The People's Perspective on Medicine

New Eliquis (Apixaban) Alert: Unexpected Side Effect

Side effects of the new generation anticoagulants like Eliquis (apixaban), Pradaxa (dabigatran) and Xarelto (rivaroxaban) can be scary. What's the latest?

A few years ago we received alerts about an increasing number of serious bleeding episodes associated with the anticoagulant Eliquis (Apixaban). This medication is prescribed to prevent blood clots in patients with an irregular heart rhythm called atrial fibrillation (AFib). The drug is also used to prevent blood clots after knee replacement surgery and to reduce the risks of blood clots in the legs or lungs from deep vein thrombosis (DVT). 

Eliquis is one of a new generation of anticoagulants that are being substituted for warfarin (Coumadin). So is Xarelto (rivaroxaban). Many physicians believe that the new drugs are safer and easier to take than warfarin. But in March, 2019 Johnson & Johnson and Bayer settled roughly 25,000 lawsuits involving Xarelto. Lawyers for the plaintiffs asserted that the drug companies did not adequately warn patients about the possibility of life-threatening hemorrhages. How much did the companies fork over? $775 million!

According to Katie Thomas, writing in the New York Times (March 25, 2019)

“In 2014 the German drug maker Boehringer Ingelheim agreed to pay $650 million to settle about 4,000 lawsuits over a similar drug, Pradaxa, which was also blamed in bleeding deaths and injuries.”

Established Eliquis (Apixaban) Side Effects

Regardless of lawsuits, what we know is that apixaban has some pretty serious adverse effects. They include:


  • Serious bleeding in the gastrointestinal tract
  • Serious bleeding in the brain (hemorrhagic stroke)
  • Serious bleeding within the eye



Blood clots if the drug is stopped suddenly. No one should EVER discontinue Eliquis suddenly without careful medical supervision. This “rebound” clotting effect could trigger life-threatening events.

Spinal procedures such as epidural anesthesia can be very dangerous for people taking Eliquis.

Serious allergic reactions (skin rash, anaphylaxis)

Other, Less Common Side Effects:

  • Low blood pressure
  • Breathing problems
  • Bruising
  • Nose bleeds and bleeding gums
  • Bleeding at the site of surgery

We don’t know about you, but whenever we see a long list of side effects our eyes glaze over. Reading real stories from visitors to this website makes such complications far more concrete. We received this message from Joe:

“Eliquis is the worst drug I’ve ever taken in my life. After only six days I developed all of the following side effects:

  1. SEVERE exhaustion. Couldn’t even walk to the mailbox.
  2. SEVERE breathlessness.
  3. Hypotension (low blood pressure)
  4. Blurred vision.
  5. SEVERE cognitive failure. Felt like my head was stuffed with cotton.
  6. Periods of rapid heart beat.
  7. Insomnia.
  8. BPH (benign prostatic hyperplasia)
  9. Ravenous appetite; absolutely craved carbs. Would have to get up in the middle of the night and eat.”

Many of Joe’s symptoms (insomnia, BPH, cognitive impairment and increased appetite) are not listed in the official prescribing information so it is hard to know if they were really brought on by Eliquis.

This story is from Margaret is far more worrisome:

“I live in Queensland, Australia. My cardiologist transferred me from warfarin to Eliquis 5 mg morning and night in October 2014. I am 78 years old with heart failure plus AF [atrial fibrillation]. Yesterday afternoon I suddenly had a very major nosebleed, 6 paper towels were soaked, 3 hand towels were soaked and one bath towel was wet.

“I rang one of my daughters and she rang the ambulance while she was on her way. The paramedics arrived and quickly brought the nosebleed under control. I was advised by the doctor at the 24 hour clinic to not take the Eliquis and to go see my normal doctor today. I have an appointment to see him at 2.30 pm this afternoon.

“I will be telling my doctor that I want to go back on the warfarin…Yes, it necessitates regular blood tests but it is far safer than Eliquis and the other two drugs that have been developed to replace warfarin. 

“No way will I put myself at risk with these new anticoagulant drugs!”

Margaret isn’t the only one concerned about the new generation of oral anticoagulants. The Institute for Safe Medication Practices (ISMP) issues a publication called “Quarter Watch.” It too monitors the FDA’s Adverse Event Reporting System. In the January 9, 2013 issue it noted that:

“Strong signals continued for three anticoagulant drugs, warfarin (COUMADIN) and newcomers dabigatran (PRADAXA) and rivaroxaban (XARELTO). The three drugs accounted for 1,734 reports to the FDA in 2012 Q2, including 233 patient deaths, reinforcing the conclusion that anticoagulants rank among the highest risk of all outpatient drug treatments…”

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On October 17, 2013 the ISMP Quarter Watch reported that anticoagulant medications such as dabigatran (Pradaxa) and warfarin (Coumadin) contributed to the leading drug safety problems reported to the FDA in 2012. The conclusions:

“The 2012 adverse event report data show, in our judgment, that a major priority in drug safety should be to reduce the serious and fatal hemorrhages resulting from treatment with anticoagulant drugs, particularly in the older population with atrial fibrillation.”

Kathy shared this story about visual problems with Eliquis:

“I am having really bad eye issues. Has anybody else had negative eye problems? Sometimes in the night I literally have to use my hands to open my eyes.”

The Bottom Line:

Anticoagulants are important drugs. They reduce the risk of blood clots that can cause strokes and other serious health problems. But these medications must be treated with kid gloves. They require careful dosing and regular monitoring. Patients must be warned about the potential for serious bleeding complications and what to do if they happen. We agree with the experts at ISMP that:

“Numerous steps can be taken to enhance the safety of anticoagulants… More and better information for clinicians is needed about how to manage hemorrhages that occur either as a side effect or as a result of accident or trauma.”

There is now an antidote to to reverse bleeding from drugs like apixaban or rivaroxaban (Xarelto). It is called andexanet alfa (AndexXa). Dabigatran (Pradaxa) has an antidote called idarucizumab (Praxbind). Clinicians need to educate patients about the symptoms to watch out for so that they can recognize a potential bleeding episode early, before it gets out of hand. That way an antidote has a better chance of working. 

Want to know more about Eliquis and Xarelto. Here is a link:

Some Eliquis and Xarelto Side Effects NOT in the Prescribing Info

Share your own experience with the anticoagulants both positive or negative. Insert your story about Coumadin, Eliquis, Pradaxa or Xarelto in the comment section below.

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About the Author
Joe Graedon is a pharmacologist who has dedicated his career to making drug information understandable to consumers. His best-selling book, The People’s Pharmacy, was published in 1976 and led to a syndicated newspaper column, syndicated public radio show and web site. In 2006, Long Island University awarded him an honorary doctorate as “one of the country's leading drug experts for the consumer.” .
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I take warfarin for Afib, and the only side effect I notice is the necessity, on occasion, to have to open my eyelids with my fingers during the night. The blood test every 2 weeks is not really a problem for me.

I have been taking warfarin since 1996. I hate it. Why? Not so much for adverse events from using it, but because it interferes with a major part of the foods and supplements that can boost and maintain our health. But I have a rule, which is that I never allow anyone to prescribe an Rx for me unless it has been on the market for at least ten years. Period.

It might be best to index all these comments or organize them in some other way. The information submitted, I believe,is crucial. I hope it is being transmitted to the FDA.

