The People's Perspective on Medicine

Amoxicillin and Clavulanic Acid


Amoxicillin is the most commonly prescribed antibiotic in the United States. Unfortunately, the widespread use of this penicillin-like drug has led many bacteria to develop resistance to it.

By adding clavulanic acid to the formulation, scientists created a medication, Augmentin, that is effective against many bacteria that are not susceptible to amoxicillin alone. This broad-spectrum antibiotic is effective in fighting infections in many parts of the body including the urinary tract, skin, sinuses, lungs, ears, throat and genital tract.

Side Effects and Interactions of Augmentin

The most common side effects of Augmentin involve digestive tract upset. Nausea, vomiting and diarrhea can be troublesome for some people. Other adverse reactions to be aware of include skin rash, itching, vaginal infections, stomachache, gas, headache and vomiting.

Less common but possibly more serious side effects include liver enzyme elevations, anemia, blood disorders and psychological reactions. Report any symptoms to your physician promptly.

Long-term treatment with penicillin-type antibiotics requires periodic monitoring by a health professional.

Augmentin may interfere with some urine tests for diabetes and produce false positive results. Augmentin should not be taken with tetracycline or some other antibiotics. Notify your doctor if you are on such a drug for a different condition.

Special Precautions

Because amoxicillin is related to penicillin, anyone who is allergic to this class of antibiotics must generally avoid such drugs like the plague.

Symptoms such as breathing difficulty, wheezing, sneezing, hives, itching, and skin rash require immediate emergency treatment. Life-threatening anaphylactic shock may produce an inability to breathe and cardiovascular collapse and can occur within minutes of exposure.

If you experience a serious reaction and you ever have to go into the hospital, make sure a sign is placed over the bed alerting hospital personnel to penicillin allergy.

Taking the Medicine

Augmentin can be taken with meals or on an empty stomach. It is generally best swallowed with a full eight-ounce glass of water.

To maintain adequate levels of the medicine in your body, it is usually recommended that doses be given every eight hours. Check with your pharmacist to see how you should adjust your schedule to get the third dose in on time.

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About the Author
Joe Graedon is a pharmacologist who has dedicated his career to making drug information understandable to consumers. His best-selling book, The People’s Pharmacy, was published in 1976 and led to a syndicated newspaper column, syndicated public radio show and web site. In 2006, Long Island University awarded him an honorary doctorate as “one of the country's leading drug experts for the consumer.” .
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I too am taking Augmentin for sinusitis. I haven’t tolerated any antibiotics very well for a long time. I take it with food and after brief acid stomach feeling, am fine. I have been an RN for over 40 years. Antibiotics used to never bother me but as I entered my late 40’s, it changed. Everyone responds different to all medications. I always encouraged patients to be an informed consumer. Web MD has a good information website for medications.

I took Augmentin for four days for an upper respiratory infection. I was suppose to take it for 10 days. Since day one the stuff made me feel awful as others have said worse than the infection I was being treated for. I had dizziness, headache, stomach pain, and nausea. By day four I took it and a few hours later had to run to the bathroom and throw up.

I immediately quit taking it and had horrible diarrhea for the next 3 days. I had to call in sick from work and laid on my couch in and out of consciousness for two days. Avoid this at all costs! Of course this could just be me but by judging from all of the other comments this stuff is terrible. Good luck if you are currently taking this crap.

I took Augmentin 625 for typhoid fever 2× 7 days… I tell you the first 3 days was mild.. After then I started having this funny feeling of upper abdominal pain,body pain, chest pain and palpitations.. It wasnt funny at all… am done with it now but I still feel slight chest pain and body ache too.. My pharmacist asked me to take more of water for the side effects to wear out speedily.. I pray I will never take Augmetin again!

I went to the dentist to get help for my teeth, found out I had decay, lots of it. I was having pain but after x rays at one place, I was told nothing was seen so I went to a different place and got help.

I was given Amoxicillin for a week taking it 3 x’s a day 500 mg. but since it takes like 6 days to kick in I was having head aches and felt poorly. On day six, I started feeling better. After more treatment and telling the dentist, he put me on Amoxicillin with Clavulanic Acid 875 mg/125 mg. two times a day, every twelve hours. The only time I had diarrhea was the first night of Amoxicillin and then it stopped after Imodium, gas x, and Physillium seed mixed up in hot/warm water. Took a total of 4 immodium and I even wore a diaper brief, just to be careful. After that no more issues.

I was glad to get help to save my teeth even though I had to get new crowns, and a root canal. I took 7 days of Amoxicillin and 7 days of the Augmentin. I see my dentist soon and hopefully I can get one damaged tooth extracted since I had an infusion of Reclast to save my bones from getting worse. So have to find out if I can get a very decayed tooth removed. I do not want bacteria staying in my jaw.

