The People's Perspective on Medicine



Zestril is one of the more recent entries in a class of drugs called ACE inhibitors. The development of this group of medications almost reads like a medical mystery, starting with the venom of a poisonous Brazilian snake.

The bite of the deadly jararaca caused severe hemorrhaging. An extract from the venom was found to affect the kidney and ultimately blood pressure regulation through the conversion of angiotensin from one form to another. This led to the creation of enzyme blockers in Capoten, Vasotec and Zestril which are revolutionizing the treatment of hypertension and congestive heart failure.

Zestril is prescribed to lower blood pressure.

Side Effects and Interactions

People with kidney problems must be monitored extremely carefully, as Zestril can make kidney function worse. Even healthy people should have their physician monitor the kidneys periodically.

Zestril can cause a number of less serious but uncomfortable side effects. Be alert for skin rash, headache, tiredness, an annoying dry cough, chest pain, nausea, vomiting, diarrhea, muscle cramps, low blood pressure, nasal congestion, heart rhythm disturbances and sexual difficulties.

Report any symptoms or suspected side effects without delay.

There are a number of compounds that can interact with Zestril. In general it is important to avoid potassium supplements, including low-sodium salt substitutes. Diuretics such as Dyazide, Aldactazide and Moduretic which preserve potassium also can cause dangerous elevations in potassium.

Other drugs that can interact with Zestril include other diuretics, the arthritis medicine Indocin, the gout medicine Zyloprim and lithium.

Check with your doctor and pharmacist to make sure Zestril is safe in combination with any other drugs, or herbs, you take.

Special Precautions

The very first dose of Zestril you take may cause dizziness, especially for older people. Be especially careful until your body adjusts.

When you first start taking Zestril, be alert for a rare, but serious reaction. Some people have experienced swelling of the face, lips, tongue and throat which can make breathing difficult if not impossible. This requires immediate emergency treatment.

Another uncommon but dangerous reaction is a drop in infection-fighting white blood cells. If you develop chills, fever, sore throat and mouth sores contact your physician promptly. Blood tests are required to detect this problem. This risk is greater for patients with certain predisposing conditions such lupus, scleroderma or kidney problems.

Zestril should not be taken by pregnant women in their second or third trimester unless there is no alternative. It may damage the fetus.

Taking the Medicine

Zestril may be taken with food or on an empty stomach. It should be swallowed at the same time every day to maintain consistent levels in the body. Don’t swallow Zestril within two hours of taking an antacid, though.

Do not stop taking Zestril suddenly, as this could lead to complications. If you must discontinue the drug, your physician will instruct you in tapering off gradually.

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About the Author
Joe Graedon is a pharmacologist who has dedicated his career to making drug information understandable to consumers. His best-selling book, The People’s Pharmacy, was published in 1976 and led to a syndicated newspaper column, syndicated public radio show and web site. In 2006, Long Island University awarded him an honorary doctorate as “one of the country's leading drug experts for the consumer.” .
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I’ve been absent for some time, but now I remember why I used to love this website. Thank you, I’ll try and check back more frequently. How frequently you update your site?

Lisinopril is a very dangerous drug with severe side effects for many people and should be taken off the market. I speak from personal experience. After taking this medicine for 5 weeks, I developed a severe cough that finally went away 2 months after I stopped ingesting this medicine. It was the worst two months of my life!

Aged 79 I have been taking a Beta blocker and an ACE inhibitor since age 65 (mild MI). As I log my BP I have seen it rise from 140/80 to 155/85 with some systolic spikes of over 200. A month back Dr added a calcium channel blocker, this had been tried a couple of years back but the dizziness was too much, anyway I have tried it for over a month with no change in mean systolic.

Yesterday I persuaded Dr to re-prescribe Isosorbide-dinitrate as I know it will drop BP to 120/60 (I had a couple of pills left over from 2003!). However, as we checked my graphs it was noticed that on the day of my visit my BP had dropped to 140/85 for most of the day. Why? When I got home I remembered that in the morning I had used a fair amount of LowSodium (50-50 NaCl-KCl), table salt on a tomato, first time for years that I had used any salt!

Today I’ve been taking the odd pinch of the LowSalt and my systolic has been mainly 140 but towards evening there has been a spike oto 160.
Guess I have to keep on with the Beta Blocker and ACE I for a while yet – I’ll drop the Beta blocker down from a daily 25mg X3 to 25mg X1.

I began taking Lisinopril February 2nd ’15 – 10mg with amlodipine 5mg as prescribed after taking Adrenaline and Thyroid supplements that were over the counter “helps” for better health- I thought. I had a severe reaction to the supplements which led me to the doctor and the prescription for high blood pressure. My blood pressure had dropped 38 points on its on at the first visit after stopping the supplements and before taking the supplements. February 5th the doctor saw me again. The lisinopril and amlodipine prescription dropped it down another 20 points. (My blood pressure norm was around 150 for years). He then prescribed a 20mg dose of Lisinopril and continued 5mg amlodipine. My first ingestion of the 20mg I became light headed and had a bit of “kidney-area” ache. I reverted back to the 10mg dose until the bottle ran out and I then started taking the 20mg the first week of March. The light-headedness returned and the ache too. The light-headedness has now gone but the ache has gotten stronger to the minor discomfort stage. It has been one month. My search on Lisinopril led me to this site. I am 53 years old and I believe that my blood pressure while matching my age (50 ish years/150) is the result of my extra weight that I am in the process of losing (21 pounds off in a month) with a goal of 45 lbs more to lose. Only thing is, I do not want renal failure as a result of BP medicine.

sorry, I meant to say that my blood pressure had dropped on its own after stopping the supplements and beginning the prescription.

I took 5 mg of lisinopril for many years with no problems. After my heart attack and stent my doctor increased it to 10 mg. Again, no problems – except my BP wouldn’t come down so he doubled it to 20 mg. After a few weeks my BP was still too high and he doubled it again to the max dose of 40 mg. I feel like I have been hit with a truck. Since cardiac rehab I have maintained working out in the gym 3 times a week, now I can barely do anything there anymore. I also take metoprolol, HCTZ, and Klor-Con. BP STILL avergaing 140s/high 80s. Getting a little discouraged. Hard to even do my job each day I feel so bad.

It’s been over a year. Has anything changed? I am in the same situation, started Lisinopril 10 mg at 180/105 BP, then increased to 20 mg, it’s at 170/100 BP, about to start taking the 40 mg. I’m afraid of the side effects and that it won’t work.

What happened for you?

I had posted back in August. I had to stop taking this med as I stated before. It’s a long road back it seems. I compare it to taking heroin. Even though the drug has left your body its effects linger. They call it the “100 day hangover” Im sleeping better, back to doing some weight training. But I’m not back to where I was and I don’t know if I ever will be. If only I had checked websites like this I never would have taken the snake poison. Oh yeah, I’ve had blood test, CT scans and X-rays, and no one could find anything wrong. I know its the drug.

Experiencing dry cough. Shortness of breath. Weakness

I’ve been on Lisinopril 10 mg once/day for two years, and my bp has stabilized from very high to normal. I had a dry cough for about a month, but that symptom has passed. I’ve lost 30 pounds now and am thinking of lowering my dosage with an eye toward getting off it completely. I see VA doctors, so it’s not easy to get a consultation on this, but I hesitate to do it on my own.

I am 56 years old. I had a number of bad nosebleeds which took hours to stop. I went to my doctor. My blood pressure was 160/140. She prescribed Lisinopril and told me to start on 5mg/day. That proved to be sufficient. My blood pressure is now around 120/80. The medication is working well at a low dose, but I do have some some effects: occasional muscle cramps in my legs at night and an annoying tic in my eye.

I am 40 years old, and I was given lisinopril for blood pressure. As far as I am concerned it has destroyed me. I was going to the gym daily for last few years but few months after starting this medication I could not manage going at all. I am off of it now, but still have the extreme tiredness, poor short term memory, mental confusion, and weak limbs. I lost 2.5 stone in 3 months. I’m struggling to hold onto my job due to vision problems. Never ever again will I entertain this poison. Beware.

I am 50 years old and am having the same problems. I have been taking this medicine for almost 2 years and haven’t felt good since I have been on it. I have always had arthritis but in Sept my ANA blood work was high. I explained my concerns to my Dr. about taking the med. but she says all of them have side effects. This month my tongue is getting sore and red. My fatigue and joint paint is getting worse. Not to mention, neck and upper back rash, headaches, blurred vision. I think after reading your thoughts, I’m gonna demand a different med.

Anyone else having issues of sore/tender/bothersome muscles in the arms. From the elbow up. Front and back of shoulder, chest, sides. PLUS sore throat that does not want to go away. I’ve started getting sore arms around the time I’ve started taking this med.

