Gardiner Harris has written a powerful front-page story for the New York Times titled “Medicines Made in India Set Off Safety Worries” (Feb. 15, 2014). If anything, the headline downplays the seriousness of the problem. Here is the first sentence of the article:

“India, the second-largest exporter of over-the-counter and prescription drugs to the United States, is coming under increased scrutiny by American regulators for safety lapses, falsified drug test results and selling fake medicines.”

We have been warning about drugs imported from abroad for more than a decade. That’s because readers of our syndicated newspaper column and visitors to our website have been telling us for years that there were problems with the generic medicines they were taking. At first we were skeptical of these protests, thinking there might be a psychosomatic component to some people’s bad experience. (We had long been big supporters of generic drug quality and the savings that can be gained by substituting generic for brand-name medications. It was hard to accept that we might have been overly enthusiastic.)

Eventually the sheer number of complaints and the compelling nature of the stories convinced us that there was something very wrong with the way the FDA approved and monitored generic drugs. The article by Mr. Harris confirms that there is indeed a scandal of immense proportions that has pretty much been ignored by physicians, pharmacists, patients, regulators and Congress. Here’s the straight and skinny.

India now supplies roughly 40% of the active pharmaceutical ingredients found in our prescription and over-the-counter medications. Until recently, the FDA was incapable of inspecting most of India’s manufacturing plants. It didn’t have the resources or the manpower. New legislation has allowed the FDA to accept money from the generic drug industry to speed drug approvals. Some of those funds also go to inspections. Last year the FDA visited 160 Indian manufacturing facilities, triple the number from four years ago.

In the process the FDA has uncovered fudged data, shoddy plants and questionable quality control in a number of facilities, including India’s largest drug maker, Ranbaxy. Just recently, the FDA banned all active pharmaceutical ingredients made at Ranbaxy’s Indian facilities from the U.S. market. This was one of the first large foreign generic drug makers to make a splash in the U.S., starting its exports to this market in 1998. Perhaps coincidentally, that was the year we began to receive enough complaints to make us start to question our trust in the FDA’s ability to guarantee generic quality. Here is just one example of the kind of story we were receiving from readers at that time:

“I have been treated for hypothyroidism for over thirty years, and have been on Synthroid 0.125 mg for the past ten. This year my doctor wrote the prescription for a generic at the same dose.

“By the fourth day on the generic, I felt as though I was on the end of a tightly coiled spring. I couldn’t sleep; I had a slight case of diarrhea; I was sweating more than usual and my heart felt as though it would pound out of my chest. When I finally realized all this might be due to the change in medication, I had the pharmacist give me Synthroid instead. Almost immediately I calmed down, my heart stopped pounding so hard and I was back to my normal self.” [published May 18, 1998]

We now know more about the flaws in the Indian drug regulatory system. The head of the Indian drug monitoring program is G. N. Singh. In response to a question about quality control he replied that:

“If I have to follow US standards in inspecting facilities supplying to the Indian market, we will have to shut almost all of those. We are not the US, the infrastructure and resources available there are much different from those in our country. Our priority is to make medicines available and affordable to all.”

If the goals of Indian regulation are availability and affordability over quality, then it is little wonder that the FDA officials are finding problems. It was alarming to read in Mr. Harris’s article that many generic drugs are under the supervision of state health departments in India rather than the national authority. He points out that:

“The making of medicines that have been on the market at least four years is overseen by state health departments, many of which are corrupt or lack the expertise to oversee a sophisticated industry.”

The other large supplier of generic ingredients and products to the U.S. and the world is China. The former head of China’s national drug regulatory authority was executed for corruption in 2007. He had taken office in 1998, the year we started hearing from our readers about increasing problems with generic medications. The FDA has historically had difficulty making unannounced inspections of drug manufacturing facilities in China. Here is what Gardiner Harris of The New York Times has to say about oversight there:

“Using its new revenues, the F.D.A. tried to bolster its staff in China in February 2012. But the Chinese government has so far failed to provide the necessary visas despite an announced agreement in December 2013 during a visit by Vice President Joseph R. Biden Jr., said Erica Jefferson, an F.D.A. spokeswoman.

