graveyard, potassium interaction

The Popularity of NSAID Pain Killer Pills:

Physicians, pharmacists and patients love NSAIDs (nonsteroidal anti-inflammatory drugs) like ibuprofen (Advil, Motrin, etc.), celecoxib (Celebrex), diclofenac (Cataflam, Voltaren), etodolac (Lodine), ketoprofen (Orudis), meloxicam (Mobic) and naproxen (Aleve, Anaprox, Naprosyn, etc). Billions of such pills are prescribed, dispensed and swallowed every year. It is estimated that over 20 million Americans swallow at least one NSAID every day to relieve arthritis pain as well as discomfort from headaches, sprains and strains.

Are Ibuprofen and Naproxen as Safe as You Thought?

Because ibuprofen and naproxen are available over the counter we tend to think of them as low-risk drugs. Even with clear instructions about only taking small doses of such a pain killer for short periods of time, many people barely bother to read the label. Surveys have discovered that one-fourth of consumers take more than the recommended dose and roughly half are unaware of the potential for NSAID toxicity or just plain don’t care.

The Dangers of Your Pain Killer:

A study (The Lancet, Aug. 31, 2013) suggests that such a cavalier attitude toward your pain killer could kill you. Investigators analyzed data from over 600 clinical trials of NSAID-type pain relievers involving more than 350,000 patients. Here’s what they found:

 • NSAIDs like ibuprofen and diclofenac taken in “high doses” for long periods of time are just as likely to cause heart attacks as the drug Vioxx that was pulled off the market several years ago.

• Ibuprofen more than doubled the risk of a “major coronary event” (heart attack or cardiac-caused death) when taken in doses of 2400 mg a day.

• Coxibs  such as celecoxib (Celebrex) or etoricoxib (Arcoxia) raised the risk of a major vascular event by about a third and a major coronary event by two thirds.

• Naproxen was the least likely NSAID to cause heart attacks and would be our first choice for treating pain or inflammation.

• All these NSAID pain relievers (including naproxen) doubled the risk of congestive heart failure, a serious and potentially deadly heart disorder.

• All NSAIDs (including naproxen) were implicated in digestive tract disorders including serious or life-threatening bleeding ulcers.

What Are the Hazards of a Pain Killer at Lower Doses?

What we do not know is what the risk of NSAIDs might be when taken in lower doses for shorter periods of time. It should not be assumed that such pain killer regimens are perfectly safe. Apparently, drug companies have taken such admonitions into account and are offering “low-dose” regimens (Pain Management, April, 2016).

Drug safety experts have estimated that tens of thousands of people died from heart attacks and strokes triggered by Vioxx. It is entirely likely that far more people are dying from other NSAIDs like those listed above.

The FDA is incapable of identifying these drug-induced deaths. One of the highest-level FDA officials admitted to us after the Vioxx scandal that the agency could not detect such deaths because heart attacks and strokes are so common that they couldn’t tell when one was caused by a pain reliever like Vioxx and when one was just a “normal” event that would have occurred anyway.

NSAIDs and Atrial Fibrillation:

This new research comes on top of a realization that NSAIDs can trigger atrial fibrillation (A-fib) or flutter (International Journal of Cardiology, April 1, 2015). These can be serious arrhythmias with devastating consequences. Because the upper chambers of the heart are not beating forcefully, blood clots can form in the left atrium and travel to the brain, leading to a stroke.

That is why people who are diagnosed with A-fib are often prescribed blood thinners such as warfarin (Coumadin). Although this anticoagulant can reduce the risk of developing a blood clot and a stroke, it carries its own risks.

Here are some comments from visitors to this website:

“Quite unfortunately and surprisingly, I was diagnosed with atrial fibrillation earlier this year and now (ugh) I have to take both Coumadin, a blood thinner, and sotolol, a beta blocker. I’ve never even used an antibiotic! Nothing but homeopathics, herbs, etc. So you can imagine how I feel about having to take those meds!

“Anyway, in researching all the risk factors for that darn A-fib, NSAIDS were cited over and over as a major risk factor for the development of Atrial Fibrillation. I only took ’em on heavy skiing or hiking days, as I’ve had multiple injuries to both knees. But needless to say, I haven’t taken one NSAID since.” Cindy

“I am on high blood pressure medication and was prescribed meloxicam for a painful back sprain/strain from yard work. Within three days I was in the ER with extremely elevated high blood pressure. Just be careful if you take these types of drugs.” Dee

“I was a victim of Vioxx (a COX-2 inhibitor similar to Celebrex) ten years ago this month, nearly died from it. I am still suffering from the A-fib and the effects of the drugs to control it.” Hank

“I can confirm that NSAIDs cause my A-fib. I had bouts with A-fib for several years that got progressively worse. My cardiologist carried out a cardio-version about three years ago and the A-Fib completely went away. But about 6 months ago I strained my back working at my parent’s house.

