Even before Prozac, there was Wellbutrin (bupropion). It was the first of a new generation of antidepressants and was introduced in 1985, almost two years before Prozac received FDA approval.

The company started shipping Wellbutrin to pharmacies around the country, but before prescriptions could actually be filled, a problem arose. A small study involving 50 women with an eating disorder uncovered an alarming statistic.

Four out of the fifty (8 percent) had suffered a seizure. This unexpected and alarming discovery created consternation at the FDA and the feds had the drug pulled off pharmacy shelves.

The FDA demanded additional tests, but the company resisted, maintaining that the bulimic subjects in the study were not representative of depressed patients. Prior research suggested that the seizure incidence was similar to that for other antidepressants.

For more than a year the company and the FDA argued. Eventually the company capitulated and studied an additional 3,000 patients.

The results redeemed Wellbutrin: The seizure incidence turned out to be 0.4 percent, not that different from other antidepressants and nowhere near the 8 percent seen in the small bulimia study.

Finally, in August 1989, Wellbutrin returned to pharmacy shelves, but it was almost too late. Prozac, introduced in 1987, had become a shooting star. Its incredible popularity made Wellbutrin an also-ran.

Although Wellbutrin works differently from Prozac and similar drugs (Paxil and Zoloft), doctors seemed to remember only the initial concern about seizures.

Despite its initial lack of success in the marketplace, Wellbutrin is roughly comparable to Prozac-like drugs in effectiveness.

Unlike traditional antidepressants, Wellbutrin does not cause weight gain, drowsiness, blurred vision, mental confusion, cardiovascular problems or impaired memory.

And it has one huge advantage over Prozac and other SSRI antidepressants. It does not lower libido, produce impotence or impair orgasms. If anything, Wellbutrin may actually stimulate sexuality for some people.

Side Effects and Interactions

Side effects associated with Wellbutrin include headache, dry mouth, agitation, insomnia, tremor, sweating, skin rash, nausea and constipation.

Other possible side effects include dizziness, nervousness, confusion, weight loss and blurred vision. Report any symptoms to your physician promptly.

Certain other medications may change the metabolism of Wellbutrin: The AIDS drug ritonavir can lead to large increases in the blood levels of the antidepressant, while the antiseizure medicine Tegretol lowers blood concentrations of Wellbutrin.

Taking antipsychotics, antidepressants, theophylline, or oral corticosteroids in combination with Wellbutrin may increase the risk of a seizure. So can sudden discontinuation of anti-anxiety pills like Ativan, Halcion or Xanax.

Other possible interactions may occur in combination with levodopa, phenelzine and tricyclic antidepressants such as amitrityline.

Because of a concern that ginkgo biloba could possibly make a person more vulnerable to seizures, it probably should not be taken together with drugs known to increase the risk of seizures. Antidepressants such as Wellbutrin belong in this category.

Interactions between the herb St. John’s wort and Wellbutrin are possible. Switching between antidepressants and herbal treatment calls for medical guidance (physicians can find a suggested protocol for gradual substitution of St. John’s wort in Hyla Cass’s book, St. John’s Wort: Nature’s Blues Buster).

Animal experiments indicate that compounds that act on dopamine in the brain, such as Wellbutrin, may affect or be affected by the herb chaste tea berry.

Check with your pharmacist and physician to make sure Wellbutrin is safe in combination with any other medicines and herbs you take.

Special Precautions

Even though the seizure risk with Wellbutrin is not as high as originally feared, a 0.4% incidence must not be ignored. The dosing schedule is extremely important in reducing this risk.

The maximum daily dose of 450 mg should not be exceeded. In the case of the sustained release (SR) formulation, the total daily dose should not exceed 400 mg.

Alcohol and certain other drugs (oral decongestants, other antidepressants, theophylline, oral corticosteroids) may potentiate the risk of seizures, so please check with a physician before consuming alcoholic beverages or taking any other medications.

Some drugs, such as Ativan, Halcion or Xanax, should be used cautiously, if at all, with Wellbutrin, because stopping them suddenly may make some people more vulnerable to seizures.