Personal experience (minor compared to those I’ve scanned): My husband began taking Eliquis prior to and following an ablation for A-fib. About a month after the procedure he developed petechiae covering his lower legs. (Petechiae are small areas of capillary hemorrhage–he was polka-dotted with red spots). The on-call cardiologist had us go to the ED for platelet testing–which was normal. He was repeatedly questioned about itching. There was none. It was not a “rash”, which is a known side effect. The ED physician just shrugged. Said petechiae was not a known side effect. He had to have a follow-up visit to cardiology–the response there was also shrugs.

He never had any other signs/symptoms of abnormal bleeding. The petechiae eventually resolved. He’s supposed to continue this drug for a total of three months following the ablation. I did report the side effect to the FDA adverse event system. Unlike warfarin, Eliquis is prescribed in a “one size fits all” dosage. It’s convenient for the FDA that there is no required testing–but scary that there is NO test to evaluate whether anticoagulation is optimal, or whether the risk of bleeding is imminent. And the drug which might reverse resultant bleeding is VERY new and unproven.

Thankfully, he’ll be able to ditch the Eliquis and resume aspirin soon. Aspirin isn’t without risk–but he was on it for years without issues.

We’re not just ticked off about the cost of the drug, but also the cost for the ED visit AND the requisite follow-up appointment with cardiology. Not to mention the angst! His cardiologist wouldn’t even consider an alternate drug prior to or following this incident, despite my concerns as a 40+ year registered nurse. pHarma scores $$ yet again.

I knew 2 people personally who were killed by Xeralto. Fortunately, our good friend who has had 3 heart attacks was unable to get that or a similar drug because his insurance would not pay for it; so he has to take coumadin. Yes!!

I have been on Coumadin since 2001 and have had no problems. My cardiologist recommended Eliquis but I ignored her advice, as I have had no problems with Coumadin which has an inexpensive antidote (like Vitamin K, which can be used as antidote).
As it is, drug companies make billions on drugs that may be harmful to patients

My husband has been on Eliquis since 11/5/18. They say he developed a blood clot from surgery to remove his cancerous esophagus. We could not figure out why he wasn’t feeling better. EVERY test they ran came back excellent, but he still felt tired, achy, foggy-headed, headaches, rapid heart beat, weak-very weak, low blood pressure, and on and on and on. I was going through my email and came across the Peoples’ Pharmacy newsletter and read about the side effects of Eliquis. He had every single side effect that “Joe” had.

We are now doing our homework so that on Monday we can call every one of his docs to let them know what we found. What I have a hard time understanding is why you can’t just come off of Eliquis. He has a procedure done every 2 or 3 months, and they tell him to stop the Eliquis 5 days before the procedure and to not go back on it for 7 days after the procedure. He has been off of it for almost 13 days at that point, with no problems, only to have to go back on it…crazy.

THANK YOU from the bottom of our hearts for “sharing” what folks put out there. We would have continued to go on in life-changing pain and discomfort if not for your very informative posts.

I started Xarelto 15 October 2018. after hip replacement. During October last year, I had genital bleeding and nose bleeding that could only be stopped at the hospital, and shoulder bleeding. I am still taking Xarelto since I have A-FIB.
What can be done?????

For years I had irregular heart beat and took digoxin and lanoxin. The irregularity got worse, and I had rapid beating to the point I would nearly pass out. These episodes would come on suddenly. I never knew where I would be, and it was very scary. After a couple of trips to ER I went to a different cardiologist, and he prescribed Eliquis 5mg twice daily, along with another drug. That was 13 years ago, and I have had no bad side effects and no problem with Afib since. So for me this has been a great drug and has made my life much easier.

I am 87 and last year, 2018, I was diagnosed with A-Fib. Dr put me on Pradaxa. My stomach felt terrible. Went to ER, and I was hemorrhaging horribly. Later the dr put me on Eliquis. I didn’t want to take it but was told I have to take it with A-Fib. The same thing happened as it did with Pradaxa. Now I am on 325 Aspirin. I will never take blood thinners again. Also, my husband had horrible nose bleeds, bad enough to go to ER. He is also now on Aspirin.

When seeing all of the commercials on TV pertaining to all of these brand new drugs. You just wonder if it is worth it taking the drugs. With all of the side effects that goes with it. I sometimes wonder when are grandparents were growing up they did not have any of these new drugs. They used the old fashion way of treating their aliments. I wonder if we all go back to the old ways of treating ourselves the old ways. Would it be worth it?

I have been using Eliquis (5g, AM & PM) with no side effects and no bad reactions. I began the Eliquis two years ago when I developed afib. At the time I was also on aspirin and clopodigrel due to a stroke, and I immediately developed what I thought of as “thin skin” or a tendency to bleed rather heavily from a minor scrape. My doctor advised me to quit the clopodigrel, and then the aspirin and that annoying symptom went away.
Not everyone has a bad reaction.

I’m a 56 year-old heart patient and three heart attacks in my life. I recently had triple bypass surgery and was put on Eliquis and isosorbide 30 mg.

Ever since I got out of the hospital I have been experiencing no sleep filled with vivid dreams. I can fall asleep but I wake up dreaming, going back to the same dream over and over. I’ve been doing this for almost 4 months. I just can’t figure it out those are the only two new drugs I’ve been taking since my surgery but on the other hand I was also having prescribed medical marijuana for the last several years for my anxiety agoraphobia. I’ve never had a real problem sleeping until my surgery. I was in the hospital for almost a week.

I’ve quit smoking pot (medical marijuana) and started taking these two drugs and I’m just having these very vivid dreams every night. I know I’m not getting any sleep so they did a sleep study on me and said I have sleep apnea. I never had it before the surgery and now all of a sudden I have it. Can anesthesia cause this or the pills or not getting stimulated by the marijuana and just cold turkey stopping it’s been over 3 months. I really need some help they say that sleep apnea and using the mask should help but I haven’t seen any so far I’m just getting to my wits end I haven’t slept in over three-and-a-half months.

I had aortic and mitral valve replaced with tissue valves in September 2019. Had Afib 3 weeks post- pop and was on amiodorane for about 3 months. Also was taking warfarin for about 7 months until cardiologist switched me to Eliquis. I have been taking Eliquis for 3 months, 5mg twice a day. I also take a low-dose aspirin and 12. 5 mg of metoprolol.

After a routine CBC it was discovered that my platelet count was 104.PCP Had me go to a hematologist. Platelet count went up to 110 then 122 and now back to 114. Now hematologist is wanting to do an ultra sound of spleen and liver. This is freaking me out. WBC, RBC! And hemoglobin are normal. Do you suppose low platelet count is related to medicine I am taking?

Glad I’m not the only one who seems to be suffering ill effects from this medication. I’m 74 and am starting to develop Afib. Actually, I’ve had it for several decades but it seems to affect me a lot more lately. So my doctor put me on 2 Eliquis 5mg tablets daily, plus a heart pill, Cardizem. Right away, I noticed extreme fatigue, shortness of breath and pressure in the top of my head. If I bend over, it increases the pressure greatly. My tinnitus kicked into overdrive, and I can hardly sleep at night because of the breathing issues. I can barely get out of my own way! Gardening has become a drudge, and I tire immediately. I’m beginning to think that the cure is worse than the ailment! I agree with the person who said it was the worst drug they’ve ever taken in their life.

Headache is my Apixaban issue. It can be quite strong at times and then again moderate, but it never fully goes away.

I am 88 years old. I was on another med for 6 months and had nosebleeds. Then I switched to eliquis, and I have hematuria.