I did not have any more problems with the antibiotics and plan to keep taking probiotics 50 billion a day to help my gut. I think I may need to take more antibiotics after getting the tooth pulled. Can not believe all the trouble with dentists and happy to find a good group of people to help me. I was shown the decay and could see the problem with my own eyes. No problem with this med although I guess problems can come later, but just eat right and take probiotics. Keeping the infection in your body is worse for your organs, so I would rather take the antibiotics.

I was prescribed Amox-Clav(Augmentin) for 5 days for urinary tract infection and after 3 days developed a blistering type clusters on eyelids,above eyes, below eyes and on areas of face. This itchey rash leaves skin looking like you had a bad sunburn with scaling, also stomach pains and cramping, bloating and diarrhea. I did finish taking however, I will definitely will not take again.Still recovering. I am 80 yrs. old(female).

I am also taking Augmentin now and have felt nauseous and have had stomach pains that feel like severe gas expanding my stomach. I have taken Amoxicillin alone many times with no side effects at all. I also stopped taking the Augmentin after the second day when I took it on a partially empty stomach and felt worse than the condition I was taking it for was making me feel. I have 3 days left and believe me I have put on weight over the last week just from ensuring my stomach is full before I take it. Seems nuts. I am going to contact the pharmacist and see if they can give ma an alternative to finish out the week. The symptoms of the sinusitis I am taking the med it for are reduced but have not been eliminated. smh

I was prescribed AmoxClav for a sinus infection. I took the first one and a few moments late, I got an intense fever with sweats – my body just kicked all the bugs out of it! My stomach is so painful, nothing helped, not even paracetamol or nurofen. I had to take my 2nd dose lastnight :s I couldn’t sleep because of the stomach ache! It was so unbelievably unbearable, I almost cried…and I’m the type that can tolerate loads of pain. I mean, I was laughing through childbirth for goodness sakes! My sinus infection is still there, but I’m tempted to just give up on these certain antibiotics.

I took Augmentin in May 2014 for what I thought was a sinus infection. Three days into taking it I was extremely nauseous and couldn’t eat anything but bread. I felt so horrible that I stopped taking it (after 3 days) even knowing you are supposed to take all of a prescribed antibiotic.

My urine turned a dark, dark orange color and smelled like smoke. (I don’t smoke.) I went to my doctor and she did a urine test and discovered blood in my urine, but no infection and no signs of cancer cells. I then had to go to a Urologist for a kidney ultrasound and a bladder scope to see if there was anything wrong that they could see. Fortunately everything checked out OK and I’ve gone to the urologist every 6 months since then and they still detect blood in my urine (the mircro kind —not like you can see blood).

I am tired or worrying about this and tired of not knowing what happened. All I know is that I was fine before I took Augmentin and I haven’t been fine since.
If anyone has any insight, I would be very grateful.

I am currently taking this medication for an ear and sinus infection. Day 1 and so far no problems and praying for nine more days problem free. Will keep you guys posted!

Shawnda from GA, Your Microscopic Blood appearance is a different issue from your use of the drugs, I am not a doctor however. I have Micro-blood, and all the doctors can do without knowing a source is keep an eye on the amount. Keep up with CBP every year which will measure the amount of blood.

Treat any and all UTI’s as directed. I went through all the tests to see where the blood was coming from including a MRI, and the same tests you got. Nothing was there thank goodness. The only other option is exploratory surgery which I was unwilling to do at this point. Final diagnosis was a Hematora of unknown origin. that was 3 years ago. Just get your blood panels check every year and keep an eye out with your urine content.

was prescribed this medicine for A finger laceration on my right pointer finger a five-day course and five days worth of diarrhea and stomach pain but at least I pick up my last pill yesterday and hopefully things will start to clear up also,had weird hot flashes while taking them but no fever

I was admitted to the hospital for a perirectal abscess, and was given a regimen of intravenous antibiotics (along with morphine every four hours to control the pain). I was prescribed Amox/K Clav (20 pills) after I was released. I had night sweats for a couple of days, but they went away. I made sure I took the medicine with food, along with a Zantac which helped to control some of the stomach distress, although I did find myself having more frequent bowel movements. I had some problems with insomnia and a general feeling of “loopiness”, although I can’t contribute that directly to the medication. The abscess is gone, I’m not in pain, and I didn’t need surgery this time. Taking it was worth the side effects for me.

Have been on Amoxicillin and Clavulanic Acid for a tooth that had to be extracted and for a hole in a sinus cavity with the infection still up there. Was already on 7 days of just the amox and felt great prior to going to the dentist. The tooth still had to come out since it broke apart and abscessed the week before. The oral surgeon gave me a numbing agent, which only lasted for hour. The tooth came out in pieces, and they patched up hole, along with giving me this drug.

