woman scratching an itch on her side, scabies

“So glad to come across all these posts online and realize what is happening. I have been on Zyrtec (cetirizine) for 10+ years. I originally was put on this antihistamine because I was experiencing hives (uticaria) but did not have any other allergies. I experienced the hives a few times and they told me to start taking this drug every day to prevent getting them.

“Well, after years of taking these pills, I finally started questioning why I needed to take them every day. I went off of them for a few days to get allergy tested and when I went to the allergist he gave me a hard time and told me that people takes these pills their entire life. It’s working so why am I trying to get off of them, etc. They first refused to test me for allergies but then finally did but only tested me for about 10 different allergens to which I was negative.

“Those 5 days trying to get off the Zyrtec were the WORST of my life, I literally laid on the couch and scratched and got hives all over. And, I thought, wow I really can’t live without this drug that’s how bad my body is.

“Well obviously it’s not, it’s the drug or the withdrawal from the drug. Before I started taking this drug I didn’t get random itching all over my body. So slowly but surely I’ve come to this point. I’m on day 5 of the Zyrtec withdrawal. For me, this time is a little different. I’m eating very healthy food, at least much as I possibly can. I’ve realized that the initial hives could have possible been some sort of allergy to the food I was eating or drinking and now that has been covered up for 10+ years by this drug so just imagine how much damage has been done to my body.

“The first two days were fine, day 3-today has been pretty bad. Today I have had some slight improvement. When I wake up I’m fine but then slowly but surely the itching will start and it is HORRIBLE. It seems to travel and I can itch in multiple places at once. The absolute worst is in places that you would never want to itch.

“Here is how I’m coping:

– I’m drinking as much water as possible, when I drink lots of water it actually seems to help

– I’m 100% gluten free, dairy free, sugar free. I have an inkling that this is helping me so much more than the first time I did this. I’ve had some grains (rice and quinoa) but plan starting tomorrow to be grain and soy free and potentially nut free while I’m going through this.

– I started taking Vitamin C yesterday and it does seem to help

– Hot showers for me work much better than cold

– I’ve started dry skin brushing (in the morning and before I go to bed) and then applying coconut oil that I’ve whipped into a natural moisturizer so as not to put any chemicals on my already having a hard time skin

– I’m trying to juice in the mornings (all greens for breakfast) and then eat fruit until dinner. However, from what I can tell I have the least reaction when I eat cooked vegetables.

– When all else fails, I find that keeping all my skin covered (long pants and sweatshirts) and focusing on breathing normally even when I’m in excruciating itch mode can bring me back to some state of normal.

“I hope some day that there is something done about this drug. At a minimum there should be some sort of disclaimer about the withdrawal effects. I wish when I was put on this drug that there was more information out there like these posts so that I would have never taken it in the first place.”


We never knew about the cetirizine withdrawal itch until visitors to this website began sharing their experiences. Three years ago we received this message:

Q. I have had terrible trouble trying to stop taking Zyrtec (the generic is cetirizine). After using this antihistamine for about three years while having allergy shots, I first attempted to stop taking it in preparation for allergy testing. Within three days, my entire body itched. It was so horrible that I was crying and preparing to go to the hospital for relief.

Confused by the relentless itching, I forgot and took a Zyrtec by accident. Lo and behold, before I could get dressed and get in the car, my symptoms were GONE. Now, seven years later, I have tried unsuccessfully at least 10 times to quit this drug, and the reaction is more severe each time.

Today while I was researching this problem online, I found a community of thousands of people who have had the same problems I have. There should be better warnings about this withdrawal problem.

On May 5, 2010 We answered:

Cetirizine is an antihistamine that is often used to treat itching due to allergies, but the withdrawal phenomenon you and other patients have experienced is not included in the medical literature.
Please discuss this problem with a dermatologist. She might have a solution to weaning off this antihistamine, perhaps with a short course of corticosteroids.

