The People's Perspective on Medicine

Can Medications Change Hair Color or Curl Your Hair?

When you think of changing hair color you probably consider hair dye. What if your oral cholesterol medicine or RA drugs turned gray hair black or curly?
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We are always intrigued to read about medications that change hair. Usually people complain that beta blocker heart medicines like propranolol or metoprolol lead to thinning hair or hair loss. Others want to know if the medicine they are taking could change hair color.

Several years ago we heard from a woman who was upset that rosuvastatin (Crestor) changed her hair color:

“I have had gray hair since I was thirty-five and over the years it has turned white. Now I have black hair growing from the roots and it seems to grow every day. I am very unhappy about this, as I have never had black hair.”

Cholesterol-Lowering Drugs and Hair Color:

We have heard from other people that statins such as simvastatin can alter hair color.

One woman wrote about her mother’s experience:

“My 84-year-old mother let her naturally black hair go silver gray about ten years ago. Several years later she began taking Zocor and after about a year she noticed the roots of the new growth were black! She is not pleased about this because it makes her otherwise lovely silver hair look ‘dirty!’”

Among the earliest reports we received on this phenomenon was this one:

“I have read in your column that cholesterol-lowering drugs might affect hair color. I was relieved because I was afraid I was going nuts.

“My hair has been pure white for years. Since I started taking Zetia I have noticed that it has turned steel gray with black mixed in. My doctor has never heard of this side effect and is skeptical.”

We also heard from another reader with a similar story:

Q. A year or so ago, you had a letter from a reader who said a pill she was taking turned her gray hair dark again. I know it’s not guaranteed to work, but I’d like to try it. Do you know what she was taking?

A. She was taking two cholesterol-lowering drugs, Zocor and Zetia. Her report was strange because her original hair color was blonde, but her gray hair started growing in black on these drugs.

We invited other readers to tell us if they had similar hair color changes, and many did. Most were on Zocor or Zetia or the combination (Vytorin), although a few other drugs, such as Crestor (also for cholesterol) and Xalatan (for glaucoma), were also named.

We’d discourage you from taking such medicine on the off chance it might affect your hair color, unless you also need to lower your cholesterol. This reaction appears to be uncommon, and these drugs can cause other side effects.

There is very little in the prescribing information about statins and hair color changes. The simvastatin (Zocor) label offers this: “changes to hair/nails.” Pretty ambiguous, eh? There is no mention of hair when it comes to atorvastatin (Lipitor) or rosuvastatin (Crestor). 

Gleevec (Imatinib) and Hair Color Changes:

One of the more important cancer breakthroughs has been the development of imatinib (Gleevec). It changed the course of treatment for people with chronic myelogenous leukemia (CML) and gastrointestinal stromal tumor (GIST). It can do some strange things to hair. Some people report depigmentation of hair while others regained color.

French cancer doctors treating CML patients with Gleevec reported (New England Journal of Medicine, Aug. 8, 2002): 

“Among these 133 patients, 5 men and 4 women (median age, 63.4 years; range, 53 to 75) with gray hair before treatment had progressive repigmentation of the hair (on the head in 8 patients and on the body and head in 1) during treatment.”

“How imatinib mesylate might induce hair repigmentation is a mystery. We would be interested to know whether other groups have observed this peculiar side effect.”

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As far as we can tell, researchers have not been interested enough to study this intriguing side effect. A reader of our syndicated newspaper column wants to know about a different kind of side effect: curly hair.

Drugs for Rheumatoid Arthritis and Curly Hair:

Q. I’ve been on medications (Plaquenil, methotrexate, Medrol and folic acid) since around 2000 to treat rheumatoid arthritis (RA). My former rheumatologist kept me on these old medications since he was conservative in what he prescribed.

A new rheumatologist has recommended going on the biologics. My question is: since I was on the old standard medications, my hair has curled and I love it. If I go on a biologic and stop taking my old meds, will my hair revert to its former straight look?

A. There is nothing in the medical literature about your medications making hair curl. Hydroxychloroquine (Plaquenil) can cause hair changes, and some people have reported curling, even though it is not in the prescribing information.

Hair loss appears more common than curling, though, even with the new biologics for RA. It is hard to predict how your hair would react to drugs like adalimumab (Humira) or etanercept (Enbrel).

Another reader responded with a comparable experience on methotrexate:

Q. I was on weekly methotrexate for three years for rheumatic symptoms. My hair permanently changed both color (from blond to brown) and texture (slightly wavy to quite curly).