“My mom gave me a COX2 drug and I also took some ibuprofen that night. My A-fib came back the next day and lasted for a couple of days. I suspected a causal relationship and asked my doctor but he didn’t think it was necessarily connected.

“Then last week I tore my Achilles tendon while traveling overseas. They gave me some diclofenac rub to help with the pain and it really seemed to work. I didn’t realize that diclofenac is also a COX-2 drug. After using it a couple of days, my A-fib came back again and is now very persistent. After a week, I still have it and now have to go back to the cardiologist. I’m guessing another cardio-version may be in order.

“I would like to thank the drug makers for all of the extra money I’m going to have to spend to get my heart back in rhythm. And who knows how many years these drugs have taken off of my life. I would think they would do a better job of warning their customers about this very serious side effect, especially those with a history of A-fib.” W.R.A.

Add your own story or comment below. If you would like to learn more about non-NSAID pain relief, check out our book, The People’s Pharmacy Quick & Handy Home Remedies or our Guide to Alternative Treatments for Arthritis.

An NSAID pain killer also doubles the risk of heart failure (Prescrire International, Jan., 2016). We think it is time that the FDA alerted physicians, pharmacists and the public to the dangers of NSAID-type pain relievers. Although no one seems to want to worry about side effects from drugs like ibuprofen, celecoxib, diclofenac or naproxen, we want you to avoid a premature heart attack or stroke. There are other ways to control pain and inflammation that are far less risky!

Revised 4/11/2016

Get The Graedons' Favorite Home Remedies Health Guide for FREE

Join our daily email newsletter with breaking health news, prescription drug information, home remedies AND you'll get a copy of our brand new full-length health guide — for FREE!

  1. Dave
    San Jose, CA

    I wish articles/posts like this would list healthy alternatives. All I know is I’ve been fighting daily flare ups since pulling something in my lower back in December. I finally went and saw my doctor because healing was progressing slowly. I took Celebrex, which had helped me in the past.

    By the end of the day, and since that appointment. Most all of the pain is gone, mobility is way better, and it’s not like pain killers that make you constipated or have crummy side effects. Obviously, I don’t want to take it forever, but while I build up my core and get strong, doing passive exercise, it’s nice to have this option. Both my parents who are older take it for arthritis and it really helps them too.

  2. JLW

    Just want to follow comments. I like the Voltaran gel but I still take Advil at a low dose and not everyday.

  3. Torrence
    Boardman, Ohio

    I’m having a REAL probem with all this news. Is it the over dosing or just plain old dosing? AND what about aspirin? People have been taking this drug for centuries. AND many of us have been told by heart doctors to take an 81 mg tablet a day. It seems to me NOBODY knows exactly what is going on. Maybe all of the heart attacks they speak of are NOT related to drugs at all, but just plain old heart attacks. They even said that they couldn’t tell if the heart attacks were related to the pliis they tell us to stay away from. I have been on the 81 mg aspirin for years and I’m still here. I guess, according to the news related here, I should plan for my funeral???????????????

    • Terry Graedon

      Aspirin is not the same as the other NSAIDs. Instead of increasing the risk of a heart attack, it reduces that risk. Be sure that your doctor knows you are taking aspirin, as there ARE some dangers there, especially GI bleeding.

  4. SGH

    My physician switched me to Tramadol for moderate to severe arthritis pain. I had been taking 2,400 mg/day of an over the counter NSAID, and was concerned about the dosage needed to relieve my pain. I take Tramadol as prescribed, get good relief of my pain, and have no difficulties or side effects.

  5. MsM

    Painful knees, no relief from Mobic, limited from Celebrex but only for a few weeks. Wary of Tylenol and I have known this info about ibuprofen so rarely take it. Saved for really needed.
    Plain old aspirin works as well as anything along with ice (or heat) and occasionally a pain patch (flector).