People have tried a number of ways to overcome the chronic and nearly intolerable itching that may begin shortly after discontinuing cetirizine. Some people report that a gradual reduction in dose helps a bit and that after about two weeks, the itching slowly recedes and eventually disappears.

Here it is three years later and there is still nothing in the medical literature or official prescribing information about withdrawal symptoms associated with cetirizine (Zyrtec). We have notified the FDA that people are suffering but no one seems particularly interested or concerned that patients are suffering. There is no warning and no recommendation about how to get off this allergy medicine. The medical and scientific community seems equally indifferent.

The problems of cetirizine withdrawal points up a huge flaw in the FDA’s regulatory system. The agency seems oblivious to what has been called “discontinuation syndrome” or withdrawal from a number of medications. It took years for the FDA to figure out that anti-anxiety agents like diazepam (Valium) or alprazolam (Xanax) could trigger withdrawal symptoms when stopped suddenly. Ditto for antidepressants like sertraline (Zoloft) or venlafaxine (Effexor).

Even now that the FDA requires some mention of this problem in the official prescribing information with anti-anxiety agents and antidepressants, there are no guidelines or recommendations about how to gradually discontinue such medications. That leaves physicians, pharmacists and patients at a loss to come up with a solution to this huge problem. People make up their own regimens, but it is very much hit or miss and many suffer if they phase off too quickly, whether it be a seemingly benign OTC antihistamine like cetirizine or an antidepressant like duloxetine (Cymbalta).

Here are some additional stories and successes. Please share your own story in the comment section.

Cetirizine (ZYRTEC) Withdrawal

“Just found this thread on Zyrtec and am so glad to find I am not alone. I have taken Zyrtec and its generics for years now, but back when it was prescription only, if I’d forget to refill on time I would get itching within a few days. First, I would random get itches on my scalp, then my arms would begin itching, and it would go on from there. I vaguely recall even getting hiveish little bumps.

“It is good to know it’s the pill and not in my mind. It actually was ON my head… as a type of withdrawal symptom. When I was hospitalized recently, I had to tell the doctors I had to continue the Zyrtec generic or my burns would be getting itchy and maybe break into hives.”

“I took zyrtec for many years (both brand name and generic) for allergies. A couple months ago I decided to go off of it ‘cold turkey’ and I was miserable for a full two weeks. The itching was uncontrollable… and scratching made everything worse. I did find a little relief by putting ice packs on my body when I itched, taking Quercetin several times a day, going for acupuncture 2x week, yoga/meditation several times a week, and by slathering Sarna cream all over my body.

“It was total torture going off this drug! 
For the spring allergies when pollen levels are off the charts I do use a nasal spray and sometimes have to take an advil & sudafed for headaches.”


“I’m in the same boat too. Been taking it for about 14 years, since I was 16. For the last month or so I’ve been weaning down. 1/2 a tablet every day for a few weeks, then 1/2 tablet every second day.

“I’m now on 1/4 tablet every second day. Itching starts about 24 hours after the last tablet, but I can push through to the 48 hours before taking another 1/4. Will try the vitamin C and other remedies mentioned here. I too told my doctor and he said he never heard of it. Maybe I should tell him to google it… :-)”

Dermot, March 25, 2013

“Ok, I posted about almost month ago, still tapering off. Its definitely the way to go (rather than cold turkey). I reached a point where I was taking 1/4 tablet every 2 days, but the last 12 hours of each 2-day period were a nightmare.

“Instead, I take it every 24 hours, but just reduce the amount. So instead of 1/4 tab every 48 hours, take 1/8 of a tab every 24 hours. Last week I reduced it to a few tiny crumbs of a zyrtec tablet every morning, about 1/16th of a tablet (Thats 1 tablet every two weeks!).

“I’ve crushed a tablet up between two spoons, and tried to divide up the resulting powder into 16. Pretty hard to do. now I just lick my finger and dab it in the powder and take a few particles of the tablet every morning. I’m still reducing it every few days. I’m probably at about 1/20 of a tablet now.