After severe screaming pain on Friday, I am now on my 3rd day of Amox/Clav. So far the worst side affects are the pressure in my upper gut, burping from acid reflux, breathing problems, and trouble falling asleep. At 2 or 3 in morning I am still awake.

I will go to holistic doctor soon so he can help me through and neutralize any side effects. My tooth is better but my gut hurts. Taking a potent drink of probiotic prescribed by my holistic doc, not like any you can buy, really helps.

That is a wicked drug, and I’m so sorry for the side effects everyone is having. I have 7 more days on this. So, the breathing problem and not sleeping are the worst. I do wake up with a headache, and then it goes away. But I get dry-mouthed, and my lips crack. I can’t wait to get to a holistic doctor. If you’re having serious issues, get off it.


I had a reaction to this medication as a child, a full body skin rash, but not serious at all, I wouldn’t have noticed it if not for the funny looks of my family. Just now have had a very similar to amoxicillin, though I’m pretty sure I’ve been prescribed it before without any reaction. Perhaps it’s because this time was in conjunction with an anti-inflammatory?

Anyway, it’s a little disappointing to read many of the comments here. Severe infections can be life threatening, and it’s very sensible to prescribe a strong medicine. Thousands of people take this and other medicines daily, and many lives are saved. Of course it’s terribly unfortunate that a few people have severe reactions, but that’s not to say the medicine is bad. Biochemistry is extremely complex, and killing an invasive debilitating organism without any collateral damage, especially since we are all slightly different, is impossible. As a suggestion to those with ongoing digestive tract problems, remember that antibiotics kill bacteria, and your body hosts many bacteria that are actually necessary to our digestion, so it’s likely your troubles are from lack of this bacteria, rather than the medicine itself, per se. Probiotics (yoghurt family) may help, or in extreme cases a fecal transplant – an unfortunate name, since no fecal matter is actually transplanted, what happens is the intestinal bacteria from a healthy donor is given to someone else, fixing their lack of digestive bacteria.

I was prescribed Augmentin and a steroid just to get the inflammation out before taking a scan of my sinuses. I have been suffering for three months and see no end to it. Can only eat a bland diet. Have stomach pains and no appetite. Doctors have done all the tests and can find nothing. They say this was caused by Augmentin. How long will my stomach be messed up?

I was given this medicine for a severe ear infection and white patches on my tonsils. From my first dose I experienced severe dizziness and nausea. I’m a type 2 diabetic I took my 4th dose and it will be the last. This medicine is absolutely horrible. Be careful

My husband is having severe headaches ( like lightning striking with pain in his head) and fever with this, guess some people do well on this medication and other do not.

I was prescribed amox clav for a sinus infection. I started taking it on a Friday, and by Sunday I was miserable. I couldn’t eat anything without being sick, I had a headache, chills/sweats, and was exhausted. I kept taking it for 1 more day and then called my doctor to see if I could switch to something else. She just told me she would prescribe anti-nausea medication. I tried that and it still didn’t help. I stopped taking it on Tuesday night and am still feeling sick, but I can at least eat some bland foods now. I’m really hoping I feel better soon as it’s been a very unproductive week for me at work because of this awful medicine. I will definitely be requesting something different if it is prescribed to me again!

I took this medication as directed, after reading the horror stories here. I read every bit of the paperwork and took the augmentin with a meal and made sure to drink plenty of water, in my case it was well over an 8 ounce glass. I had no problems at all. Fifth dose today, with breakfast, juice and lots of water, still no issues at all..and it’s working. My advice is to talk with doctor or pharmacist and take all the rest with a grain of salt.

I was prescribed Augmentin for some sinus problems. I had previously told this new doctor I couldn’t take it, because of stomach issues. Well he gave it to me anyway, abd I stupidly thought ‘well it has been 15 years, and things change.’ So I took one days dose. And then proceeded to have stomach issues for over 3 weeks.

Every time I ate anything that contained protein I had issues. In the beginning it caused bloating and vomiting. Later it just lead to heart burn, bloating, and nausea. It didn’t matter if it was meat, dairy, or soy protein I wasn’t able to tolerate it. I couldn’t even eat my daily yogurt to help make it better. It has finally begun to get a little better. It is crazy that 2 pills can do that much damage, almost a month of issues. No thank you Augmentin, I’ll stick to the ones I can handle if absolutely necessary. I still believe a lot of medicines do more harm to us than good.

Urgent care nurse practitioner prescribed Augmentin for my sinus infection. I was shocked to see that there are 20 tablets for the entire course. Dreaded that. 3 tablets and 3 bouts of diarrhea so far. Thanks for sharing your experiences everyone. I am now convinced that I should stop taking it. My stomach has not stopped being queasy. It keeps churning and making noises. I am nauseous and my head spins a little. Furthermore, just read an article that our body naturally cures sinus infection (viral or bacterial) without the help of antibiotics. Antibiotics shall just be given with patients with illness that make them weaker to fight eg diabetes, etc.