My husband suffered a massive stroke 3 1/2 years ago and was on warfarin since then until he was recently switched to Eliquis. Suddenly it’s like he “woke up.” He is more alert, tries to talk more, is moving his paralyzed toes on command, and tries to do more things on his own. So glad we made the switch. He has had no side affects and has been on Eliquis about 2 months now,

Been on Eliquis 5mg twice a day, less than a month after being hospitalized with multiple PEs. I have a PFO, which will be fixed sometime in the fall after being treated with Eliquis. I too have felt much of what others have said. I am still severely short of breath on exertion, extremely tired, and depressed. I even take a medication to combat fatigue, and it isn’t touching it. I’m hoping that once the hole in my heart is fixed, I can come off this drug. I’ve also been told that my symptoms are related to pulmonary hypertension that resulted from the PEs. No one has said it could be the Eliquis. Clearly not the case.

My mother was put on Eliquis for blood clots. A side effect which is often listed is Rectal bleeding to death.

It was listed on one site in a triangle and skeleton.

When this happened the hospice nurses were attending her they continued to change and clean her without checking into it or contacting anyone to see what to do if possible.


Another side effect listed in the skeleton triable was DYSPHAGIA: It used to say that a person could stopping able to swallow. Now it says that some swallowing difficulty may occur.


I was put on Eliquis December 2016 after having 2 TIAsa and having history of intermittent AF at the age of 48 years. I had some side effects for about 3-4 months: severe bruising, bad headaches, dizziness,thirsty through night, drank loads of water, and anemia because of heavy menstrual periods. I think a lot of drugs give you side effects but I say if you can stick it out for a least 6 months or so then they should pass. I’ve now been on them 2 years and 6 months. All 👌

My husband recently had surgery on his shoulder, then after his post-op appointment they sent him to the ER because of pain in his leg. They found a clot and diagnosed him with DVT amd immedately put him on Eliquis with no discussion. He has been on it for about two amd a half weeks now, amd has developed severe mood swings and outbursts and unusual anger issues. Has anyone else had any experience with this on Eliquis?

My husband started taking eliquis about a month ago, for DVT in his right arm (with a 2nd case of cellulitis in 1 1/2 years). He has a prior history of cancer, most recently in his salivary gland. His vein is partially collapsed from surgery and radiation which they feel contributed to this. He feels awful: shortness of breath, symptoms of anemia (has nearly fallen over a few times in the last week) as well as stomach pains. He is absolutely miserable and severely fatigued, can barely make it past 7-8 o’clock at night. His appointment with the V.A. is not until June 13. We are going to try to get it bumped up due to his symptoms to see if they can switch medication. It’s horrible and heartbreaking to watch, being he is only 43. Hopefully they can move up the appointment and switch him to something else that doesn’t have the same effects.

Hello and thank you for this helpful forum
I am 79 years old with permanent fib..because of a Chad2 score , I was prescribed Xarelato.
After 8 months on this drug i Started to break out in itchy rashes and pimples that spread throughout my body a point where I would get blood filled pimples that burst leaving drops of blood on my skin..the itching was so unbearable i would wake 3/4 times a night having to take hot showers to ease the itching only to have the same symptoms return every 4 hours.
Recently Doctors tried changing me to Eliquis…and now my condition is even worse…I am depressed and stressed out over this. Can any good people or Medical professionals out there suggest what can be done to help…ablation, lariat procedures are out because of my type of Fib.
I was getting along fine with aspirin until my Chad2 it really that dangerous to go back to Aspirin..or last resort to try Warfarin?

Just been on Eliquist a short time after my first A-FIB. So far 2 RED itchy spots showed up on my legs. Then I was so short of breath i can not hardly walk to the corner. Sounds familiar to the other comments. name is Lisabeth.I have to take Eliquis for a DVT I got in my leg.I have some of the same side effects as Joe.severe fatigue.My head feels like it is cotton and I am winded when I try to go for a walk.Hopefully want have to be on it for a long time.I have been on it for only6 days.

Not sure what to say, but here is my story, I am 76years old still working full time indeed 7 days a week, don’t drink or smoke and keep fit. in March 18 I had a pain in my calf [I jog every night] my daughter forced me to see the Dr who prescribed Quinine Sulphate, that night I took my first dose, by mid night I was delirious, but I carried on for a further 5 days and my whole body was on fire. I was sent for a scan. 4 days later driving to a meeting my phone kept ringing, I pulled over and it was from a Dr who asked where I was, I said on my way to a meeting, she said please go immediately to the day A&E dept. On arrival there were 2 Drs and 3 nurses waiting for me, they carried out a whole raft of tests including putting me on a running machine, lung tests, heart, test, blood tests and many others . At the end the main Dr said they cannot believe it, he said I have to huge blood clots on my lungs and one in my leg. I immediately stopped taking Quinine Sulphate and I was prescribed started Eliquis Apixaban 5mg twice a day, the only symptoms I have had are unusual red marks on my arms and I occasionally get a head ache and dizziness. Later I had another blood test which showed my WBC count had gone up to 83000 and I was diagnosed with Chronic Hodgkin’s Lymphoma blood cancer. My consultant sent a letter to my Dr and a copy to me in which he said that the Catalyst that caused my cancer was the prescribing of Quinine Suphate.

Since march 18 I have had 4 appointments with my consultant and 5 blood tests. 2 things: First Quinine Sulphate is banned in many countries and the NHS advises Drs not to prescribe quinine sulphate except as a last resort. Second: Since taking Eliquis Apixaban the only symptoms I have suffered are as above, except in the past 2 months my dizziness has become more frequent at 4 x a week with tingling in my fingers. I am still working full time but my symptoms worry me as it may affect my driving. 2 nurses I met in my work said that they had been on Eliquis Apixaban and now don’t take it as they feel it needs more testing. Another nurse who was taking Quinine Sulphate and then Eliquis Apixaban said it has ruined her life and she will not take it any more. I have now taken the decision not to take any more medication. Summary: When being prescribe Eliquis Apixaban or any drug ask your Dr, what happens if I don’t take my prescribed take, how will it affect any other drugs your currently taking. In the UK our Drs prescribe more medication than in any other country in the word not to mention they get back handers for the more they prescribe, with repeat prescriptions with out follow up test.

I had a PE on 22 nd March, started on rivaroxoban but had severe dizziness, then they changed it to apixaban. 2 weeks in and I was in agony with back pain ( I am 42 with no previous back issues) it is a less common side effect. Saw consultant yesterday and asked for it to be changed and now on edoxaban. I’m just praying the side effect wears off soon!

I had been on Warfarin for six years for Afib. I changed cardiologist; he then switched me to Elouise. It has been four months now, and even though I called in immediately to report my symptoms, he told me to give it more time. My symptoms are: dizziness, some nausea, mood swings, itching, and sweating profusely. I went back to see him and he said that unless I was coughing up blood or breaking out in a rash, to stay on the drug.
I am calling again today and insisting he switch me back. I never want to take Elouise again. If he won’t, I will change doctors!

I had heart bypass surgery in November 2012 develped A/F so was put on Warfarin. Luckily, after 6 weeks I was able to stop Warfarin. In December 2016 I developed Fast A/F and was given Apixaban which I have been taking quite happily. However in January 2019 I had an Angiogram which was fine but when I was watching the TV at home with the subtitles it looked as if there was pink tissue paper over the words. My Opticien did a load of tests and said that I had a bleed on the Macular, she asked me to have blood tests which I did and my ferritin levels are low so I am now awaiting my hospital appointments with the ophthalmologist, and gastroenterologist. I’ve already seen the cardiologist. Anyway watch this space for updates.