“I know it seems a bit extreme, but if I stopped cold turkey, even from 1/8 of a tablet to nothing, I started itching all over so much it was unbearable.

“Just keep taking less and less until you’re taking a couple of tiny crumbs, then one crumb, then 1/2 a crumb (!!), then nothing. I hope to be off it completely within the next 4 – 6 weeks.”

Dermot, April 14, 2013

Duloxetine (CYMBALTA) Withdrawal

“I was on Cymbalta for about a year for pain in my shoulder & neck. Then they realized it was a torn rotator cuff. The doctor said I could get off of it. He gave me 30 mg for a week & said I would be fine. I had been on 60 mg.

“I did as I as told. Once I finished the 30 mg for the week, I was sick as you can imagine; my stomach was killing me, diarrhea and headaches. I felt so nauseated & dizzy. It was absolute misery. I had never ever had an experience like this with any other meds. It’s been 3 weeks and I’m still nauseated. I have headaches and my whole body aches. I’ve gained weight & have no clue why? I get these hot & cold sensations like hot flashes.

“I feel like I’m in outer space. I fly off the handle easy. I’m just tired & feel like I never get enough rest. It’s the worse med I have ever been on. It helped only for pain like fibromyalgia but otherwise I’m still struggling with this after 3 weeks & wondering how long will this take. When will I feel better. They should really tell people to wean off slowly and not so suddenly. This is an awful drug.”

V. Ross

“I’ve been on Cymbalta for six years. I was put on it by my rheumatologist for the neuropathy in my feet that was a result of fibromyalgia. I was feeling like I was keeping my feet in the bonfire all the time. She couldn’t put me on it “officially” because it was only for depression at the time. She put it out there that “You’re depressed, aren’t you?” so she could put that on as the diagnosis and start me on it. I leapt at the chance.

“I floated between 60 and 120mg, at first the 60 so that it would stop the pain. But I started having real depression, crying jags, and such. I ended up on blood pressure drugs and gained 100 pounds. I ended up going to a psychiatrist who upped the medication to 120mg to cover the depression and added an anti-anxiety drug.

“This last October my husband lost his job. We found the Cymbalta was going to be over 600.00 a month. We knew I was having bad liver enzyme tests so I decided to just wash out of it so that we wouldn’t worry about the expense. We did try to go through the company to get help affording it but Eli Lilly denied us because they counted his severance as “income.”

“I took three weeks to come down from 120 to nothing, the longest I could make it stretch. I’ve had the “brain zaps”, violent outbursts that have had me hitting my beloved husband of 20 years, screaming, throwing things, terrorizing the dogs, everything. I’ve cut my hair, pulled it out, hit myself until there were bruises, and destroyed things I loved. And I can barely remember it. My husband has hidden our guns and my medications because of the suicidal threats I’ve made over and over. I can’t sleep, my neuropathy is back with a vengeance and the pain from the fibro is worse than ever. I’m in a daily flare. Sleep? What’s that?

“This stuff is real, this Cymbalta Withdrawal Syndrome. The manufacturers don’t tell you this is going to happen but believe me, it does. Every time I see a commercial for this drug, I get angry all over again. It’s not a panacea, it’s a death trap in a pretty bottle. Maybe not when you are on it, but like Hotel California: “You can check-out any time you like, But you can never leave!”

“Getting off Cymbalta is challenging but not impossible. I, too, experienced the light-headedness, dizziness, and “brain zaps.” I described it as being able to “hear my eyes move.” It sounded like the light sabers on Star Wars. Very strange and disconcerting.

“The key is to do it very very slowly. Take the capsules apart and begin by removing 5 or 10 of the tiny balls inside. Do this for a week or so, then slowly increase the amount you remove each week or two as you can tolerate it.

“Your doctor will probably be no help at all. Mine wasn’t. He instructed me to wean off over a two to three week period and I almost lost my mind. I did it myself over about a YEAR or more. Be patient. I am completely off now and feeling GOOD.”

