everywhere where people make recommendations for healthy eating they tout garlic as being so great for you; it’s a veritable superfood. But for me garlic causes a bad stomach ache. There are some other foods that cause problems also, like onions, but nothing is as bad as garlic.

  4. Susie

    Very interesting story and information. Thank you so much for sharing!

  5. Larry

    No mention of the ‘Garlic Thieves’?

  6. Elaine

    When my late husband ate garlic or onions, he would have digestive problems, that then triggered phantom limb pain. Living in Miami, he learned to ask the waiter for “no cebolla, no ajo”

  7. Judy
    Youngstown, Ohio

    Fascinating article!

  8. sarjula s.

    In the Jain religion Onion and Garlic are prohibited. They always give reasons people can follow
    but the religion is based on science.

    I wonder if those Gurus knew something.

  9. Mary Jane

    This is fascinating, alerting us to seemingly unconnected conditions.

  10. Count
    North Carolina

    Garlic is a potent, dangerous substance for some of us, and it’s everywhere. I learned (the hard way) years ago that 40-45 minutes after ingesting minced garlic as an ingredient in any dish I would become violently ill with extreme diarrhea. Once I made the connection (duh!) I was able to track down the source of a long history of intestinal maladies including both sharp and dull, short and long-term “stomach” pains, as well as a litany of dysfunctional digestive issues. From there I was able to determine which variety of garlic (powdered, whole, etc.) was being used in any given recipe and the affect it had on me. Now I avoid it entirely, although it isn’t always easy. As far as I’m concerned, garlic is poison. Maybe I’m part vampire?

  11. Mary
    Raleigh NC

    This article is fascinating!

  12. Joel

    I am a regular reader of The People’s Pharmacy, which I do mostly for intellectual interest in common medical complaints, but I have never commented on an article before. This one, “Is There a Medical Basis for Stories about Vampires,” is so good that I had to write to thank both its author and The People’s Pharmacy for sharing it. Great publication timing right at Halloween!

  13. Bonnie

    Very interesting story! Recently I was looking into various foods for several of my health problems and different diet programs for weight loss and optimum health. What I found was astonishing in that it said to completely eliminate
    foods in the allium family! I was so surprised as I pondered how I would give up garlic and onions! There may be something to this, and after reading this article, I may eliminate it for a week or more and see what happens. Thanks for sharing!

  14. Gerry

    Interesting that his reaction occurred at age 67 or thereabouts. I’ve noticed different friends have allergies now that they didn’t have when younger. Wonder if certain things your body can handle when you’re young, it just can’t handle any more as you age. My angioedema started when I was 64.

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