The People's Perspective on Medicine

Global Amnesia Is A Very Scary Statin Side Effect

Have you ever heard of transient global amnesia (TGA). It is a temporary loss of memory that can last for hours. Are statins associated with attacks of TGA?
Brain zap

No doubt you have heard of amnesia. It is a kind of memory loss that can vary in both nature and intensity. After brain trauma, some people cannot remember who they are or what happened recently. It can be a terrifying experience. A few medications can cause amnesia, including narcotics and benzodiazepines. To the surprise of many health professionals and patients, statins can occasionally trigger something called transient global amnesia (TGA).

A Reader Describes Global Amnesia after Atorvastatin:

Q. I had been on atorvastatin for only a few days when I was taken to the emergency room after a 12-hour episode of transient global amnesia. I had a battery of tests, but all were negative.

My doctors denied that atorvastatin could have had anything to do with this complete blank of my memory. The doctor said I will probably never have any recall of the day I missed, and I still don’t know what happened then.

It’s a very strange feeling. Is there any more recognition of the role of statins in transient global amnesia?

A. We first heard about transient global amnesia (TGA) in connection with statin-type cholesterol-lowering drugs from Dr. Duane Graveline. This astronaut/physician shared his story with us nearly two decades ago.

He reported a six-hour episode in which he lost his memory and couldn’t recognize his wife. A year later, he was put back on Lipitor and once again suffered TGA.

Statins, the FDA and Amnesia:

Since then, we have heard from many other readers who, like you, had experienced this scary reaction. The official prescribing information for atorvastatin (Lipitor) describes it this way:

“There have been rare postmarketing reports of cognitive impairment (e.g., memory loss, forgetfulness, amnesia, memory impairment, confusion) associated with statin use. These cognitive issues have been reported for all statins. The reports are generally nonserious, and reversible upon statin discontinuation, with variable times to symptom onset (1 day to years) and symptom resolution (median of 3 weeks).”

Is Transient Global Amnesia Nonserious?

We find it intriguing that the FDA categorizes global amnesia as “nonserious.” Imagine losing your memory for several hours. In our opinion that’s pretty scary.

You might think that neuroscientists would want to know more about this phenomenon. In particular, you would imagine that they would wish to explore what mechanisms behind statin-induced transient global amnesia. To our disappointment we could find very little about this adverse reaction in the medical literature.

We did find this article in BMJ Case Reports (Feb. 26, 2009)

“A 57-year-old man treated with statins developed a range of amnestic features that led to concerns he might be suicidal; however, he did not appear to have depression. His problems began after starting rosuvastatin and cleared on discontinuation.”

“This is a first report of what may be transient global amnesia linked to rosuvastatin, although is as likely to be a general problem linked to statin intake. There are reports of possible transient global amnesia linked to simvastatin or pravastatin.”

Other Cases of Transient Global Amnesia and Statins:

We suspect that we have received more case reports about TGA than exist in the world’s medical literature. We won’t hazard a guess as to why that might be. Here are just a few of the many anecdotes we have received over the last two decades.

As described above, the very first story came from Dr. Duane Graveline. Several years ago he submitted this account of his research on TGA to our website. Here is a link to his article:

Transient Global Amnesia (TGA) & Lipitor

Other Stories About Global Amnesia and Statins:

Leida had a kind of amnesia after taking simvastatin:

“I have been taking simvastatin for several years. Lately I have experienced episodes of forgetfulness, confusion, memory loss and foggy brain. While driving to work on a road that I have traveled for 15 years I suddenly got completely lost. I did not recognize the area at all.

“My doctor said there are no reports of statins causing such problems. I stopped taking the pills. A week later I was normal again. My pharmacist denied any connection between the statins and cognitive problems. What is going on? I know I am not crazy.”

Gwen described this case of transient global amnesia:

“My husband had a heart attack six months ago and was put on a statin. Yesterday he had a Transient Global Amnesia episode. He was taken to emergency and was tested for stroke or seizure and had an EEG and MRI of the brain. All tests came back as normal.”

Gene shared this experience:

“I found out about statins by reading People Pharmacy and I credit Joe and Terry for saving my life. I have been off statins for four years and some of the problems do not go away. I have very little short-term memory and I still have back pain although not as bad as it was. I think the Transient Global Amnesia was the worst and almost caused me to have a car accident.”