“The United States has become so dependent on Chinese imports, however, that the F.D.A. may not be able to do much about the Chinese refusal. The crucial ingredients for nearly all antibiotics, steroids and many other lifesaving drugs are now made exclusively in China.”

Despite all these concerns, the FDA still maintains that generic drugs are “identical” to brand names and that “FDA requires generic drugs have the same high quality, strength, purity and stability as brand-name drugs.”

If you are having some doubts about the FDA’s ability to guarantee quality in drugs from foreign manufacturing plants, you may want to get the rest of the story. Twelve years ago we interviewed key players at the Food and Drug Administration about these very issues. You can read what we discovered in our book, Best Choices from The People’s Pharmacy. More recently, we uncovered another scandal at the FDA involving the process for approving generic drugs. We document those problems in our book Top Screwups and also provide guidelines on how to use generic drugs more safely in our Guide to Saving Money on Medicine.

Share your own story below. If generic drugs have worked well for you, please let us know. We’re also interested in your experience with therapeutic failures or complications from generic medications.

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  1. Robin

    This happened to me- I took Wp thyroid which doesn’t have gluten fillers and the pharmacist switched it on me to Naturethyroid. My hair started to fall out and I got exhausted on it- I gained weight..all of this in one month. I went to Duane Reade and the pharmacist said it’s from the same list different brand. Big deal that he apologized, he didn’t notify me of the change and this set me back. Frustrating!!!

  2. Donna

    I have had problems a number of times with refills of Metoprolol! This is all so scary & infuriating! Honestly, it seems that even if you are clued-in & somewhat vigilant, you are probably taking something destructive to your health!

  3. Lynn M
    Grass Valley, CA, USA

    I have been taking medication for my hypothyroid since 1998 and was taking the generic Levothyroxine quite successfully. One month when I went to pick up my prescription at CVS the pill looked different. I asked the pharmacist and he said it was from another pharmaceutical company. I thought okay, no problem. I was not prepared for what happened me.

    About a week or so into this “new pill” my heart began to throb uncontrollably fast in my chest. I felt as if I was having a panic or anxiety attack, which I have never experienced before. I thought I was having some sort of heart issue. I felt horrible and asked my husband to take me to emergency. They ran every test on me they could think of and came up with nothing to report. I went back to the CVS pharmacist and asked him about my new medication.

    He said I may be allergic to the “filler” that was used. I gave the medication back to him and asked my doctor for an Rx for Synthroid, which I continue to take to this day. It’s 4x more expensive but I have no adverse symptoms. Still to this day wondering what was in that Levothyroxine generic?????

  4. Elisa

    I have been on exact same dosage of levothyroxine for 12 years for hypothroidism. New Dr. increased my dosage, and I just happen to switch from Walgreens to CVS, not thinking that the generic manufacturer would make a difference. Walgreens uses Lannett, CVS uses Mylan. I wound up in a hospital ER 6 weeks later. Heart pounding like crazy. Blurry vision when driving. Yes, the dosage was determined to be too high (only by 25 mcg) but now I am wondering about the problem with generics in general. Always check your prescription bottle and look for the manufacturers name. Sometimes the pharmacy just switches up, without notifying you. I am going on a brand name from now on.

  5. Dan

    I just received my monthly supply of Lisinopril and am concerned by the vendor change. It was Lupin from India which I’ve used for many years and now it’s sourced from Solco which manufactures in China. I’m concerned after reading comments on this site I may have adverse effects from this drug.

  6. GottaQuestionPharmaIngredients
    South Carolina

    I have been taking generic adderall for over 3 years for my diagnosis of narcolepsy. I’ve tried many different manufacturers and haven’t had a problem until I recently received pink tablets, marked with COR 135. Within 2 hours of taking the first dose, I found myself dozing off. This happened while I was driving which is why I sought medical attention to begin with.