Should you wish to learn more about how others have phased off the antihistamine cetirizine (Zyrtec) or antidepressants such as duloxetine (Cymbalta), check out these links:

Zyrtec Withdrawal Stories

Cymbalta Withdrawal Stories

Share your own experience below.

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  1. Dot

    Started an allergy on Saturday. Already had puritan on hand, as have had allergyies before.This time they didn’t work. So next day I went to doc, and he gave me a antihistamine beginning with F to take one a day. That didn’t work so next day I went to my own doctor. He gave me 5 packets of 10mg tablets to take four times a day. Also some Cetraben cream. My symptoms are just the same: hives and itching. And I can’t make up my mind whether it is the pills or cream that is making the allergy worse. Usually you just need to take one antihistamine, and you are feeling better. After reading the reviews of cetirizine, which is what the doctor gave me, I have decided to stop taking them after two more days.

  2. Dave

    I’ve been taking Claritin (loratadine) for the better part of 17 years, after being advised to take it for a potential post-nasal drip issue, and just continued taking it. I’ve never actually been tested for allergies, but I never had any bad reactions like most people I know who are allergic to pollen/seasonal/etc. I decided to go cold turkey, not even thinking there would be much difference b/c I figured how big a deal is Claritin.

    Well, I’m itching all over, under my skin, head to toes in spurts for the past 2 weeks. I suspected this might happen b/c I have itched in the past, but couldn’t definitely tie it to being off Claritin. This is definitely the cause, though. I took 1 pill on a night I just couldn’t stand the itching, and it was nonexistent within a couple of hours. I’m relieved to see I’m not the only one, and I’m going to buy some liquid Loratadine to maybe try tapering off a little more. If this could actually last 4-6 weeks, I might be insane by then.

  3. Pricilla
    Illinois (IL)

    Going to the allergist next week. STOPPED taking Xyzal Saturday and was itching like CRAZY mad last night (Tuesday). Gonna bring it up to the allergist. Has anyone else gotten feedback from their doctor about this?? Can’t wait to hear your answers. Hopefully, I will remember to update after my appointment next week.

  4. Anna
    kampala, Uganda

    Hi everyone. Just like anyone here, am experiencing difficulty in withdrawing from taking cetirizine. It’s been five years now. It’s hell skipping a pill. The inconvenience caused by the itching is intolerable. Thanks for sharing your stories. Am gonna try out some of the remedies shared.

    I also read that quercetin helps a lot in relieving the allergy. I pray we all get fine….

  5. Fuyuko

    I was given this medication for a sinus infection I had a few years ago. It worked well, but after the antihistamine started to dry out my sinus I decided to quit. I began a horrible cycle of painful itching the likes that I have never seen before. I even went back on the drug to stop the itching, but now the drug itself makes me itch.

    Worse still, after ceasing this medication, my body has never recovered. I have increased itching caused by the drug I’m sure. I never used to have any problems with itching, but somehow this drug made me more sensitive to histamine than I was prior to taking it. ITs like a bad rebound. worse, my body has never been the same. I now get itchy much more frequently, as my body is now more sensitive. I seriously think this medication poisoned me and made me more sensitive to histamine than I have ever been before.

  6. Jessie
    Chicago, IL

    I am happy I found this thread. I’ve been taking Zyrtec for at least 2 years straight. My bottle ran out, and I decided to wait until I go shopping to buy another. It’s been 3 days, and I have had unbearable itching/hotness and hives on my scalp. For some reason my palms, fingers, and scalp are the worst but the itching continues everywhere. It comes in waves. Nights are terrible. I wish I would have known this drug has withdrawal symptoms. I am going to try ibuprofen and turmeric pills, as someone suggested, but honestly I’ll probably buy a new bottle soon and maybe try to slowly stop taking it. Can’t stand the itching!

