inhaled steroids, sex hormones

Inhaled corticosteroid medications such as beclomethasone or fluticasone are prescribed to calm lung inflammation. Such drugs make it easier for people with asthma or COPD to breathe. Doctors have felt more comfortable prescribing inhaled steroids rather than pills like prednisone. Presumably, they believe that inhaled drugs produce fewer systemic side effects.

Do Inhaled Steroids Have Long-Term Consequences?

A large Dutch study now throws that assumption into question. The investigators reviewed the records of 140,879 people participating in the Lifelines Study Cohort.

Approximately 10 percent of this group held a prescription for a corticosteroid drug in some form-topical, inhaled or systemic. Further analysis showed that women using inhaled steroids were 40 percent more likely to have metabolic syndrome. People with high body mass index (BMI), blood pressure and sugar and fats in the bloodstream have metabolic syndrome, or MetS.

What Is the Problem with Metabolic Syndrome?

MetS is a risk factor for a number of other chronic diseases. Obesity, fatty liver disease and even neurodegenerative diseases like Alzheimer disease or Parkinsonism have all been linked to metabolic syndrome (Motamedi et al, Metabolic Brain Disease, March 30, 2017).

This is an association. As such, it does not prove that inhaled corticosteroids cause MetS. But since this cluster of risk factors increases the danger of diabetes and heart disease, doctors and patients may want to monitor inhaled corticosteroid use more closely.

Endocrine Society annual meeting, Orlando, FL, April 3, 2017

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  1. Katie

    I’m 23 years old, normal-lower BMI, who eats healthy and well balanced meals. However, I’ve been starting to have many of the characteristics associated with metabolic disorders such as abnormally high LDL-C, LDL-P, Apo B, and low HDL-2 C (cholesterol related stuff). As well as being in the pre-diabetic range with high blood sugar and HbA1c and indicators of insulin resistance such as high leptin and low adiponectin.

    I have been taking Advair for almost 18 years now, and I believe that this might have played a role in developing these symptoms as I am young and have never been overweight nor am I sedentary. My asthma is still not well-controlled without my corticosteroid, and I had an allergic reaction to Montelukast as a child, so that’s also not an option. What are some LABAs that have been successful in controlling moderate asthma?

  2. Linda Petersen
    Morris, IL 60450

    Recently. after taking Symbicort for a very long time, My doctor changed it to Breo Elipta. It says in the instuctions that it could cause death. Now I am afraid to take it. Does anyone else use this medicine?

  3. Marge

    I use Symbicort. I feel like the doctor was to quick to use them on me. I am afraid to stop using I’v have been using them about 4 years. Between my high blood pressure Drugs and my Inhaler, my energy has gone down hill. I hate being dependent on these medications.

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