Wellbutrin may cause an exaggerated sun reaction, so people taking this antidepressant should stay out of the sun, wear protective clothing and use a broad spectrum sun block.

Taking the Medicine

Wellbutrin can be somewhat more complicated to take than other medications.

The SR (slow-release) formula is usually given as 150 mg twice a day with at least eight hours between the two doses. If the dose needs to be increased, this must be done gradually with medical supervision.

The SR (slow-release) formulation should not be chewed, crushed or split, as this might alter the absorption of this medicine.

The immediate-release tablets are usually given three times daily. No single dose should exceed 150 mg.

Dosing is usually started at 200 mg a day, given as 100 mg twice a day. This can be gradually increased to a total of 300 mg a day total. The daily dose should not be increased by more than 100 mg in a three-day period.

To minimize insomnia, the last dose of the day should not be taken at bedtime. However, immediate-release tablets should be spaced approximately six hours apart.

Food does not appear to have a significant effect upon  absorption, so it may be taken with or without food.

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  1. Sylvia
    Moreno Valley


    I have been on Wellbutrin for over 9 years now. To be completely honest, I didn’t even know there was a difference between the generic (Bupropion) or the normal prescription Wellbutrin. I just looked at my prescription bottle and it says “Bupropion Generic for Wellbutrin XL”. I take 3 150mg each morning. I started taking 150mg, and at some point it went from that to 300mgs/day. I can’t say that I’ve lost weight with it, as many of you have mentioned, but then again 15yrs ago I had a gastric bypass so the eating matters have also changed for me way before taking the meds. So maybe it has helped me not gain weight? Who knows? Either way I’d be in deep trouble if I had a medication that makes me gain weight. So I’m not sure I’m understanding all that I’ve been reading.

    I came across this site because, after taking this medication for some while, I too have been experiencing a few issues lately. I feel like it I am no longer as effectiveness as in my life as I was before. I use to suffer from iron deficiency, and usually I’d go do blood work, and it would be the reason why I felt so tired and not up to doing much. Unfortunately, the past 2 years I’ve been so good with my iron levels which only leads me to think that i’ts the medication. I also haven’t gone back to see my Psychiatrist so maybe this is the time to do this.

    I would not want to change my medication because the last thing I want is to be experimenting with meds that might make me worse and gaining weight is truly not an option for me. As it is, I still weigh 197 lbs, and that, according to my Dr., is unacceptable after a gastric bypass. So I previously tried getting off the meds or reducing the dosage (without telling my Doc), and it wasn’t a pretty sight. I noticed a lack of energy, fatigue, no enthusiasm towards life. I still struggle with wanting to be active and go out with my family which makes me truly sad because they see me as a boring person, and I’m barely 45yrs old, which means I shouldn’t be that way. I also saw a super-high level of irritable symptoms. I’d get upset over the stupidest things that truly didn’t matter. So I couldn’t control that, and not to mention that I now cry over the silliest things – although my son being deployed to Iraq isn’t silly at all. I think I still cry over who knows what at other times.

    So I’m a little confused. I’m not sure if the medication should be changed, or like some people mention here, maybe I should try lowering it, but I’m afraid because after several attempts of reducing my dosage or getting off it I’m truly scared. I didn’t believe that I would never be able to get off the meds like my Dr. told me once. I thought that maybe exercising, getting into church and praying to God would help me in removing these depression symptoms but I was wrong. Plus, I hate to admit it but I commute 3 hrs each day to work, and truly I don’t know if it’s the pill, the commute, life in general or what that truly is making me doubt about many things in my life and how I feel :(

  2. D.

    I started on Wellbutrin 11 years ago due to severe major depression and have been on generic bupropion 300 mg XL for 10 years. At the time I had tried all of the SSRIs out there and none had helped me and I would agree that Wellbutrin was a life saver. Although side effects were difficult initially my body adjusted after a month or so – the main problem was really bad constipation caused by the drug – and I haven’t had any major physical symptoms.