Started Eliqus 9 mos ago due to an afib episode, hearing and eye sight were very noticeable from the beginning. Then left side numbness of my face, arm and hand. I had all kinds of tests to rule out TIA or a mild stroke. ENT Dr couldn’t find anything so off to a Neurologist who ordered CT scans, and still nothing showed up. At this time I was feeling dizzy, no energy, along with previous symptoms. I can’t change anything because I’m going in for an ablation, but I am convinced it is this damn Eliquis. Thinking about talking to the Dr and going on warfin after the ablation.This sucks!

Was on Xarelto for 6 months due to a pulmonary embolism. No evidence that it came from a blood clot in my legs.
2 months after beginning this medication my hair began thinning and falling out. I now have developed several bald spots on my scalp. Am receiving injections on my scalp and have 2 different prescription shampoos. Nothing is helping. Used to have thick shiny hair. My mother also had thick hair into her 90s.

I also developed extreme dry eyes around same time. Had to have eye plugs along with 2 different prescrip drops and steroids. This also is not resolving. Too coincidental for it not to be related. Also short of breath, tired and brain fog. Anyone else have these symptoms together? Just being treated for symptoms, not the underlying cause. Treatment not being coordinated or linked together.

For 23 years I have been on Warfarin because of 3 pulmonary embolisms due to a blood disorder called Prothrombin Mutation deficiency. It is hereditary. Now my granddaughter has it. Now a new hematologist wants me on Eliquis. I must be blessed to find this page about all the side effects of you people. I am so sorry about what has happened to you all. I will not take this drug. I would suggest you all demand CHANGE. Sometimes tried and true works better it seems. May God bless all, and please help yourself to get better advice. Many Blessings.

I have been on Eliquis for nine weeks now due to a DVT from a broken leg in a cast. Since taking it I have been very tired, fatigued and have muscle aches. I went in for blood work, and all came out normal except my liver enzymes were elevated above normal range and have never been in the past. Is this a side effect? I plan to retest once I have stopped taking it in three weeks.

I’ve been in Elequis for 4 weeks. I have become depressed, irritable and having a hard time sleeping. It was given to me because of a DVT. They did a Ultra sound yesterday because Km having terrible lower leg pain. They didn’t see any blood clots, not even the original one. I’m wondering if Elequis is causing the leg pain, Depression, moodiness and trouble sleeping. I starting getting really bad lower abdominal pains lastnight.

Been on Apixaban since Jan 2016 and Bisoprolol for Atrial Fibrillation Felt terrible with ,tiredness and breathlessness all the time In 2017 changed my bp tablet to Atenolol felt a bit less breathless when walking.Also have had severe abdominal pain for a while for which .I have had various tests all coming back clear.Then last weekend suddenly developed a bright red pin prick type rash on lower part of one leg only Doctors not sure what it is but on looking up forums have found rashes to be a side effect of the medication.Will just have to put up with effects,

I’m new to eloquis. I gave polycythemia Vera. FVI protein C and C disorder. I had a massive stroke as a result. I’m 48 years old . I’ve been on eliquis for 3 months. Two words: awesome drug. All I hear is complaints about it. LOL I wonder if these negative reviewers aren’t anti Vaxxers as well. Geez, it sounds like you copied a book report! Optimism is the key, people!

Does eliquis cause liver cancer? My husband was on it for 16 months and then developed liver cancer. Had no sign before taking eliquis.

Eliquis has been linked to liver injury. No reports of liver cancer, though that doesn’t mean it isn’t connected.

There is an antidote to Pradaxa … it’s called by its brand name Praxbind in Canada and the generic name idarucizumab, This makes Pradaxa the first in its class of new generation oral anticoagulants to have a reversal agent. I had my cardiologist switch me from Xarelto (with no antidote) to Pradaxa when I saw how potentially dangerous Xarelto could be.

I took Xarelto for A-fib from March to August of 2014. It “zombified” me physically and mentally, and each time I urinated the toilet water was red with blood. My gynecologist also found blood pooling in my uterus. I took myself off it and got my life back.

I was fine until another A-fib episode in December of 2017. Since then I have been taking Eliquis. I currently feel “crippled up” with joint and muscle pain throughout my body and physically zombified. My cognition is fine. My current life existence is like trying to run in thigh-deep water. When I was admitted to the ER for the A-fib episode in 2017, the doctor there told me that if I didn’t take the medications they prescribed me, I’d be dead in a year. I tried four different heart meds but couldn’t tolerate them. My doctor finally threw up his hands and said that I MUST at least take the Eliquis. Now I am just existing, not living my life. It’s all just a waiting game for me now, as far as I’m concerned.

I posted earlier. After further consultations have been recommended to try and continue on Elquis but for long periods especially in mornings my head feels fuzzy, and I worry in case my mind is being effected. Anyone else had this problem? I have a long drive to do tomorrow (Sunday 28/4/19) and hope my concentration will be ok. Any helpful comments will be welcomed.

I was admitted to the hospital for blood clot in my left calf. The Dr put me on 20mg of Eliquis for 7 days then 10mg for 21 days..not sure what then. But my leg feels better, and the swelling went down. The only thing different I’ve noticed is blurred vision. Ive been taking Eliquis for 5 days now. I’m worried now after reading all the side effects. I hope and pray Ill be ok.

I have been on this drug for just one week and having awful stomach pains, and my throat has swollen. I constantly feel sick and am unable to sleep. I have stopped it until I can contact my Doctor.

84 year old male taking Eliquis for two weeks. Yesterday started having pain near left kidney, anxiety and inability to sleep for more than four hours. Will check with Dr today to see if I can go off this Med. Eliquis was prescribed after I had a flutter recorded on a machine that tracts my heart at night.

Been on Eliquis for three months. I have noticed I have uti symptoms but no uti. I took multiple ute tests, and all negative. I don’t really have the burning when urinating but I have that constant urge to go and a little burning when just sitting. Seeing if it could be caused by Eliquis.

My mother is experiencing the same side effects from eliquis. Weak, nose bleeds, sore legs, and more.

I was started on Eliquis one week ago for upcoming cardiac ablation . I am a runner and a very active . I only weigh 124 pounds literature says anyone under 60 kg (think I’m 54 kg) should only take 2.5 mg twice a day . My electrophysiologist has put me on 5 mg twice a day . The same amount my 240 pound brother-in-law takes . Needless to say I feel horrible. Weak feel like I can’t stand on my legs at times hard to get through the day. I tried to talk my cardiologist into cutting my dose back to 2.5 twice a day but he won’t. Any thoughts . Very discouraged as I am type A and right now my life is sedentary except that I do make myself go out and do a run every day just not as far . Thank you for your input

Started Apixiban (eliquis) one month ago after diagnosed with DVT. I no longer sleep through the night. Takes an hour or more to fall asleep and then I only sleep about a half hour before waking and then taking another hour or two to fall asleep again. Since I started on this drug I feel drained and exhausted all the time. I can’t stand on my feet for more than about 40 minutes or walk more than a hundred feet or so without being totally winded. I have a cough all day long and a hoarse throat and sometimes trouble catching my breath. A trip up or down even just a few stairs wipes me out.