Linsinopril will leave you in a weakened state for months, even as long as two years. I’ve been off of it for 7 months and I still can’t get back on my treadmill. My doctor insists that medicines cannot cause the problems I described but after I got off of it my muscle aches and pains diminished and I am now left with just the complete loss of energy.
I’m thinking my energy will return but I don’t know when. My symptoms were–muscle aches in arms and neck area, cramping, coughing, muscle aches in kidney area, muscle aches in lower back, leg cramps, cold chills and severe hand tremors, feet burning and numbness and a general weak feeling to the point where I could no longer walk across a street without stopping for rest. I still am having difficulty getting across a store the size of Walmart.

I’ve been on Lisinopril for about 8 months and my muscles from my elbows up have gotten very weak, I’m a very avid golfer and I’m having trouble just swinging a golf club from weakness and pain in my arms. My neck and shoulders have been painful off and on for about 6 months. I’m done taking Lisinopril. I hope I can get some strength back in my arms.

I started out on linsinopril htz 10 mg, later just straight linsinopril…. I had a dry mouth and weakness.. but nothing so bad as allergic reaction… thinking if you drink or have high acid fruits you were probably over-dosing because you didn’t read the warning label. Alcohol and acid fruits can double or triple the effects of the drug. All I ever took was Biotine for the dry mouth a lot of pills cause dry mouth over long periods of time.

There has been a lot of suffering with this drug. But I have seen where people have benefited and experienced hardly any side effects (or so they say). I was not one of them. I had to stop taking lisinopril /hydrochloroziade it messed me up but nothing like some have posted here. I been off it now for almost seven weeks and I’m still not back to normal. My blood pressure is back to where it was before but I still suffer from insomnia, tiredness, imbalance, weakness in the legs, and brain fog.
Anybody have any idea how long this is going to last?

So I was prescribed this medication a few days ago. My Mom is on it and is very sensitive to medication and is on a very low dose but it works for her. When it came to me and my blood pressure was staying steadily high I was prescribed lisinopril. I take klonopin for panic attacks and Zoloft for OCD. I’ve been on these meds for years. For the past four days I’ve taken the lisinopril, within 20-30 mins of taking it I have severe nausea and have found my legs and feet cramping. I thought it was something I ate at first but 4 days in a row I took to Google and found I’m not crazy, there are many others suffering. I’m at 20mg once a day at night. The heartburn and acid in my throat coupled with nausea is just ick. My Dr is on vacation for a week so now do I stop the med OR suffer through and hope I come out the other side feeling ok.
Thank you

If you will look on 11-4-2012 I shared what happened to me. I still am having troble with my intestines. I have to take Mylanta every night thirty min. before I go to bed. I still have lots of pain in my intestines. I have been off of Lisinopril 10 mg almost a year.

About 15 years ago (age 65) my BP started going up to around 190/xx. My dr. put me on a once daily dose of 20mg Lisinopril plus 240 mg Verapamil. My BP stabilized at 120-125/80 for about 8 years, when a blood test showed I had a high creatinine level. The doctor cut my Lisinopril dose to 10mg once daily. That lowered the creatinine level, while not changing my BP readings at all. I have not had any of the other severe side effects that others on this blog have reported, with the possibility of waking with a dry mouth, but normal daily activities soon got rid of the dry mouth.
At my last blood chemistry test the creatinine level was again slightly above the recommended range, so my doctor replaced the Lisinopril with Losartan 25mg. My BP is still averaging 120/80 but I’m waiting for another blood test to see if the creatinine level has lowered. Every person reacts to drugs differently, but I really wonder about those who are taking 40mg of Lisinopril several times a day; it seems excessive to me.

I took 10mg a day and 5 days after I started it I was admitted to the hospital. I had a SEVERE allergic reaction that is extremely rare and it took doctors 2 1/2 months to figure out it was an allergic reaction. Everyone reacts to medications differently. My mom took Lisinopril with no problems. My dad got the really bad cough and stopped it. I had an intestine closing and went through HELL while on the medication. I read through a lot of the comments when I first found this page and never found anyone with the reaction I had. Only a handful of people have had the angioedema (swelling) but none had it in their intestine. I would not wish the pain I had on my worst enemy…it was THAT bad. Labor pains weren’t as bad as the pain I got. I was sick for almost 3 months and within weeks of stopping the medication I was back in the hospital because my blood levels were so out of whack the results came back “panic”….not low but panic. I could have had a heart attack, seizure, or some other things happen….all because I was so sick and wasn’t able to eat properly while on this medicine. Please don’t make it sound like we’re all just overly sensitive or exaggerating because I definitely know I’m not!

I was given lisinopril 20mg once a day several months ago for high blood pressure. I am still taking it daily at this same dose. I have never had any side effects and don’t know anyone who has. I live in a 55+ community so a lot of people here are also taking lisinopril and are not having any side effects. From the comments I am reading here, it seems as though people are either sensitive to the side effects or are being given too much lisinopil a day.

I’ve been taking Lisinopril for about three years and it has really worked very well for me until about a month ago. My blood pressure without medication is high, about 140/90 when I first wake up in the morning. I take my pill and it settles at about 125/80, so all was well.
Now I’m getting early morning spikes as high as 155/90, but when I take the pill it goes into the proper range however in the evening, around 5:30 my blood pressure drops to somewhere between 101/65 to 93/58. I am light headed, slightly queasy, weak kneed and I have to sit down or I’m afraid that I’m going to fall down.
The only change in my life is that I was diagnosed with cancer in January and had a hysterectomy in April – could this be causing a problem, or any other ideas or is it all in my head? Other than this I feel pretty good most of the time for a chubby 61 year old woman.

I finally convinced my doctor to take me off Lisinopril and all the problems of aches and pains, including high blood pressure went away after I decreased my salt to a minimum and went on a small dosage of Amlodipine, 5mg once daily. I also got off my Metoprolol because I discovered it reacts against other Blood pressure medicines. I also discovered that Doxazosin is a bad drug that causes severe muscle aches that last a long time after one gets off that drug. Rather than stay on drugs that have debilitating effects, I had my prostate cleaned out. Now, the only drug I am on is 5mg of Amlodipine. My blood pressure is now 125/72 nearly every day all day. Lisinopril is a bad drug for many people. If you are on Lisinopril, and are having muscle aches and pains, get off of it and have your doctor try Amlodipine, a small dosage works for me.

My husband starting taking this medicine after going to the doctor. He prescribed him 20mg of lisinopril first time he’s been on bp medicine. After taking it about 3 weeks he developed severe muscle spasms in his back, shoulders and chest area. It was so severe he couldn’t move and brought him to tears! Never had this problem before and I noticed he was more tired and slept more. I began looking up the side effects of this medicine and was shocked! He went back to the dr and he said to keep taking the medicine and muscle spasms are rare! Don’t sound like their rare to me if people are having these issues! I told him to stop taking the medicine! So we will see if the muscle spasms stop! This medicine needs to be treated more!

My mother’s blood pressure has been high. She went to the hospital a few weeks ago, with very high blood pressure. They thought that she had a stroke, but she didn’t have one. She is taking Lisinopril. When she left the hospital, she was taking 20 mgs. of Lisinopril and 10 mgs. of Amlodipine. Last Thursday, she went to her doctor. Her blood pressure was 173/86, so he increased the dosage of Lisinopril to 30 mgs. She went back today, four days later, to have her blood pressure taken again and it was 156/88. He increased her dosage again, to 40 mgs. She is 84 years old. I have read, that it takes a few weeks for Lisinopril to take effect. I am very worried that the dosage was increased too soon, without seeing if the 30 mgs. would be sufficient. I am so worried about her. I would appreciate any assistance. Thank you

Yes this drug does cause angioedema. At least you were lucky enough (considering all you dealt with) to be diagnosed and treated in a few weeks. I had angioedema in my intestine and it took over 2 1/2 months for doctors to figure out that it was the Lisinopril because it’s such a rare reaction. They couldn’t believe I didn’t have the swelling in my mouth, throat, etc. as well.
I don’t blame the doctors because not everyone reacts to medications and the same and unfortunately you don’t know if you’re allergic until you take it. There were only 22 reports of my allergy to it from 2000 to 2010 out of 80,000+ reports of various side effects. I wish pharmacies put the rare reactions on the info about the drugs but they usually only list the “common” side effects. I am glad you are better. It’s a long road to recovery. I had 2 surgeries and spent a month total in the hospital because of this medicine.