    Hours later, I took another dose, as directed and again, felt drowsy and unaffected by the medication. I spoke with a friend who had received the same generic adderall as I did and compared notes on its effects. This prompted me to search online to see if others shared my experience. I was absolutely shocked to find pages and pages of identical complaints!

    The maker of this generic adderall is CorePharma. Not only were there pages of complaints but these complaints have been going on for years!! I have written the company to voice my concerns and will be contacting CVS Pharmacy (where I got my prescription filled) as well as my insurance company in the morning. I also found that consumers can file a complaint with the FDA (Food & Drug Administration) on their website. I’m not sure that much, if anything will be done by them BUT if everyone who has had the same problems with this medication will file complaints as well, perhaps someone will finally listen!!

    I plan to continue my research on this company and share my experience & suspicions about the ingredients (or lack of) to as many doctors, pharmacists, pharmacies and consumers that I can find. I would love to have someone with higher powers investigate this company. I’m also trying to find out if the DEA investigates these companies and if so, how to file a report with them. I strongly suspect that the amphetamine salts that are supposed to be part of CorePharmas ingredients, are landing in the wrong hands & quite possibly the black market. I feel sure that there are problems with other narcotics as well. Surely SOMETHING can be done???

  7. carol
    new jersey

    I have been on oxycodone for rsd for many years. In 2009 there was a generic shortage so I bought the brand. It worked so well I dropped two pills a day the first month. I stuck with the brand since it worked so much better. It cost 200 per month and my brand name copay was 60.

    A few years ago the brand was sold to Mallenkrodt and the price more than doubled each year, this year 1800 per month, the copay is now 85.00. With the dramatic increase I am in the donut hole quickly. Medicare part d used to pay 100% for the rest of the year once out of donut hole, no more – now 5% for brand.

    I tried the generic my small pharmacy carried -Advantis- manufactured 15 miles away. It was in no way comparable for pain relief and I had a tremendous anxiety I had never experienced before. The anxiety and pain increased overnight to the point that I was afraid to be alone. I called the pharmacy and they allowed me to swap out the remainder for my usual brand name.

    My husband was furious and called my doctor to fill him in on my condition. He also called the fda. The fda advised him there were 11 manufacturers of oxycodone and perhaps I should try another generic. They took the report and said good luck. The pharmacist said they felt the advantis was one of the better generics and with no complaint from others, usually sold as a combination with tylenol. My prescription is just oxycodone since I need it daily. Perhaps that was the difference. I am too afraid to try another generic. Since the laws have become overly severe I would no longer be able to switch back with a bad experience. This is a hardship and I use my credit card since I can not afford to pay the donut hole costs.

    In the early years of my rsd many alternative drugs were tried that were supposedly off label for pain. The first tried – tegratol – made me think I should go kill the doctor. I felt very calm and rational. My partner was scared by my behavior and the things I was saying.

    Next – Neurontin- made me head for the street, it seemed like a good idea to go stand in the middle of the busy county road I lived on.

    Another, dibenzyline – compounded to a tiny dose since I was deemed “sensitive” gave me a horrifying violent bloody nightmare every night for over a year, then weekly, monthly and so on- took years before it left me completely. The same nightmare – never varied. There were more but these three were the worst. One pill of each was all I took to make me homicide and suicidal. Terrifying. I will never again try these dangerous drugs. Neurontin was actually sued twice for billions since the chronic pain relief connection was a marketing lie.

    The fda needs to be completely stripped of pharma alliances and funding before safe effective drugs will be properly had. Unfortunately congress is de regulating allowing drugs and devices faster approval based on “observational” studies. If you read worst pills best pills then you know the studies are mostly a farce anyway. Damaging devices are another entire topic, just as bad.

  8. Max

    I was taking Paxil by TEVA, USA for over 10 years, then was given the auribond brand from India and it did not work, then was given a Chinese brand, by SOLCO and had severe diahrea and stomach pains for 6 weeks so I weaned off rapidly. I was forced to get a echocardiogram for the sudden high blood pressure and a colonoscopy to see if the colon had parasites. Test were negative but now I have big bills for the procedure and suffering with all these other trials of antidepressants. I am severely anxious and depressed now.