    My sister also takes the drug and has told me that lowering her dose has helped with memory and word finding problems. She said her psychiatrist told her this is a common side effect. I would like to experiment with lowering my dose but when I tried this about 7 years ago, I was not able to do it successfully as, after several weeks of taking 150 or 200 mg (I don’t recall which one) I noticed that my mood was lower and returned to the 300 mg of XL. I’m wondering whether this was simply a withdrawal effect that would have gone away had I stuck with it. I can find no advice on how to gradually lower my dose and it seems difficult since, if I stay on the XL I would have to halve the dose to 150 mg or else go on the SR version twice a day and to take 200 mg.

    Another concern I have, besides the word finding problems, is that recently I’ve developed muscle aches in one arm which have persisted for months with no apparent cause. I have no idea whether these could be related to the bupropion but it’s the only drug I take.

    Can anyone advise me on either of these issues? My sister also claims that she can’t take any of the generic forms of Wellbutrin, only the brand, but my insurance will only cover the generic. Thank you for any advice or referral to articles I could share with my doctor.

  3. Yvonne

    I must be a rare one. In being on the medicine for 2 months, I’ve packed on 40#, have no desire to do anything, feel flat almost all the time. If I feel anything at all, it’s deep sadness to the point of being unable to make myself move. I have terrible body aches, high BP and HR, and before I was doing great and feeling healthy. Right now I’m tapering down and it feels like I’m dying most of the days. Nauseous, fatigue, dizziness & vertigo… I’m coming to the point that I’d rather just be depressed and self harming than take this or any other depression “medicine”.

  4. Marilyn

    Been taking bupropion S R 150 mg twice a day for many years and have never had any side effects. Suddenly I am experiencing a very dry mouth. Could I suddenly have this side effect from it? I’m not on any new medications that could be causing it. It changes the way food tastes and I have a very foul taste in my mouth.

  5. Donna
    saint louis

    Just started taking bupropion . . .Sandoz. 2x day; 150 mg.

    Felt better almost immediately (in terms of depression). No real side effects (okay – not sleeping as well. . . wake up almost every night, like clockwork, at 3 am for about an hour. Dealing with it by going to bed earlier.)

    BUT. . . a few days ago, started itching LIKE crazy on the tops of my forearms. It is unbearable (even with benadryl and a hydrocortisone cream 1%). Doctor suggested I go off the drug for a few days to see if the itching goes away.

    I’m not normally allergic to anything.

    I’m bummed b/c I’m responding so well otherwise. I’d even put up with the itching if I thought my body would adjust. (But did I mention it’s almost unbearable?)

    I won’t take any other anti-depressant b/c I really struggle with my weight (lost 85 pounds 2 years ago). Most other drugs cause weight gain.

    Does this mean I have to choose between being depressed or having itchy arms? It’s insane.

  6. Tonya K.

    Since I’ve been taking bupropion 150 mg I have chest discomfort and aches and headaches the headaches are not to bad but I don’t have any appetite at all. Foods I used to like I really don’t want anymore and itching I didn’t have this at first cause I just went to my doctor to see how I was doing since she put me on it. I told her I was doing good no more crying moments but now after I went to her all of these side effects start up if it keeps up I will probably have to switch to something else and I have nausea too. I told her that she said that should go away its a side effect.

    • Joe E

      Used to take branded WB. Switched to generic in late 2015 (by Sandoz) for $$ reasons. Then moved and so went to a new pharmacy. Was given WB generic made by Mylan. Got one hive (thought it was a mosquito bite) and within a couple of weeks was covered with horrible itchy hives. Stopped all shampoos, detergents, foods etc. Finally decided it must be my med. Switched back to previous generic–but problem persisted. That’s weird to me. Why would I be allergic to the generic that had NOT been a problem? Weaned off WB entirely. Depression unbearable but hives all gone. Going to doctor this week to get branded WB. Hope no more hives b/c I was taking 6 Allegra per day just to keep them in check. That can’t be good, long-term.

  7. joe h.