This drug called lisinopril is a very dangerous medication. The side effects can be life threatening. People we need to wake up before it gets to late to do anything about it.
On Oct. 8 I had my doctors visit and was prescribed 20 mg of lisinopril 3 times a day. I didnt think anything about it as I thought great, now I have some meds to help with my high blood pressure. I think I was around 185 over 110 which the doctor said was pretty high. I told him I just thought it was high because of me being obese at 280 lbs. and 5 11.
T o make a very long journey short by the 12th of Oct my tongue had been swelling everyday to the point that breathing was getting very difficult for me. This was all happeneing by my 4th day of taking my new meds.
I was taken by my son and his girlfriend to the ER in town around noonish on the 12th. The nurse in ER took my readings and said I was in heart attach territory at 225 over 170. I was taken back to a room to be examined as my tongue was swelling so much and not one doctor knew what to do. I really thought I was going to die from suffocation as breathing was almost impossible at this point.
By this time other family members were arriving and for 2 weeks I don’t remember anything other than what I was told by family and doctors later. The doctors put me in an induced coma and in order to breathe doctors had to do surgery to perform a tracheotomy so i could breathe during my coma.
They diagnosed me with Angioedema caused by taking lisinopril. WOW!
During my coma I also developed pneumonia and had to be put on dialysis. The doctors told my family that they should all be up here because I wasnt expected to live through this ordeal. They told family members only about a half percent of a percent ever live. The only reason I survived, according to the doctors, was I never drank or smoked. If I had done one or the other I would not have lived. I beat the odds and survived thanks to God.
When I woke up from my coma I couldnt walk, talk, or even write a simple sentence and I was only down and out for 2 weeks mind you. I started my therapy in the hospital and it sure was difficult. After great hospital care and family helping me I learned really quick all the tools needed to walk and talk and write again. The hospital had done their job and I was transfered to a nursing home for my rehab. It sure seemed like it took forever but my goal was to do my rehab and be home by thankgiving. I pushed hard and did accomplish my goal but don’t think I deserved to almost die for one, and then end up losing 2 months of my life for something that was not my doctors fault or mine.
When my doctor saw me next he let me know he was so sorry and told me he kept checking up on my health daily. He even cried when we talked about my ordeal. I have such a great doctor. People taking lisinopril need to know about the hazards of this drug.

before I could finish editing my comment for typos and such- my tablet pops phrases in the middle of sentences- I somehow inadvertently sent it before completing my last sentence… I am waiting on the Dr, to call me back so I suggest maybe lisinopril without the hctz, so worried about my heart. But trying to get back to complete my comment I came across so many more that have the cough and even stopping the med still have the cough, I prayer it is not too late for me and another comment said she is taking for her heart, then one says to put your health at risk, after my husbands reaction and has been on amlodipine with no problems hope this can work for me. Because thanks for everyone’s comments, I am tired of this coughing.

Yes you have my symptoms exactly except for the diarrhea. 52 yr back down to 178 from 194 early part of the year, and past 2 years 186 my last checks up determined to lose more for my heart health I’ve been taking Lisinopril hctz for almost 4 weeks and as soon as I lay down at night, there it goes since my husband told me that was one of the side effects as soon as I took it and started waking up coughing, my pressure has been good all my life I checked it about 2 weeks ago because i had vertigo to the point of panic, i associated it with my allergies due to being sensitive to most scents. So since during my overdue physical my pressure was so high. I urged the MA to check it 3 different times, Dr ordered an ekg I reluctantly agreed to lisinopril hctz even after knowing my husband took it for almost 6 yrs his lip swell beyond recognition after Dentist + Er visit we found out that to was an adverse side found effect. The Dr. reasoned with me every isn’t affected the same and he said it has an ace inhibitor and best of another i suggested and my heart was enlarged due to having hypertension for some time. We have hearty disease in the family and I was suppose to keep my pressure low so as not to complicate my afib i take an allergy pill daily and an extra Decongestant for extra pressure which he suggested not to take due to raising blood pressure. So the bottom line this cough and think draining saliva all day i believe its from the hctz which is drawing out my always inflamed sinuses and post nasal drip that my regular allergy pills can’t handle so I just called my Dr. Office and asked for something else I tried enduring it. I usually take my med at nigth then coughing worsens so last night I didn’t take a pill and I only woke up coughing once. l may continue to take the last 3 pills during the day until my Dr. Can change my prescription I am waking for the nurse to.

Dear John, I have had the same problems on this drug. I have told my doctor about the leg cramps but she just advised me to eat a banana every day. This has not helped, I think I am going back and complaining a little louder.

It’s hard to believe you put your trust in doctors and supposedly the best medical system in the world and this is the results. I was put on lisinopril for mildly elevated blood pressure. Big mistake- sick, dizzy, no appetite, feel like crap.
I was on it for about 3 weeks and I told the doc this stuff is killing me and he relented and said I could go off of it. I asked well you mean just stop altogether or do I need to wean off? He says no just stop but monitor your blood pressure. So I did and I’m 10 days off now and still not back to normal but getting better.
It’s clear from all the postings on the web this stuff is bad news and I question whether you need any meds at all unless your resting bp is consistently over 180/90. I think doctors are over treating people and the drug companies are glad to sell the stuff.
From now on I’m not taking anything on a doctors word alone until I check it out. Now honestly do you feel better taking bp meds? From the comment here mostly no. Blood pressure, how high is too high? Depends on who you believe. You believe your doctor? You believe the drug companies? Every night on tv during the evening news drug companies run their commercials. I’m just saying do some research and don’t just blindly accept everything your doctor says or what you read. I learned my lesson.

I am a 35 year old African American Female. I was recently diagnosed with high blood pressure and lisinopril is one of the medication my doctor is trying to use to curb the problem.
I started this medication 7 days ago and after the 3rd day I notice I was feeling off. My sleep patterns changed drastically, I was sleeping for whole days. I also felt depressed and life-less (more like a zombie). The worst side effect of this medication is the lost of appetite. Everything I ate had no flavor, no taste, and no desire to eat it. I even try to eat things that I normally loooove and it had not flavor at all.
I know my body and I know myself. This is not me. I do not sleep that many hours even when I do not have anything to do. I rise at the same time everyday and sleep at the same time. I do not just fall into deep sleep (to the point of night terrors) without having some form of fatigue.
I called my doctor and informed her of my symptoms, and while she did say she has never had a patient that complained of those symptoms from the medication, she trust that I know myself and advise me to stop the medication immediately and we are going to try a new medication.
I respect doctors and their profession, but as patients we must know ourselves and if we are not getting the results we want from our doctors, you have the right to get a second opinion regarding your health. We also should be aware that every time you take a medication you are a test subject for this medication because we all react different to certain medications.
The doctors do not know how you will react they only know what studies have told them. Being a researcher myself I know that there are always outliers in a study. This means that you might have a different reaction than what the test suggests.

I am a 80 yr old man, I started taking lisinopril 10mg for about 5 yrs. My bp was 140/70 my bp came down a d I stopped taking the med. For about 2yrs my bp rose a little and I went back on 10mg a day last month my Dr raised it to 10mg twice a day now my bp in the am is about 98 over 50 and I get lighted quite often when I stand other than that I find no problem, but I wonder if I should go back to 10 mg a day.

I am 59 in October I feel 90 I walk and exercise and am not over weight I exercise regularly. Since I started taking this drug. I have heart palpitations with a dry cough all over pain. I went to the emergency room for sever spasms under my shoulder blades.
Before I started taking this I was ok. I had been in a rear-ended in my vehicle and went through hell for a few years but this is not the same I wake up at night with this running nose I feel like I’m drowning in my own fluids. This is all new and I started having nose bleeds also. I’m going to stop taking this to see if it stops I will let you know.

White male 57, 213lb, 5’6 I have been on 5mil lisinopril for going on 20 yrs. I have developed leg cramps over the last four years, and have recently started getting the clear saliva, and back pain… as well as cramping in the oddest places including my hands… Always tired…. as well as a slowing down of sexual drive.
I also had diverticulitis which I wondered if was caused or triggered by the drug. I ran out while was “on the road” awhile back…. and I felt better, cut cramping to nothing… and was horny as a 20 year old. Blessings on whomever came up with this website/list!!!!
I was taking this stuff for kidney health, but I think I am go let it going to be careful with my food, and skip the drug. [I will chat with the doc about this].

The problem with what happened to you is that it’s fairly rare that angioedema happens and so many doctors don’t put 2 and 2 together. I took this medication and within 4 days my intestine was closing and it took 5 hospital trips, an ER visit with no admission, a series of TONS of tests, and 2 surgeries for them to figure out that it was because of the Lisinopril.
Intestinal angioedema is what I had and is EXTREMELY rare. Once we determined it was the medication (gastro doc basically took a guess because nobody had ever heard this reaction happening) the docs were baffled as to why I didn’t get the swelling in my tongue, lips, throat, hands, etc. because the pill touched all those parts before it actually hit the intestine.
I went through hell with this damn pill but the bizarre thing is that whenever I was in the hospital and I took it (went many days not being allowed to eat or drink a thing) I didn’t have any of the symptoms. I don’t know if it was because of all the I.V. fluids or what but I was fine when I was in the hospital and was taking the Lisinopril.
Good luck and I hope you feel better soon.