I was prescribed this medicine for a sinus infection. After the first dose, I began having diarrhea. Next day, the horrid headaches began and the fever. By Day 4, I was in so much stomach distress I had to miss work and slept most of Day 5. Sweats, chills and fever not to mention the aggressive diarrhea and stomach pains. By Day 7 I quit taking the medicine and now trying to cure my diarrhea, stomach pains and fever. This is Day 8. I will never take this again. If you have to take this medicine, proceed with extreme caution. After reading other comments I’m hoping I stopped soon enough and I’ll be able to get to my normal self soon.

White pus on tonsils*

My doctor was closed last Thanksgiving and an urgent care Center prescribed me Augmentin for severely bad strep throat (ugly puss blotches all over my stomach) 3 days on the pill did nothing, the puss spreading, when. You doctor returned I got Z-pack and the infection went away immediately, with that said, my stomach has not been the same since Augmentin my bowel movements have changed for the worst and my gastrointestinal doctor could only surmise that the augmentin rewired the way my stomach works

Stay away from this drug

2nd day using this med and it resulted in serious uncontrollable diarrhea… hope this was a one-time event- very uncomfortable…

I was pre-prescribed this medicine amox clav for 10 days for a nasal infection… minutes after taking it, I broke out in sweats. I have used the bathroom diarrhea 4 times in 4 hours worst of all I have severe chest pain which I have NEVER experienced before. Feels like you’re dying when you take this gross medicine

I am 71 and have trouble swallowing pills. Can this medication, AMOX TR-K CLV 875-125 MG TAB, be crushed and taken with applesauce?

Worked just as intended to treat an infected cat bite. No side effects.

I was given augmentin for a toothache. I took one pill and went to bed. When I woke up my face was swollen beyond recognition. I went back to the hospital only to find out I was having an allergic reaction. Funny I never had a reaction before. 100 cc’s of benadryl and steroids for a whole week.

I was given Augmentin for a sinus infection at the beginning of the year. Right after finishing my two week course, I stated getting extremely itchy and was tested for a yeast infection which came back negative. I also had blood work done and had an elevated lipase… No liver or pancreas inflammation, but have changes in my duodenum plus inflammation, chronic stomach and intestinal issues, chronic loose sticky stools, am now lactose intolerant and can’t eat red meat, pork, can’t tolerate gluten and have lost weight.
I am currently low FODMAP diet, gluten and dairy free. I’ve been to numerous doctors. No one seems to be able to heal my gut, not even with high dose probiotics and bland diet. One test (CDSA) showed Augmentin pretty much wiped out all of my good bacteria. I took OTC probiotics while taking it and for weeks afterward, but obviously it didn’t help. I didn’t have any of these issues before. I think someone needs to look into this drug and the side effects more. What good is an antibiotic if a person is sicker after taking it? It has been nearly eight months since I took it and I’m still sick and low energy since I have malabsorption now as well.

I took this about 4 weeks ago and am still extremely itchy, like my skin is oversensitive. I have been so miserable. I have an appointment in 2 days. I am changing doctors in hopes of an answer. What did they say was up with your itchiness?

I am having pretty much the same issues. Took this in May and it somehow broke something in my stomach and now I also have low white blood cells!!

Diagnosed with a sinus infection and was given this antibiotic I have only taken two pills out of the 20 I have to take and each time immediately after I got a severe headache and stomach pain. I then got diarrhea and it felt like bugs were crawling on me. The side effects seem to last for hours. I hope that it will fade as I continue to finish my antibiotics if not the doctor may need to put me on something else because this is horrible.

Age 57 male was given this drug (amox tr-k clv 875-125 mg) for sinus infection but was in there because acquired a tick bite from three days early…. take drug two times a day for 10 days… about the 7th day a little nausea but didn’t think about it to much..
but then day 8 super joint pain, headaches, chills, slight fever, sweats… by the way sinus infection gone in three to four days.
I was reminded by the doctor to finish the medication.. yeah yeah heard that before.. went back to doctor day 8 I knew either drug or tick bite.. doctor examined me was told not tick that this drug can cause ALL KINDS OF POSSIBLE SIDE EFFECTS…STOP TAKING THIS
Started on 5 June now the 16th still.. still joint pain, headache, woke up this morning in a full sweat…just soaked head to toe, try to take the pain as much as possible.. use advil.. 20 minutes later its like unlocking the body everything felt as before I ever took this drug… sorry forgot also pain on both sides of body… now I think was my kidneys… not a drinker, smoker, drug user.. believing in healthy living… never sick… work in public for over 25 years… I am never… NEVER JUST GOING TO TRUST WHAT DOCTOR PRESCRIBES…
I can’t tell you all the checking a do with businesses, contractor, companies, and peoples on the NET…. why didn’t I check… IF YOU CAN STAY WITH THE OLD TRIED AND TRUE… DON’T GO OUT OF THE BOX ON THIS… I swear the pharmaceutical companies are using us as guinea pigs… and getting away with it… and ours laws are letting them…. so many death are acceptable in their eyes… I CAN’T BELIEVE I DIDN’T CHECK…… WARNING…. WARNING… WARNING….