    Have just been switched from Activis pharm to Par pharm, immediately began have tremendous side effects. Sever abdominal pain, severe dull headaches and nervous. Went back to old pills and most side effects went away. Tried 2 separate times, same result. Has anyone had a problem with BUPROPION 300XL from PAR PHARM? My insurance and medicare don’t want to pay for name brand WELLBUTRIN.

    • Susan J
      NY, NY

      The bupropion made by PAR Pharmaceuticals made me very jittery and tremulous to the point that I could not continue. The brand name drug, Wellbutrin, does not have this effect on me. Also, I took a generic bupropion in the past that did not have this effect, but I don’t remember the manufacturer.

    • Greg
      Los Angeles CA

      Hi Joe: If you want brand name Wellbutrin XL for next to nothing, you can get it from Direct Success Pharmacy in NJ. Google them. They are contracted by the brand company. Totally legitimate. Basically, for $50 (no shipping charges, either, unless you want it rushed), you get a 30 day supply. 150 mg or 300 mg. Same price for 30 day supply. You can’t beat that. When it comes to XL, I, too, had a problem with PAR, but not the same as your problem. The problem with XL generic from any manufacturer is that they don’t have the timed-release part right. With PAR, I’d get a sudden burst of bupropion sometime in the day and then not much else after. The timed-release mechanism in the brand name is far more steady and consistent.

      • Jen

        Thank you for this information on the company. I have contacted them via email in hopes of getting the name brand as my insurance are dragging their feet. I currently take generic and the side effects I find seem to corolate with the generic brand. I love wellbutrin energy but not the side effects. I am willing to pay for the RX myself at this price. Thanks for helping others out!

  8. richard

    I have been on bupropion now for a year and was wondering does it lose its effectiveness? I am on 150mg slow release. I do not feel a real need to increase.

  9. Jae

    I switched from a generic brand to another genetic brand of bupropion about 2 weeks ago.
    Now I feel like I’m dying. Constantly dizzy…. Bad bad dizzy. I feel like I am in a fog all day. Like I just woke up all day long.
    For about a week, I had body aches like I had the flu. I also have foggy vision and headaches. This sucks.

    • Shay

      Same here! I switched from the Sandoz 200 mg SR to the Watson 200 mg SR, and I am miserable! I will definitely be going back to the Sandoz ASAP!

  10. aa

    My Dr put me on bupropion for anxity, it has worked wonders for me. I feel more awake, alive, able to run erands by myself. Before I wouldn’t leave my house if I didn’t have too, not alone anyway.
    I have had side effects like chest pressure as if someone was sitting on my chest. My Dr told me to stop it and changed me to xanax, horrible, horrible, horrible felt like a zombie.
    I stopped it after two weeks and restarted bupropion, just recently I have had small blistering, clustered rash develop in my inner upper and lower eye lid with lots and lots of itching. I have read about the allergic reaction on the skin but not in the eye. I’m going to stop my med and see if it goes away. I will repost if it returns after I restart it.
    The price I pay to be able to live normally!

  11. lizzie

    Taking Wellbutrin SR has made a big change in my well being, but the most important thing I want to comment on is that a smaller dose helps me much more than a larger dose. I had to find this out through painful trial and error with my doctor.
    It seems the way my body metabolizes Wellbutrin causes serious side effects when taken in normal doses, but quitting it altogether was not the answer. Decreasing the dose was what worked.

    • Elizabeth

      Very helpful. Thank you.

    • Greg
      Los Angeles CA

      Lizzie: Your post really resonated with me. Same with me! I’ve been using Wellbutrin/Bupropion for nearly 19 years. There was a time when my body could deal with 300 mg just fine, but not anymore. Like you, I find I do much better on a lower dose.

    • Em
      Pgh, Pa

      Please please tell what the painful trial error is. I’m on the SR as well. And just recently my doc upped it bc the first month dose stopped working as well. I started noticing headaches that turned into 24hr migraines. Now not even a 1week into the increased dose the migraines are frequent and the last dose of the day just started making me feel like I was going to pass out. I love that its helping with my issues but not sure if the migraines are worth it. Or if the migraines are caused from the vitamin I’m taking it with.

