The People's Perspective on Medicine

Quetiapine

Seroquel is used in the treatment of bipolar disorder. It is also prescribed to treat schizophrenia. 

Full prescribing information is available at:

http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=5606

Check out Wikipedia for more user-friendly information:

http://en.wikipedia.org/wiki/Seroque

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About the Author
Joe Graedon is a pharmacologist who has dedicated his career to making drug information understandable to consumers. His best-selling book, The People’s Pharmacy, was published in 1976 and led to a syndicated newspaper column, syndicated public radio show and web site. In 2006, Long Island University awarded him an honorary doctorate as “one of the country's leading drug experts for the consumer.” .
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Seroquel was given to my father-in-law at at nursing home where he was to recover strength after a stroke to then go to a rehab hospital. The nursing home gave him Seroquel along with a host of other drugs to keep him in the bed. This is known as chemical restraint. We later found that he was trying to get out of bed because he was in pain with a urinary tract infection. My father-in-law began having trouble swallowing immediately began loosing weight and was put on a pureed diet. He also became completely disorganized and delirious. The nursing home then wanted to surgically implant a feeding tube.
There is an FDA Black box warning on Seroquel (https://web.archive.org/web/20110909105727/http://www.fda.gov/Safety/MedWatch/SafetyInformation/Safety-RelatedDrugLabelingChanges/ucm123259.htm) that it should not be given to seniors because it increases the risk of death.
We had to rush him to another doctor to get an order to override the nursing home doctor and get him off the Seroquel. The new doctor gave him a low dose of haldol to deal with the side effects of withdrawal. Eventually the nursing home badgered the new doctor into increasing the dose of haldol and adding new drugs to keep him in the bed.
I could never get anyone to treat the delirium, which I felt was the major problem. Finally, I flew out and rented a handicapped van to take may father-in-law to another doctor who admitted him to a hospital to get him off the haldol/ativan that had been prescribed to help with the withdrawal of the Seroquel. Amazingly in the new hospital the doctor requested a psych consult and the psychiatrist prescribed a low dose of Seroquel to help with side effects of haldol/ativan withdrawal. Even though it was a very low dosage, my father-in-law immediately began choking, being unable to swallow.
They again did barium studies and wanted to put in a feeding tube. After many calls to the psychiatrist, we had to fax him the black box warning with a letter saying that the family did not want him on Seroquel under any circumstances, and wanted the drug discontinued immediately. Once he was off Seroquel the swallowing was no longer a problem. He recovered a great deal and was able to receive a major award from the University were he had been a professor and administrator.
At the award ceremony he knew everyone and enjoyed it. Eventually the multiple urinary tract infections he acquired in the nursing home or hospitals took a toll and he was hospitalized multiple times with UT MRSA. Each time the hospital would prescribe ativan or some other drug that would kick up delirium again. He hung on this way for about a year and recently passed away.
I feel that the use Seroquel by the nursing home not only compromised his chance of recovering from the stroke, but robbed him of his clarity of mind in the last year of his life. It is too often used by nursing homes that solve staffing issues by drugging patients. If the nursing home had bothered do a urine test instead of prescribing Seroquel, my father-in-law could have avoided much suffering.

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