  9. Tracy
    Suffolk, VA 23434

    I was given generic tramadol for continued hip pain. By the 2nd pill I woke up dizzy, extremely nauseated, cold sweats, extreme headache, sensitive to light, sound and threw up all the 1st day and part of the 2nd. When I asked the pharmacist about it he said that others have had a similar reaction, did I have diarrhea? I said no, not so far. It seems Rite Aid bids on best generic price from various manufacturers. They say the active ingredient is the same just varied inert ingredients. I think the FDA does not care what inert ingredients are used and do not test for what is used. I have been struggling for 3 days. Still weak… and yes I had a flu shot and no one around me had or has had the flu. Felt like I had been poisoned. I have taken brand name Tramadol before and it worked well in past. FDA needs to tighten up. Not sure how to make this known so this is my attempt. Why aren’t those mess causing known problems taken from shelf?

  10. CYNTHIA K.
    Nevada USA

    I had been taking VALSARTAN 320mg (generic for Diovan) for my hypertension for almost 4 years now. I still remember that the color of this medication was Yellow..but…only 2 months ago I AM SUFFERING FROM SHORTNESS OF BREATH & DIZZINESS everytime I take my dose in the morning. This feeling will last for MORE THAN an hour, so I just lie down and wait until this effect subsides. I also noticed that the color of this tablet is now BROWN.

    I decided to check the information around the bottle and it says: MANUFACTURED BY ZHEJIANG HUAHAI PHARMA IN ZHEJIAN, CHINA & Distributed by SOLCO HEALTHCARE US , LLC IN NEW JERSEY, USA…

    ATTENTION FDA: Please do not cut costs at our expense & pls inspect all these chinese & india pharmaceutical companies because I watched 20/20 on TV last year and it showed how dirty & filthy these laboratories are. Is these what you sell to us Americans?

  11. Linda

    I had been taking Zoloft for a long time for depression and then had to go to generic Sertraline for insurance to pay. Generic had always worked fine until I noticed my depression coming back. I checked the manufacturer and it had been changed to Aurobindo a manufacturer in INDIA . My Dr thought maybe I needed to change the prescription since I had been on Sertraline a long time. He switched me to Venlafaxine ER, manufactured by Teva in Israel I believe. My depression is getting worse and worse. I have to go back to the Dr now. I have researched that Greenstone manufacturers Sertraline and they are 1 of the top 10 generic companies. I think they are located in the US in New Jersey. I am grasping at straws at this point to find something made in the US.

  12. Gail

    Just started taking Pantoprazole in March. The first prescription worked, the refill made me feel like I was off the meds…looked at the pills…the 96 printed in the middle of the pill was off to one side or the other, the number faded on some…brought them back to the pharmacy…no questions asked, they refilled the prescription as soon as they saw the pills…these new ones look okay, but I am asking for non-generics from now on…

  13. john
    west yorkshire

    here in the uk,its getting the same.i was on tramadol slow release,for severe pain,i recieved a letter from my doctor saying i was being put on a generic for price reasons,do not worry it is exactly the same they said. i felt ill within two days,but pressed ahead to give them a go,my health went downhill rapidly,and as for pain relief ,i may as well have taken a smartie sweet. i told my pharmacist who was most unhelpfull,saying they are the same,to my shame,i kicked off,but it worked,they admitted they were held by price and headoffice to give everyone cheap generic drugs. i went to my doctor,who is fantastic and a man among men to me. he went mad, put me stright back on zydol,and made sure it said zydol on my presciption,since then ,no probs. i now no longer believe a word my pharomacist says. see your doctor.

  14. Casey
    North Carolina

    My name is Casey J. I am a patient at the VA Hospital in North Carolina. About two years ago I received hydrocodone from the VA for a painful condition. I noticed that there was something different about this particular batch that I received. It’s potency was far less than what I received normally, (although there was some hydrocodone in there). In addition there was something else in the medication, particularly more like a benzodiazepine than hydrocodone.

