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If Statins Cause Diabetes, Why Should ALL Diabetics Take a Statin?

Evidence from many studies indicates that statins cause diabetes. People who are at risk for this metabolic disorder should be wary.
If Statins Cause Diabetes, Why Should ALL Diabetics Take a S...
Statins cholesterol statin drugs

The guidelines from the American Heart Association and the American College of Cardiology are crystal clear. Middle-aged people with diabetes (both type 1 and type 2) should be on a statin-type cholesterol-lowering medicine! There are no exceptions to this recommendation for patients between 40 and 75, and people older or younger than this may also be candidates for statin therapy. Any physician who strays from the path of prescribing a statin to his or her diabetic patients is presumably practicing bad medicine. We find this perplexing, given the growing evidence that statins cause diabetes.

So, doctors prescribe the very drug that induces elevated blood sugars. Theoretically, this will reduce the cardiovascular risks associated with the development of drug-induced type 2 diabetes. Does this seem as odd to you as it does to us? We heard from a reader who agrees that this is counterintuitive.

Statins and Blood Sugar Control:

Q. My dad was on statins. (He really needs the help controlling his cholesterol.) We immediately noticed an increase in his blood glucose measurements. His type 2 diabetes was more difficult to control and it was very upsetting for him, as he was trying so hard.

He is now off statins and is taking a different kind of cholesterol-lowering drug. His blood glucose is under much better control than before the switch.

I too developed diabetes. My cholesterol and triglycerides are, and always have been, in great balance. I put my diabetes in remission with weight loss and got off statins as soon as possible. I think it is ridiculous to put someone on statins when they have great cholesterol levels.

The Research Evidence:

A. As mentioned above, guidelines for physicians recommend statin prescriptions for nearly all patients with type 2 diabetes. However, a study in JAMA Internal Medicine (Oct. 4, 2021) reveals that some patients have a harder time controlling their blood sugar levels while taking statins.  They often have to increase the dose or the number of diabetes medicines they take.

Uncontrolled or poorly controlled diabetes can cause many health problems. Doctors need to take that into consideration if blood sugar goes up on statin therapy. Some patients, like our reader’s father, may need other approaches to lowering their cholesterol.

Do Statins Cause Diabetes?

Do you doubt that statins cause diabetes? Research on this connection has been building for years (Dormuth et al, BMJ, online, May 29, 2014). Investigators analyzed data on nearly 140,000 patients in Canada, the UK and the U.S. All the individuals had been hospitalized either because of a heart attack, stent placement or some other serious cardiovascular procedure. Some were given low-potency statins while others were placed on high-potency statins such as rosuvastatin (Crestor) at a dose of 10 mg or greater, atorvastatin (Lipitor) at a dose of 20 mg or higher or simvastatin (Zocor) at a dose of 40 mg or higher.

None of the people in the analysis had been diagnosed or treated for diabetes prior to being placed on a statin. Within two years of starting on the medicine, 3,629 patients were diagnosed with type 2 diabetes. Those given high-potency statins were 15% more likely to end up with blood sugar elevations compared to patients prescribed lower-potency statins or lower doses.

The lead author, Colin Dormuth, was quoted by Reuters:

“Physicians need to weigh the small increase in benefit against the increase in diabetes risk.”

Other Studies of Whether Statins Cause Diabetes:

This is not the first study linking statins to diabetes. The first meta-analysis involved six studies and nearly 58,000 patients enrolled in randomized, placebo-controlled trials (Rajpathak et al, Diabetes Care, October, 2009). Another meta-analysis of 13 clinical trials with over 91,000 patients also confirmed this connection (Sattar et al, Lancet, Feb. 27, 2010).

The trouble with such clinical trials is that they do not necessarily represent real-world conditions. They were not designed to detect diabetes. That is why this study is so interesting. By comparing high-potency statins to lower-potency statins, the researchers were better able to determine a true statin effect.

Another researcher, David Preiss, who has also studied the relationship between statins and diabetes, was quoted in Reuters about this connection:

“Commonly used statins, such as simvastatin, atorvastatin and rosuvastatin, taken at a lower dose probably puts one at 10 percent higher risk of developing diabetes,” Preiss said. “Taking these same statins at high doses probably pushes this up to about 20 percent.”