My blood pressure has dropped slowly from 140/95 prior to Apixaban to 107/77 today. I have been experiencing unsteadiness with intermittent breathlessness and have periods when I feel thickheaded. 61 years old and have been on Apixaban 4 weeks due to PEs after surgery. My heart rate has also dropped but this may be because of PE resolution. While taking double dose at beginning the symptoms were worse. However, they are there everyday and if due to side effects they are severely hampering my recovery.

I have just been reading the comments from people using the drug apixaban. I am somebody who has to be regulalary transfused due to a rare blood disorder. Feb 2018 i was diagnosed with AF and was put on to apixaban. My transfusions at the time were every eight weeks, I started the drug and suddenly my transfusions started to become more regular 6 weeks then 5 and this time 4, I feel very unwell headaches tummy pain ( something i have never suffered before). I am very depressed and i am struggling to keep going my limbs hurt i am breathless i can’t sleep and just feel generally unwell even sometimes feeling like i don’t want be here, although not a suicidle type of person, just very fed up and unhappy. If anybody knows of an alternative drug that will not compromise my red blood cells, i would be glad to hear from you..

I have been on Eliquis for over 3months after being on Warfarin for 12 years. My first side effect was rash on arms & legs…then scalp dryness & scaling.
In the past two weeks my vision started to deteriorate a great deal. Today in a restaurant I could not read the menu. I now realize I must take a magnifying glass.. although I have not had great vision for the past yearIt has greatly deteriorated very recently. I asked my primary care Dr. about it & she ordered blood tests which I took today. I asked technician what tests were ordered & she stated CBC & thyroid….since my daughter is her patient & has thyroid.
Also my hearing is getting much worse. True I M 85 years old & find it strange to get so many things wrong so recently. I feel ThevEliquis is somehow responsible. Next step. Report to FDA ?

I have been asked to take Apixaban temporarily pre and post my cardiac ablation surgery. I have been taking it now for five weeks. I felt VERY ill at first, and caught a cough which devleoped into the worst chest infection I have ever had in my fifty two year long life. I could not shake it but actually got worse and worse, until I thankfully remembered Black Seed Oil which cured it quickly. I thought it was senseless to take antibiotics just in order to stay on the drug that was making me ill, and was intending to stop taking the drug as my surgery would have to be delayed anyway. Luckily I got better in time.
Here are the symptoms I felt: groggy, exhausted and unable to do things except the required minimum, depressed, and a lot of mental fogginess which is totally unlike me. Now, these feelings are decreasing as my body presumably adapts. I was not warned about stopping suddenly. I have to wait until four months post op for an appointment with the cardiologist. I want to stop taking this drug before then but had better find out how to do so safely, and how long to stay on it post surgery.

A couple of days after starting eliquis I began having vivid dreams & sleep disturbances. They are the type of dreams that when you wake up you’re not sure if it was a dream or a memory of something that really happened, and you don’t feel like you slept. I wake up after about 3-4 hours and am awake 1-2 hours before I can get back to sleep. Now after being on Eliquis for 1 month, I am hungry all the time. None of these are known side effects of eliquis. I’ve spoken to my pharmacist, my perscribing doctor & the manufacturer.

I have been on Elouise for a couple years, never bruised. 5 months ago I quit drinking and now I’m bruised everywhere, mostly fingernail size red purple ones on my arms, some on legs but for no reason. They just pop up. I look diseased. Is this normal?

I think Eliquis causes throat spasms tightness in the throat

I have a undiagnosed blood clotting disorder. When I was 27 I had a D.V.T. That went from my Knee to the base of my aorta. I was bedridden for 2 month. Warfarin (Coumadin) saved my life. I took it the first time for 6 months and then I was done with it. About 6 months after I came off it I had (and still have) chronic edema in my leg and I developed Cellulitis after being laid up in bed with that for a couple of days I developed a second clot. The doctors concluded that I was prone to spontaneous blood clotting and put me on Warfarin for life. They are now 9 years later trying to change me to apixaban. I worry because I am a lot younger than the average person who would take this drug for the rest of their life and if I live an average life I’ll be on it for 40-50 years. I wonder If you have any information from long term users with information that can help me to decide whether or not to move to apixaban. Any help, advice or information would be very welcome. Thanks.

6th post on this great site,we are all suffering our awful side effects,I have been on apixiban 5mg bd got 3 years following small partial lobe strokes.i Know can’t walk far my knees are huge due to arthritis but this condition has exculated due to drug ,I’m very short of breath and unable to walk far or climb Stairs,I m a nurse still working part time I’m 55 but feel 85 wish I had the courage to stop ✋ taking it ,all my gp and medical colleagues tell me it’s the best drug but I feel it is taking my quality away unable to do much can’t walk my dog or go shopping or meet friends if it involves walking,so low and a depressed,Keep strong all of you and let’s pray for a miracle 🙏

I went in for a CT scan of my chest and they saw two blood clots in my left lung. Everything else looked good. Which they said it’s from the birth control pill I was taking. So then I was prescribed Eliquis for three months, ( my three months are done). I have just taken another CT scan and now I have cancer in my chest they think it might be lymphoma. It just seems like a weird coincidence!

I’m 80 and have been on 2.5mg of Eliquis twice day for Afib. It’s my understanding that Tumeric works just as well as a blood thinner and has many other benefits. I’m going to discuss with my Doctor but don’t expect him to agree with this finding. I’m ready to,get of Eliquis.

After many hours of research I’m finding that Tumeric is said to be just as effective as a blood thinner as eliquis with no side effects and many more benefits. I would like to discontinue eliquis and take Tumeric. I’m going to discuss this with my Doctor but don’t expect him to agree. I’m on 2.5 mg twice a day. A fib is the reason I take it. I have an irregular heartbeat but it never races. Heart itself is healthy. I’m 80 and don’t take any other medication.

My husband has had severe side effects from 3 different blood thinners: Xyrelto, 3 x bleeding eyes. Then Eliquis with extreme lethargy, breathless, extreme dry mouth, unable to walk up stairs, has to pull himself up with handrails or I pushed him from behind. He used to walk everyday and was extremely active. Now he spends his days doing a little activity and then sleeping, lying down or sitting in a chair. Then he was prescribed Pradaxa, and he deteriorated even more. Doctor did an ablation for his AF. Now Dr has stopped all meds. Doctors would not acknowledge blood thinners are the cause. We are hoping and praying he will be 100% improved. Never again will he use these drugs!

Three years ago just days after starting beta pace and Eliquis I got up one morning and my feet and legs felt like lead. I went thru visits with my doctors, scan of my legs, visit to a foot doctor, told every physician I met, no one seemed to have any clue, to include the rep for Eliquis. My cardiologist thought it might be neuropathy but I had that checked out and no. So here I am three years later. My a-fib is in pretty good control, but my legs are the same or worse and I now have occasional stabs of pain, in my toe, back, neck, chest, hand etc. etc. I also can only sleep about 2hours at a time and have to get up and move around. I really am sick about it because I am really in pretty good health for 84. I really hate meds.