  7. Raffinee

    Day 4 off Zyrtec for allergy testing tomorrow and the itching is driving me mad! I have been on it for 20 years! My God! Give me relief! I never want to take this again and the allergist is going to have to help! I ITCH EVERYWHERE CONSTANTLY!

  8. Tati

    I am going on day 4 without it and i have been taking it every day since over 6 years. I have been irritable, sad, and waking up randomly throughout the night throwing up, i can’t eat sometimes due to the anxiety I have. During the past years, I have been snappy, irritable, uncontrollable outburst. Nights i forget to take it, i wake up feeling like im going to jump out of my skin. This is almost as bad as pain meds, praise God I was able to quit that 4 years ago. Am i the only one that is not experiencing the itching but all the other symptoms?

  9. Marc

    I have been taking fexofenadine (Allegra) during Fall for my seasonal allergies. I have recently tried stopping and noticed that I was itching like crazy. I thought that there must still be allergens in the air causing this itching, so I went back on the medication. Then, yesterday, I stopped and noticed the same itching. It’s the dead of winter. There are no more allergens in the air at this time. So I thought, “I wonder if it’s the medication.”

    After a single Google search, I’ve discovered that my hunch was right, and that I’m not alone. No more allergy meds for me. Hopefully, the withdrawal doesn’t last too long. I’m going in for rotator cuff surgery in two weeks. I’m hoping to be clear by that time. These drugs need to be off the market, or at least there needs to be advertising as to what you will go through if you subject your body to these drugs.

  10. Mel
    Sydney Australia

    I’ve been using antihistamines for about 2 years now. I was suffering from urticaria and later found out that it was hives. It started off on my back and then spread on my whole body. I visited a GP and was told to get onto Allegra (Telfast) ASAP on two tablets a day, but this later worsened. It developed into breathing problems, wheezing and having shortness of breath..

    This was a rare and uncommon ‘reaction’ and was referred to a specialist. I was undergoing tests and found that I suffered from mild asthma which could’ve sparked the breathing phases every single night. I was told to change to Zyrtec and take four tablets a day and I listened, but I did gain weight and I have been gaining weight, I find it very hard to lose weight and having a urge to eat is really annoying.

    Before being on medication, I would lose 3-4 kilos every week, now I can barely lose one. I went three days without the antihistamines and found that it only got worse. It was the worse three days of my live and I wanted to think that I could survive without this drug but; I couldn’t. It was scratching every day and every night, every minute of the day.

    I do want to stop taking it but I know it will trigger my body as it is used to the drug already but I feel like I could get used to it as I’m still young and still have room for improvement. Even with being on the antihistamine I still receive my breathing phases and hives hence why I have to take four a day. I really really really want to find a cure to my condition but I don’t think I could survive without the drug. Would allergy shots help with my urticaria and breathing phases? I really need you help. (PLUS + I need tips on how to balance weight loss with being on this drug)

  11. Judy
    North Carolina

    I have been taking xyzal for about a year. I stopped taking it 3-4 days ago and started having severe itching. Yesterday morning I scratched my sides so hard I had dark bruises by the evening. I thought I was gonna loose my mind. Finally today I searched for meds that cause itching when stopped. Antihistamine type meds were the first to come up. Oh my gosh, finally an answer. Meds are supposed to help but seem to cause more problems that keep you running back to the doctor.

    • Allie
      NEW YORK

      I’m about a week in to my withdrawal for Xyzal and I’m really struggling. I don’t know what to do. I don’t want to go back on this drug. Any suggestions that helped you get through it?

  12. Shamsa A

    My doctor suggested I take zyrtec daily for the rest of my life to avoid hives that I get sesonally. Mind you I only got hives maybe once a year, and my old physician would just prescribe me a small dosage of prednisone for 6 days that would put the problem at bay. So it seemed kind of unnecessary to make such a commitment to take zyrtec everyday, when I don’t have a chronic hive problem at all. Anyways, I still used zyrtec for a good month, and then I genuinely just forgot to take it one morning, and I broke out into horrible hives all over my body, much worse than my seasonal hives.