    As this lessened the efficacy, and I was no longer managing my pain, I reported it to the VA . At that time I was able to ascertain the manufacturer, which was Mallincrodt, and the batch number, which the VA ceased doing sometime after this incident. I also filed a complaint with the FDA, hoping that because it was making me queasy that they would test this medicine, especially because it was affecting veterans. Anyway, nothing happened.

    Fast forward to the present time: I experienced this again about five days ago when I received it. This time it feels somewhat similar to the experience mentioned in the aforementioned part of my previous experience. There were some differences though, as this almost felt like there was some hydrocodone that was being inhibited by something like an antagonist.

    I immediately went back to the VA pharmacy with nearly a full bottle and explained it to the person working in the pharmacy, what I was experiencing, and that they needed to replace the remaining pills as the medication was not doing what it was supposed to do.

    I was informed by the VA Pharmacy worker that there was nothing that they could do. I asked the name of the manufacturer to which I received the information, and I was told that the VA gets its medications from many sources.

    I returned home that day and went on the FDA’s MedWatch website and reported this. I did this several days ago and haven’t heard anything back from them.

    It is very poor to treat veteran’s like this. I know that there has to be other vets at the VA that must be experiencing this too!

  15. RaRa
    Philadelphia PA

    A few years ago I was diagnosed with breast cancer in my early 20’s, and I decided on a reconstructive surgery option which utilized my back muscles and left me with chronic upper back pain. Following this surgery, I was on oxycodone for about 2 years.

    Towards the end, when it became too burdensome to stay on a narcotic pain regimine, I was able to lower my dose down to the 5mg tablets, the dose I had started on 2 years earlier, at which time I had never experienced any issues receiving varying generics. Then, one day, the pharmacy I had been using for most of those two years had switched suppliers and I received my first 30-day supply of the Malinckrodt generic.

    Instantly, I noticed a difference: I received little-to-no pain relief and I felt SICK. Constantly Nauseated. Just overall very ill feeling. After 3 days I suddenly realized I hadn’t used the bathroom since the day before I had started the Malinckrodt generic – and decided to finally talk to my doctor. Thankfully, since I had been with my doctor since the beginning of my pain issues, he wrote me another script and advised me to go to the pharmacy they frequently worked with, seeing that most pharmacies would label me a drug abuser for trying to fill another script.

    I received the usual generic I had been taking before, but it took over a week and a half for me to finally be able to use the bathroom again. What’s worse, I had often bragged about the fact that I hadn’t vomited in 20+ years and that I had an iron stomach – even through 3 of the strongest chemotherapies I had not once gotten sick – and yet this medication had made me so constipated that the food I ate literally had no where else to turn. It was like it had turned my lower digestive system into cement, and finally one day after eating what I assume was the final piece of food that my stomach would allow – I vomited for the first time in 20 years. I had spent the entire night before feeling uncomfortably full after having only eaten a small amount that day, and never have I EVER experienced constipation in this way, nor have I EVER experienced it again.

    I have no idea what was in that generic, but for months afterwards I had to fight my pharmacy to give me another generic when, despite having told them I could not take the Malinkcrodt, they continuously attempted to fill my script with it. One day, my fiancé picked up my prescription for me while I had gotten stuck at work – and accidentally picked up the script without looking at it like I had asked. Malinckrodt. Literally MINUTES later I dropped everything at work to have him take me directly to the pharmacy, at which time they told me there was absolutely nothing I could do. I had already left with my medication – and according to them that’s the medication I would be stuck with for the next 30 days. Even after I had told them how sick it made me, how God forbid I had taken it any longer what could have happened to my digestive tract, because according to all pharmacists “all generics are the same.” I am so sick of hearing that.

    Today I’m no longer on the narcotic pain medication, but often run into this problem with my other medications. It has DEFINITELY gotten much worse this past year. It makes me sick to think of all the times I’ve had to suffer an entire month due to a bad generic – and have felt so helpless seeing that every one in any position of power seems to believe the FDA.

  16. elizabeth

    I just completed a rx for cephalexin after having used keflex many times in my life without a problem. Now I’m battling an allergic reaction with around the clock benadryl and steroids. My son in law had tongue swelling and ER visit from levothyroxine, and a friend just got out of ICU for a reaction to his routine BP medicine.