I’m 82 and always in good health no heart problems other then Afib 3 years ago and as far as I know never had it again. Walking 3 miles daily, fishing on Lake Michigan by myself putting a 21 foot boat in and out of the lake by myself. Avid hunter with gun and bow. Plus have guardianship of my great grandsons 8 & 9. I had been put on Xarelto 3 years ago for Afib after being on this medication for about 6 months developed a colon bleed and lost over 1/2 of my blood. I was rushed by ambulance to a hospital in a larger city. Very scary and close to dying when my body started to produce blood. The hospital stopped the Xarelto and put me on Eliqiist 5mg twice daily and after 3 days in hospital finally got to go home. Since starting Eliquist I have developed the following
1. Head and eyes feel like I have a bad cold most of the time 2. Blurred vision which sometimes lasts all day 3. heavy legs 4. Loss of balance and have to be very careful walking 4. No energy have become a couch potato. Loss of memory in the last 6 months. 5. Very short of breath. 6. light headed, dizzy. 7. Blood pressure high160/75 most of the time after running in the 120/65 for 2 years. 8. Kidney function at 46 before this drug ran over 60. All I know is I feel terrible since being put on Eliquist and feel sure that it is the cause of my problems and I want to get off this drug but my doctor advises that I will be on it lifetime. I have cut the 5mg twice a day to 2 1/2mg twice a day but still feel the same. If my doctor doesn’t take me off this drug will have to chance stopping myself

I was very briefly prescribed Eliquis because cardi thought he saw an AF in a test. Almost immediately I began having nearly every symptom the posters here have suffered thru. Worst of all were the leg muscle and hip joint’s awful pains. Then came the severe red rash on one leg. My GP said exposure to sunlight interacting with normal skin while on this drug was the cause. He gave me a steriod based creme which has been slowly helping. Also the extreme fatigue, loss of cognitive function, weight gain, general malaise have ruined my previously active (runner) military lifestyle. I very scared about the future effects of this drug. I take no other meds. The website that tries to track compensation given to prescribers shows over $4500, trips, dinners and such he has received to prescribe Eliquis.

I was put on Eliquis from Coumadin back in May. Was on it for about 3 days and ballooned up to 284 pounds with swelling. Couldn’t wear my shoes. Couldn’t breathe. I was swollen all over my entire body.
My cardiologist put me back on Coumadin (my family doctor was the one who switched me and wouldn’t switch me back. Said it wasn’t the Eliquis making me swell). My cardiologist also had me do an adverse event rwport with the FDA. He said they needed to know about an adverse reaction that severe. After he switched me he put me on Lasix 20mg daily to help get the fluid back off. It took a couple of months. Finally in October I am back ro normal and happily back on Coumadin. Never again will I complain about getting my INR checked. Never again will I put that drug back in my system.

I think they should take it off the market

Commenced on Eliquis by cardiologist who told me that it was a much better drug than plavix. I had an ablation for AF which was mostly effective, only having short bursts now instead of hours of AF. Have been on it for almost 10 months. I have no energy, not sleeping more than 3 hours until completely exhausted after a few days, then sleeping 10-12 hours, still waking up tired. Binge eating, craving the carbs. Having Nose bleeds. Can’t go for long walks without getting breathless. I preferred taking plavix because fewer side effects. Only mild bruising when I accidently knocked into something. Now when I do knock myself the bruises are large and painful.

I am a 67 year old female. Never been ill or broken anything, Fell in snow in March and broke my ankle, a couple of toes and my shin bone. Lying about for 8 weeks but only given 3 weeks stomach injections to avoid clots. Got PE in both lungs and put on apixaban. Got a few symptoms, light headed, dizzy a few palpitations but it all calmed down. My legs however feel so heavy, like lead in the morning, getting down the stairs is a nightmare. My doc says I’m OK now and can stop taking it middle of November. Just stop? All the warnings are that this shouldn’t be done? Anyone else taken it for six months and just stopped please?

I am a 53 year old female who went through a double pulmonary embolism 04/18. The Dr’s called it an unprovoked event. I spent two days in ICU, spent some time on coumadin, when that failed I was put on Eliquis. Now I am feeling dizzy and my heart rate is out of control. I want my Dr to take me off this medicine. I went from being very active to feeling like I cant get off of the couch.

occasional hunger pangs. I am very concerned about the long-term side affects of Eliquis, such as colon cancer, dementia especially if one has been on the meds for years. What are we all facing in the long run from being on Eliquis?

on Apixaban for a second time in 2 years. First time was ok. Have been on this current prescription by same cardiologist for 2 months. Absolutely no energy, can’t sleep , wake after 3 hours, and lie awake for hours, then very disrupted sleep. Dizzyness, disoriented, bouts of double vision, legs feel like concrete. 5mg x 2 daily. Renal Dr recently suggested Apixaban could be the culprit. Cardiologist denies it but I have experimented with cutting dose in half and feel much better. I see GP today to discuss other alternatives, as I cannot function like this. Am a 73 yr-old male. It was prescribed for occasional AF.

Update: Swapped to Pradaxa. All above side effects have eased over a period of 6 weeks. Some faster than others. Generally feeling much better. More energy, fewer head spins and double vision (down from around six events a day to 0-2). Extreme fatigue has gone.

Hi, Following my hip op it was discovered that I had A F.(atrial fibrillation) I was prescribed apixaban 2.5 twice a day.

For six weeks I was so sick nauseous and dizzy that I thought I was going to pass out at times. I had a severe thirst which lasted through the night as well as during the day. Food felt like cotton wool with no taste and the sharp pain in my stomach was on going. Before my op. I took CLOPIDOGREL. After discussion with my G. P. I am back on clipidogrel. I am told clopidogrel is not as good as apixaban for A. F. because of the risk of a stroke.

It’s two days since I have stopped apixaban and I am feeling better. I am able to eat again and hopefully will start to recover from my operation.

I was diagnosed with afib last year and placed originally on flecinide (sp?) which caused my feet to balloon up at night while in the bed and the swelling would not cease. Was then put on Eliquis.

I had never had any kidney functions problems before starting this drug. My creatinine was .89 and my GFR was great. The Eliquis was started in December 2017. From Jan 2018 until May 2018, my kidneys changed and I am now in stage 4 kidney failure. I had to have a kidney biopsy in august, and as a result was told to stop eliquis for 6 days prior to the procedure and 2 weeks after. The day I left the hospital, the day after the biopsy, my kidney function was turning around a took a sharp trend toward normal.

After 2 weeks I was told to start Eliquis again, and have done so. In the past month of resuming the drug, my kidney function has worsened even more and I am looking at kidney failure and dialysis if this trend does not stop. I told my doctor that I thought it was eliquis, which, she said is not a drug that affects the kidney. Well, if it doesn’t I don’t know what it could be.

Taking it is the only thing different, and obviously stopping it caused improvement. I have to stop taking this drug and give my kidneys a chance to rebound somewhat. They will never recover to the normal function it was before taking the drug, but I feel I have to be proactive and try to literally save my life and the surety of dialysis in the near future. Any one else having this sort of reaction? Well wishes to all of you.

I hope you have stopped the Eliquis because I think you are correct. The doctor will never admit the Eliquis caused your kidneys to fail because you may sue her. That’s just my personal opinion, of course.

I am a 58 year old male that experienced unprovoked pulmonary embolisms. ! was placed on eliquis for blood clots. I believe the medication has helped thin the blood, cause the slights cut or scrape I leak like a sieve. My legs feel so heavy and memory is more than just foggy. An overall tiredness has taken over and I’m sleepy all the time. When I ask my doctors about the side effects it seems to fall on deaf ears. I have asked how I might have got the blood clots and I have been told by more than one doctor that it didn’t matter, it would not change the way I would be treated. This is frustrating I have never been sick other than an occasional cold up until 2015 and I got sick and was treated for Pneumonia. After treatment I still had a persistent cough it seems now that I had a condition called scardious. They have treated the lungs and I’m breathing great. But I still do not know why I got the blood clots. My legs feel so heavy and after I sit for a few minutes because of the leg pain it is a real effort to walk again. Overall weakness of the body and legs make me feel really bad. I do not like this feeling. Has anyone else had scardious and Blood clots and some of the same side effects from eliquis?

on elequis about a year , I’m very active , couldn’t figure out what was happening with my legs , felt like lead , espsicaley in the glute region , an back of legs , have hiked a lot , and with dogs , don’t ever remember this , now i think its the elequis , trying to figure this out ! and yeah , its scary to no how to handle it .

