The People's Perspective on Medicine

Did Sleeping Pill Cocktail Leave Insomniac Zombified?

When chronic insomniacs have a hard time getting a good night's sleep their doctors sometimes come up with some worrisome sleeping pill cocktails.

Tens of millions of people have a hard time falling asleep or staying asleep. They are frequently told that inadequate sleep can contribute to a variety of health problems from weight gain and hypertension to confusion and diabetes. Sometimes in desperation they turn to a variety of supplements and sedatives. This reader was on a sleeping pill cocktail that was off the charts:

Q. I have terrible insomnia. My cocktail for sleep is 600 mg of Seroquel, 40 mg of baclofen and 15 mg of temazepam. This gives me a full night of sleep, but it is difficult to wake up completely in the morning. The Seroquel dose used to be much lower but my doctor has increased it over time.

A. We are amazed you can even get out of bed given this sleeping pill cocktail. Your doctor has pulled out some very heavy guns to help you get a full night’s sleep.

Seroquel Indications and Side Effects:

Quetiapine (Seroquel) is prescribed for schizophrenia and bipolar disorder. The FDA has not approved this powerful drug for insomnia!

Using a major tranquilizer in a relatively high dose is risky since side effects can include fatigue, drowsiness, dry mouth, dizziness, constipation, weight gain, blurred vision, cataracts, insomnia, irregular heart rhythms, uncontrollable muscle movements and high cholesterol, to name just a few of the many serious adverse reactions associated with Seroquel.

Restoril (Temazepam) Indications and Side Effects:

Another part of your sleeping pill cocktail involves a “hypnotic” called temazepam. It is a benzodiazepine like alprazolam (Xanax) or diazepam (Valium). The FDA specifies that:

“Restoril (temazepam) is indicated for the short-term treatment of insomnia (generally 7 to 10 days).”

The FDA goes on to offer the following precautions:

“Since the risk of the development of oversedation, dizziness, confusion, and/or ataxia [unsteadiness] increases substantially with larger doses of benzodiazepines in elderly and debilitated patients, 7.5 mg of Restoril is recommended as the initial dosage for such patients…If Restoril is to be combined with other drugs having known hypnotic properties of CNS [central nervous system]-depressant effects, consideration should be given to the potential additive effects.”

Seroquel is considered a powerful CNS depressant. That means you are not only getting a big dose of temazepam, you are adding it to a major antipsychotic medication.

Temazepam can cause fatigue, dizziness, drowsiness, hangover, confusion, amnesia and unsteadiness. When you combine temezepam with Seroquel these adverse reactions can be amplified.

Lioresal (Baclofen) Indications and Side Effects:

The third drug in your sleeping pill cocktail is a muscle relaxant. The FDA has approved it primarily for “the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis…” The drug is not approved for insomnia!

Side effects of baclofen include drowsiness, weakness, fatigue, confusion, headache, insomnia, low blood pressure, nausea, constipation and urinary retention.

When you combine three powerful sedative-type drugs you are asking for all kinds of trouble. Not only would the chances for a morning hangover be dramatically increased, you are also risking memory problems, unsteadiness and lots of other serious side effects. That said, you must not stop any of these drugs suddenly!

Do NOT Stop Your Sleeping Pill Cocktail Suddenly!

Withdrawal from benzodiazepines like temazepam can be challenging all by itself. Symptoms can include anxiety, irritability, insomnia, panic, depression, impaired concentration, restlessness, headache and agitation. Learn more about this process at this link.

The FDA warns that: “Hallucinations and seizures have occurred on abrupt withdrawal of baclofen.” The agency warns doctors to reduce the dose of the drug slowly when the drug is discontinued.

Alternatives to a Sleeping Pill Cocktail:

You will likely need to consult a sleep expert to find a way to gradually wean yourself off these three heavy-duty drugs and come up with some other ways to deal with your insomnia. To help you get started we are e-mailing you our Guide to Getting a Good Night’s Sleep, which offers alternatives to the sleeping pill cocktail you are currently using. There is information about a number of herbal remedies including valerian, fennel, passion flower, hops and lemon balm along with information about melatonin, tryptophan and tart cherries.

It is available for download at

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About the Author
Joe Graedon is a pharmacologist who has dedicated his career to making drug information understandable to consumers. His best-selling book, The People’s Pharmacy, was published in 1976 and led to a syndicated newspaper column, syndicated public radio show and web site. In 2006, Long Island University awarded him an honorary doctorate as “one of the country's leading drug experts for the consumer.” .
Getting a Good Night’s Sleep

Tips for beating insomnia: foods to avoid, foods that help, herbal remedies, sleeping pills. Newly revised (November 2016), our online guide (too long to print) includes drugs that may cause insomnia. Learn about the latest medication, Belsomra.

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I generally do not have trouble getting to sleep, but have had some trouble sleeping soundly and/or waking and having trouble getting back to sleep. I have found that Doxepin (Sinequan) works well, and I gather is pretty benign. Originally, in larger doses, it was an antidepressant medication, then found to be useful for sleep. My prescription allows for one to two 25 mg. capsules at bedtime, but a single 25 mg. capsule is all I need. I hope this may be helpful.

OMG… why bother to try and sleep if the stuff you have to take to get that sleep is just about guaranteed to make you much older, much faster, and much more likely to get Alzheimer’s!

Yes, the medications for sleep can lead to brain problems down the road….but so can sleeping 2-3 hours a night for years upon end. And if you give me the choice between taking a drug and sleeping, and thus enjoying my life, and not taking a drug, and being exhausted, and chronically ill and not enjoying my life, the choice is dead easy! Both roads MAY lead to the same place, but one is enjoyable and the other is a living hell.

Experiment with Inositol powder (not the capsule form), a substance grouped in with B Vitamins and a partner with Choline. Package directions recommend starting with a 1/4 teaspoon in a small glass of water and increase by 1/4 teaspoons over time to find the amount that will aid with sleep. Can take up to 2 grams daily. Take just prior to bedtime. A safe alternative to sleeping medications with no side effects.

Tell your doctor to run a B vitamin panel to test for other deficiencies in the B vitamin family.

I took Ambien for a short time about 6 years ago. NEVER again.
And that was only one drug.

Veterans that are returning from war are often diagnosed as suffering from post traumatic stress syndrome. I discussed this phenomenon with a medic that just returned from Afghanistan. His view on the subject was this, how do they expect a soldier to react when you keep feeding them amphetamines ( uppers) then have them use benzo’s to catch some sleep.Ativan alone could cause post traumatic stress syndrome in the form of panic attacks. Caffeine as far as I am concerned is an amphetamine so will rest my case!

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