  12. MH

    After trying Prozac for 1 year and gaining almost 50 pounds I had to switch to something that was going to make me a much happier person. Gaining weight on top of MDD is almost the worst thing ever. So I have been on Bupropion for about 6 months now and I have to say, this was a life miracle. I felt an instant change in my mood and I have nothing but good things to say about this medication. Bupropion will make you much happier, and it will give you the motivation to actually want to do something & if losing weight is something you want to accomplish (It was for me) then this is the pill for you! You will be ready to get up and work out.
    For anyone who is curious I started at 215 I’m now at 140.

    • Kari

      How long did you start noticing a weight loss? I JUST started the 100mg twice a day today, I have been on 75 twice a day for about 2 weeks. No noticeable weight loss, although my appetite has reduced… Just curious, I have about 30lbs to lose :)

  13. ABR

    I have read a lot of helpful information shared by others taking Bupropion after having taken the brand name Welllbutrin. I will be calling my doctor TODAY for a consult to try to get back on the brand name.
    I was put on Wellbutrin XL in 2003 after being diagnosed with breast cancer at 42 yrs old. Initially, it was 150mg, then a month later, upped to 300mg. It was prescribed for extreme fatigue, lack of energy and also to lessen the extreme hot flashes that were induced by the chemo putting me into early menopause. I didn’t really want to admit I was also depressed, but I’m sure I was. I felt wonderful! It gave me back the energy I had lost, I began exercising again and definitely helped lessen the effects of the hot flashes.
    It’s been so long ago now, that I don’t remember when I was switched a couple of times to generic brands… but it was several years ago. I just didn’t pay close enough attention! I do believe it was at the same time that I began to feel like it wasn’t working. I was upped to the max dosage of 450mg. Nothing really seemed to improve, but I was afraid to go off it. I was gaining weight due to lack of energy again, feeling very discouraged and anxious, when I hadn’t been in so long. I thought it was just me possibly becoming immune to the medication!
    Then I noticed my memory started to get worse each year, to the point I have been in tears thinking I might be getting early-onset Altzheimers. I also get fluctuating degrees of ringing in my ears. It wasn’t until a few weeks ago that I started to question the medication and not myself! I found this site and read a few of other’s stories and realized I might actually have a chance to get my life back!
    I was still a little concerned that I was grasping at straws and that it might still be me, but after reading more stories today, I’m convinced it’s not all in my head and I’m determined to find a way to feel better! BTW, even when I was concerned about the cancer recurring, I never felt so despondent, in general, as in recent years. I believe, now, that this is due to the Bupropion HCI XL, that I’ve been taking for most of the 11 years I’ve been a cancer survivor!

    • Patricia SAddler

      Wow thats amazing!!!!

    • Just Me

      Your story sounds almost like mine. I was diagnosed with blood cancer at 36 and had situational depression.
      I was put into an early acute menopause from the chemo which also gave me hot flashes and probably added to the depression itself.
      I gained due to the chemo killing the ovaries.
      I was put on zoloft 200mg & it wasn’t working. I was so tired that I felt like a zombie. I could only get out of bed in the morning for about 1 hour before my mind just couldn’t “go” anymore.
      My Drs said Zoloft shouldn’t make you tired me 300 mg of it! I said “No. I’m not tired because I’m depressed,….. I’m depressed because I’m so tired!”

      I was switched XL 150mg. I 1st gave my 2 month break altogether & started to get my energy back. Once I started generic WB XL, I got a little more energy & I lost 20 of the 40 # I gained from chemo. I switched pharmacies & I swear there is a difference in the medication.
      Does anyone know if brand name Wellbutrin is better than generic?

      I’m severely itchy after being in the sun for one hour. I have a darker complexion. I never burn.