Since its been a most a year since your post, I am curious how you are doing because I have similar effects as you after taking this drug for 11 days… thanks..

SGS – Upon reading your post and having been treated in the past for acute Lyme Disease, under care of USA’s top LLMDs (Lyme Literate Medical Doctor), what you describe regarding the correlation of having been bit by a tick and the reaction you experienced from Augmentin COULD POSSIBLY very well be a Herx reaction.

IF you had a spirochete infection, the antibiotic upon killing the organisms will release this killing off of toxins into your blood stream which exacerbates your symptoms. HOWEVER – the good news is that you’re victorying over the infection, killing of infection. Many patients undergoing Lyme Disease treatment will state, “I feel worse on the antibiotic,” not realizing they have to get worse before they get better. Sinusitis is not uncommon for those infected with Lyme Disease, it is multsystemic and affects throughout your system. Hopefully you are doing better, and hopefully it was only sinusitis. IF you have infection of Lyme Disease as well, it will have been a blessing regarding that the onset of your sinusitis allowed you to encounter and examine further the possibility for Lyme Disease and its treatment. Best to you – JJ

I was prescribed the amox/k clav for a severe ear infection. Along with this prednisone steroids. I took my first dose this morning. 5 hours later I began to get queasy. 5 minutes later I was throwing all my breakfast up and into the garbage can. I will try it once more but if it happens again I will discontinue using it.

I was told to take this with food, but forgot one time on my fourth dose. Within minutes of taking the pill, I started to get severe heartburn and nausea. It was so intense, I swear my esophagus was burned. Now it feels as though there is a lump in my chest in that spot, and it hurts to swallow anything when it passes that spot. I stopped taking the medicine in fear of the pain, but it’s been three days and I’m still feeling awful. I keep burping up stomach acid and I’ve hardly eaten since then because of how painful it was. Never had heartburn before like this!!

I Am so glad to be reading these comments. I am being treated with Augmentin for a sinus infection and have the worst heartburn/chest pain of my life. I feel like I am dying. Wow this stuff is awful. Comforting to see I am not alone and not life threatening. Thank you.

I too experienced terrible heartburn – thought I was having a heart attack! The absolute worse I’ve ever experienced. My throat and chest literally burned! I thought is was the sandwich I had eaten with onions! I drank milk, drank water, ate a slice of bread, tried Rol Aids, and it finally subsided. I took it with food and have continued to take it with food, but still have some heart burn – not as severe as the first time! I’m hoping this sinus infection will hurry up and heal, but so far, I’m still fighting it and it seems a bit better every day. Just can’t stand the heart burn!

Well I’ve been taking this drug for fours days now, I have black stools? Is this a common effect?
People’s Pharmacy response: Black stools generally warrant a call to the doctor’s office, with the exception of Pepto-Bismol. It could indicate intestinal bleeding and should be checked out.

I have been prescribed Amoxiclav for 100 days for a spinal infection. I am usually very stoic but three weeks in to the course I am suffering very bad nausea and am trying to work with difficulty. I am wondering if this situation passes off with time. I have tried to eat more, peppermint and ginger ale but nothing works. I know I need to take the whole course to try and cure the severe back pain I have endured for the past 7 years. Any advice welcome I am very despondent if I can continue on with this…

Hi CAS. I was recently prescribed Amox. for the same type of thing. I noticed you posted in April of 2014. Did it work for the back issues? How did it work out? Did it cure the back pain? How did you end up dealing with the other side effects? Any info is much appreciated. Thank you.

I was prescribed Amox trk clv 875 125 for bronchitis. I have only felt tired and hurt around the heart area with a warm feeling. I haven’t been able to sleep well. I was given z PAC 2 weeks before with only minimal results. Hope this is working, tired of checking compatibility of drugs. I am type 2 diabetic and blood tests are very low at times with amox. I will continue to use if no other problems are encountered.

I was given this medication for a sinus infection and the first day taking it I noted could not sleep that night. I ended up with fever, horrible aches, hallucinations and it wired me so I could not sleep. Worst night of my life, would not take again.