    So I went to an urgent care center, where they prescribed me prednisone once again for like 5 days, and boom, I’m all better, and the hives didn’t come back until the following year as per normal, and i haven’t taken zyrtec since. So if you go cold turkey trying to stop taking zyrtec and you break out into hives, I highly suggest you go to an urgent care center or your primary doctor and tell them to prescribe you prednisone. I’ve personally had better experiences with urgent care doctors because they usually prescribe you something that will take care of the problem asap, while my primary doctor doesn’t listen to anyhing I say, and tries suggesting me things like taking zyrtec for the rest of my life. And yes, Prednisone is a steroid and should not be taken a lot. The only reason my physician used to be okay prescribing it to me was because I only had an allergy reaction once every 1 to 2 years. Those are my thoughts, and I hope my experience can help someone.

  13. Cathie

    I have taken either Zyrtec or Xyzal (they are related) for about 9 years. I was going to have testing, and it was HORRIBLE trying to come off of it. When I had my daughter I had to come off and take claritin while nursing in 2010, and I didn’t get itchy then, but I did lose weight…I attributed it to having my daughter and nursing. When I went back on the Xyzal when she was 3 months old, however, I gained weight.

    I decided around Christmas 2015 that I needed to come off of it to test some theories. I dropped weight SO FAST. I’d weigh myself in the morning, then at night and there was already a difference. I lost about 10 lbs. I used claritin and turmeric to get through the worst of it, and it took about 5 days to regulate and no longer be itchy.

    When my spring alelrgies were coming back, I had to go back on it (spring 2016) and have been on it since (fall 2017). Recently I started getting a bunch of eczema without explanation so I made an appointment with my allergist. I’m on day 2 and soooooo itchy but I can’t take anything…this sucks.

  14. Anna

    I’m on my second go around of stopping this awful “medicine”! The first time I didn’t replace because I was no longer having symptoms. I wish I had researched these side effects then! I’m currently 2 days in and my scalp, face, neck, shoulders, upper back and arms are covered in a lovely shade of red! :( My heart is racing and I can’t stop ITCHING!!!! If that wasn’t bad enough, I suffer from YOPD (young onset Parkinson’s Disease) so my tremor and anxiety are out of control! When will this stop? Why isn’t this side effect listed on the packaging?!

  15. Ev

    I’m sorry everyone here is suffering from the same thing, but boy am i glad to discover there’s a community online where everyone is pretty much experiencing the same suffering!! I’ve been using Zyrtec and Telfast (Allegra) for 10 years now. Same symptoms of withdrawal – I thought it was my chronic urticaria, but after reading others’ experiences I see it might be the drug itself! And I do notice that sometimes when I take the drug, I get an instant itch reaction before it calms down.

    Someone shared her experience on this page, an interesting alternating with gradual dosage approach:

    Good luck everyone! I would be so so grateful for this to be out of my life :p Having said that, there are worse things…

  16. Laurna

    I have been taking the 10mg tablet of ceterazine for months now due to allergies. I didn’t take for about a week, started with intense itching, finally went to doctor and was prescribed prednisone, doxepin, and a steroid ointment which helped clear things up, But now I’m off the prednisone, and the severe itching has returned. This is affecting my sleep, and I’m very uncomfortable due to the itching. This is caused from the allergy medicine from what I’m reading?

    • Joan

      I started taking Zyrtec several years back because as I told the Dr., I was itching all over. I didn’t have hives as such, just itched. He said I had high “histimine” (sp) in my system and Zyrtec would stop the itching……..which it did. This spring I’ve had such bad pollen allergies that I finally stopped taking Zyrtec and went to the Dr. for a shot. Yep you guessed it! I’m itching so badly I don’t know where to scratch first. Do I break down and take a Zyrtec for the itching or is it unsafe after having an allergy shot? Anyone?