Sparrow had a close call while taking atorvastatin:

“Eight years ago, while on Lipitor, I was flying a glider and experienced an attack of Transient Global Amnesia. Fortunately the regression was back to after I learnt to fly and I landed safely. I was thought to be a ‘bit off’ and was carted off to hospital where my condition was diagnosed.”

GRD also had a close call:

“I took simvastatin for two years. Shortly after I started taking it, I developed lower back pain that was so bad I could hardly breathe. Because of Peoples Pharmacy, I stopped taking it and my back pain lowered to about half what it was. It is still with me. It has been about three years since I stopped but many problems are still there. I have weak legs, back pain and memory loss (mostly peoples’ names that I have known all my life).

“The worst part is the Transient Global Amnesia (TGA). I have had five episodes so far even after stopping statins. The last one almost caused a car crash and I don’t remember anything about it except suddenly seeing the car coming at me. Scary stuff.”

Stan’s experience with rosuvastatin (Crestor) was scary for his family:

“I was on Crestor for about two years and stopped a few months ago due to rapid growing cataracts in both eyes. My wife had noticed a personality change and said my temper and violent behavior was unbearable and I can now attribute this to the medication.

“My biggest scare, which caused my wife to start researching the side effects, was a 5-hour episode of amnesia. I apparently chased my wife and son with a loaded handgun because I didn’t know who they were. I was at the mental capacity of a 5-year-old. My doctor can’t find anything wrong. I just hope nothing more comes as a side effect from taking that medicine.”

Global Amnesia and Statins?

Health professionals are unlikely to connect the dots between statins and transient global amnesia if there is no research into this side effect. Please share any stories about TGA or memory problems in the comment section below.

We recognize that some people must take statins because of severe heart disease. We would just like to know more about why and how statins can affect memory.

You can learn more about statin side effects in our book, Top Screwups. It is available in the Books section of the store.

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About the Author
Joe Graedon is a pharmacologist who has dedicated his career to making drug information understandable to consumers. His best-selling book, The People’s Pharmacy, was published in 1976 and led to a syndicated newspaper column, syndicated public radio show and web site. In 2006, Long Island University awarded him an honorary doctorate as “one of the country's leading drug experts for the consumer.” .
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I have been taking simvastatin for several years. Over the past 3 years I have experienced sudden memory loss while driving in very familiar areas. I am fully aware of where I am (city, state) but I have no idea how to get to my house. I feel confused about what street I am on and which way I need to turn to get home. It is very short-lived, thankfully, and I snap out of it and recognize what I need to do. It used to happen near a certain intersection but now it occurs at a few different locations. I can’t help but think it is medication related.

A few years ago, I awoke and jumped into the shower. While in the shower, I began thinking of my day’s upcoming activities. To my surprise, I soon discovered that I had a serious memory loss. Didn’t even know my home phone number. I called a friend to take me to the hospital, thinking that I was having a stroke. I couldn’t even remember the friend’s phone #, or mine. I did know how to look his up though. Emergency room personnel gave me a battery of tests and admitted me. All was normal. My memory came back clear after about six hours. I have not experienced Transit Global Amnesia since. I was, and am still taking 20mg Lipitor daily. I did read up on the subject and sometimes this type of amnesia happens if one gets up quickly and jumps into a shower and is hit with cold or hot water. That’s what happened to me.

After a heart attack, I was put on 80 mg atorvastatin. When my cholesterol numbers did not come down enough, they upped me to 40 mg rosuvastatin. Although I had negative side effects, my cardiologist insisted that they had nothing to do with statins.

After moving toward a plant-based diet, we lowered the dosage to see if the numbers would be acceptable. That is when I realized that I had been having significant memory problems and cognitive dysfunction at the higher dose. It was like not knowing you had been in a fog, coming out of it, and looking back and seeing it behind you. I did not notice any TGA though.

We have continued with our diet change and lowered the statins to 10 mg atorvastatin. There is marked improvement in the side effects, but my cardiologist won’t let me go off of statins completely.