A commentary in Postgraduate Medicine (Chrysant, online Feb. 24, 2017) noted that the incidence of new-onset diabetes in people taking statins ranges from 28 to 43 percent. Dr. Chrysant defends the use of statins, however, as having higher benefit than risk. Nonetheless, he recommends that physicians monitor patients’ blood sugar or HbA1c and adjust the statin treatment if diabetes develops.

How Do You Interpret These Findings?

What are we to make of this research? Statin enthusiasts maintain that anyone with diabetes must take a statin, even if the drug caused the condition in the first place. There is no doubt that people with diabetes are at increased risk for cardiovascular complications. But if statins cause diabetes or make it harder to control blood sugar, it seems somewhat counterintuitive to routinely recommend such drugs to every such patient. At the very least, lower doses or lower-potency statins should be considered. People on statins should definitely discuss the pros and cons of lipid-lowering medicine with their prescribers.

We are not the only ones who find the official insistence on statins for people with diabetes questionable. A recent essay asks, “Are diabetes guidelines truly evidence based?” The authors suggest that the evidence to support statin therapy in diabetes is inconclusive (Bouchonville et al, Diabetes Research and Clinical Practice, May 2017).

Statins and Exercise:

There is one other reason to be concerned about insisting everyone with diabetes be on a statin regardless of blood sugar elevation or other drug side effects. EXERCISE! Ask any health professional about the role of exercise in the management of diabetes and you will be told that it is crucial. Not only is exercise essential for good blood sugar control, it can help with weight loss and cardiovascular function.

But here’s the kicker! A study in JAMA Internal Medicine (Lee et al, Aug. 2014) concludes that statin use is associated with reduced physical activity. The investigators suggest that statin-type drugs might trigger muscle pain and weakness. Subsequently, this adverse reaction could contribute to a decline in exercise or other physical activities. Needless to say, that would be a highly undesirable outcome.

Patients Weigh In:

Here are some comments from visitors to this website regarding this controversy.

MBC wonders if statins cause diabetes:

“I started taking Crestor 20 mg. after my triple by-pass in 2011.  I began to have severe muscle spasms and general weakness, confusion, and lethargy.  Finally, I felt so bad that I stopped it altogether and my doctor tried several different statins in different strengths.

“I complained over and over to both my family doctor and the heart doctor to no avail.  Both insisted that I take the statins, even though I felt terrible.  I suffer from fibromyalgia and the statins seem to exacerbate the condition.  My feet were so sore on the bottoms, walking was very painful.

“Finally the heart doctor suggested I take 5 mg. and if that was too much to cut the pill in two and take 1/2 as many days as I could tolerate it.  I began to feel somewhat better on this dose.  I now take 1/2 of a 5 mg. tablet of Crestor about every other day.  Since beginning the statins, I have elevated sugar in my blood.

Do All Statins Cause Diabetes?

“I complained to my Dr. about this and asked him to change to a statin that wouldn’t cause my blood sugar to go up.  He said, ‘They all do that, and if you get diabetes, we can do something about that’.  I hit the roof and told him I never had a problem before the statins and I would watch my intake of carbs very closely until my next check up.  If my blood sugar is elevated, I would stop taking statins.

“I also developed arthritis in my hands which are becoming deformed with the swollen knuckles and joints and they ache terribly.  My total cholesterol was 201 my last check up.  The LDL is still too high.  The heart doctor was going to put me on an additional statin to bring it down and I refused.  Will have my next check up in July.”

Rosemary had a problem with a different statin:

“When I was put on Zocor (simvastatin), I noticed a lot of leg cramps. Close to a year later, I was told I was diabetic. Do you think taking this medication could have triggered type 2 diabetes?”

GJ has had joint pain rather than diabetes:

“‘Figures don’t lie but liars can figure!’  I had been on simvastatin for many years, as it was considered a miracle drug.  About the same time I started taking a statin I was diagnosed with Type 2 diabetes.  I have no way of knowing if there is a connection but more and more evidence is leaning that way.  About six months ago I stopped taking simvastatin and have noticed my hips and knees are feeling better.

“My latest lab results from a month ago show an increase in LDL to a bit over Standard Range.  HDL remains well within Standard Range.  I had also experienced general sexual problems but I attributed those to paroxetine.