I’ve been on Lisinopril for about 5 years. I never realized that the bad muscle cramps I had in my back and my legs could be from Lisinopril. I thought my thyroid levels were just down.
I’m writing because I’m experiencing something that I never knew I would go through with this drug. About a month ago, I noticed swelling around my shoulders, above my collarbone. I never really thought much about it. Then, I started having difficulty swallowing. I went to the ER, told them my symptoms: Can’t swallow, feels like my tongues swollen, swelling above my collarbone, and swelling behind my knees, and a rash. The ER ran blood tests, all were fine. They did a scan to see if I had cancer, all clear. Then they gave me 2 Benadryl, and that seemed to help.
I think the biggest mistake was telling the doctor that I sometimes had panic attacks. I could see the change in her face. The skin rash? Just a part of kidding older. The swelling around my collarbone, she didn’t see it. The tongue swollen? The put a tongue depressor on it and told me it looked fine. Basically, I was a nut because I must be imagining this since I am prone to panic attacks.
It took me 10 days for me to see a Ear Nose Throat doctor. While waiting to see the ENT doctor, I again visited the same ER. I told them I couldn’t swallow, that for 9 days I’ve been on a liquid diet because I can’t swallow from swelling. I was told that they could not help me, that they didn’t find anything wrong last week, and that I just had to wait for the appointment with the ENT doctor.
The next day I walked into the ENT and she looked at me and said, “This is angioedema caused from the Lisinopril”. Stop the drug immediately, and keep the Benadryl with you at all times and call 911 if you have difficulty breathing.
The next day I had an appointment with my Primary Care Doctor (I hadn’t had insurance for a year due to no job), and he looks at me and says “It’s angioedema, and in about 4 days this swelling will stop”. Like it was no big deal. I told him how I had to wait for another 2 weeks before I get a swallow test, and he tells me that isn’t that long. Ok… I haven’t eaten anything for over 2 weeks (solid) and feels like I’m choking to death, but another 2 weeks isn’t a big deal.
So now, that same night I noticed that the swelling that was actually leaving, was bigger than ever and the feeling of not be able to swallow was now not by my tonsils, but by my collarbone area. I went to the ER and they gave me predisone. Good the predisone will stop my swelling.
Well, the next night, I noticed that my tongue was swelling more than before. I went back to the ER and the doctor told me to continue with the Predisone and Benadryl, but if the swelling of my tongue didn’t respond soon, I would have to be admitted and have a tube put in my throat until the swelling subsided. I’m praying like crazy that this predisone starts working and that it doesn’t come down to me having to be in hospital.
I’m really mad about the first ER that I went to. I took the Lisinopril for another 10 days because the doctors there were clueless about what was wrong with me. When I went to a new ER, the RN that checked me in knew what it was from… the Lisinopril.
I’m also irritated because my Primary Doctor acted like this was no big deal. I’ve got swelling, can’t eat, and it’s all very nonchalant. I’m stressed out of my mind! I’m missing work, and since it’s a temp job, doesn’t look very well to have missed 3 days because I’m freaking sick.

Hi. I am on Lisinopril for about the same amount of time and I get Charlie horses in my feet sometimes. Dr. Oz had a show and he said to drink pickle juice.
Well this really works. Every time I get these leg problems I drink a few sips of pickle juice and they are gone within minutes, even the worst ones that wake me up out of bed at night. I just drink about three mouthfuls of pickle juice, sweet pickle or any kind.

causing me constipation, weight gain. now after more weeks, fatigue, leg muscle pains, weakness.

Regarding the lady who had the leg cramps, I am in a similar position. I’m 66 and started taking Lisinopril for high blood pressure two months ago. The leg cramps are awful and they can occur anytime, but especially at night or when my feet are cold. The water helps, but I use homeopathic quinine tablets that help. Also there are two pressure points that my reflexologist told me about – one on the back of the calf – the other on the foot (make a triangle going back from the big toe and the second toe and you will find the point to press). Good luck. I also have low back pain from the medication. I stop it periodically and every time I go back on it, by the third day I am in pain. I cannot live on Motrin, which I know is also not good for you to take every day.

Please tell me how long these symptoms will last? I have swollen raised bumps all over my hands and scalp. My shoulders hurt so bad. I haven’t taken lisinopril for a week and the symptoms are still there. My belly doesn’t hurt super bad anymore, but the swollen red area w/ the join and muscle pain is driving me crazy.

My blood pressure had been trending up over the past two years. Other than the concern for my blood pressure escalating I have always been healthy and never had to take any type of medications. I thought that maybe the increased blood pressure might be due to being premenopausal. At my last doctor visit, a month ago, my blood pressure was 158/102. She put me on Lisinopril. After being on the medication for about two weeks I noticed that I started becoming extremely short of breath and felt tired most of the time.
I just refilled my prescription and read the side effects. I have not taken the medication for the past three days and plan to call my doctor first thing Monday morning. I have always been active and I am not overweight. My diet hasn’t always been the best but I’ve been working to change that. Since I started this medication I feel horrible, the shortness of breath is the worse, I have trouble even walking up our stairs and now I don’t even feel like exercising.

I agree. I was given lisinopril for my blood pressure. Within 2hrs after taking it my back started aching, urine decreased blood pressure dropped low. My doctor said to continue taking it by the third day I was at the urgent care clinic the next night the ER. Missed work the whole week severe muscle spasm in the mid back right side. Stop taking it that 3rd day but still in pain and having to go to physical therapy. Some doctors have said its not a side effect but I didn’t hurt myself or had symptoms until after taking it and this isn’t the first time blood pressure medicines have cause similar problems. I’m slowly getting back to normal.

I am having the same symptoms. I’ve been taking the 10mg once a day and these attacks are killing me. I’m going to talk with my doctor

Don’t be recommending others stop a drug because you had a bad experience. I have been taking Lisinopril for over 10 years (now age 78) with no side effects like you describe. I started with 20 mg once daily, but have been at 10 mg for the last 5 years, reduced because of a high creatinine level which the reduction seemed to fix. I stopped once for a few days when my Rx ran out; after three days my systolic started rising, was up to 135 before my Rx was resumed.

Age 19 height 6’3 weight 240 I was put on lisinopril 10mg by my doctor because my blood pressure was a little high and for about 6 months I was taking it regularly with horrible side effects such as dizziness, dry cough, fatigue anxiousness and just an overall bad feeling inside. After a couple months side effects seemed to die down but not completely, so I got tired of feeling like this so I had stopped without telling my doctor.
After stopping I did feel a lot better but not too long I had gotten a lot of tightness in my chest, shortness of breath, heart palpitations, dizziness, anxiety attacks, all from a result of rebound hypertension, since my blood pressure went down on the medication just stopping the lisinopril had its adverse affects because my body did not know how to react without the meds keeping my blood pressure down. So I went in to the doctors and they were telling me it’s just my anxiety and sent me to a psychiatrist and it was hard to think this medication was making me feel like this, so they prescribed me xanax to help me calm down and told me to continue taking the lisinopril.
So I started taking it again and it felt like the side affects were starting all over again no matter how calm I was even if I had no anxiety feeling I still felt horrible. I went back to the hospital and told them how I was feeling and was having a rough time sleeping because of it so the doctor told me try taking the lisinopril at night along with a xanax for sleep instead of the morning because I would take the lisinopril around 5pm when I would get off work trying to avoid side affects during the day. So I skipped the dose at night just took my vitamins, ate healthy, and felt good enough to get a little cardio in. The next morning I woke up feeling great no anxiety no dizziness or any side affects whatsoever. Then it came time to take it in the morning and again I took it and started to feel the side affects coming back, all the anxiousness and the horrible feelings so I am now convinced this medication is what is causing me too feel so bad day in and day out and give me bad anxiety because before taking this medication I felt normal and as of now I can’t even remember what normal feels like. I’ve made a few more appointments and I’m going to try to convince my doctor to either ween me off this medication or switch it because I can not go on living like this it truly is keeping me from living a full life feeling like this everyday.