I was given this drug, like others, for sinus infection, along with Methylprednisolone. The Prednisone made me very irritable, very restless and gave me insomnia. I was so focused on those side effects from the other med that I didn’t notice the side effects from the Amoxicillin at first. Or perhaps they weren’t there – not sure.
But with about two days left for the antibiotic, I started to have lower back and lower abdominal cramping. I had this once before but in my stomach when I took clindamycin, a very dull, aching throbbing feeling. Other than the cramping I have had no other side effects. The sinus infection appears to have gone away – with the exception of the swollen left eye that I always seem to get when I have a sinus infection. Hoping that the dull aching pain will go away now that I have stopped taking the meds since yesterday.

My dentist prescribed this medication for an abscessed tooth. The dose is described as 875/125 mg. The pharmacist cautioned me to take only with food. I made a point of eating a substantial lunch and took the first dose mid-meal. After approximately one hour I began frequent projectile vomiting, which lasted about 24 hours, and began to decrease in frequency after 8 to 10 hours.
My distinct impression is that a second dose would have put me in the E.R., a third may not have been survivable.
I’m a 66 year old male who is not allergic to penicillin. In fact, my dentist switched me to penicillin, which worked fine.

I have been prescribed this drug a handful of times. It works every time, but as I get older (now 43) I find that I tolerate ALL antibiotics poorly. No matter what the antibiotic I always have a severe yeast infection. I talk with my Dr. and he writes a prescription on the same day as the initial visit… I’m not waiting on this anymore. Yeast is my most severe and bothersome symptom… but fairly easy to fix. I always now get diarrhea as well, and I have to admit this is the quickest onset of the problem and worst one ever… sorry for the details, but I almost feel I am leaking. However…. I was absolutely miserable with a sinus infection. I cried at the silliest thing for an entire day which made the symptoms worse. I was so dizzy that if I closed my eyes, moved them, then re-opened I almost fell down. I felt I had been kicked in the face because the pressure was so bad. So if I had to choose to continue that or have a yeast infection and severe diarrhea…. I’ll take the meds. 4 doses later I can tell a major difference. I’ll talk with the pharmacist and see if they recommend anything for the diarrhea.

I too had the same reaction from this drug, which was prescribed for a slight infection from a dog bite. A few days after quitting the 5-day regimen. I developed thrush and very sore lips. Instqtin, a fungus fighting mouthwash, was the answer to that , said the P.A. It was, I guess, but that has taken nearly a month. A mistake to have taken anything in the first place.

The doctor proscribed me Amoxicillin/clavulanic acid. Everybody saying that they have had rashes, heart burns, and bumps popping out. Maybe I shouldn’t take it. I’m really scared.
People’s Pharmacy response: Keep in mind that people who have had no problems, just good experiences with this antibiotic, don’t usually post here. It is meant to cure a serious infection that could also cause you harm.

I was prescribed this med. For a sinus infection and have not bad any problems at all my prescription was 875-125 mg twice a day. After the third day I felt a lot better with no side effects at all

I suffer from chronic sinus infections (about twice a year when the weather changes). I take Augmentin for them. I have recently developed GERD and upon taking my latest round of Augmentin, have been experiencing TERRIBLE heartburn/ reflux. I only have two days left, so I will persevere, but I am going to explore other antibiotics.

See my comments from May 14, 2013. If your itching is really bad, you may be having a reaction that’s toxic to your liver. I started itching 3 days after I finished my round of Augmentin, and by then my bilirubin was up to 15 (should be less than 1.5). If you’re itching all over, you may want to get a blood test, either through your doctor or the ER, and take a look at your bilirubin and ALT (liver enzyme) numbers. Hope you don’t have what I had!

I had taken Amox TR-K CLV 825-125mg that night I began to throw up. The next morning when I have awoken I had red colored bumps all over mainly the top of my legs everywhere on both then on stomach and on my chest, sides and my back. Its freaking me out and I’m starting to feel some pain in my stomach. I don’t want any more problems than I just got over, is this just a bad skin rash from this medicine and even my face itchs. Will it go away?? PLEASE LET ME KNOW

Got prescribed this after I thought I was bit by some insect or bug (or w.e)(doc says it wasn’t a bug), but since I had swollen lymph nodes still and 6 months before I had swollen lymph nodes as well she prescribed me Augmentin 875 2x Day for 7 Days. I would say on the first day I was ok, I guess it had to kind of build up in my system before I got some bad effects. I eat when I take it like I am supposed to though and avoid milk as the precautions say.
One day I was at work and needed to take a dose, and I just wish I didn’t have to take it at work because I became sort of zombie like (mostly just sluggish) and clumsier than usual (I don’t think its hard to fill a 3 oz cup with liquid and you keep dropping the cup) … that made no sense, at any rate I haven’t really felt as bad as that afterwards, still feeling a bit weird but it is helping my infection because I don’t have the pain in my neck anymore (where the insect bit me).

I was just prescribed this medication for a sinus infection 2 days ago. So far my only bad symptom is diarrhea! I am hating it! I might lower my dose to one horse pill a day. Those pills are HUGE.