  6. Chris

    There are other solutions outside the pharmaceutical chemical box. For exercise and gardening induced muscle soreness, homeopathic Arnica 30C or 200C and Bellis Perennis 30C or 200C help enormously with no nasty side effects. Comfrey ointment is also wonderful. For arthritis, a personal consultation with a homeopath (and there are many in the USA) would be an effective and safer option for pain control and maybe even elimination. Worth a try.

  7. Jenny

    I am age 87 and have been taking 1 baby aspirin per day as a preventive measure and have been. diagnosed with age related macular degeneration, Could this be attributed to the baby aspirin?
    I have been taking the aspirin for about ten years

  8. Jenny

    I am age 87 and have been taking 1 baby aspirin per day as a preventive measure and have been. diagnosed with age related macular degeneration, Could this be attributed to the baby aspirin?

  9. Nancy
    Arlington Heights, IL

    Why, when there is so much evidence pointing to the harmful cardiovascular side effects of NSAIDs, do doctors tell patients with symptoms to ignore the warnings and continue with the medications?
    And, on the same subject, no matter what the side-effects of blood pressure medications, blood thinners or cholesterol lowering drugs, doctors keep telling patients to ignore the warnings and keep taking the damn stuff? Do they think we are just sniveling hypochondriacs?
    Don’t you love the commercials on TV where the advertiser touts the benefits of some medication but its followed by a long, long list of “possible” side-effects including death? Really wants a person run out and buy the stuff.

  10. Bob
    Chapel Hill, NC

    Naprosyn 375 mg. twice a day regularly for several years lead to borderline failing kidneys. I had my shoulder replacement before learning that.

  11. Jay

    There are two things that every household must have especially if you are over 50. 1> is an OXIMETER and if you have every had an A-FIB attack you should get an Oximeter that can measure you heart rate and oxygen level while you are sleeping. About $100.00 and worth every penny. 2> a data recording blood pressure machine the best cost $65.00 – $75.00

  12. Gaby

    Please clarify whether voltaren gel used topically on knee or spine carries the same risk as NSAID pills. I use a fingertip size portion on a knee, and fingernail portion on one irritated verterbra as needed. I’m having no luck asking doctors. A rheumatologist prescribed it.

  13. kate

    I’ve been on 650-2600 mgm of enteric coated aspirin daily since 1968, 45 years, with no adverse side effects. I keep telling people this but no one listens. Throw out the garbage, take the basic.

  14. dcwriter

    I need two knee replacements and have been on Celebrex (after Vioxx) for years. My doc gave me some samples of the new Pennsaid drops, which I believe is similar to the voltaren gel mentioned above. I didn’t get much relief from the Pennsaid, but the voltaren sounds worth a try. My job/insurance just ended and I need something generic (and hopefully won’t give me a heart attack!). Knee replacements on hold until Medicare kicks in. Tramadol has been suggested, but I see that comes with its own problems.

  15. AOL

    I also have arthritis and have a lot of hip pain. My doctor’s p.a. recommended voltaren gel. I apply only a small amount to the area and I get rapid relief.

  16. Bruce R.

    I am a gardener who has some back pain from time to time, and take ibuprofen occasionally. Usually only 400mg once or twice that day, and perhaps 400mg the next day if it is bad. Mostly I try to think about how I am working and avoid stupid maneuvers. I take 1/2 aspirin a day with my vitamins for blood thinning, so I try to wait at least an hour after the aspirin to take the ibuprofen.
    My main question is this . . . . what about the impact of an anti-inflammatory diet? I have read about ginger tea, but not really memorized the items that might be inflammation inducing in my diet, nor other inflammation reducers. Can anyone here share foods/drinks that they use to reduce inflammation or things they avoid that have helped with inflammation? I know that the whole inflammation issue also impacts cardio-vascular as well as joints and many other parts of the body.

    • C

      I am 70 years old and am active in outdoor sports with dogs. To avoid inflammation in both me and my dogs, I take and give fish oil caps. and turmeric with pepper. Plus I take tart cherry juice. Have NO aches or pains and the dogs, at age nine years old are active and healthy and no lameness. We all eat whole foods and never prepackaged foods. Fresh and whole.
      Re fish oil. Make sure it has no soy. Eat organic.

  17. CA

    I hate it that I started having pounding fast heartbeat after being on diclofenac several days, and my doctors (both family and cardiology) told me there was no connection between diclofenac and heart.
    The cardio did a heart monitor test, and found my heart was skipping as many as 400 – 500 bpm, but both doctors assured me it was fine to continue taking the high doses of diclofenac, even though I knew better.