A. Scientists do not seem to know why this happens, but you are not alone. We have heard from others who report curly hair in response to this drug.

Another reader shared,

“My hair thinned for a while after starting methotrexate; then it grew back undeniably curly.”

If any readers have experienced hair color changes or curling, we would love to hear about them. Please share your story in the comment section at the bottom of the page.

Bimatoprost and Longer Eye Lashes:

One final note about drugs and hair. A glaucoma medicine called bimatoprost was found to stimulate the growth of eyelashes. One reader offered this anecdote:

“My sister has been on Lumigan for glaucoma and her eyelashes are amazing–long and thick! What a nice side effect! I would love to have my eyelashes grow but I think it would be irresponsible to take a prescription medication just for that.”

There is now an FDA-approved version of bimatoprost for eyelashes. It is called Latisse. When this liquid solution is applied to the base of the eyelashes they grow thicker and longer. One less desirable side effect of bimatoprost: it may make blue eyes turn brown. Latisse is also pricey. A 5 ml bottle can cost between $170-$230.

If you are interested in this repurposing of bimatoprost for longer eyelashes, here is a link.

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About the Author
Joe Graedon is a pharmacologist who has dedicated his career to making drug information understandable to consumers. His best-selling book, The People’s Pharmacy, was published in 1976 and led to a syndicated newspaper column, syndicated public radio show and web site. In 2006, Long Island University awarded him an honorary doctorate as “one of the country's leading drug experts for the consumer.” .
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I am a 69 year-old woman, and I have always had straight, dark-blonde hair that I found super easy to style. About 5 years ago my hair started growing in kinky but only on the back of my head. The shape of the hair is like you had folded the hair as you would fold paper to form a fan; the hair has ended up with a very frizzy look, but no change in color. A couple of years after the change in hair texture, my body (mouth, eyes, skin and hair) have become EXTREMELY dry.
I have no idea if the two symptoms are related, but I would love for both of them to go away. I take 21 medications for various diagnoses including hypertension, osteoarthritis, sleep apnea, peripheral neuropathy, osteoporosis, chronic back pain, plus too many to list. I do not take any statins, but for multiple years about the time I got the symptoms, I did take metoprolol. I haven’t taken it for the last year, but I my hair and body haven’t changed back to the way they used to be.
My doctors don’t seem to have any idea why I may have experienced these symptoms. Is there a place or type of doctor I could go to to find out why I have these symptoms, and how (hopefully) I might make them go away?

I was diagnosed many years ago with RA so I’ve been taking plaquenil, prednisone and leflunomide for several years. I had pretty, thick hair prior to the meds, and now my hair is frizzy and actually quite wiry on one side more than the other. My rheumatologist had never heard of this either. I’m happy the meds have helped my condition, but sad that I no longer have pretty hair.

Over 10 years ago, my physician prescribed me an antibiotic for in infection. Couple days of later, guess what? Part of my hair stared to turn orange. Went back to my physician to see how the infection was doing. Told him what happened to my hair. He did not say anything. Just looked at me if I was crazy.

I’ve been on Metformin for pre-diabetes for several years.
My current GP doubled the dosage about 6 months ago, and my silver gray hair has begun to turn black at the roots. No other medication change has been made so I am glad you came out with this article.

I am currently taking a Krill Oil supplement for cholesterol control. (Side effects of statins put me in a wheelchair). Since starting this supplement, my silvery white hair now shows darker strands mixed in (although the hair at lower back of my head, at the nape of the neck, never went completely gray, just darkened). The darker strands are mostly shades of auburn, (my original hair color). The overall effect makes my hair look pale reddish blond at top and front of head. My current hairdresser, who never saw my original color, even asked me if I was originally a blonde. The color change doesn’t bother me

Doxycycline turned my salt and pepper hair to more pepper than salt. The original brown color is now black.

I have been on biologics for RA for 12 years, and since the first year my hair went from wavy to very curly. I hate it because it doesn’t feel like the hair I have had all my life. I have been on numerous different RA drugs but my hair has stayed curly. I had never heard of this happening before reading this article.

I take none of those aforementioned drugs, and the right side of my white hair turned curly from my temple to the back of my head on right side. The back of my hair changed texture, and is not soft but wiry and frizzy.

I have been taking Hydroxychloroquine for years, no hair changes. As I have been put on some other medications, though, the combination along with the Hydroxychoroquine has made my hair curly. My hair was straight all my life until about 2 years ago. I’m not sure which of several medications would have caused the change, but I’m ok with it.