  17. SL

    I just came to investigate this issue on the internet when my own generic drug was not working as it should. I was given tramadol for a major dental procedure. I have a sensitive stomach to most drugs, esp narcotics which cause me to vomit. Tramadol will not cause me to vomit but will make me nauseous. Well, I took the generic tramadol last night and not only did it not decrease my pain even a tiny bit, but also did not cause any nausea. It was like a took nothing.
    The last time I took this medicine was a while back for another dental procedure so it could not be because my body build tolerance to it and I have not taken any pain medications since then. I went to the pharmacy this morning to bring up my concern. This generic was made in India but they have no way of filing my concern to a central data bank within their pharmacy. Without a central reporting agency, how can this quality control issue be brought to light to others? I have lost trust to the pharmaceutical world! India drug manufacturers have already been known to make poor quality drugs, yet we continue to import our generic drugs from there. Very Scary!

  18. AZR

    I have the exact same problems with my generic pills. Ambien, Meloxicin, Tizandine, Pantoprazole to name the most inconsistent ones. I thought it was just me being weird. I have wondered often if the problems were caused from the generic pills. Besides the irritation of my pills changing shapes and colors, I have often thought they were just not working. I will investigate the name of the company to see if there is a pattern. Thank you for sharing this information. I am so glad my husband found your Web site.

  19. mnd

    Yes- the generics from one pharmacy can absolutely differ!
    The pharmacies I have dealt with have one or two different generics for a particular drug that are dictated by the parent company and stocked by that chain’s warehouse. Another pharmacy may or may not have the same generic. That is the problem I ran into when my neighborhood chain pharmacy was bought by another chain. The warehouse that supplied them also changed, and I received a prescription for venlafaxine (Effexor) that plunged me back into depression. The new generic was manufactured by an Indian company that has had some of its generics banned by the FDA due to underdosing.
    I inquired as to what generic I had received previously (and that had worked fine), and found it at another pharmacy, to which I transferred my prescription. had to fight the insurance company for three months, however, since I had a 90-day supply of the inferior drug on hand that I could not use. You need to find out the manufacturer of generics that work for you (usually the name of the company or an abbreviation will be on the bottle)and make sure you receive it next time. Good luck!

  20. TJ

    I wasn’t aware of this mess until I got a bad script of my ADHD medicine from Actavis. I suffered muscle pain so severe, I was bed ridden and couldn’t hold my son. I had headaches and nausea depression, and fell asleep on the medicine. It was awful and I was just furious.
    I highly doubt the prescription had any active ingredients. I felt better as soon as I stopped taking the drug which is how I realized it was the meds and not something I caught. Got the script changed but the new medicine is bad too. I won’t be taking this again unless I can count on quality. I’m so happy that I’m not sick like I was….terrible experience.

  21. MW

    Here’s the solution. If a drug is found to be non bio-equivalent by the FDA, then for the remainder of the company’s existence, they must submit a sample of each drug batch (weekly) to independent testing to a facility of the FDA’s choosing, at the company’s expense, to prove that the drug is bio-equivalent. If a second batch of that drug or another drug the company makes is found to be non bio-equivalent, then all drugs that the company and its subsidiaries/parent company manufactures that are sold in the United States must undergo this weekly testing at their expense.
    If the company is bought, or sold or transferred out of bankruptcy, that requirement flows to the purchasing/new company.
    That will fix the problem.
    But of course, the government isn’t really interested in cracking down on cheap generics, is it?