  18. LAD

    For years I have been prescribed meloxicam for arthritis pain, and I also developed high BP. I disliked or could not tolerate the medications prescribed for HBP.
    I decided to take only half of the 15mg meloxicam tabs daily, and I began taking L-argenine daily. My BP has been in an excellent range since then, however, the arthritis in my hands has increased but is tolerable.

  19. Mary

    I use Voltaren twice a day for foot and knee pain. How much of this topical would cause a problem?
    I try not to use other NSAIDS very often because if I take them every day I start bruising.
    I’m not supposed to take acetaminophen due to fatty liver. Ice helps, I may need to just be more diligent with ice.
    Are any topical over the counter meds (e.g. Icy Hot) also a problem?

  20. Linda

    I would also like to know whether aspirin has the same problems as other NSAIDs. My doctor recently told me to take advil instead of aspirin for occasional back pain because of potential problems with aspirin, even though I have never had a problem with aspirin. A few years ago a pain management doctor told me that aspirin can cause kidney damage and other problems like any other NSAID, but I couldn’t find research to back this up.
    People’s Pharmacy response: Aspirin does not carry the same cardiovascular risks as other NSAIDs. It certainly can cause gastrointestinal damage, but it seems less likely to cause kidney damage than other popular pain relievers. Of course, that does not mean aspirin never harms the kidneys.

  21. dcwriter

    I was on Vioxx when it first came out, then transitioned to Celebrex for my severe arthritis pain. I’m still on it after many years. I just saw my physician yesterday to talk about pain control, asking if there were an alternative, something between NSAIDs and narcotics. The only thing she suggested was tramadol.
    I don’t like the side effect profile of that drug either. I have no idea what to do, I’m in chronic pain but can’t afford alternative therapies like massage, acupuncture, etc. It is affecting my ability to work and am considering disability. I guess there is no miracle cure, but at least I wish there were drugs that could at least help without the potential to kill you.

  22. Bird

    What about aspirin as compared with other NSAIDs? Does it cause the same problems?
    People’s Pharmacy response: Aspirin does not cause cardiovascular complications like other NSAIDs do.

  23. Sherrie

    I decided just this week to try to stop taking my Celebrex and see if just Tylenol Arthritis would work as well for the pain. I was still hurting even when I was taking Celebrex. Wanted to see if I could see a difference. I am hurting worse but I worry more about inflammation. You say there are other things to use. What are they?

  24. Marta Y.

    Ok…so what am I going to do about the pain in my calf resulting from stenosis? I had the MILD procedure (laminectomy) and it didn’t help one bit. I have done physical therapy for 2 years whole taking 75mg of diclofenac potassium a day.
    My pain is under control, but I do worry about taking the NSAID. I am a very active (golf, walking, swimming) 66 year old female.
    Thanks for your help.
    Marta Y.

    • Marilyn

      Have you gone to a Chiropractor or a Pain Management Doctor? You may need an adjustment to the spine. A Pain Management Doctor may be able to do Radio Frequency shots to kill a few nerves to give relief.

  25. Mary

    Two years ago I suffered from a stroke, the cause of which has still not been determined. I was 53 at the time and in what I thought was tip-top cardio shape. However, in the weeks prior to the stroke, I was taking Advil regularly, mostly as a prophylactic to prevent muscle soreness from some rather intense hiking, as well as sinus-like headaches that had developed.
    I called this my “wonder drug” because it was so effective in preventing soreness. After the stroke, which was a watershed event where the symptoms developed gradually, I read about the dangers of ibuprofen and stroke. I haven’t touched one since and won’t, even though I’m unclear if this had anything to do with it.
    My neurologist poo-poo’d this as a potential cause of the stroke, but it is the only thing that makes any sense to me. My arteries were checked and no blockages found.
    The good news is that I am recovered now and running and hiking again. I’ll gladly suffer muscle soreness and will treat it the old way — with stretching and ice!

What Do You Think?

We invite you to share your thoughts with others, but remember that our comment section is a public forum. Please do not use your full first and last name if you want to keep details of your medical history anonymous. A first name and last initial or a pseudonym is acceptable. Advice from other commenters on this website is not a substitute for medical attention. Do not stop any medicine without checking with the prescriber. Stopping medication suddenly could result in serious harm. We expect comments to be civil in tone and language. By commenting, you agree to abide by our commenting policy and website terms & conditions. Comments that do not follow these policies will not be posted.

Your cart

Shipping and discount codes are added at checkout.