Woman with heartburn, gallstones, PPI complication, take omeprazole

Gallstones are hardened lumps of cholesterol or bile acids that can build up in the gallbadder. If they get stuck in the bile duct, they can cause severe abdominal pain. Doctors think a number of risk factors can make the diagnosis of a gallstone more likely. Women are more susceptible than men, especially in middle age. Native Americans and Mexican Americans are also more vulnerable.

A sedentary lifestyle and the excess weight that may accompany it also add to the risk, along with a diet that is high in fat and low in fiber. Even though overweight is a risk factor, rapid weight loss can also bring on gallstones. In addition, a number of medications that can trigger gallstone formation. Estrogen is one, but there are others. One reader wondered about the cholesterol drug fenofibrate.

Does Fenofibrate Trigger Gallstones?

Q. I have recently been diagnosed with gallstones and my liver function tests are high. I’ve been taking fenofibrate for some time. I wonder if that may be the cause.

A. Fenofibrate, a drug prescribed to lower triglycerides and cholesterol in the bloodstream, can indeed trigger gallstone formation (Caroli-Bosc et al, Digestive Diseases and Sciences, March 2001).  The official prescribing information advises doctors to discontinue fenofibrate if gallstones are discovered. This drug can also raise liver enzymes. Moreover, it may have a deleterious effect on kidney function (Kim et al, Korean Journal of Family Medicine, July 2017).

Statins don’t appear to elevate the risk of gallstone development, although they may affect liver enzymes occasionally. Restricting the amount of processed carbohydrates, including sugar and alcohol, can help reduce triglycerides without increasing the risk of gallstones. Following a Mediterranean dietary pattern can lower cholesterol. At the same time, it can reduce the chance of gallstone development. Other nondrug approaches to lowering blood fats should also prove useful, with or without lipid-lowering medications.

Weight Loss:

Previous research has shown that crash diets can precipitate gallstones. People who added a few pounds over the winter may become impatient about shedding them. When standard diets don’t do the trick as quickly as we would like, there is a great temptation to take extreme measures. That is especially true if there is an upcoming event like a family reunion or a wedding.

Restricting calories severely, however, has a serious downside (Johansson et al, International Journal of Obesity, Feb. 2014). Swedish researchers collected data from more than 6,000 dieters. Roughly 50 percent were on a low-calorie diet of around 1,200 to 1,500 calories daily. The other half were getting just 500 calories a day for up to 10 weeks.

Although people on the super-strict diet lost more weight, they were also three times more likely to land in the hospital with a gallstone attack. This complication is painful as well as dangerous.

Get The Graedons' Favorite Home Remedies Health Guide for FREE

Join our daily email newsletter with breaking health news, prescription drug information, home remedies AND you'll get a copy of our brand new full-length health guide — for FREE!

  1. Ann
    East coast
    Reply

    I have gallstones and don’t know how I got them. I’m not on the medications listed in your article. I’m not bothered by them. I’m now wondering instead of using medication or surgery to get rid of them, is there a natural way for them to be dissolved?

    • Terry Graedon
      Reply

      If you look online, you will find some descriptions of “cleanses” to remove or dissolve gallstones. There is, however, no scientific evidence to support these practices. They might work, but we don’t know if they will. Usually, if the gallstones aren’t bothering you, the doctor won’t insist on treating them.

  2. Nick V
    North Carolina
    Reply

    What is your opinion on preventive value of DNA testing? I am tempted by the idea but potential privacy issues and especially insurance implications stop me. Companies such as 23andMe accumulate a large database of personal information and the temptation must be great to sell it to drug and insurance companies. Has anyone heard of anonymous testing?

What Do You Think?

We invite you to share your thoughts with others, but remember that our comment section is a public forum. Please do not use your full first and last name if you want to keep details of your medical history anonymous. A first name and last initial or a pseudonym is acceptable. Advice from other commenters on this website is not a substitute for medical attention. Do not stop any medicine without checking with the prescriber. Stopping medication suddenly could result in serious harm. We expect comments to be civil in tone and language. By commenting, you agree to abide by our commenting policy and website terms & conditions. Comments that do not follow these policies will not be posted. Learn how your comment data is processed.

Your cart

Total
USD
Shipping and discount codes are added at checkout.