Cascara sagrada, Spanish for “sacred bark,” comes from the American buckthorn tree native to the western coast of North America, from California to British Columbia, and as far inland as Montana. The Spanish priests of California may have learned about it from the Indians.

In any event, this laxative was not widely adopted until the nineteenth century. A member of the same genus, R. frangula, is the European buckthorn tree, which had been used at least since 1650.

Cascara sagrada is one of the few herbs approved as an over-the-counter drug by the U.S. Food and Drug Administration. The portion of the plant used is the bark.

Active Ingredients

The main ingredients are anthraquinones.

Emodin and aloe-emodin have also been identified, along with a number of nonlaxative ingredients.


Cascara sagrada is used as a laxative. The anthraquinones stimulate the bowel, leading to evacuation after approximately six to ten hours. This herb also provokes secretion of fluid and minerals into the large intestine and inhibits their reabsorption. It is suggested for situations in which a soft, easily passed stool is desirable, such as hemorrhoids or following rectal surgery.

Cascara sagrada is not appropriate for regular use and can cause problems such as dependence if it is used too often.

Studies are being done to see if it is helpful in treating drug overdose, as a way of removing the drug from the lower intestine.

In addition, anthraquinones applied topically can protect skin from ultraviolet damage.

Extracts of R. purshiana can inactivate herpes simplex virus, but this property has not been utilized medically.


The usual dose ranges from 20 mg to 70 mg daily of the anthraquinones. Products containing cascara sagrada should not be used for more than eight or ten days.

Special Precautions

Fresh bark can cause nausea and vomiting. The bark should be stored for at least a year or undergo heat processing to eliminate this problem.
Pregnant women and nursing mothers should avoid cascara sagrada.

People with intestinal blockage, undiagnosed stomach pain, or symptoms that might indicate appendicitis must avoid laxatives such as cascara sagrada.

People with diarrhea, inflammatory bowel disease, or intestinal ulcers must not use cascara sagrada.

Children younger than twelve with constipation should not be treated with cascara sagrada.

Adverse Effects

Abdominal cramps or diarrhea have been reported.

Chronic use of laxatives may lead to excessive loss of potassium or other electrolytes, which may be dangerous. In addition, anthraquinones can cause pigmentation of the large bowel.

A serious problem associated with chronic use, however, is that a person may become dependent on such a stimulant laxative and become unable to evacuate without it. This leads to problems that resemble ulcerative colitis.

Possible Interactions

If cascara sagrada results in excessive potassium loss, heart rhythm irregularities may occur. This problem could be especially severe for people taking the heart drug Lanoxin.

It would be unwise to use cascara sagrada together with other herbal medicines that can cause potassium loss, such as aloe or licorice.

Medications such as hydrochlorothiazide, Lasix, Hygroton, Lozol, Bumex, and other potassium-wasting diuretics are probably incompatible with cascara sagrada, at least if it were used more than very occasionally.

Cascara sagrada, like other strong laxatives, may reduce the absorption of other medicines taken orally.

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  1. JWH

    I have used aged Cascara Sagrada Bark with great success many times. It works every time and is quite gentle.
    I take it with a large amount of water before I go to sleep; the water does not cause an urge to urinate during the night (because it passes into the fecal matter?) and I wake up a few minutes early because I’ll have to defecate immediately, up to three times within an hour depending on the degree of constipation being relieved.

  2. N W

    As a eight year old child, I was often given what was then an over-the-counter laxative called CascaraQuinine Cold Tablets. I loved to take it, as I secretly enjoyed the pounding pulse, and hallucinations that occurred. When I told my mom that I was able to have the repeated nightmarish scenario at will, she was horrified and that was the end of my great drug times. Who knows what it may have been doing to my major organs.
    Even though now it appears to have only one ingredient, I personally would not like to know children have been given it.
    Considering the gory nightmares I began to have when I recently started taking Singulair (until I switched to administering it in the day, not later than 4 pm), I wonder if certain individuals are sensitive to many drugs. Perhaps some casual questioning about sleep and dreams should be part of a parent’s observation when a child receives any new drug.

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