  17. Lee

    I THINK I CAN HELP! I’ve been dealing with Cetrizine dependence for 10 years now and have been off the drug AND symptom-free for over two weeks now. I’ve been taking Loratadine (Claritin as it’s known by brand) every day. Although I can feel my skin crawl a little bit sometimes, it’s usually cleared up by taking another Loratadine tab, and I never really need to take it more than every 18-20 hours to prevent symptoms from flaring up.

    I can’t say I’m healed of this nonsense yet but I firmly believe I’m on the path to freedom from it. I feel for everyone here. If you’re reading this share your story. We need to help one another out. I hope I’m on to something, I will update you all.

    • koro

      So how is it by now? Are you still cetirizine-free?
      Also, did you manage to be off anti-histaminics, or did you just substitute cetirizine by loratadine?

  18. Colette m

    Go glad I found this blog. I’ve been taking Allegra for 10+ years and finally decided to get tested to see what it is that I’m allergic to. Well, that was 4 days ago and I’m about to lose it with the itching. The first day was not so bad but these past few days have been brutal. this has also affected my moods. Tomorrow is my test and I plan to take one as soon as I leave the office but will be tapering off this awful medication even if it takes me a year to do so. The allergy doctor who scheduled my testing tomorrow never warned me about these side effects. I’m definitely going to bring the subject up to him, not sure he’s even aware.

  19. Amber H.
    Atlanta, Ga

    I’m currently weaning off Zyrtec, after reading MUCH about how to, what’s worked for others, and what hasn’t worked. I’ve been on Zyrtec for about 5 years for environmental allergies, but we’re looking to start a family in the upcoming years, and I don’t want to have a baby addicted to Zyrtec at birth, and would prefer to be off everything for pregnancy.
    A week ago today, I cut down to half a tablet a day. I read how Vitamin C can help with withdrawal symptoms (including Opiates, which thank the gawds I don’t have addiction to), so I’ve been taking a packet of Emergen-C throughout the day. It’s 1000mg a packet, which is the maximum amount of Vitamin C I read you’re supposed to have to avoid stomach upset. I basically take 1/4 a packet 3-4 times a day, and right before bed. I take a prenatal vitamin at dinner which also has some Vitamin C. So far, I’ve had very little breakthrough itching. I’m thinking about cutting back to taking the 1/2 a Zyrtec every 36 hours, but I’m scared I’m pushing it too quickly. I’ll try to remember to update my progress here, in hopes of helping others going through this same nightmare.

    • Amber H.
      Atlanta, Ga

      After about a week and a half of doing the 1/2 a tablet every day, I skipped my dosage Friday morning, in hopes of going 48 hours without it. I did have some itching Friday night before bed, but didn’t cave in, though I did take two Benadryl. I figure the Benadryl would help me sleep through the night, at least take the edge off.

      I made it to Saturday morning, took the 1/2 a tablet, but by Sunday night, was itching like CRAZY. I once again took Benadryl Sunday night before bed, and took 1/2 a tablet this morning (Monday). I’ve continued using the Emergen-c, but I ‘m going to stick to a more regimented schedule now that I’m down to 1/2 a Zyrtec every 48 hours, to see if I can keep the breakthrough itching to a minimum. I think I can see a light at the end of the tunnel though!!

      • Amber H.

        I’m now down to half a pill every 2 days. However, if I don’t take a Benadryl the night before my dose, I will wake up with the itches! I plan to do this schedule for another week or so, and see if I can get down to half a pill every 3 days. Every time I think, “Okay, I think I’m done with this crap!”, the hives rear their ugly heads again. And when I was on the full dose, where my itching would be isolated to my hands and feet, the itching is now widespread. It’s still mostly focused on hands/feet, and weirdly my wrist, but I’ve also had more generalized itching on my scalp and body.