I was having severe pain in eyeballs,bleeding in urine,very bright and a lot,nose bleeds,numbness in legs,nightmares,itching,rash,went to doctor,they couldn’t find any infection in kidneys,eyes ok,numbness blamed on back,sodium so low,told if I didn’t get it up,would have to be hospitalized and put on I V,stopped eliquis,told to drink Gatorade,and extra salt on food,5mg twice a day,also heart palpitations,went t 1/2 pill still symptoms,cut out completely, and all better, was on it a year.

I have been on Eliquis for a few years have gained significant weight am Dizzi and lightheaded, hard breathing very tired, many more A-Fib events! Etc

My consultant haematologist changed the Clexane I was taking to Apixaban on 9 August 2018, and since then I have been feeling light headed and dizzy.

I also cannot sleep. I stay awake at nights until 4 or 5 in the morning and get up around 8 or 9am. After a few days of this I am so exhausted that I sleep for one night. Then the pattern starts all over again.

I am a 62 year-old female who had DVT with blood clots in my leg and abdomen caused in part probably by Ulcerative Colitus.

I will be seeing my doctor and requesting a change of blood thinner, as I can’t go on like this.

Had bypass surgery 3-01-18. Started A-fib on the second day. Was started on Eliquis, 2 per day. It has been six months. I lost my smell and taste right after surgery. Went through Rehab thinking I would regain smell and taste. It has been 6 mths. No smell or taste and problem thinking at times. I have discussed with Drs. and have no answers yet.

On eliquis 8 mo. Rashes itching wakes me up. Feeling of burning under my skin. Unable to sleep swollen face and eyes wake up craving carbs Put on drug after broken back. No other follow up by dr who says it’s unnessesary. 77 year old female formerly healthy.

I’m a 64 yo male who was prescribed eliquis due to a blood clot in my calf that came from a minor car accident. Took it two months. Had vertigo, vertigo,vertigo;2 ER visits; depression; light-headedness all the time in between vertigo attacks; can hardly function. Doc tells me I have Meniers disease.

I took charge of my own life and threw the Eliquis that I paid nearly $500 a month for in the trash. I figured the way I was feeling I had nothing to lose. I almost wanted to die. Two weeks later after stopping I’m feeling a bit better. Have a better outlook on life with the dizziness getting better.

I have been on Eliquis 5mg twice daily for about 4 months. Started with a blood clot forming in abdominal artery which the Eliquis managed to dissolve. No previous history of blood clots, nor any since. Unknown cause according to the doctors which numbered many at the hospital. Was told I would have to stay on the Eliquis ad infinitum to prevent the possibility of future clots inasmuch as the source could not be found. I am scheduled in 4 days for a spinal procedure (open back surgery) which necessitated my withdrawing from Eliquis for a week prior to and a week after the operation. I have been off it for 3 days and I am going through some awful withdrawal symptoms. Diarrhea, upset stomach after eating, tiredness and much of the same problems repeated throughout this page. The upside however is that I am beginning to wonder if the symptoms for which I am undergoing back surgery are not also being caused by my use of the Eliquis. I may end up cancelling my back surgery if I discover that after a few more days off this stuff I discover that it was the cause of my tired legs, loss of balance etc.. The bottom line is that this is one powerful drug with many side effects and I doubt that, regardless of the outcome of my operation should I decide to go through with it, I will ever take that drug again. I will go on aspiring and take my chances. At 75 years old I figure if it’s my time to go then so be it, but I’m not going to live with all the side effect from this drug.

Have just spent 3 days in hospital suffering from shortness of breath, weakness ,tingling in my legs , confusion and depression. This is after being on Apixaban(Eliquis) for 2 years and ‘blaming’ every other medication that I’m also on for high blood pressure and odema, now believe it’s Apixaban that has been causing the problems.

I like your attitude. I’m not even sure the doctors know that I have a-fib. In 20 years with the same doctor, it NEVER has shown up after testing. I’m sick of tests, such as a device called The Loop, which I didn’t want to begin with. Now it’s implanted in my chest. Diarrhea after eating is worse than IBS. No control, omg.

Since starting Eliquis on June the 29th: I can’t sleep, feel worn out, memory not what it was, and now I have shakes, plus paying $440 a month. Open for suggestions.

I’m a 66 year-old male who started on ELIQUIS. Last week, after awakening with an irregular heart beat and calling 911, was diagnosed with AFIB, after several hours in the ER, they got my 180 BPM heart rate and 200+/100 BP back to normal. I was taking 81mg asprin, but after awhile was scared into taking ELIQUIS. I’m on 5mg twice a day.

Today, 5 days after beginning it, I felt unreal. I took my bath, felt scared as I felt like I’m not here, restless and agitated, and extremely short-tempered. I feel unwell. I already have prostate cancer. Have tried hormones/radiation. Couldn’t handle the side effects, and now I feel like I’m on my way out. I wish I would not have started Eliquis. felt like cutting my wrist. Just had blood work done. Starting to feel like a pest to the Drs. My older brother has occasional AF. He’s on aspirin. He refused any blood thinner. What do I do? I feel for everyone who is going through this.

I have been on Eliquis for 6 months, and have developed neuropathy in my feet. It is getting worse each week. I cannot walk on uneven ground without losing my balance. Has anyone else had this? I am an 82 yr. old female with Afib, not overweight, but not very active.

I have had satisfactory results with magnesium water. Dr William Davis suggested this in one of his books or you can look it up online. It might not be the solution for everyone but the only times my heart has gone out of normal rhythm was either when I forgot to drink it or once when I decided I was “cured”.

I am in my middle 80s and don’t take any blood thinners because I have normal heartbeat. For the price of a bottle of seltzer and a bottle of milk of magnesia, isn’t it worth a try?

How much water and how much magnesium?

After receiving a defib unit (Boston Sci.) and 4 drug-eluting stents, I was taken off Prasugrel and given a really expensive “new” drug, Eliquis. Within 72 hours, I began to have increasingly lengthy nosebleeds which were difficult to get stopped. The worst was over 15 hours.
After discontinuing Eliquis, but continuing my daily regime of simple 81-mg aspirin in the a.m., I have had satisfactory checkups for 2 years with the Echo machine and a complete cessation of any nosebleeds.

Been on Eliquis a few years. I was about 100 lbs over weight and was breathless etc. also had leg swelling. Decided to lose some weight.

After losing 35 lbs I no longer am breathless my legs are not swelled up. I ride my bicycle 1 hr every day. I am 71 yr old female. This drug has helped me I have a fib and high blood pressure and hope to improve my blood pressure.

Now, lost about 65 losing. I feel wonderful every day losing the lbs has truly changed my life.

