Dale Bredesen, MD

Alzheimer’s disease is a prospect as frightening to many of us as cancer, and the treatment options are not promising. Most of the costly medications used in treating this type of dementia do little more than delay its progression by a few weeks or months. The idea that anything might be done to turn back the ravages of this memory robber has seemed an impossible dream.

Optimizing Multiple Factors for Cognitive Recovery:

Now, however, research shows that a novel, multi-faceted approach may be able to reverse cognitive decline. Nine of the first ten patients on this comprehensive, personalized therapeutic program have shown improvement. Not only have the markers of inflammation underlying Alzheimer’s disease become less severe, but they also have had lasting improvement in measures of memory and ability to function and reason. What are the elements and lessons of this therapeutic system?

This radio program first aired on May 30, 2015. We are offering it for re-broadcast on March 5, 2016. You will not want to miss it. Let friends and family know that this could be a game changer for people concerned about cognitive function.

Find a radio station near you or stream the audio live from a station that airs the show. Here is a link to all our participating stations. And if you live in an area where no public radio stations carry The People’s Pharmacy, please ask the program director to consider carrying the show. It is currently free to all public radio broadcasters.

This Week’s Guest:

Dale Bredesen, MD, is the Augustus Rose Professor of Neurology and Director of the Mary S. Easton Center for Alzheimer’s Disease Research at UCLA. He is also Director of Neurodegenerative Disease Research at the David Geffen School of Medicine at UCLA and Founding President and CEO of the Buck Institute for Research on Aging in Novato, CA. His research has been published in the journal Aging (Sept. 27, 2014), and in EMBO Molecular Medicine (May 23, 2013) on next generation therapeutics for reversing Alzheimer’s disease. Here is a presentation he gave to the California State Assembly.

Listen to the Podcast:

The podcast of this program will be available the Monday after the broadcast date. The show can be streamed online from this site and podcasts can be downloaded for free for four weeks after the date of broadcast. After that time has passed, digital downloads are available for $2.99. CDs may be purchased at any time after broadcast for $9.99.

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Air Date:May 30, 2015

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  1. Gina

    I just listened to the podcast & was impressed & interested in learning more about how to adopt some of the suggestions to prevent alzheimers. However, Dr. Bredesen used about 4000 medical & technical terms in a rapid-fire style, & there is no way I could discern much specific information. I got the message that diet & exercise are important, but is there any place that provides specifics, here or elsewhere?

    Thanks for any further info.

  2. Terri
    McKinney, TX

    Since these hopeful study results from Dr. Bredesen’s study first aired on May 30, 2015, I have not heard ANY follow up reports on the original people involved OR that any NEW patients have been able to participate in this multi-faceted approach that actually REVERSED cognitive decline!!

    I was SO very impressed and encouraged when I heard the original podcast in 2015, but it has been 2 YEARS and if this study had actually been as effective as stated, I would have hoped that doctors all over the nation and world would have been trained in this approach to start successfully “treating” MANY alzeheimers patients all over the world!

    I was SO encouraged by the UCLA study reports because my mom suffers from Alzheimer’s, but SO disappointed that more people suffering from Alzheimer’s aren’t being helped by the study’s findings!

    • Carl

      I have family history of dementia, soo i started the diet of no sugar no wheat flour, amd the vitaman regimen he used. It has been 18 months +. I too had begun to find it challenging to adequately do my job as a real estate broker. So i begin to put retirement in motion. I did/do feel much more alert, less foggy mind, function just fine. I did not go back to my job but i am super active with the nonprofits i now work with in areas i really enjoy.

  3. Cassandra
    Hampstead, NC

    If you missed the broadcast, there are a number of You Tube videos of Dr. Bredesen. Most are dated in 2016, coinciding with a major article that was published.

    It appears that this is a run up to a marketing effort to promote his “Bredesen Protocol,” and software that is being marketed to doctors to help identify specific types of dementia and personalize an approach to treatment.
    Dr. Bredesen also has a book, “The End of Alzheimers,” being released in August 2017.