My guess is that there is little about statins and TGA in the literature because Big Pharma doesn’t want yet another problem with their cash cow publicized.

I had a TGA incident and have never taken statins.

Our family has experience with the type of amnesia called Anterograde amnesia which occurs after the event that caused it. In the case of my stepmother, it happened after she had taken a sleeping pill and was inadvertently awakened. My stepmother had it twice caused by zopiclone. In the emergency ward they thought that she had had a stroke. They determined she had not, but had no other diagnosis and released her. It was the family that later figured out that zopiclone was the problem.

Here’s some information from Wikipedia:
“This disorder is usually acquired in one of four ways: One cause is benzodiazepine drugs such as; midazolam, flunitrazepam, lorazepam, temazepam, nitrazepam, triazolam, clonazepam, alprazolam, diazepam, and nimetazepam; all of which are known to have powerful amnesic effects. This has also been recorded in non-benzodiazapine sedatives or “z-drugs” which act on the same set of receptors; such as zolpidem (also known as Ambien), eszopiclone (also known as Lunesta), and zopiclone (also known by brand names Imovane and Zimovane).[3] A second cause is a traumatic brain injury in which damage is usually done to the hippocampus or surrounding cortices. It may also be caused by a shocking event or an emotional disorder.”

My husband, now deceased, had problems while on statins for a long-ish time. Relevant to this discussion, he once (that I know about) got lost in a place he should have been vary familiar with. I needed to drive over to get him “unstuck”. He soon after died following an unexpected fall; suffered a fatal brain hemorrhage. His cholesterol just before this “early” death was 140. I later found out from friends that he had fallen several times before his fatal fall and had trouble orienting to “right himself.” I think he was trying to hide some of this difficulty from me.

I often have wondered if some of his difficulties were promoted by long-term statin use. I came off them myself years before for problems with pro-prioception (or so it seemed) and have felt much better since. My husband was sure he had no difficulty using statins. Shortly before his death he assured me he had stopped using statins; said his cholesterol level had remained unchanged after several months off the drugs.

I experienced transient global amnesia over six years ago, and I know it was due to a stressful situation. I have a strong fear of speaking in front of a large group of peers, if unprepared. And, that’s just what happened. I was caught off-guard and asked to speak to a large group without having any preparation. I ended up speaking (I’ve seen it on tape) but I had no recollection of doing so. I quickly exited; family members checked me for the possibility of a stroke and drove me home. They were worried, since I kept acting surprised that I had spoken at all. After seeing a doctor,he,too, cleared me, and said hopefully it won’t happen again. And, it hasn’t. But, it was the weirdest experience I’ve ever had. (Fifteen years prior to that, I did have a skiing accident where I ended up having a bruised brain and had cognitive difficulties for about 6 hours that felt similar.)

This happened to me, female aged 66, no medications and I believe it was stress related. My husband was so good. I had faxed a long note to our doctor about husbands health, and re-reading that helped bring me back. I asked strange questions, like who had vacuumed (I had), sounded neurotic and aggressive because I could not remember certain things that just happened, and I feared a stroke too. the internet search showed TGA (thank you search engine DuckDuckGo.com….it doesn’t ‘track’ you), and I slowly got myself together with my darling husbands calm approach and explanations. Short lived, thankfully (about 30 minutes), but very scary. I now keep a note about it in my purse, just in case it should happen again. Hopefully it will not. Being aware that this could happen to anyone makes it less scary. I certainly won’t be taking statins!

Very interesting and informative! Thanks

It always seems extremely odd that doctors so often react with anger or at best patronizing disbelief. Makes me wonder how many get direct benefits from the drug companies hmmm…

I took zetia (ezetimibe) for a short time. I had a scary incident where I became confused and couldn’t find my way driving home (same route for over 10 years). I couldn’t figure out where I was. It did not look familiar. I stopped taking it, and this did not happen again. My sister was having serious memory problems. I discovered she was taking zetia and told her of my experience. She stopped, and they went away. She’d been on it longer, and it took more time to go away.

Beatrice A. Golomb, MD, PhD, at UCSD was studying it at the time and found this to be a side effect. All my doctors had strongly denied this could be a problem, so lucky that I found Golomb’s research. She has done similar research on statins.

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