In February, my cardiologisty changed my m d from warfarin to Apixaban I have suffered with head and knock a herbs and come out n with little spots all over my body even my face very tiny I very itchy tir dress dizziness tingle feeling in my jaw I’m seriously thinking of asking my doctor to put me back on warfarin, which I have been on for st least 15 years or more for my atrial fib. Would it be safe to do this?


I am taking 5mg apixaban morning and evening. I have been hospitalised twice in the past 9 months for total stay of 6 wks. I collapsed on the golf course with very severe dizziness. I have had numerous tests in hospital including brain scan, heart and lung check, kidney, electrolytes, hearing, carotid artery. They found I had a sticking heart valve, massive blockage of carotid artery but none of these problems would cause the dizziness. The specialists finally diagnosed that my medications for bp and heart were causing the problem together with dehydration. I stopped a bp tablet but still get dizzy, muscle pain, and feeling of tightness in my chest after walking for 3 hours. If I reduce my apixaban to 2 and a half twice a day I don’t seem to be dizzy. I have finally discovered by myself that this tablet is causing my problems. It’s a pity I have had to sort myself out.

Has anyone ever had severe constipation and diarrhea on this drug?

Been on this for 2 months and up until recently I’ve been having the worst case of constipation and diarrhea for 3 weeks.

I haven’t had any other side effects besides this showing up out of nowhere.

I must say after reading everyones comments about eliquis, I agree with you’ll. It has certainly done a number on me. I have COPD, AFB, and am overweight, but I still could get around and at least walk where I wanted to, but as each day goes by I am robbed more and more of my agility.

My nights are like so many of you that have commented about waking around 2;30 to 3;00am and ten lie awake another hour or two. Then all day next day feel wiped out, no energy, hard to breath etc. I feel like the meds I take daily are doing more harm than good. May need to change cardologists or do something, I just know I certainly dont like the way im feeling now.

Any comments?

I have the same symptoms taking Eliquis. Don’t like the way I feel.

I have been on Eliquis for 3 weeks as a result of a PE. I’m told I must be on them for the rest of my life. I’m in my 50’s. The first week was taking 10 mg twice a day. I was so fatigued weak, dizzy,fuzzy headed. Week 2 I reduced to 5 mg twice a day which will be the dose I will take permanently. I am dizzy and suffer headaches every afternoon. Followed by flu like symptoms. Also tooth sensitivity. I hate taking meds, and I’m struggling about what to do. All these anticoagulants have extreme side effects. I asked the doctor if she will monitor me but she said no, there is no need. I beg to differ. I’m not feeling well. But because of blood disorders Imust take them. I’m told this is the safest drug, but I sure don’t like it. Not sure what to do.

My husband, who is only 63 years old, recently was sent from his doctor’s office directly to the hospital for Tachycardia and AFIB and pancreatitis. Upon arriving at the hospital they immediately put him on medications for all of the above including a blood thinner. That blood thinner was Eliquis. About 3-4 days into his treatment I started noticing some cognitive disorders. He was very confused, disoriented, unsteady balance and was sleeping much more than normal. The doctors ended up doing a Cardio Version on his heart to get his heart back in rhythm. I mentioned my husband’s confusion. A staff doctor told me it was probably just hospital delirium? I didn’t really buy it then but they are doctors.

The morning after the Cardio Version they had planned to released him. However, his blood reports came in, and it showed that his kidneys had received a traumatic injury. His levels had more than doubled OVER NIGHT. They began treating that, and 2 days later (a total of 8 days altogether) they released him. He still seemed very confused and disoriented. These symptoms continued to get worse not better, It was like taking care of a mid to end-stage Alz. patient at home.

I began searching his medications, looking for some answers when I found out about these major side effects. I was terrified. I called his PCP the very next morning and told him I had pulled the Eliquis from his daily medication routine. And he told me to have him in his office the following morning. He will be doing a brain scan to check for a brain bleed, and this has been one of the most horrifying experiences I have gone through. I can only hope that there is no long lasting effect from this drug.

With all the information I was able to find on the internet how in the world can they still use this drug!

I have blood in my eye and am so tired I can hardly move. This is bad medicine.

I’m reading through all of these comments, and I am astounded by the number of people with the same side effects from this drug. I started doing research for my mother who has lost her quality of life, and I believe it’s from this drug. Has anyone considered a class-action lawsuit against this company for not putting these side effects on the label? There’s something wrong here!!!! People need to start taking their health back and demanding change.

I am a 43 year old female who was prescribed eliquis after a dvt 2 months ago. I was in the er a week after i started, and had elevated liver enzymes, but after a pulmonary embolism was ruled out the dr mentioned the liver numbers in passing but didn’t seem concerned. A few weeks later, i had a bout of nausea and vomiting followed by chronic nausea, loss of appetite, extreme fatigue and all-over itching. At first I thoought it was a virus, but it kept coming back. By the time I went back to the dr, my AST and ALT were 20x the upper limit of normal – one was almost 800 and the other over 1000- labeled high alert on the lab report. I’ve been off eliquis for 4 days and am still feeling terrible. Had blood drawn today and hope to start seeing a slow but steady trend down soon. Drug-induced hepatitis from eliquis is no joke. I am also reporting to FAERS. This website is one of the pieces I used to figure out something much more than a virus was going on, so I aporeciate the alert. Can’t always rely on eliquis to help with pulmonary embolism – I’m still trying to get my doctors to pay attention and switch my medication as my symptoms have been increasingly worse after switching from clexane to eliquis (tachycardia, shortness of breath when walking a few feet) but noone is taking ownership and listening….

Update: So I found out I was wrongly diagnosed with a pulmonary embolism due to a misinterpretation of the scans. The whole time I was taking Eliquis I felt dreadful: shortness of breath on any exertion, fast heart rate, dreadfully heavy periods, dizziness, bloodshot eyes sometimes. When another team of doctors realised after 7 months that a mistake had been made, I was finally told I was allowed to come off the medication. 2 weeks after coming off it I started to feel so much better. I’m now 4 weeks off it and feel great and back to normal health. And yet the doctors denied it was the tablets causing the symptoms. I have reported it through the yellow card scheme – everyone who experiences side effects should do the same.

I am 81 years old I had a stroke at the end of Jan of this year and they immediately gave me the clot buster medicine when I got to the ER so I don’t have any after effects from the stroke. Now comes the crap part since I was told I had 1 incident of Afib the ER docs put me on Eliquis and high blood pressure meds to “prevent another stroke” about 6 weeks into taking the Eliq. 5mg in AM and 5mg atPM seems to be the usual dosage.

My left arm muscle started to hurt like the devil and I had a hard time using my arm then that eased up but my right arm started to do the same thing only worse, hurt all the way up to my collar bone and down to my wrist. I couldn’t lift my arm to brush my hair. or to take a glass out of the cupboard. told the doc and the answer was “the nerves are trying to re-connect after the stroke” so I being a dumb-I bought it, but now after reading some of these other problems brought on by these meds I am having doubt and will bring this pain up again with my doctor, nerves connecting HA! BS

If it was’t for the the misdiagnoses our country would not be hooked on morphine my own thoughts…thanks for reading my blabbering hope all of you get well soon

I have been on Eliquis for about 3 mos now. and I have had a little itching , but over the counter anti- histamine took care of that, and I have had no bleeding problems , but the main problem that I have notice is that my temper is very short and it doesn’t take much to set me off. I don’t know if that is the result of the Eliquis or just the fact of that I have been through the past months,, ie: Double pneumonia , lung infection, and the Blood Clot in the lung on top of it. I would be curious to know if any body else has had the same problem.

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