Since being on Letrozole for breast cancer I have noticed some hair thinning around my face, replaced with baby fine wisps of hair.

I have always had fairly thick hair. After receiving the first dose of the Shingrix vaccine, my hair suddenly started falling out, and the texture changed completely. I also developed purpura on my forearms. Both continue even a year after the second dose. I’ve been to several doctors, and none seem to be able to pinpoint a cause.

Interesting article.
My hair’s always had waves, but started coming in with tigher curl. It never occurred it me it could be related to the new prescription for cholesterolmeds I was taking when this started. After stopping this med, it went back to waves, and again, I didn’t relate the two.

Before my mother died her gray hair had started to turn black like it had been when she was young. I never knew her that way because she was already gray by the time she had me at age 25. She used to joke that she was getting younger while I was getting older! Thanks for reminding me of that time in my life!

I’m not alone! Thank you People’s Pharmacy! I’ve long had what I’ve labeled wavy hair. Then started on methotrexate and high dose prednisone for autoimmune diseases. Hair thinned for while, then grew back undeniably curly. Switched from mtx to azathioprine over a year ago and take 10 mg prednisone daily, and curls continue. (Plus now biologic Benlysta 4+ months.) Rheumatologist and neurologist somewhat baffled/amused.

Additional weird “benefit” is that I no longer need shave my armpits They are pre-pubescent bare since shortly after starting mtx and pred years ago. Almost makes up for the increased facial hair due to prednisone. ;)

When I’m on higher dose Prednisone ( 20 – 60 mg./day) for lupus flares, my hair gets curlier in a dose-dependent manner. Family at first thought I was getting perms …

I’ve observed that the individual hair shafts also thin (hair becomes finer) while on the higher dose Pred. Perhaps that allows my naturally minimally wavy hair to be curlier?

Sadly, the curls fade as I wean down on the pred. No joy with my regular 5 mg./day dose.

When my daughter was 4 years old she had a prolonged grand mal seizure as a result of a spiked fever. She was on Depakote for 2 years. Her hair went from wavy to tight curls in that time. When the Depakote was discontinued, her hair returned to the previous waves.

I stopped dying my hair in 2014 and went completely naturally white in 13 months , which made me very happy because I get compliments everywhere I go. About 9 months ago, I started getting a very dark streak in the front of my hair, and my hairdresser was baffled that the new hair coming in at my temples are very dark brown. My doctor went over every medication I take and couldn’t explain it. I’ve taken simvastatin for a few years now, and the drugstore sells from different generic makers all the time. I’m so relieved that I’m not the only person this has happened to!

I was put on to Methotrexate (with Folate) ten years ago for RA. Before long it became apparent that my head hair had acquired some wave as it grew longer between cuts. It had been thin and completely straight for the 63 years prior. There’s still a hint of curl at the ends now that I’ve quit Methotrexate some 10 months ago.

I was on weekly methotrexate for 3 years for rheumatic symptoms. My hair permanently changed both color (from blond to brown) and texture (slightly wavy to quite curly).

My hair was always been really straight,, and then a few years ago it went real wavy/curly. Don’t know if it’s the medication or not. I am on a statin, a blood pressure med, a thyroid med, and Warfarin. Now I wonder if it was a medication that did this.

It is well-known that optic prostaglandins (for optic hypertension which could lead to glaucoma) will irreversibly change eye (iris) color from blue or green to dark brown. It is in the patient insert for drugs like Latanoprost and Travatan.

Of course the ophthamologist may not tell you this until after the change has taken place.

As to the hair-thinning effects of beta-blockers: I experienced this when my eye doctor prescribed an additional eyedrop, Cosopt, for my worsening glaucoma (was already on one drop but my pressure began rising in spite of that). After about two weeks, I saw significant hair loss with a balding spot on the top of my head. I found a discussion about beta blockers online with a suggestion to take Vitamin B12 orally. I did that (1,000 mg. daily), and within one week the hair loss stopped. Still taking the B12; the thinned area has now grown back.

I had a liver transplant last year. Consequently I am on a medley of drugs, including rosuvastatin-. My hair has always been stick straight.To give it body, I have always had a perm every 3-4 months. Last time I went to the hairdresser, about 4 months after my last perm, she commented that I still had a lot of body. Then as she trimmed it she said, “I think your hair has turned curly,”. I said I had wondered about that myself. Now, a month later, it is still curly”. She may be right!

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