I was prescribed these for a swollen lymph node/persistent strep throat infection. I would literally rather die than take this antibiotic again. I took amoxicillin years ago and had a little trouble like I do with most antibiotics (easily upset stomach), but this time, I took one pill and it felt like I was being stabbed in the stomach.
Eventually I was curled up in a ball sobbing from the pain and cramping, and I had nausea and severe diarrhea for three days from just the one pill. There was nothing that would help. I refused to take it again and had my doctor prescribe something else; she was frustrated with my intolerance but I’m convinced this medicine is straight from HELL and I’ll never go near amox-clav again.

I was prescribed AMOX/CLAV XR 1000mg/62.5mg 2x daily for 10 days along with Prednizone 20mg for 5 days for what the Dr thought was a severe allergic reaction on my face that was infected. I am diabetic, and was told that if my blood sugar went up [???] to just take double the medicine I take, [I take 4 pills in the AM and 1 in the PM].
After breakfast the first day my blood sugar dropped to 62, but by bedtime it was still over 200. My face is much better except for being dry and rough. I have felt good, very energetic although last night I couldn’t I couldn’t sleep.
After reading the comments from people taking these 2 meds I have decided not to take any more and maybe my withdrawal won’t be as bad as some of the ones I read and I can get my blood sugar back to normal.
People’s Pharmacy response: We think that when taking an antibiotic for an infection, it makes sense to follow the course through unless you experience a severe reaction to the drug.

These were the exact same symptoms I had at the beginning of my ordeal. I hope you are OK. If not, post again and maybe my experience in getting through this nightmare will help you out.

I was prescribed Amox Tr-K- CLV for a gallbladder infection. I broke out in hives/skin rash. My urine in very dark. I have not been myself since taking this med.. I have a doctor apt. in the morning.

Hi RW, our son has the same problem since yesterday. Took him to ER and doc prescribed another antibiotic for the ear infection. But since then hes been to the bathroom at least 4 times with loose motion. What ended up helping your daughter for the stomach? Thanks.

I was prescribed generic Augmentin for a sinus infection. I took one pill at 10:30 pm, and by 12:30 am, I was up vomiting, which lasted through the night. I spent the next day in bed. I’ve taken straight Amoxicillin many times in the past with no adverse effects. I feel that it had to be the addition of the Clavulanic Acid that caused the nausea. Won’t take this medication again.

I was given this for a sinus infection and have been on it for about 4 days with another 10 days to go. So far my side effects are diarrhea, nausea and seem more tired.

I was prescribed Augmentin by my dentist after a crown repair. It was a short 3 day course. 2 days after I finished, I started feeling itchy all over. We went to the E.R. and they found my bilirubin was at 9.1 (shouldn’t be higher than 1.2), and my liver enzymes (mainly ALT) were elevated. They admitted me, and ruled out gall stones, cancer, etc. They discharged be and had me make an appointment with the doctor on call at the hospital.
In just 48 hours, I was much, much worse. He referred me to a hepatologist. They checked my blood and bilirubin was up to 15; ALT was up to 100 (shouldn’t be higher than 55). The doc asked me what medications I had taken, and as soon as I said Augmentin, he said, “of course!”.
My first symptoms appeared right after Thanksgiving. By Christmas, my bilirubin was up to 28.1 and my ALT was up to 438. They were talking about the possibility of putting me on the liver transplant list.
Before I got sick, I rode my bike 150 miles per week; at year’s end, I couldn’t get up the stairs without getting exhausted. With my bilirubin so high, the itching felt more like electrical shocks all over my body, about 30 per minute, 24 hours a day. I couldn’t get more than an hour of sleep at a time.
Fortunately, I had a great doctor, and after 11 weeks, I started to get better. My liver was finally restored to full health the middle of March. Apparently, there are around 35 million doses given per year, with around 1,000 reactions like mine.
My doc said my reaction to Augmentin was probably genetic. It was by far the worst experience of my life.

Severe cat scratch and bite after rescuing my cat when she had her claws stuck in her cat perch. PA gave Amox TR-K CLV 825-125mg twice a day. Day 6 I am back at Doc with what I think is the starting of thrush – my mouth feels burned, dry and the inside of my lips is inflamed, red and VERY sore! She indicated was a reaction to the ‘acid’ part of the amox. – great, just great. Now on Amox regular for another week and a lovely yeast infection now from the higher powered stuff – I just can’t win!

I took Augmentin for 6 days for an ear infection. Five days after stopping the antibiotic, I developed a rash over trunk, upper arms, upper legs. That took 3 days to clear. Two days later, I experienced chills, mostly in legs and arms. A really odd feeling. I am taking mutli-vitamin B, and hoping this disappears. By the way, the ear infection appears to be cured.