      • Greg

        Yes, when it comes to XL, brand name is the only way to go. This is because generic manufacturers are only required to duplicate the bio-equivalency of the drug itself, not the time-release mechanism. With generic XL, particularly with PAR, the time-release is inconsistent. You might get a sudden burst of bupropion sometime in the day and not much for the rest of the day. Whereas with brand XL, the time release is more steady and consistent. You can get Wellbutrin XL (brand) for $50 a 30-day supply from Direct Success Pharmacy. They’re in NJ. You can order by phone. They are contracted with the manufacturer. It’s the greatest thing. No shipping charges unless you want it rushed.

  14. AE

    We Texans can refuse generics? I had no idea, THANK YOU FOR YOU POST :D . I was reading all the other posts and then I knew that I too was doomed to be switched from Wellbutrin… you just saved me from a nightmare!

  15. FN

    People say Wellbutrin may slightly help you lose weight. When I started Wellbutrin, I weighed 360 pounds. Normally I eat 3-7 POUNDS of food a day. Because of Wellbutrin, I feel like not only eating LESS THAN A THIRD of the amount I normally eat, I feel like AVOIDING JUNK-FOOD and DRINKING MOSTLY WATER. I’ve been taking it for 16 weeks now. It’s like a diet pill that won’t kill you and has many other purposes.
    Granted I sometimes experience confusion, a ***lack of self-awareness*** or very occasionally a headache, it’s definitely a great trade-off for not eating like a pig and feeling like I should just quit waking up and leaving my bed.
    So if you’re a fat depressed bastard (no offense :P) like I still sort of am, definitely try Wellbutrin if your doc recommends it.

    • Iamflysandy

      I used to lose weight and be full of energy on Wellbutrin, but not since switching back to it from Effexor 3 years ago. Maybe I should ask for name brand cuz getting motivated and dropping 20 lbs of bloat right now would be awesome.

  16. Erin

    Hi all,
    Just wanted to share with you my experience with bupropion. I had been taking it since last fall, mainly because I needed some energy (I have mild hypothyroidism)… most anti-depressants make me sleepy, but bupropion seemed to be good for me… it never really stimulated me at all, but at least I stayed awake and it helped my mood and definitely libido!! It was awesome for seasonal affective disorder. I don’t think I could have survived the fall and winter last year without it. So, it was a good medication for me, at least in the beginning.
    My thyroid levels are under control, but I started having really bad acne and it really concerned me. It was mainly on my cheeks, the edge of my face, around my mouth and on my chin… very big and painful cystic acne and it would bleed a lot when I washed my face. My doctor put me on ortho tri cyclen and said it might help, but months later my skin was still breaking out.
    For a week I was on vacation and I skipped taking bupropion and my skin started to get better. I stayed off it for a month or more and hardly had any acne at all, but then I started to feel very tired and was sleeping a lot during the day. I tried to take the bupropion again (by the way I was taking 75mg of immediate release generic bupropion 2x/day by Mylan) and within a week of starting it again, the bad acne came roaring back, so now I once again have scars that have to heal and the new breakouts have not completely stopped yet.
    I stopped taking it as soon as I realized what was happening again. I seemed to be out of options as far as what to do for energy and stress, so I bought a supplement called Adrenal Support (by Solaray) and when I went to my latest doctors appointment, she looked at me like I was crazy for thinking something natural would work.
    She gave me a prescription for 10mg Adderall 2x/day and I only took one today because I was a bit skeptical about it. All I can say is that I was not physically more stimulated, but mentally, yes. I felt like I could have given a seminar on pretty much anything… I had so many thoughts going through my head that I felt like I could talk someone’s ear off. I don’t know if the doctor thinks that is getting more energy, but it’s not. It’s just getting tons of extra thoughts going through my head. But I am all out of ideas because there was no way I could have continued taking the bupropion and having a face full of acne.
    I believe that it wreaks havoc on hormones, especially to those people who are sensitive and who may already have a history of hormonal issues. So if anybody reading this is taking bupropion and has developed acne, that might be the culprit for you!!!

