Ambien is out, Chinese fungus

According to the CDC, 33% of Americans don’t get adequate sleep. Chronic insomnia is linked to all sorts of serious health problems including diabetes, hypertension, obesity, heart disease and depression. In addition, many people feel less alert the day after taking a sleeping pill. As a result, they are  more susceptible to automobile accidents. Not all those people have trouble falling asleep. Many individuals fall asleep without difficulty but wake up in the middle of the night to pee and can’t get back to sleep. This woman shares a familiar story:

Q. My husband has tried many sleep aids over the years, but they don’t KEEP him asleep. He falls asleep in just minutes but wakes up about four or five hours later and cannot get back to sleep.

He currently takes trazodone and it doesn’t help. Neither have Ambien (zolpidem), Lunesta (eszopiclone) or melatonin.

He is active during the day. He tried counseling, but dropped out and refuses to go back. Do you have any ideas that might help?

A. There are two prescription medications that are supposed to help with this problem. One is Intermezzo (zolpidem). It is for treating insomnia “when a middle-of-the-night awakening is followed by difficulty returning to sleep.”

Intermezzo (Zolpidem) if you Can’t Get Back to Sleep:

Intermezzo contains the same active ingredient as the prescription sleep pill Ambien. It is a sublingual tablet (under the tongue) that goes to work much more quickly.

This is only appropriate if there are at least four more hours before time to get up, though. If he has to get up in two or three hours, he may have morning grogginess and might not be able to drive safely. It may also cause nausea or headache.

Other Intermezzo (Zolpidem) Side Effects:

  • Fatigue
  • Mouth ulcers, blisters, mucosal irritation (from the pills)
  • Driving impairment the next day (with less than 4 hours of sleep after taking Intermezzo)
  • Severe allergic reaction (anaphylaxis) and angioedema (swelling) of tissues involving the tongue and throat
  • Abnormal behavior: People taking zolpidem have experienced unusual behavior including aggressiveness and agitation. Some have reported sleep walking, sleep eating and sleep driving.

Silenor If You Wake Up and Can’t Get Back to Sleep:

Silenor (doxepin) is for “the treatment of insomnia characterized by difficulty with sleep maintenance.” That is a fancy way of describing your husband’s problem.

This antidepressant medicine can also cause next-day drowsiness, nausea or a rise in blood pressure. Unlike Intermezzo, which is taken if and when the patient wakes up, Silenor is taken half an hour before bedtime.

Other Silenor Side Effects:

  • Sedation, performance impairment the day after taking Silenor
  • Dizziness
  • Upper respiratory tract infections
  • Digestive upset
  • High blood pressure
  • Rash, sensitivity to sunlight
  • Suicidal thoughts, worse depression
  • Blood disorders, anemia
  • Sensitivity to heat, heat stroke

Doxepin also has anticholinergic activity. Will it affect brain function? Here is a link to an article we have written on this topic:

Natural Remedies to Help Get Back to Sleep:

Your husband will need to discuss either of these with his doctor. He might also try a natural remedy. According to Tieraona Low Dog, MD, California poppy can also help a person stay asleep, especially if muscle pain or cramping is waking him up. Look for a tincture of Eschscholzia californica. This is not an opium poppy.

Anyone who would like to learn more about how to fall asleep naturally or get back to sleep may find our recently revised Guide to Getting a Good Night’s Sleep helpful.

Share your own sleep story below in the comment section.

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  1. Karen
    Baton Rouge, LA

    I get up, drink a cup of milk, and get in a different bed. Works for me. ;)

  2. Jean

    My husband’s PCP prescribed Silenor, 3 mg, but warned it will be expensive. This repackaging of doxepin would cost $400 retail for one month. On line, I found liquid doxepin. PCP changed the prescription to liquid doxepin, 3 ml, mixed with water or juice, one hour before bedtime.

    Did not want to wait for our insurance to approve this “off label” use so paid the whole thing out of pocket. For one month, $10.99! It is working well to help him stay, or return, to sleep in the middle of the night.

  3. mary

    My sister used Xanax to sleep at night. An addictive drug if taken over long span, it took her short term memory and her life last December. Her dau, a nurse and I tried to tell her not to continue drug, but she did not heed our WARNING.

  4. Annilu

    If you have no objection to alcohol, try a shot of red vermouth.

  5. Ash

    For years, I had problems going to sleep and staying asleep, and I had terrible nightmares with Melatonin. My doctor readily wrote a script for Ambian, which I dutifully took every night and I slept well, too well!

    After a few years, I had two horrifying sleepwalking experiences. The first was so serious it should have scared me off the Ambien immediately. But it didn’t!

    The second time I woke up in the morning and found indisputable evidence that I had walked around my house during the night, doing things I would not normally have done, then gone back to bed and slept until morning. I was totally unaware that I had ever left my bed. This time I swore off Ambien and any similar drugs forever.

  6. S.H.
    Branson, MO.

    When ever you wake up during the night, never check what time it is; Turn your alarm clock out of sight; turn your cell phone face down; do not look at the wall clock, and what ever you do, do not think about what time it is or try to calculate how long untill you have to get up.

    I suspect that for some people, the waking up during the night might be from a person’s blood sugar dropping, resulting in their body releasing some adrenaline. A rapid heart beat, etc., would wake up some folks.

  7. Linda A K

    Maybe, you just do not need the same amount of sleep as others. I sleep exactly 5.5 hours every night. That is all I need.

    My mother treated it as an issue at first when I was just a little girl. Fortunately, my mother had enough common sense to realize eventually it was not a problem.

  8. Tom

    I use 100 mg of 5-HTP. Usually works.

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