pile of pills

A Danish study has found that a common combination of medications can increase the possibility of serious or even lethal hemorrhage.

People with the irregular heart rhythm called atrial fibrillation (A-fib) are at risk of a blood clot forming in the heart and moving to the brain to cause a stroke, so they are given an anticoagulant to prevent this. In the past this was often warfarin (Coumadin).

The researchers reviewed the records of more than 150,000 patients with atrial fibrillation. More than one-third of them were prescribed an NSAID during the study period.

Taking an NSAID pain reliever such as diclofenac or ibuprofen, even for a short time, more than doubled the risk of serious bleeding, from 1.5 per 100 to 3.5 per 100 individuals.

[Annals of Internal Medicine, Nov. 18, 2014]

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  1. Cindy M. B.

    When I had A-Fib (now resolved thanks to a cardiac ablation), I did lots of studying on the subject and read, in NUMEROUS PLACES, that NSAIDS not only contribute to negative side effects and negative cardiac events in people with A-Fib, but can and do actually contribute to the onset of A-Fib in the first place! Needless to say, I’ve never taken any NSAIDS (which include ibuprofen) since that time.

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