  22. md

    Some years ago,I was prescribed Effexor XL 75 mg. daily for anxiety and mild depression, and took the brand name drug with good results. Two years ago, I again was prescribed Effexor and had good results, even though this prescription was for the generic drug. In March, I refilled my prescription and within two or three weeks, felt very depressed, anxious, and teary. I checked with the drugstore that had filled my prescription (as well as all my past prescriptions). I found out that their supplier had changed since the drugstore chain was bought by another well-known drugstore chain. Many of their generics were now made by different manufacturers. This had caused them to switch me from the generic Effexor made by Aurobindo to one made by Zydus.
    I also found out that some drugs made by Zydus have been banned in the U.S. due to possible underdosing. I got a new prescription, fought with the insurance company for refilling my prescription too early, and switched pharmacies to one that could give me Aurobindo’s generic. Now I am back on an even keel. My husband and I have since switched all our generic prescriptions from the original pharmacy, after finding more instances of their new supplier having generics from companies, some in India, with complaints about their quality.

  23. mb

    A reputable Pharmacy will have the following on each and every prescription label-name of drug (manufacturer) color of drug if caps or tab-will tell what it is generic for if generic-also auxiliary labels
    to advise how to be taken-with-without food-plenty of water etc-and if a mfg is changed upon refill (due to various reasons) the new color and the new mfg.
    Also take the time to read the literature given with each med and don’t be afraid to question the pharmacist-even if you have to wait a few minutes-most reputable pharmacies have private consultation areas-if you don’t like the manufacturer ask for another brand that your ins will pay for.

  24. mb

    try natural sleep inducers such as valerian-melatonin-get the Tv out of your bedroom (too much excitement at bedtime) try some hops-chamomile-all these have no adverse effects and develop a routine for getting to bed-be repetitious!

  25. Don

    It may be impractical, but I would like to see a legal requirement that all generic-advocating lobbyists, legislators, insurance executives, etc. be legally required to take only foreign-manufactured generic drugs (that are sole in the U.S.). Country of manufacture and manufacture’s name to be randomly selected, not their choice.

    • Fern

      This is SUCH a good idea!! Geeezzz…wouldn’t it be a boon for economy to start only manufacturing these drugs in the US instead of India and who know where else. I was taking an anti depressant that was only available by Brand name for years. It went generic and I thought….hmmmmm…is it working as well as the Brand? Thus began my slow slide back to a horrible depression. It quit working. I am becoming such a sleuth these days researching things and cannot believe my ignorance and apparent ambivalence as to what I put into my body without knowing where it comes from (I do not eat processed food which is good). I think the united states should be where our medication are manufactured and tested…As tough as the FDA is on some things I am so totally amazed we and they let this important matter slip though the cracks. I smell a rat somewhere.

  26. CN

    I have used the birth control Yasmin for nearly a decade, with no noticeable side effects at any point. The price increased slowly over time, until about 2010 when it skyrocketed, at which point my insurer had the pharmacy dispense the generic equivalent. However, within just a few months I began to notice weight gain, as well as mild depression. I demanded a switch back, explaining my plight to the pharmacist each time the generic was suggested, and within just a couple of months felt back to my old self.

  27. c t

    I started a new generic for Lipitor 5,5 months. Four months ago I came down with diarrhea. I switched brands … manufactures, and we’ll see what happens. Anybody else having this problem?

  28. J.

    I used to take 25 mg of Cozaar (losartan) for hypertension. Even though my bp was really high, this low dose worked. For insurance reasons I switched to generic. At 50 mg, not only did it not work, but seemed to make my bp higher. For 3 years, Dr. did not believe I was taking med. I had a small brain bleed last year attributed to bp spikes. Finally went to a different doctor and went back on brand (although a different ARB), lowest dose. Working very well. Stay away from losartan made by Lupin and/or Zygenetics. Both made in India. I reported to FDA Medwatch.

  29. ab

    20+ years in the industry convinced me the FDA is powerless, having been sold lock, stock and barrel to the pharmaceutical industry. Our legislators are also well represented in the industry, as are many of their family members. The pharmaceutical industry is interested in one thing only, market share and the resulting obscene profits that generates. PATIENT BEWARE is an understatement.
    I have absolutely no faith in the “integrity” of the FDA, with the exception of my respect for Dr. David Graham.
    Things are only going to get worse.

    • Fern

      No kidding. I feel so angry about this and so powerless. These medications that are supposed to help us….hmmmmm. The pharmaceutical companies are greedy little jerks.

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