“I stopped taking the paroxetine about two months ago and the sexual problems have completely disappeared!  Whether the statin contributed to this I don’t know, but I feel better overall after eliminating both drugs.  Funny that a person can actually feel better going off drugs that are supposed to make you feel better!  I suspect the only people who feel better when we take many drugs are the drug companies.”

Susan’s husband had a range of side effects:

“My husband took Lipitor for about 5 years and for most of that time, was in a great deal of pain when walking.  He tried dozens of different types of shoes, orthotics and treatments to no avail.  It was like walking with stress fractures in his heels.  Then he started  having trouble in his elbow.  He went thru cortisone shots for a couple of years and then had to stop as he had reached his limit.  Dr. was ready to do surgery but as a last resort, recommended physical therapy.

“During the PT, he began talking to colleagues about his pains and several of them had experiences similar and all were on LIPITOR.  At one PT session, the therapist said his muscles were so tight she couldn’t do anything (said the sheath was ready to rupture) and asked if he was on any statins.  When he said yes, she advised he visit his doctor and get off the Lipitor.  He did and within days was 100s of times better.  After 30 days, he was put on another statin and the pain returned.  Now he does not take any statins and warns others of their danger.

Statins Cause Diabetes as Well as Foot Pain:

“He was also diagnosed with type 2 diabetes during this time and has had cataracts removed also.  Since he has stopped taking any statins, he is basically pain free and can wear any type of shoe he wants and plays racquetball & pickle ball twice a week which he wouldn’t have been able to do with his foot pain. He can even ride his bike pain free which he couldn’t do before.

“It’s amazing to me that these drug that are supposed to help you, can cause so much damage and doctors don’t tell you about it.  His doctor said the muscle pain was a minor side effect.  BS!  It was life altering, expensive and totally avoidable.”

The People’s Pharmacy Perspective:

We recognize that many people are able to take statins without side effects. That’s great! Those who have had a heart attack or angioplasty benefit from statins and reduce their risk of experiencing another cardiovascular event.

There is still a great deal of controversy about whether people who are not at risk for heart disease will benefit. With evidence that statins cause diabetes, people who have trouble controlling blood sugar levels need to discuss their treatment with a health professional (Betteridge & Carmena, Nature Reviews. Endocrinology, Feb. 2016).

It is actually surprising how many medications can either raise blood sugar levels or actually cause diabetes. To learn more about which drugs can cause this complication, check out our eGuide to Managing Diabetes.

Share your own statin story below. We like to hear from people who have not experienced problems as well as those who have. Others may benefit from your story.

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About the Author
Joe Graedon is a pharmacologist who has dedicated his career to making drug information understandable to consumers. His best-selling book, The People’s Pharmacy, was published in 1976 and led to a syndicated newspaper column, syndicated public radio show and web site. In 2006, Long Island University awarded him an honorary doctorate as “one of the country's leading drug experts for the consumer.” .
Citations
  • Mansi IA et al, "Association of statin therapy initiation with diabetes progression: A retrospective matched-cohort study." JAMA Internal Medicine, Oct. 4, 2021. DOI: 10.1001/jamainternmed.2021.5714
  • Dormuth CR et al, "Higher potency statins and the risk of new diabetes: multicentre, observational study of administrative databases." BMJ, online, May 29, 2014. doi: https://doi.org/10.1136/bmj.g3244
  • Rajpathak SN et al, "Statin therapy and risk of developing Type 2 diabetes: A meta-analysis." Diabetes Care, October, 2009. https://doi.org/10.2337/dc09-0738
  • Sattar N et al, "Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials." Lancet, Feb. 27, 2010. DOI: 10.1016/S0140-6736(09)61965-6
  • Chrysant SG, "New onset diabetes mellitus induced by statins: current evidence." Postgraduate Medicine, online Feb. 24, 2017. DOI: 10.1080/00325481.2017.1292107
  • Bouchonville MF et al, "Are diabetes guidelines truly evidence based?" Diabetes Research and Clinical Practice, May 2017. DOI: 10.1016/j.diabres.2017.02.035
  • Lee DSH et al, "Statins and physical activity in older men: The Osteoporotic Fractures in Men Study." JAMA Internal Medicine, Aug. 2014. doi:10.1001/jamainternmed.2014.2266
  • Betteridge DJ & Carmena R, "The diabetogenic action of statins - mechanisms and clinical implications." Nature Reviews. Endocrinology, Feb. 2016. DOI: 10.1038/nrendo.2015.194
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