boxes of Advil (ibuprofen) 200 mg

There is nothing more annoying than waking up in the middle of the night with a strong urge to pee. Well, actually there is. Waking up to discover that you have had an accident in bed is uncomfortable and embarrassing. Unfortunately, some people have to get up multiple times during the night to go to the bathroom. That messes up their sleep. It’s not always easy to fall asleep once you have to get up a few times. Is it safe to take an NSAID like celecoxib to prevent nighttime urination? This reader wants to know.

NSAIDs to Prevent Nighttime Urination:

Q. My husband read that celecoxib could reduce his number of nighttime trips to the bathroom (nocturia). That has worked, but now he is complaining of stomach upset and his blood pressure has inched up.

He likes getting better sleep but not if celecoxib causes more problems. Do you have any safer suggestions?

A. There is scientific support that NSAIDs like celecoxib (Celebrex) can help control hard-to-treat nocturia (nighttime urination). In one small study celecoxib reduced nighttime trips to the bathroom from 5.17 to 2.5 (Urology, Oct. 2008). 

Ibuprofen to the Rescue?

We heard about NSAIDs to prevent nighttime urination several years ago. A runner told us that if he took ibuprofen to alleviate post-exercise soreness, he was much less likely to have to get up at night to pee.

After some digging, we found articles that confirmed this observation. A Japanese study tested loxoprofen (not available in the U.S.) on 93 men with benign prostatic hypertrophy (BPH).

The investigators reported that:

“Nocturia improved or disappeared in 74.2% of patients: excellent, improved, unchanged, and worsened results were obtained in 37.6%, 36.6%, 21.5%, and 4.3% of patients, respectively. The effects were better in patients whose baseline nocturia was > 2 times than in those with a lesser frequency at enrollment  Loxoprofen can be an effective and useful treatment option for patients with BPH complaining of refractory [hard to treat] nocturia.” (Acta Medica Okayama, Feb. 2004). 

A British study published in European Urology (April, 2006) reported positive results with diclofenac (Voltaren).

The authors concluded:

“NSAIDs are effective in the treatment of nocturnal polyuria [nighttime excessive urination] causing a decrease in nocturnal frequency with subjective symptom improvement. Our study suggests a novel treatment option for this common condition.”

The Downsides of NSAIDs to Prevent Nighttime Urination:

NSAIDs like celecoxib, diclofenac or ibuprofen to prevent nighttime urination carries substantial risk. Such drugs can increase the risk for indigestion, stomach pain, ulcers, hypertension, heart failure, heart attacks and strokes.

There is another complication. NSAIDs affect the kidneys. Such medications can cause renal damage in susceptible patients. Sodium and fluid retention are potential problems, especially in older individuals (Pharmaceuticals Basel, July 2010).  In our opinion, that makes such drugs inappropriate for a lot of people, especially when taken regularly.

Raisins to Prevent Nighttime Urination?

Your husband may find that a handful of raisins before bedtime may help with his nocturia. Many readers report improvement with this simple approach.

Lyn in Arizona shares this experience:

“Raisins work for me. If you get up only one time to pee you need to take an extra raisin. I take 8-9 sometimes once or twice a day and the every-2-hour-waking-up-to-pee cycle is gone. I use dark raisins.”

William in Whitby, Ontario, warns about a raisin risk:

“I’ve been on Flomax (tamsulosin) for years and it is not working as well as I age. I sometimes have to get up 3 to 4 times a night to pee. I wasn’t getting proper sleep and as a result I was tired during the day.

“Recently I had to get up 6 times. Before I went to the doctor to increase my dose of Flomax I decided to try the raisin solution. To my surprise and amazement it worked incredibly well. I ate about a dozen raisins before bed, and only had to get up once in the night, after sleeping soundly for 5 hours! This continues to work, but it’s necessary to brush your teeth after eating the raisins as they are high in sugar content and small pieces stick to your teeth.

“I have read about the raisin remedy for years but was very skeptical. Now I’m a believer. Thanks to People’s Pharmacy!”

