Millions of people have an underactive thyroid gland. This is called hypothyroidism and is usually treated with synthetic thyroid hormone called levothyroxine. There has been controversy about the best time of day to take this medication.

To determine whether it makes a difference whether the drug is taken upon arising or at bedtime, 105 Dutch patients were randomized to take one capsule in the morning and one in the evening. One was levothyroxine and the other was placebo, but neither the patients nor the doctors knew which was which. After 3 months the patients were switched.

When the code was broken, the investigators found that the measures of thyroid function in the blood improved with bedtime administration. Patients also reported feeling better. According to the scientists, “clinicians should consider prescribing levothyroxine intake at bedtime.” [Archives of Internal Medicine, Dec. 13/27, 2010]

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  1. carol

    can i take my thyriod at night

  2. Liz

    I decided to take my levothyroine at night. Done eating at 6:00 pm. And take at 10:00pm. Then I keep my morning routine. The only thing is I take gabapentin also and I don’t know if it interferes.

  3. Souganthi

    I am planning to take my thyroid tablets at night. When should I take it? Before Dinner? How many hours before / after dinner? Kindly clarify. Thank you!

  4. karen

    Please keep me up to date on this topic.

  5. MAJ
    United States

    I, too, find this idea of taking my thyroid medicine at night intriguing. Like others have stated, I have been on thyroid meds for many years – too many – and even when my levels are under control, I find that I still experience bothersome symptoms; primarily, fatigue. So, I’m curious if taking it at night will benefit me as well.

    However, I do take 3 different blood pressure medications each evening beginning at 7:00 p.m. because they make me so drowsy that I can’t function during the daytime. I can take the thyroid medication last after the others (maybe an hour or two) before going to bed. Any other thoughts or precautions I should take into consideration???

    • Terry Graedon

      If you take your thyroid medication last as you have described, just remember not to have any milk, yogurt, or snacks (with calcium) before bed or as a midnight snack.

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