  17. Shay0414

    How are you doing these days I read your article from March? I hope things are better :)

    • annie
      toronto, ontario

      Your post is a couple years old now, but I wanted to still say thanks and chime in on your experience.

      I have been taking wellbutrin xl 300 for about 7 years. In the last 2-3 years my hormones went haywire. Same type of acne you describe and I’m basically in a constant state of PMS. Periods are also extremely painful. All the doctors I’ve talked to about it have told me its my age (30) and hormones change at this time- my family doctor told me that if i stop drinking coffee things might improve. I took her advice and, yes, coffee does seem to have a major influence on my acne. BUT, I only drank one cup a day in the morning. So, it seemed strange that suddenly this small amount of caffeine would wreck havoc on my hormones.

      From what i’ve read coffee and wellbutrin have similar hormonal effects (both are dopamine re-uptake inhibitors and dopamine stimulates estrogen.). If that’s the case could my acne not also be a result of the wellbutrin? Or, the combination of coffee and wellbutrin?

      10 days ago I reduced my dose to 150 xl (hoping to taper off completely) and my craving for coffee skyrocketed. So much so that I don’t even care if i break out… the coffee is making me feel human and productive again. I have had one morning coffee for a week now and interestingly enough I have not broken out terribly. One or two on my chin but nothing like before. Is this because my estrogen levels are lower?

      I’m also expecting my period in one week, and in this part of the menstrual cycle estrogen drops dramatically. Unlike some people who see more acne during this time, I usually have less and get more after my period when estrogen starts to increase.

      As I begin to connect the dots, it seems as tho wellbutrin is messing with my estrogen level (which only gets worse with the addition of coffee, and maybe age).

      There is also a lot of info out there on the connection between high estrogen levels and acne (for women).

  18. Bamon718

    TO TMC-
    I don’t know that the drug being generic or not was what caused the difference. Listen to this.
    I took regular bupropin ( Generic ) 150 in morning, no problem. Had a bout of depression,[ mostly tearfullness for no reason-and not being able to leave the house by myself.]
    Doc put me on bupropin 300 XL, not only did my symptoms contiue-they got worse !
    Doc then tried 2 doses of bupropin 150 2 x a day [I know, same amount!] and it worked fine ! I’m still levelling out, but if anything I am more wound up than depressed.
    I know it doesn’t make sense-but as ong as I am not crying for reasons like ‘the mail was late’-I don’t really care which, what, or why.

    • jody

      Did you give the adrenal support a try…. I was wondering if it helped.. I had a headache everyday and didn’t attribute it to the Wellbutrin until one morning I forgot to take my synthroid and had only take the Wellbutrin and a short time later bad headache… so I stopped the Wellbutrin and the headaches stopped as well… along with nausea… I need the energy and the get up and go I felt while taking the Wellbutrin but I do not want to have to take meds for headaches everyday either… I would love to find something natural that would give me the ability to “want” to get up and do things…

      • Em
        Pgh, Pa

        Did you find something for the migraines without having to stop the bupropin? I’m getting terrible migraines but love everything else about the med.

  19. Jess

    I’ve been on Mylan’s generic (immediate release)for a week and am going to try the brand version, SR or XL because I get a huge rush as the pill breaks up as designed. I have been getting things done and feeling better (Major Dep, PTSD, etc.) I do, however, have to time when I take these carefully so I won’t be driving, having important conversations, or making decisions that have significant consequences, because I’m never sure if the initial flush, itching, anxiety (easily self-talked out of, not like real panic/terror) will strike too hard and skew my judgement, or make me speedy/sleepy.
    I’m not able to pay 300 for the brand. I’m looking into coupons, Canadian pharmacies etc. I get dry mouth and weird breath, but feel sooooo much better. I’m sorry other people have had the same less-than-ideal experience on the generics, but glad to have validation. I would not wish dealing with heartless, ignorant drones while depressed on my worst enemy.
    Some of our most amazing contributions have been made by those who saw the world differently. Invalidation by committee compounds/triggers symptoms and does not fall into the helpful category! Glad not to be alone in this.
    Good luck to all.

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