Raisins won’t work for everyone. Some folks tell us the raisin remedy does not prevent nighttime urination. Hey, that’s true of home remedies as well as potent prescription drugs. There are no guarantees.

You can learn more about this and a beet soup recipe for reducing nighttime urination in our eGuide to Favorite Home Remedies. It can be found in the Health Guide section at

Please share your own experience with the raisin remedy to prevent nighttime urination in the comment section.

Newsletter Reading List

  1. 1Will Hot Water Help You Move Your Bowels?
  2. 2Vitamin B12 Deficiency Can Cause Cognitive Problems
  3. 3Will Soy Sauce Ease Your Burn Pain?
  4. 4Why Aren’t Docs Outraged by Inadequate Generic Drug Approval?
  5. 5How Can You Prevent Tick Bites?
  6. 6Decongestant Spray Addiction is Hard to Kick
  7. 7Generic Furosemide Disappoints | How to Afford Lasix?
  8. 8Show 1169: What Are the Problems with Generic Drugs?
  9. 9PPIs are Safe! New Study Contradicts Prior Research
  10. 10Warfarin and Green Leafy Vegetables Can Be OK
  11. 11Diabetes Risk No Lower with Vitamin D Supplements
  12. 12Could TV On All Night Make You Gain Weight?

Get The Graedons' Favorite Home Remedies Health Guide for FREE

Join our daily email newsletter with breaking health news, prescription drug information, home remedies AND you'll get a copy of our brand new full-length health guide — for FREE!

  1. Michel

    Just get up and pee..or put a pot next to your bed…and stop all the pills

  2. STAN

    Regarding the Peeing problem… I was prescribed DDAVP as a pill @ bedtime by my Urologist; that worked for a while, and he added Finasteride when the problem started returning. Later, when the problem again started raising its head, my Internist suggested a banana @ bedtime. That helped significantly, and now I usually ‘go’ once per night.

  3. Barbara W.
    South Carolina

    Nighttime urination is a huge problem for me, has been all my life (I am 65). What I finally found that worked for me is DDAVP, a prescription nasal spray. It reduces me from a 8 or 9 times/night to a 1 or 2 times/night need to pee.

  4. Joyce
    Chapel Hill, NC

    I have found that pumpkin seed oil works for my bladder at night. After chemotherapy, I had a lot of trouble controlling my bladder – accidents during the day and getting up to pee multiple times during the night. Then I saw online (somewhere) that pumpkin seed oil might help. At first, I took one softgel per day and saw some improvement. Then I decided to up it to 3 softgels per day. Voila! No more accidents, usually not getting up even once during the night.
    And no side effects.

  5. Jane

    Over the counter OXYTROL has helped a lot. They are patches, placed on the tummy and they stay, even through bathing. One patch lasts 4 days, 4 nights.

    I will add a few raisins each night as well. Thanks everyone for help.

  6. Elizabeth
    Austin, Texas

    Raisins work for me, and to avoid re-brushing my teeth I take them as though they are pills – just swallow them whole.

  7. Paul R

    Nocturia – I have gotten relief from Pumpkin Seed Oil capsules which I learned about on this forum. I am now sleeping about 6 hours at a stretch.

    The raisin treatment is a no-go for me because of a different side effect.

  8. g

    Celebrex is dangerous, as in 2008, prior to hip surgery I was prescribed celebrex for the pain and as the result of the celebrex: A-Fib. In addition celebrex messed up my kidneys big time. I resolved the kidney issues with cranberry juice and fasting. Not eating: Only water and cranberry juice.

What Do You Think?

We invite you to share your thoughts with others, but remember that our comment section is a public forum. Please do not use your full first and last name if you want to keep details of your medical history anonymous. A first name and last initial or a pseudonym is acceptable. Advice from other commenters on this website is not a substitute for medical attention. Do not stop any medicine without checking with the prescriber. Stopping medication suddenly could result in serious harm. We expect comments to be civil in tone and language. By commenting, you agree to abide by our commenting policy and website terms & conditions. Comments that do not follow these policies will not be posted. Learn how your comment data is processed.

Your cart

Shipping and discount codes are added at checkout.