I got pancreatitis from taking lisinopril for 6 months. I kept telling my primary care Dr that it was causing me problems but he said it couldn’t be the med. Now after many years of debilitating pain, many surgeries, ercps, and a perforation during an ercp at Johns Hopkins, and traveling this country in search of help- desperately begging for help with this incurable disease, my life has completely came to a halt… an unrecognizable life- an extremely painful life- a life where no ER Drs are trained to help with pancreatitis and only approx 12 major pancreas centers exist and some want to perform a pancreas transplant (tp-ait) where they dissolve or melt down the pancreas and then inject your islet cells into your liver ducts BUT this might even make things worse.
For certain, I will quickly become a brittle diabetic now and might be forced into more tube feedings and surgery. And if I end up having the tp-ait (still quite controversial- Mayo calls it barbaric), well, my life expectancy will be very short. This has been a fight for getting just basic care as no one see’s anything on the 53 cat-scans they’ve done since 2009… and since Drs don’t see anything on my labs or scans, they’ll label you a drug seeker or alcoholic and demean you and humiliate you and not help you, when even Dr David Whitcomb of the univ of PA-Pittsburg says this is worse pain than cancer, and Dr Morgan at MUSC-Charleston says cancer patients are the lucky ones as at least they’ll GET TO DIE!!! thanks a lot, LISINOPRIL- you’ve ruined my life and I’m going to get even, believe me!!! there are laws and you can’t poison people and get away with it.

My new doctor took me off Lisinopril and after taking 365 mg of iron, 100 mg of Vitamin B-2 and a healthy dose of vitamin-A, my cough is gone. It was gone in one month. My doctor told me it would be with me for months, possibly years but the iron did the trick, plus getting off a bad drug. The aches and pains associated with Lisinopril have not yet gone away and it looks like those might be my new norm.
Unfortunately, the new drug I am on, Doxazosin is an alpha blocker and I am a heart patient. It is possible I may not suffer from the drug and I do not appear to have any side effects so for now I feel comfortable taking it, but Lisinopril is just about as bad as the statins I had to take; they too almost killed me. I would tell people to get off Lisinopril but I am not a doctor. In fact, my doctor says I have a very big imagination.
I guess I imagine it when my hand suddenly refuses to hold a cup and the cup falls to the floor because of the sudden pain in my arm. I guess I also imagined the cough and the kidney damage that Lisinopril gave me. I wish everyone on this drug a whole lot of luck and hopefully, your doctors will get you on something better.

My husband has been taking Lisinopril and Atenolol for several yrs. He had bariatric surgery 9 months ago. He is now 348lbs (down from 625). Ever since surgery his potassium has been trending down. Before surgery it was 3.8-4.4, but after surgery it’s been 3.4, 3.3, and 3.2. He’s been having leg cramps in the mornings making it difficult to walk. Can he take a potassium supplement? How do you know when you don’t need the Lisinopril anymore?

I started reading all these posts about Lisinopril and wonder if my symptoms are from this pill!! I’ve taken Lis for bout 5 or 6 yrs now and over the last year or so I’ve had severe ear itchiness [my left ear only] and it drains a watery liquid that drys and becomes crusty in my ear canal. I’ve been to my doc and an ENT several times with no help. I’ll dig my ear till it bleeds! I’ve also had a problem with my nostril [left also] I’m getting frequent reoccurring cold sore like sores under my nostril. My nose feels dry on the outside, sore. [As I’m typing this, my nose is red and dry.] I put abreva on it and it seems to help but it takes weeks for it to totally heal. It varies how often I get them, sometimes I no sooner get rid of one then I have another. Sometimes I go months without one appearing. I’ll also getting runny nose for no particular reason.
I was in the hospital er a few months ago with my heart double beating. It felt like it was gonna pound outta my chest!! It felt almost like it was rolling or flipping in there! They put my on a med that I took for awhile but stopped on my own. It still happens from time to time but not as bad.
About 2 yrs ago I was diagnosed with RA. I had severe pain in my joints, started in my big, right toe!! Went up to my hips, lower back, shoulders and neck. I couldn’t raise my arms over my head or turn my neck! I took Methotrexate[?] for bout a year and slowly took myself off of it because I was worried about the side effects. [Never thinking this may have all started with my blood pressure meds.] The pain has SLOWLY gone away, thank goodness, but I’m worried it’ll come back. Now the arthritis doc says I DON’T have RA… Hmmmmmmmm.
If anyone has similar symptoms I’d like to hear from you. I’m a 49 yr old white female, approx 170pds. Thank you!

I had to look online about drug effects since I have been getting sicker and sicker so I started with lisinopril. I have now been taking it for more than two years and I am having serious side effects from drugs. I am so headachy, have severe leg, foot cramps, dreams are off the chart, so vivid, long and detailed, horrific and yes, I remember the details. I am so tired of feeling this way, yawning constantly.
I have always been very active and I still am; however, I am a heart patient and cannot do what I was doing three years ago. I had double bypass surgery, but all of the drugs I am on makes it difficult to actually say which ones are doing the most damage. I am on carvedilol, glimeperide for type two diabetes, suppose to be on amlodipine along with my 40mg of lisinopril. I have been on more different bp meds than I care to recall and sooner or later, I have been taken off because of all the side effects. I do ok for a while, but after an extended period, I am back where I started from.
I feel like ditching all of them. This is no way to live. Every time I complain about medications, it is brushed under the rug or ignored. I am also an African-American 63 yr.-old female. My body just cannot tolerate all these different meds and some of them have caused me to gain weight even when I watched diet, exercise, etc.
Weight was up and down, swelling, etc. I wonder about many of these drugs being on the market and feel that many have caused most of my problems, my constant, excruciating pain throughout my body. I pray that we all get some type of resolution to these horrific feels and live a normal life once again.

I had the WORST GI problems ever. You can see my entry from 3/1/11. I would have probably just died if they hadn’t figured out what was wrong. I too was switched to Norvasc and have been fine since.

I was prescribed Lisonopril in 2010. Soon after I experienced hair loss and then began having a lot of congestion. Over the last 3 years, I have had severe joint pains, back aches, and gastro internal problems. Gases began building up in my stomach. So I turned to a gastroenterologist to find out what was causing the problems. He said my veins were shutting down. Also saw a cardiovascular surgeon to see if there was a problem with my arteries. Nothing there either. I was switched over to Norvasc in August of this year and as of the last week of October I have begun feeling better after 3 years of agony.

My name is Michelle, and I’ve been taking this medicine for about 2 1/2, months I’ve had so many problems. First I thought it was my allergies acting up with the coughing and runny nose that I’ve had ever since I’ve been taking this medicine, being tired all of the time and just recently the severe leg cramps, muscle cramps and being miserable. My muscle, leg cramps, hurt really bad and I didn’t have this problem before taking the medicine (7-1-2013). Just my average heel spurs… Since taking this medicine I haven’t been able to exercise or at least walk… Now a simple trip from the car to getting around is like 20 minutes…
I’m reading the side effects here and I have at least one or two… I thought medicine was suppose to make you feel better, when in fact it’s causes something else to go wrong in your body… I will take myself off of the medicine and schedule an doctor’s app. and try to go the healthy way…. I was on BP medicine before but never had this type or reaction. The muscle and leg cramps hurt so bad. The cough is really driving me crazy at this point I can’t seem to clear my throat… Geez I’ve been taking cough medicine and everything…
I hope things will get better for you. I’m glad I came across this site…..

My blood pressure was always normal, until I had to have a double mastectomy some years back. I resisted going on medication for it, but the Dr insisted. Since then many things health related started happening. It was attributed to changes after cancer and chemotherapy. My allergies have gotten so bad, no medications continue to work after a few months. My asthma had gotten so bad, I had to start using an inhaler everyday and I had to start using a nebulizer.
My sleep patterns were so bad, that I had to be put on prescription sleeping pills. My depression took a nose dive into the toilet! Before Cancer I took 1 pill, after Cancer I was on 11.
I convinced the Dr about 8 months back to take me off Lisinopril. Things didn’t feel any different. Then about 2 months ago, I got another part time job. I loved it! Busy again and making my own money. My ankles/legs started swelling around my socks, even leaving bright red bruising. I started taking the Lisinopril again about 1 month ago, because I was told the swelling was from blood pressure being up and preventing the blood from flowing properly back to the heart.
Issues with swelling and bruising around my socks has gone away. I have been fighting a bad head and chest cold, had to go back on the daily inhaler. And today I had to use the “rescue” inhaler. So I knew I would be back to using the nebulizer soon. I was sitting here trying to think what I was going to say to my Psychiatrist, cause I knew I had to get in right away. Not feeling suicidal, but racing thoughts, angry at everything and everyone, fighting with husband constantly, Ritalin not working, sleeping pills not working, craving chocolate and so many other things irritating me.
It “hit” me, did this crap get worse after going back on that stupid pill? So I Googled Lisinopril and found this site. I sat here and cried while I read some of the posts. Yes I was loosing my mind, but not because I was crazy. I was loosing my mind because of Lisinopril! So now I will call and make an appointment with my Family Dr. Thank You to everyone that has posted here. I only hope that all of us are not going to be effected long term by this drug.

