immune therapy

An experimental immune therapy conducted on a single breast cancer patient has captured a great deal of attention this week. The 49-year-old woman, Judy Perkins, had metastatic breast cancer that had spread throughout her body. The disease had not responded to a variety of previous treatments, and her doctors expected her to only live a few more months.

Personalized Immune Therapy:

Then, researchers at the National Cancer Institute initiated a brand new form of immune therapy (Zacharakis et al, Nature Medicine, June 4, 2018). They harvested specific immune cells from her tumors. These tumor-infiltrating lymphocytes, or TILs, were encouraged to multiply in the laboratory.

While the immune cells were growing outside her body, the clinicians gave Ms. Perkins one of the new immunotherapy drugs called pembrolizumab (Keytruda). This checkpoint inhibitor modified her immune system so that when her own natural T-cells (the TILs) were re-injected into her body they could attack the tumors. That is precisely what they did. More than three years later she is still alive and well with no signs of breast cancer. She has gone back to her active outdoor lifestyle, including a kayak race around the state of Florida.

Will This Kind of Super Immune Therapy Help Other Cancer Patients?

Researchers hope they will be able to repeat this very personalized treatment for other patients. At this point, however, that goal is uncertain. Widespread clinical trials of this type of very personalized immune therapy are a long way off. Two other women who underwent the TIL treatment at the same time as Ms. Perkins did not survive.

Such treatments are likely to be very expensive. Some cancer patients are already taking a different but related treatment called CAR-T (for chimeric antigen receptor T-cell therapy). FDA-approved CAR-T treatments can cost hundreds of thousands of dollars.

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  1. jean
    Reply

    It’s sad that these new cancer treatments are only for the well-to-do as the regular, everyday person will never be able to afford them.

    • Claire
      Texas
      Reply

      How should such treatments be paid for? The government? In that case, how would the patient to be treated be selected? Let the wealthy pay! If treatments are successful, prices will come down.

  2. Still Fighting
    NC
    Reply

    My husband developed lung cancer in 2015. In 2017 it spread to his brain. After 3 brain surgeries it has returned to his chest and side of his face. He was put on Chemo and Keytruda. After 4 infusions it was determined that the chemo was not working, and only Keytruda was continued. As of 6/11/18 it appears the disease is still progressing in the lymph nodes around his lungs. According to his doctors, “Sometimes, it just doesn’t work.” I have been told by doctors that Adenocarcinoma is a cancer that does not go away. We will continue to fight as long as he is able to, but I’m not expecting a miracle.

  3. SARA H
    Fayetteville, North Carolina
    Reply

    Could this immune therapy and pembrolizumab help someone who has had Stage 3 Colon Cancer AND a “Very Rare and Very aggressive” (Harvard Medicine’s words) type of ovarian cancer? April scan showed no tumors, but I go back to Duke June 27 for another scan.

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