Go Ad-Free
logoThe People's Perspective on Medicine

Horse Chestnut

Horse chestnut has been used in folk medicine to treat a range of conditions from varicose veins and hemorrhoids to arthritis and coughs.

Horse chestnut trees originated in northern India, the Caucasus, and northern Greece but have long been grown throughout Europe.

Relatives in the same genus grow in the United States as California buckeye (A. californica) and Ohio buckeye (A. glabra). The seeds of these plants are toxic, however.

Horse chestnut bark and leaves, as well as a standardized extract of the seed, are used in Europe.

Active Ingredients:

Horse chestnut contains several triterpene glycosides, with aescin predominating in the seeds.

Coumarin glycosides aesculin, fraxin, and scopolin and their corresponding aglycones, aesculetin, fraxetin, and scopoletin, are also found, along with flavonoids such as quercetrin. Allantoin, leucocyanidins, tannins, and the plant sterols sitosterol, stigmasterol, and campesterol have also been identified.

The commercial horse chestnut extract utilized in Germany is standardized to contain from 16 to 21 percent triterpene glycosides (calculated as aescin).


In folk medicine, horse chestnut teas were used to treat diarrhea and hemorrhoids. Traditional uses for the tea also included arthritis and rheumatic pain and coughs.

It was applied to the skin to treat some sores and rashes. But although a component of the bark (aesculin) is used in sunscreens in Europe, this phytomedicine is rarely used for topical application now.

Standardized horse chestnut extract is considered a valuable aid in treating varicose veins. It inhibits the enzyme hyaluronidase and makes veins less permeable and less fragile. Horse chestnut can improve the tone of veins and increase the flow of blood through them.

Scientific studies (randomized double-blind, placebo-controlled) have shown that horse chestnut can reduce edema.
A clinical study compared horse chestnut extract to compression stockings and placebo for varicose veins. Both the herbal medicine and the stockings significantly reduced edema of the lower legs compared to placebo.

Feelings of tiredness and heaviness, pain, and swelling in the legs were alleviated by the extract, in comparison to placebo.
Horse chestnut extract also is reported to have anti-inflammatory activity.


Horse chestnut extract (delayed release) is given at a dose of 250 to 312.5 mg twice daily, providing 90 to 150 mg aescin. After improvement, the dose is reduced to 35 to 70 mg aescin daily.

Use for up to twelve weeks has been studied.

One standardized extract that has been studied in Europe is available in the United States under the name Venastat.

Special Precautions:

Horse chestnut therapy should be supervised by a knowledgeable health professional due to possible toxicity.

Patients with varicose veins should continue to use the elastic stockings, compresses, or cold water soaks that their doctors recommend in addition to horse chestnut extract.

People with bleeding disorders should avoid horse chestnut. The coumarin glycoside aesculin can exert an anticlotting action.

Adverse Effects:

Nausea and gastrointestinal upset have been reported, although they are not common. Itching or other signs of allergic reaction may occur, but serious allergy is uncommon.

Over the course of nearly three decades in Switzerland, horse chestnut use accounted for three reported cases of general allergy and two cases of life-threatening allergic shock.

One man developed liver damage while taking an herbal preparation containing horse chestnut.
Kidney damage has been reported very rarely.

Possible Interactions:

The anticlotting action of aesculin may interact with anticoagulant drugs such as aspirin, Coumadin, Plavix, or Ticlid to increase the risk of bleeding. This combination should be avoided.

Share your own experience with horse chestnut below in the comment section.

Revised: February 11, 2016

Rate this article
3.5- 22 ratings
About the Author
Joe Graedon is a pharmacologist who has dedicated his career to making drug information understandable to consumers. His best-selling book, The People’s Pharmacy, was published in 1976 and led to a syndicated newspaper column, syndicated public radio show and web site. In 2006, Long Island University awarded him an honorary doctorate as “one of the country's leading drug experts for the consumer.”.
Tired of the ads on our website?

Now you can browse our website completely ad-free for just $5 / month. Stay up to date on breaking health news and support our work without the distraction of advertisements.

Browse our website ad-free
Join over 150,000 Subscribers at The People's Pharmacy

We're empowering you to make wise decisions about your own health, by providing you with essential health information about both medical and alternative treatment options.