I started taking 5mg of lisinopril once a day for borderline high bp about a year ago. I have had a nagging cough, enlarged tongue and hoarseness for some time.
Early june I came down with diarrea that would not go away. My doctor ran tests and prescribed Lomotil which helped.
Then about a month ago I developed a rash, became adversely affected by the sun and had a very bad pin’s and needle’s sensation on my skin. I was dehydrated and exhausted.
I went to another doctor who had a full abdominal sonogram done that was negative.
I went to still another doctor (a woman this time) and after talking with me for about 5 minutes she recommended I stop taking lisinopril. I was better from day one. Now the rash is gone, I have my strength back and my bowell’s are normal.
This was 9 days ago and I am symptom free. I am 70 and only take two med’s (one now) and feel like a real idiot for not figuring this out myself. Be careful with even small doses of this med it’s not for everyone.

Hi, Mary!
I SO feel your pain! I’ve been there!
This is my post from 2011:
“Kathleen | March 11, 2010 10:47 PM | Reply
I want to alert everyone to what happened to me when I took lisinopril. Within two or three hours of taking the first pill, I woke up from taking a nap screaming in pain. This had never before happened to me. I had a vicious attack of sciatica, also for the first time. I didn’t immediately relate it to Lisinopril. I was under pressure to bring my blood pressure down because I was having an operation in ten days.
However, after a month of terrifying pain, I stopped taking Lisinopril. Initially, I felt better, but unfortunately, the sciatica had already been triggered. To further complicate the situation, my computer monitor decided it was the perfect time to conk out. I was able to replace it in a month and found the web site Doctor Yourself in another month (that’s three months total of literally being disabled). Under their tab Back Pain at the bottom of the page, they give a protocol of taking Vitamin C for sciatica.
I was completely out of pain in six days! What I didn’t realize was that back pain that I had been experiencing for the last five years was a precursor to the sciatica that Lisinopril triggered. I haven’t had ANY back pain since. This is truly miraculous.
I wish all of you the best of health. You can figure it out. My first test before trying anything is, “Is it safe?” Check it out thoroughly. If it isn’t safe, I don’t try it. Period. The second is, “Is it readily available?” Finally, “Is it reasonably priced?” The best of everything to all of you.”
The only change is that on the Doctor Yourself web site, they have put the sciatica information under another tab. Just search for sciatica on that site. The specific testimony that I’m referring to is at the bottom of the page.
My experience is that it gets much worse without Vitamin C.
Let us know how you’re doing.

I’ve recently started the 5-2 diet to help get blood pressure and cholesterol under control. This diet requires that for two non-consecutive days each week women should limit consumption to 500 calories and men to 600 hundred calories. Any thing can be eaten the other five days.
Within two weeks my blood pressure, upon waking, went from an average 145/79 to 109/61. I still take lisinopril after taking my blood pressure but am planning on discontinuing this if blood pressure remains low. As for atenolol, I was taking that for about two years and while exercising, I felt strange. I finished my work out and took my blood pressure, which I do after every workout, and it was 75/42 with a pulse rate of 40.
The next day my G/P told me to stop taking lisinopril and sent me to a cardiologist who told to continue lisinopril but stop the atenolol. Apparently the way atenolol lowers blood pressure is by slowing the heart rate. I feel that both of these drugs aren’t the safest things to take.

Thanks for sharing that Christie, and I’m so sorry that you had to go through so much unnecessary stuff during your reaction to the lisinopril. Hubby started a new medication called Atenolol 50 mg and stayed on it for about 3 weeks and then weaned off of it because the side effects of it were bad too. IF I can talk him into asking about another medication at the Dr- I will have him ask about your amlodipine. Right now he wants to just try to lower it naturally so we are doing some lifestyle changes. It would be great if we can lower it naturally and stick with our new changes. We’ll see!
Thanks again!

this is my second month taking this medication. my hair is falling out quickly but the insomnia is bad, I stay awake for hours at night. the worst of it is the nervousness, I am biting my nails and inner cheeks along with eating more. I have gained 13 pounds in the 2 months I have been taking this medication. I am not overweight, but as a diabetic, the weight gain is a source of concern. I will wean myself off of it and call my dr. I am done with this medication.

I took 10mg of Lisinopril for 2 weeks and then was put on 15mg. and have been on that for almost 2 weeks. I started with the dry cough almost immediately and then my back started aching. The doctors assistant said the cough was a side effect of the meds but the back pain was not. The back pain has progressively gotten worse and I now have sciatica and other muscle pain has gotten so bad that this morning I quit taking these pills. I wish I had checked this site before taking this medication. I would have tied the backache to the meds a lot sooner.

My wife took Lisinopri for 6 weeks. She stopped taking it 8 weeks ago and she is still having bad muscle pain. She has a good day and then two bad unbearable days of pain. She had her tongue swell twice but we beat that with Echinacia. But she keeps having bad days of muscle pain. Is anyone else having this and has anyone gotten over the symptoms after they stopped taking Lisinopri. She is very worried this is never going to stop.

Sorry it was March 2011 that I wrote my comment. I don’t think I have even read another story like mine. Most people get the nagging cough. My dad did and he discontinued the medication.

After my ordeal w/ Lisinopril (intestinal angioedema) my doctor put me on Amlodipine. I’ve been on that almost 3 years and have had absolutely no problems. My story is posted above I believe in November 2010 if you would like to read it. I had tried HCTZ before the Lisinopril and had the WORST shakes, sweating, etc. and then the Lisinopril made me think I was going to die so I was definitely scared to try another medication but I do just fine w/ this one. Have your hubby talk to his doc and see if Amlodipine is an option for him.

Hi Steve,
My husband didn’t get rid of the last of the nasty side effects of this medicine for a whole 6 weeks, and to be honest, even 2 months after stopping, every now and then he will still have that nagging cough that he NEVER had before starting Lisinopril!!!! The only bad thing is that he is scared to death to start any other bp medicine since he had such bad side effects with this one and I’ve been checking his BP when he gets a headache and it has been as high as 155/105. I’ve got to get him to trust trying a new medication- and soon!

Hey Allan or anyone here, how long is it taking for side effects to go away after stopping this drug?

I have been taking Lisinopril for about 3 weeks…one episode of breathing difficulty, but oddly, I have lost my voice. Can only whisper. Can this drug effect your voice box? Is it permanent? Happened to anyone else? I stopped taking this drug last Friday…no difference yet

Yes it can.. I had the same issue when I was on it… I was actually taken by ambulance one of the times becuz it was so bad.. I’m no longer on lisinopril.. had my bp med changed.. I would never tell anyone to take this med it’s horrible.

I was put on Lisinopril the end of Feb. had headaches and thought it was my sinuses. By the middle of April I began feeling very ill with a constant low grade fever blurred vision, muscle aches, flu like symptoms and feeling generally ill. As I had triple bypass surgery a year before, this really scared me. I started looking up the side effects of this drug and to my surprise, fever was on the list.
I immediately called my pharmacist and asked if it was a common side effect and he said he had seen it several times and to contact my doctor immediately which I did. He told me to stop taking it right away. Within two days the muscle pain and blurred vision got better but it has be five days now and am still running this low grade fever and awful headache.
Has anyone else experienced a fever while taking Lisinopril. I feel like I am never going to feel ok again. Very depressing.

I’ve only been taking 5mg Lisinopril once a day, in the morning, for 4 days/doses. I am experiencing a constant day long ‘hot flash’ w/ lots of sweating, dry mouth, rough throat, basic lack of energy. This is not at all what my 58 year old Caucasian/female lifestyle is about. I have a call into the doc…not answer back yet.

I am 47 year old male and I took this drug for 2 years. My family doc told me it was “well tolerated by everyone”. I had an annoying cough within a week after starting it. Then I developed muscle aches that have become severe and constant chills. My doc kept prescribing more meds for each new symptom, he still told me “it is well tolerated by everyone”.
In January I went to urgent care with a stomach virus where I told the urgent care doc about my symptoms. He advised me to research lisinopril side effects. So I fired my family doc and stopped lisinopril on February 7 within 2 weeks all of the symptoms disappeared except the muscle pains. They may be permanent.
My new doc can’t find anything wrong but I still have pains. The really bad part is my BP dropped to a 3 month avg of 126/81 after stopping lisinopril. Beware of this med!

Hi J Light, YES! Others have experienced the same side effects you explained in your post. Please read my comments from May 11th and June 4th of this year. My husband has been off of this medicine now for 2 months and he finally only stopped the nagging cough about 2 weeks ago completely.
He also had the flu like symptoms (body aches, headache, neck pain etc…) way past stopping the medication. He said he would take his chances with high BP until he can get a new med, he couldn’t take it any more. And I really think that if he hadn’t stopped when he did, his side effects would have gotten worse and worse because they were quickly worsening when he decided to stop.
I hope that you don’t have to put up with the annoying side effects too much longer. It takes quite awhile after stopping the Lisinopril for them to stop completely. :(
Best wishes!