  4. Roger R

    My wife’s mother and her aunt both died of alzheimers. Her mother was in a nursing home for 5 years as a total vegetable. No talk, no walk, no recognition, etc. My wife started developing memory problems as much as 10 years ago (age 84 now). We went to the only memory doctor in our area. He tested her and said early onset. I asked him about the newspaper ads for memory loss that touted great success.

    He said he was in on the national testing of the soft gel and that it helped but not enough to make it a prescription item. It’s sold as a vitamin called NEURO PS at our health coop. Also, swanson, etc. WHAT ELSE IS WORTH TRYING!!!! Chelation therapy for one to remove as much plaque from the arteries as possible. The alternative med doc also said Ginkgo Bilboa, Huperzine A, the PS, and Vinpocetine—–all there are in a vitamin sold by Healthy Choice Naturals called MIND MATRIX.

    NOW, DR PERLMUTTER just reported that a test of feeding people probiotics improved their memory function dramatically.

  5. Judith Star Gazer
    Viera, FL

    My husband has Alzheimer’s. I do foresee a time in the very near future when a drug can assist recovery of memory. However, I do not believe it will be in time to help my husband.

    The two main things which breaks my heart is one– his inability to verbally express just what it is he wants to convey. The loss of verbal skill frustrates and angers him to no end. However, he has a wonderful sense of humor and can dish out short comebacks with good humor.

    The second thing is that he quite often does not stand close enough to urinate in the toilet bowl completely. Urine is partially in the bowl, on the floor or in the plastic waste basket. He cannot understand why this is happening.

    He is on two memory medications which are taken together.

  6. rob
    aurora, ohio

    I have been taking turmeric and now curcumin for my arthritis pain and has helped alot for almost 3 1/2 years. Glad to see it suggested as a natural supplement to avoid Alzheimer’s. My wife would also take it but she is on blood thinner (Pradaxa) for afib. Those on the med should avoid turmeric which apparently has some blood thinning characteristics. Since curcumin is an extract of turmeric, must that be avoided when on blood thinner?

  7. Dr. Charles
    Ahoskie NC

    Some annotations to the presentation from a rural primary care general internist:

    Model of plasticity of synaptic connections as being the fundamental issue in Alheimer’s understates the role of the microvasculature. It is highly likely that the brain’s microvasculature and its dysfunction is the root cause of neurodegeneration including in Alheimer’s Disease. Much of what was said during this radio show implied that but did not synthesize it, so here are my suggestions:

    1) investigate light flicker vasoresponsiveness of the retinal vessels as a potentially very inexpensive, safe and even primary care available screen for early vascular dysfunction of the retinal vessels that could be mirrored in the brain small vessels. There are studies out of Europe and the USA about assessing the retinal vasculature for assessement of small vessel dysfunction of the brain

    2) The Montreal cognition screen is known to be a better indicator of small blood vessel dysfunction than the Mini-Mental-Status-Exam. It should be part of a primary care screen for cognitive impairment and possible small vessel dysfunction of the brain.

    3) As mentioned attention to vascular disease risk factors is an important aspect of developing an overall screen of RISK for Alzheimer’s disease. As mentioned there are multiple risk factors for Alzheimer’s Disease BUT one must hone in on those Risk Factors that make up the bulk of the RISK AND can be measured in primary care practice with sanctioning of the testing by appropriate necessity coding OR I warn that the order ofr parameters such as homocysteine levels will bounce. In fact have you tried to screen Medicare patients for A1c’s, homocysteine, Vitamin D, Apo E-etc and not got a request for a necessity code justification? You need to get together a sensible test series that could be included in many cohort’s sanctioned “Wellness and Prevention Exam” at the cost of the insurance company OR faciity code pricing will stifle any attempt to do primary care risk factor screening. Consider getting the Instant Medical History (PRIMETIME Software) folks in South Carolina to develop a screening self-administered questionnaire for administration to the physician and to the patient with the answers to the questions converted into “codable entities” that can be intersected with each other and the medical literature using the free, “artificial intelligence endabled” GRUFF Browser.