My daughter caught the flu and it turned into a double ear infection.
ER prescribed her Amox TR-K CLV. She has woke up with severe stomach pain and became sick. She did not have any stomach problems before the medication I may note. She also started running a high fever and her and my husband are back at the ER as we speak.
I had called before hand and luckily was able to speak to the same doc from earlier this evening. He said because of the fever bring her back in. Just waiting to hear of any news now. But I honestly wish they would have just given her the amoxicillin alone, she has used it in the past for ear infections and it worked fine. It’s bad enough having a little girl miserable from flu symptoms and ear infection but to add stomach problem that could have been avoided is just awful.

Last year I had a terrible cough and skin rash which hadn’t gone away for over 100 days. I had seen over 5 different doctors, and none medications prescribed had worked. I was then prescribed Amoxycillin and Clavalanic Acid 300 mg for 7 days.
During the last few days of taking the medication I began to get what I thought was heat rash from wearing stockings all the time in the heat. After a few days it began to spread down my legs and become larger in size, they were itchy and raised above my skin and very red in colour. I thought nothing as I have always been allergic to raspberries and gotten hives from eating them and it usually went away in a few days.
The hives then became aggressive and spread to my arms, stomach, back and neck. I took myself to the doctors and they said it was nothing and gave me anti-heistmens for the next took weeks I went to 5 different doctors and none of them knew what was wrong with me even the one who had prescribed the medicine to me.
After going to the another doctor and getting different anti-heistimens I was finally back to normal and non spotty red. I have taken many different medications and know I am not allergic to penicillin so would I have been allergic to the clavalanic acid?

Well reading the reviews on this medication, it has convinced me to NOT take this medication that I Was prescribed for my sinus infection. I’m already diabetic, I don’t have time for that! lol Seems like a small portion of people can take this medicine and have a normal outcome, but it doesn’t seem like anyone here has had a positive result.
PEOPLE’S PHARMACY RESPONSE: Please realize that people who do well on the drug (probably most people who take it) have no reason to report their experience here, so the sample is skewed. We think it is helpful to know what the problems may be, but do recognize that many people get benefit.

I can’t remember it affecting my tongue but it gave me a severe rash with many purply pustule type eruptions all over my chest and upper arms. My urine was very dark and my LFT’s (Liver function tests) took about 6 weeks to return to normal. I have suffered from mild puritus (itching) for 6 months. Clothing containing synthetics was most uncomfortable. During the first 6 weeks of the reaction, having my back scratched by my wife was like going to heaven. The liver specialist told me it wasn’t an allergic reaction rather it was a genetic reaction – don’t really know what she meant by that.
I had a severe head injury and was given about 4 IV injections of Timentin in the hospital which contains clavulanic acid. I then had 3 weeks of Augmentin pills and I started feeling ill 2 weeks to the day after I finished them.
I think now – 7 months after the accident – I am fully recovered and I don’t think I will take antibiotics containing clavulonic acid again.

I just started Augmentin as a result of gastric attack or constipation and was hospitalized for it. Is one of the side effect getting strange sensation on my tongue???

CAUTION! Clavulanic acid can, in rare individuals (I am one!) result in quite severe liver poisoning — symptoms, jaundice, skin rash and eruptions, elevated liver enzymes (the diagnostic evidence). In my case, recovery required a full four months.

I was given Augmentin DF after a head injury because the doctors were afraid I would get bacterial meningitis. I took it for 3 weeks and then 2 weeks after I finished I started feeling terrible. I was admitted to hospital with a rash, epigastric pain, terrible pruritis and really dark urine.
My liver levels were right out of balance. I really thought I was going to die. It is now 5 months later and I have recovered by about 95% but I find now I cannot wear clothes which contain polyester – they make me feel really prickly where they touch my body. I also get slight sensations like an insect is crawling over my skin – mostly around my stomach.
To recover I didn’t take anything, I was just treated very conservatively. According to a liver specialist I had a rare genetic reaction – not an allergic reaction.

Amoxiciliin-clavulinate (Augmentin) has caused me significant heartburn and nausea. Probably not appropriate for those with GERD/hiatal hernia.

I was prescribed by a dentist with augmentin. I’ve been taking my medication for 10 days when itchy skin rashes appeared. First it was only on my legs then it spreads to my body, my nape and neck, then on my arms and back.

I was given Augmentin for a sinus infection and because I had an infected puncture wound on my palm from my cat clawing me. 6 days into treatment I developed a rash that started on my back and rapidly spread to my whole trunk… two days later it was going down my arms and legs. Now it is over 3 weeks later and I am on steroids to calm down the severe rash reaction I had to the augmentin. Can I assume that I am allergic to Penicillin? As a child I was given penicillin shots many times with no bad side effects. Have I developed an allergy?

I was given Amox TR-K CLV ( Generic for Augmentin ) 500mg three times a day for five days, for a dog bite on the lip, is this a long enough course of this antibiotic?

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