I have been taking lisinopril 5mg for about 6 weeks for high BP. After about a week I developed a dry cough, figured I was getting sick so went to the Dr. And took antibiotics for 10 days along with prescription cough meds… They did not help after two more weeks still coughing all night and having to sleep on the couch so I didn’t wake up my husband, I started having severe migraines along with neck pain… Ended up in the ER getting a shot for migraine, four days later still coughing, head hurts can’t move my neck… back to Dr…. now they think it may be a side effect from the Lisinopril, apparently it can cause a cough, migraines, and intensify arthritis, stopped taking it several days ago, still feeling miserable, neck MRI scheduled for this week. Wondering if anyone else has experienced these type of side effects?

Okay! Since my last reply on May 11th, my husband has stopped this medication completely. He had to because the flu like symptoms and cough were beyond intolerable! It has been 3 weeks now since his last pill and he STILL has the annoying cough every single evening and all through the night. And during the day, a little tickle, but the cough is only in the evening and night. The same side effect as when he was taking the Lisinopril so it is just taking awhile to get out of his system apparently. He still has to go and get a new BP med, but so far, his BP isn’t too awful high since stopping, but that cough! YIKES- it is annoying to me and I only have to listen to it. I can only imagine what it must be like for him!

Sand, I have the same experience you have been describing. I take Lisinopril. When I lay, as soon as I start to relax, I feel that shaking from inside and reeving up. I have been experiencing muscle tension, cramping and pain to the point that my joints pop. Involves all muscles and quite debilitating. Have you found out for certain if this is the Lisinopril causing the problem?

I’ve used Lisinopril about 10 years and when I started I had the worst “tickle” in my throat that kept me coughing like crazy. However, my blood pressure readings became exactly what we wanted on it. When I went to the doctor he recommended we try other B.P. medications to get away from all the coughing, as he said it was a side affect of Lisinopril. We tried about 5 different ones but none lowered my blood pressure and all of them had way worse side effects than coughing. So we went back to the Lisinopril because Doctor said he’d rather I had a cough over a stroke.
He said to take an allergy pill with it and that helped some. Over the years the tickle went away even without allergy medications. Blood pressure is controlled and I feel little to no side effects at all.

My husband began taking Lisinopril-HCTZ 20-25 MG 2 months ago. Initially, he didn’t have but one side effect, and that was sinus drainage into his throat causing a very annoying cough. I commented to him several times that he needed to contact his doctor and switch BP medication, but he kept assuring me that the side effect was tolerable and he was worried switching to a new med may come with worse side effects.
About two weeks ago, my husband started noticing he would get dizzy when it was close to dosing time or if he was a little late in taking it. Still not a bad enough side effect to risk changing to another med with worse side effects.
Then earlier this week (maybe a little longer), he started coughing constantly, complaining of mucus draining in the back of his throat, a bad sore throat, headache, body aches and tiredness. Kind of like the flu with allergies all rolled up in one. I got him some Zyrtec D which hasn’t helped one hill of beans. In fact, he is getting worse daily. His blood pressure is normal now, but he is not. He just turned 47 years old and is NEVER sick. He gets a cold once in a blue moon (in the 25 years we have been married, he’s had the flu maybe 3 or 4 times) and other than a few kidney stones over the years, he is the picture of health.
As healthy as he is, we were really surprised to learn he had high BP in the first place. He has decided to stop taking this med and call his dr to get a new one, but he is worried about dizziness if he doesn’t wean off (since he gets dizzy when it is close to dosing time). Does anyone know if these little pills can be cut in half to make 10-12.5 (full pill is 20-25? We would call the DR and ask, but it is the weekend and my husband is in agony and waiting until Monday is not an option as he never complains but he is now, which tells me, he feels horrible!!!
Sorry for writing a novel, and thank you to anyone who can help make this dilemma shorter.

I have been using this drug for 2 years and started having the same problems. I recently dropped 15 pounds and my blood pressure is now 100/65 and I feel REALLY tired all the time. I want to stop taking this drug. I believe with my weight loss that my pressure will be normal. Did you stop cold turkey or did you wean off?

I too had your experience. I took 5 mg per day. After 3 days, my stools started becoming loose. This increased to cramps at about day 5. Woke up at 4 AM with severe cramps and diarrhea about day 8. Stopped taking drug at day 10. I have now been off the drug for 20 days but the diarrhea persists. Not sure how long this stays in your system but I read one persons account who said that after stopping the drug, his diarrhea was still going on after 5 months!!! Hope mine clears up faster than that.

I have had it high for 42y. Nothing has worked. I was put on this med in 2011 and now I think of what I have read I think it has done more than I know. Went into er and it was high so they (the doc) sent me to another doc he put me on it and told me I was a in bad shape. I have had been on 20 they put me on 40 still no help then I had a pon stroke and was in hospital for 3 mo. (do not know if this was y they cannot say) and they could see was not doing no good but kept me on it. when I got out the added another med still high. I am stopping it as of today I think I am better off not taking it going to go natural. Have had a lot of health things going on since they put me on it. use to be a live and well. Like to know what natural one works.

I too have have muscle weakness and leg cramping and asked dr to take me off Lisinopril. My cough has now stopped after 2 weeks but muscles still affected. How did your muscles fare after stopping?

I was prescribed Lisinopril-HTZ 20 two weeks ago for high blood pressure… I am 47 years old and have been healthy and active all my life…In fact, I am an aerobic instructor and have been for the past 16 years, don’t smoke and drink very little… Both my parents have HB pressure so it was no surprise to me that I also have it.. All I can say is blah…This medicine has made me feel absolutely horrible to the point where I had to call off work today.. I feel so tired that I cannot even move, the nausea is horrible to the point where I can hardly eat and if I do I feel almost worse to the point of so much gas and bloating..
I think at this time I would rather have the HB pressure then feel like this everyday.. The doctor said stick it out, that the side effects should subside as my body adjusts to it but I just can’t take it and trust me; I have a very high tolerance for pain… I can’t function day to day like that I have too many things coming up in life to not feel myself.. I went off it yesterday, still feel crappy today, hoping that I feel better in a day or so, I will advise my doctor that I have stopped.

I recently took an ambulance to the emergency room with BP 210/108 and the emergency room doctors put me on Lisinopril–20 mg and 10mg Amlodipine. This was a little over a week ago. Now I suffer from Leg cramps, arm cramps, dizziness, and general fatigue. So far, I am not impressed with this drug.

I took Lisinopril for a number of years. I started having lots of problems: Cold hand and feet, tingling in one foot, abdominal bloating, terrible nasal stuffiness and sinus problems, post nasal drainage, some coughing, hoarseness, occasional leg cramps and hand cramps, fatigue, really dry eyes (two corneal abrasions) and mouth, dry skin, occasional acid reflux, occasional parasthesis, achy, sore joints, no energy, etc. Had MRI for my back and hip pain. I was tested for thyroid, reynaud’s disease, SED rate, Rheumotoid factor, Sjogren’s etc. Everything was OK. Still complaining and tested for these things again a year or so later.
Then I developed blood problems… low white count, low platelets, low neutophils, low red blood cells, hemoglobin falling, hemocrit falling, RDW increasing. I was sent to a Hemotologist and had a bone marrow biopsy (ugh) and more tests. Nothing turned up.
I was then sent to a Rheumotologist and more tests. Nothing. Just some regular arthritis.
I had already started researching the Lisinopril. It was the only medication I was taking and it was the lowest dose. And sure enough I saw the possibility of the blood problems and host of other things. So I told my family doctor that I was stopping the Lisinopril HCTZ. The new drug he put me on has a number of the same side effects. So I decided to go cold turkey for one week to see what would happen.
Immediately, I was able to breath better than I had for years! The tingling in my foot went away and I dropped 10 pounds without really trying. I started getting my energy back and have felt better than I have in years. The dryness has improved. I still seem to have some muscle problems but it is SO much better.
I wish that I had never started taking BP medication. My doctor still doesn’t think the Lisinopril caused the blood problems. He thinks it was a virus. But I charted my blood work for over 5 years and it showed a steady decline. And I sure do feel better now.

I’ve been taking this for 8 years started out terrible but now have same dose and dry cough. Normal blood pressure at 61 yrs old.