    4) Attention should be paid to the implications of the Nun Study for even how one structures one’s syntax and its protective factor implications. The use of one’s brain to discover new complex relationships and its effect on “synapse plasticity” and neurovascular unit function of the brain is an important aspect of both RISK determination and most likely therapeutic intervention.

    5) The effect of salsalate on insulin resistance & A1c, overall vascular risk factors, the denial of the existence of salsalate by CMS and its potential as both a safe analgesic for elders and multi-factorial reducer of RISK of Alheimer’s beg the question: Why can’t salsalate be made an OTC analgesic by the FDA obviating the need for a brain dead CMS to realize that salsalate might be the idea combined analgesic and anti-Alzheimer’s medication that might actually plug significantly more than a few “holes”.

    6) GoTo Kola (Centella Asiatica) has recently been shown in combination with Pycnogenol to have a significant anti-angina effect in a FOUR YEAR study. You mentioned GoTo Kola but did not mention its anti-oxidative stress and pro-endothelial dysfunction properties. One could predict that a combination of Centella Asiatica, Pycnogenol, CoQ10, Curcumin Phytosome, salsalate, Benfotiamine and Nrf2 nuclear factor activation anti-oxidants, some of which you mentioned, could possibly offer a cost-effective OTC that could be applied to one “multi-pharmaceutical intervention trial” along with other customized interventions as methylfolate (at not too large a dose).

    7) lower glycemic index / load diets (The Schwarzbein Principle), diets high in DHA/EPA (or possibly enteric coated fish oil), diets high in multigrains especially rye, oats, buckwheat, use of the purple sweet potato natural dye extract in an apple cider vinegar / olive oil dressing, the eating of dark purple vegetables in general – especially grown organically in one’s own garden, regular walking exercise – 30 minutes for covering 2 miles – deletion of artificial sweetners as aspartame, doing mental exercises like discovering new relationships, keeping a daily diary whereby one notes down in complex and compound and even run on sentences new findings and relationships between findings all together could complement a rational and inexpensive set of OTC’s.

  8. Howard

    What is the source of the supplements used by Dr. Bredesen?

  9. Kit
    Lewes, DE

    I wish I caught the name of the website the Dr. referred to. Do you have it?

  10. V Parker
    San Antonio, Texas

    Simply testing to see how bodies metabolize medications could save both quality of lives from overdoses and possibly lives. Twenty-two years as intake worker for elderly and disabled made me aware that they can’t tolerate meds like younger people. Now I am living proof of DNA testing saving me from possible overdoses and other dementia symptoms.

  11. Carrie

    I did not see that the program would be broadcast on March 5, until today, which is March 8. Too bad.

    • Coleen
      North Palm Beach, FL

      Carrie, you can listen to the podcast (as I’m doing now).

  12. RMG

    Dr Bredesen’s approach is hopeful for memory loss patients. Since age related Macular Degeneration is so problematic in today’s world, is there similar multifactoral research available for AMD? If so, I would appreciate data about AMD research.

  13. Katie
    Loomis, CA

    I missed this broadcast when it first aired in 2015, so having it repeated (March 2016) is a huge gift and very much appreciated. Thank you so much for the wonderful “service” People’s Pharmacy provides.

  14. J. David Auner
    Springfield, MO, USA

    The multifactorial approach is necessary to treat most cases of atherosclerosis, migraines, and recurrent fever blisters. Dr.Bredesen’s personalized approach to dementia should be inspiring to physicians and patients alike.

  15. Margaret

    I like others who have commented above have severe hearing loss, so podcasts are of little use to me. Is there any way to provide transcripts again? Is there any federal funding available, for instance?

  16. Curmudgeon
    matthews, nc

    I wonder. Has there always been as much Alzheimer’s, even if not recognized as such, as there seems to be today?

    Or is this some sort of modern day epidemic from seemingly out of nowhere?

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