        • koro

          Can you post an update on your situation?
          Unfortunately we have many stories of people sharing the terrible withdrawal symptoms but very few success stories of people managing to get off the drug.
          Maybe your story can give us hope…

          I’ve been taking cetirizine daily for the last 20 years, and the burning/itching/stabbing under my skin that I get after skipping one pill is so unbearable that I’d contemplate suicide if I had to spend more than a few days like that. So for now I’m stuck at taking cetirizine for life, but I’d really like to think there’s a way out…

  20. Loree W

    I’ve lived in Arizona since 1995 and have had terrible allergies every since moving here. 10mg of Zyrtec and Flonase every day were the ultimate solution. However, for reasons I don’t understand, this summer my allergies have been less. I didn’t like the dry mouth, dry eyes, and dry skin I was experiencing so I cut back to 5mg of the Zyrtec and only used Flonase as needed.

    I did that for 3-4 months. With all the heat we’ve had I felt like I didn’t need either medication so stopped both 3 days ago. Then the itching, red, sometimes hot skin symptoms started. Mostly on my shoulders and neck, but sometimes legs, back of the head and torso. My hands are incredibly itchy periodically as well. I’m glad I’ve found all of your posts, because it really makes sense that this is what is causing all of the itching. There absolutely needs to be warnings regarding withdrawal from this medication.

  21. Sandra

    I too have been on Reactine/Cetirizine for 20 years.

    I had stopped taking the medication once and thought my hives (why I was taking it in the first place had come back) so I resumed taking the meds.

    Recently, December 2016, decided to reduce the dose to 1/2 a tab….I did experience itching. But I kept on the 1/2 tab. I seemed to adjust to reduced dosage.

    About 2 weeks ago ( June 2017) I decided to stop taking the medication altogether. The first few days it was okay. Then the itching started. First on my scalp, I thought I had a sensitivity to a shampoo, which I had been using, but the itching started with a vengeance.

    The itchiness would move to different parts of my body, head, back elbows, legs, even my eyelids! it was like it moved to little hot spots, some lasting from a few minutes to an hour.

    It is by accident that looked up this website as the itching is VERY distracting and here you all are.

    One night I woke up with congestion in one sinus and blew out clear fluid from this one sinus – it felt like I was getting a cold…but that was it. Nothing more came of it.

    I am going to continue stopping. I pray this itching will leave me. Good luck to all who are trying to stop taking this medication.

    • Amber H.

      I’d love to hear how you’re progressing!

  22. Beryl

    I stopped taking cetirizine when I was going through topical steroid withdrawal, as I was going to swap to Desloratadine for the itch. I found that my hands & wrists itched more than usual. I hope that there is not a withdrawal problem with the new pills!

  23. Helen

    I’ve only been taking it around a month or so at night every night, suddenly stopped and I’m so blooming itchy. I knew it was some kind of withdrawal but needed to check.

  24. rajan

    I am taking this tablet every day, and the itching is serious, not bearable.
    Got Allergy test done, taken precaution, but nothing is helping.
    Is anyone out there able to get out of this syndrome?
    Really need to understand what is the solution to get over this.

  25. sail k

    Cetrizen tablet for itching each very helpful immediately stop itching after taking that tablet.

  26. Heather

    I also had the Zyrtec for many, many years fir allergies. I did a long tapering off process and it has been four months since my last dose. I’ve itched the whole four months although it is gradually decreasing. I discovered that 800 mg of Ibuprophen 2 x daily helped calm the hives and itching. Wanting to get off the Ibuprophen I’ve recently decided to try Bromelain and also Turmeric tablets. The results are amazing!

    • rajan

      Hello, Heather, good to hear that at last you are able to get rid of this medicine.
      Will it be possible for you to explain in detail, so that we can also try this?
      Thanks in advance.

  27. Marc
    New Zealand

    Our son took Zyrtec by GlaxoSmithKline over the Spring and Summer for hayfever. He has been getting unbearably itchy for months and would take Zyrtec to control that as well. He didn’t get itchy prior to using Zyrtec. He started thinking there was something odd and researched it on line to find out about the problems associated with Zyrtec. He discovered what the problem has been today.This product has to be taken off the market or at least have a warning about the side affects.

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