I have been taking lisinopril/hctz for about two years now and the dry mouth and side effects are unacceptable to me. I have been researching natural supplements for high BP, cholesterol and diabetes. The supplement CQ10 (Kirkland 300 mg) seems to be a viable alternative for all three ailments. Please do some research on CQ10 it may work for you. Kirkland is the COSTCO brand.
I am going to eliminate the lisinopril/hctz and diabetes medication (I take a low dose) next week for a trial period. I will personally monitor my BP and sugar levels on a daily basis while taking the CQ10. I am willing to take the risk to get off these medications. I don’t think our doctors do enough research into side effects, prescribe drugs too freely, and are unwilling to consider natural alternative supplements. We need to help ourselves and stand up to big Pharma with all their expensive drugs. Have you noticed how many “drug representatives” visit your doctor’s office while you are sitting there waiting for your appointment?
I’ll write back with some updates.

I have been on this medication for several years. I had no idea of the potassium problem with it. I do get bad leg cramps sometimes and had told the doctor and nothing was ever said of a possible problem with potassium. I thank you for your information.

I have been on lisinopril 20mg for almost 3 months. I am 55 it is controlling the blood pressure but I am having muscle pain in my arms with weakness. Just blow drying my hair is painful. Also I am having leg cramps. I walk 1 hour a day but now can no longer lift weights at the gym because of the pain and no strength. I have not ate bananas due to the potassium overload I had read about. I can’t wait to see my doctor in a week so I can get off this drug I do not like it at all.

My partner had high cholesterol and was put on statins but after reading about them he decided not to take them. He told his Gp this, his GP agreed it was ok not to take them but he had to try to get the level down by a combination of diet and supplements. He reduced his weight took cod liver oil (the orange flavoured ones are the best) also used benecol and other brands of margarine and drinks every day. Also he took anti oxidant multi vitamin every day. This combination of thing reduced his cholesterol by half. From 5.9 to 2.5.

I take lisinopril/hctz, atenolol for BP as well as simvastatin for cholesterol and I’ve noticed that after I sit for a brief time at work I have a lot of muscle pain when I go back to work. I’d read that the statin drugs can have this effect but I’m beginning to wonder if maybe it is the lisinopril/hctz that’s really the culprit.
Others have noted an intolerance to alcohol and I can bear witness to this as I’ve had to limit my intake of alcohol. I had a few beers after work a few nights ago and I was flat drunk before I realized it. I’m a 6’1 235 male who has dropped 55 lbs since Aug of 2012. My Dr has told me that if I stay the course I might be able to go off meds altogether and I’m hoping this is the case as I don’t want to be locked into a life of dependency on these drugs.

Yes please check w/ your doctor ASAP. I was started on Lisinopril June 9-10 (can’t remember which day exactly) in 2010 and by Tuesday the 15th I was heading to the hospital from throwing up and SEVERE abdominal pain. I had several other hospitalizations and issues as well. I posted my story on March 1, 2011. Please read and see if you have any of the same symptoms. This was the worst pain I’ve EVER experienced in my life and I’ve been in labor before.

Three weeks ago my Doctor bumped up my Lisinopril dosage to 40mg from 20mg, that was on a Wednesday. That weekend I had the bad stomach cramps and bloating. Its been three weeks now and no change in the symptoms. I have had no loss of appetitie, just severe intestinal cramps. I thought it was due to a constant sinus drip I was experiencing, but that usually subsides after a few days. I am seeing my doctor tomorrow to ask about a different BP med, or to stop taking the Lisinopril for a few days to see if it is the cause. I will repost if there is a connection, or at least with a follow up of what was found. Constipated too

Believe me Lisinopril is not for everyone, including me. I finally have my doctor convinced I can not take an Ace drug and am now on a calcium channel blocker plus a beta blocker and hctz. Lisinoril did nothing for my systolic pressure and gave me all kinds of side effects. I blame my gall bladder problem on it. I had that removed in November.

I’m new to Lisinopril. Started it 4 days ago. Have started experiencing extreme anxiety. Haven’t slept in 4 nights as well. Coughing.

Hello guys,
I ma glad I discovered this site. All the side effects of lisinopril described in textbooks are listed in the posts here. Well, I was diagnosed with high BP a year ago and was put on atenolol and HTZ that I took until three weeks ago. Unfortunately these two meds failed to lower my BP, which remained around 155/905. Other than that the med were without any side effects
For two weeks and half now, I have been on this famous lisinopril 5 mg and HTZ 25 mg. The problem started the very first day on this drug. I took it around noon during my lunch and within less than an hour after later lunch…diarrhea with abdominal cramps. I though the salad I bought for lunch was bad. I went to the bathroom a couple of times. From day 2 up to this day (Two weeks total), it is constipation and bowel full of gas.
The blood pressure had gone down and to 130/80 but now without some damage.
Now the worst stuff: 1) I developed an ECZEMA-like skin rash (on my stomach and in the genital area and a little down on the inner side of my laps) that is so itchy that I can’t even sleep. I am a light-skinned African American, but just in two weeks the skin had become so dark and that it looks unbelievable. Embarrassing if you have to scratch the genital area in public. Applying cortisone has not helped so far.
2) FREQUENT URINATION both at night and during the day. 3) for two days now my I am having BLURRY VISION even with my glasses, which is likely due to frequent urination and dehydration of the lens that cannot focus.
The funny thing? I am a doctor myself with a different specialty and of course I am calling my physician tomorrow. I will keep you all posted.

All of you please go to the FDA website and report your adverse reactions if you really want your adverse reactions placed on the prescription papers which are given to all patients. This way, anyone who is prescribed this drug will know what problems it may cause. Because right now, the side effects that is listed mostly is cough which is so untrue because there are far more adverse complaints that this drug causes but because people are not going to the FDA website and reporting their problems so that it will be listed, nothing is being done or reported.
All you have to do is go on this website and it asks you your medical history and medications and reactions to them and your name age and it will be listed. The more complaints they get the better. Hope you all get better and make clear choices about your health. Best wishes.

I am a 23 year old male recently diagnosed with familial dilated cardiomyopathy. I am on 25 mg metaprolol (toprol xl generic) and 10 mg lisinopril. This is the first day I have taken the lisinopril at an increased 10 mg dose (as opposed to the 5mg I was on before) and the side effects became almost immediately intolerable. I feel like I have had the flu for weeks now. This drug is NOT right for me and from the looks of it, it’s not right for a lot of people. Reading this site has me ready to contact my doctor tomorrow and let him know I will not be taking this drug at this dose any longer.

I have been taking a generic lisinopril, 20 mg, for 4 1/2 years. My last prescription was a generic from a different manufacturer and within one day I was in the ER with bp 240/110. The next day my Dr. told me to double up on the dosage. Since then my bp is around 170/90. I called the pharmacy and asked them about the change in generics and, typical of today’s mis-informed pharmacists, she told me that there is no difference between name brand or any generics. Has any one else had issues with generics lisinopril made by Watson?

has anyone else experienced anxiety on this drug?

I have only been on sandoz- Lisinopril for five days. I am very tired all the time. I’m also experiencing anxiety. I was on verapamil previously for a week and it gave me depression! I feel like a hypocondriac running back to my Dr. but this drug although reducing my pressure has these side effects. She told me depression wasn’t one, but I had such overwhelming anxiety today, it’s ridiculous. I realize she wants to bring my pressure down as it was 188/110 but is there not a drug that doesn’t cause side effects? My husband is on Diovan and seems to be doing well.

Thanks Mark,
I wil see my dr. tomorrow and talk to her about this.
Can you please find that study on the weakening of the muscles?

I have a brother that also has been on Lisinopril for about 3 yrs as well. I tried to talk him out of it after my experience, but some interesting and strange things have happened to him. He is 39, works out, good diet – basically doing everything right. in the past 3 years, he has had two muscle/skeletal problems. One was a ligament that holds the bicep to the forearm broke. Very strange because he wasn’t doing much at the time to warrant a ligament snapping in his arm. Then he had a herniated disk in his back just recently with also some degeneration in his vertebra at L4 and L5. He is now off the Lisisopril and trying other means to address his BP
We read somewhere that the lisinopril can affect the body like that (weaenking muscles). I just cant remember where now. If I get a chance, I will go back and try to find the study. Either way, I would be suspicious of it being at least a contributing factor to the problems you are having. Depending on the rest of your story, perhaps see if there isn’t another BP alternative.
I’m not a Dr, but after reading the almost 4 years of testimony above, might not be a bad thing to seek lower BP with another product. That would be the route I would take for myself personally. Mark B

A brief history for me with Lisinopril is that I was put on 20mg dose about 3.5 yrs ago. Within 3 Days, I had broken out with Hives (Never having any allergies previous). I stopped taking the medication after day three and was told that the hives could last up to 6 weeks as it took that long for the lisinopril got out of my system. Today (3.5 years later), I am on a bunch of medications trying to keep the hives at bay (which still breakout every once and a while) – oh ya did I mention 3.5 yrs after being off the medication.
Anyone want to trade hives stories, or who have had the same reaction but finally got it out of the system, I’m willing to try just about anything. Feel free to comment.
Mark B

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