Q. I was prescribed the generic antibiotic Levaquin (levofloxacin) on 6/25/13 for “walking pneumonia.” The doctor did not provide any information about the drug. The prescription was for one a day for 10 days.

After two days (2 pills) I was in such extreme pain throughout my entire body that I could not walk, get up or go down stairs. I was in a wheelchair for a week and had to use a walker for a couple of weeks more. The pain in my joints, especially my neck, upper shoulders, lower back, legs, knees, etc. was almost unbearable.

It has now been almost eight months and I am still experiencing joint pains that seem to move around my body: one day my neck hurts; another day it’s my knees, thighs, hamstrings; then my back is affected.

When the pains began, I tried to contact the doctor. I left messages with her office that I could not tolerate the Levaquin and to please give me something else.  She apparently was calling the wrong number, (the office had both my numbers!) and never spoke to me.  Finally, after taking 6 of the pills, I decided to stop as I figured I’d be dead with 4 more!

Upon returning to the doctor a week after my first visit, I told her of my experience and that I had stopped taking the antibiotic.  She insisted my side effect reactions had nothing to do with the Levaquin and were not a result of this drug!  She told me to take 800mg of ibuprofen three times a day for the pain.

A month later in July I saw my orthopedist.  He could offer no help, but his nurse shared with me that she had had the same side effects from Levaquin and that it had been a year and she was still experiencing joint pains all over; one day here, another day there.

Going on the Internet I discovered that many other people have suffered the same side effects as I had…some for years!  I called the FDA to report the above, but was not able to get any of the required information from the pharmacy (no manufacturer, expiration date, Lot.#, etc.). I completed 5 pages of information on the FDA’s MedWatch form about side effects and such and faxed them to the FDA.  I also discovered there are some 3400 lawsuits regarding levofloxacin.

A. You are not the first person to report serious complications from levofloxacin (Levaquin). This is an antibiotic in the class called fluoroquinolones (FQs) or quinolones for short. Other medications include ciprofloxacin (Cipro), levofloxacin (Levaquin) and moxifloxacin (Avelox).

You are also correct that it is hard to complete the FDA’s MedWatch forms because it is almost impossible to get the essential information they demand (manufacturer, expiration date, Lot # and NDC number).

Here are some other somewhat similar experiences posted to our website:

“I was taking a 30-day prescription of Cipro for a prostate infection. After playing full court basketball, I awoke the next morning to knees that felt as though they were encased in concrete.

“My legs constantly ache as if I had just walked 20 miles.  Many nights I cannot sleep due to the pain in my legs and, for now, I cannot play basketball as the left knee area, in particular, is too weak.

“Ever since that time (20 months ago) I have suffered in every way imaginable. Sometimes I cannot even walk up my apartment stairs. I have seen my doctor, an acupuncturist and chiropractors. No one can make it go away. This has totally impacted my life, since I can’t play tennis and have a very hard time playing basketball. Do you have a suggestion?” Doug

“I took this medicine four years ago. I was also very physically active before taking it. After 7 days on the med, I developed body-wide tendon and nerve damage that has yet to improve. There are literally thousands of people who have been crippled.” Greg

“I had a similar experience with Cipro. I took it a year and a half ago and have had terrible joint problems ever since. The problems started almost immediately after taking Cipro. I’ve had to spend thousands on tests, physical therapy and doctors’ visits. The worst is my feet and ankles hurt so bad that walking is difficult now. I can no longer exercise without suffering days of pain. All this time, there is some improvement but much of the damage is permanent.” D.B.

“I took Levaquin on Nov.14, 2012. After 6 pills I had Achilles tendonitis, small tears, muscle aches and joint pain all over. Two years later I am still suffering from tendonitis, bursitis in my shoulder joints, fatigue and insomnia. I never ached so much in my life and it continues to get worse. I walk with a cane. There is numbness in my foot and leg diagnosed as neuropathy. Levaquin was prescribed for suspected urinary tract infection. It was contraindicated with my other meds and my age. This just should not be.

“This drug has caused permanent damage and ended most of my life activities. Doctors need to be informed what this med does and care about the consequences. I hope this antibiotic gets off the market or is used only in a life or death situation.” L.P.

We could provide dozens of other stories, but by now you have the idea. According to the Food and Drug Administration, more than 21 million people get a prescription for a quinolone antibiotic each year. Such drugs are prescribed for sinusitis, urinary tract infections, bronchitis, pneumonia, prostatitis and skin infections. Cipro has been around for decades.

The FDA issued an alert about FQs last year about neuropathy:

“This serious nerve damage potentially caused by fluoroquinolones may occur soon after these drugs are taken and may be permanent… Peripheral neuropathy is a nerve disorder occurring in the arms or legs. Symptoms include pain, burning, tingling, numbness, weakness, or a change in sensation to light touch, pain or temperature, or the sense of body position. It can occur at any time during treatment with fluoroquinolones and can last for months to years after the drug is stopped or be permanent. Patients using fluoroquinolones who develop any symptoms of peripheral neuropathy should tell their health care professionals right away.”

In addition to the nerve damage, these drugs can cause lots of other serious complications, including tendinitis or even tendon rupture. When this happens it can be a life-altering event. Joint pain and arthritis-like adverse reactions are not generally recognized as a complication of quinolones in adults, though they have been noted in children. We tend to believe the people who have reported this problem on our website rather than the official prescribing information for these antibiotics. It has taken the FDA decades to acknowledge the problems with tendons and nerves, so we would not be surprised if it takes years more for the agency to recognize the joint complications.

Unlike many of the people who have reported problems on this website, we are not calling for the banning of quinolone antibiotics. Goodness knows, we are running out of effective medications against serious infections given the degree of bacterial resistance that has evolved over the years. But doctors must inform patients of potential fluoroquinolone side effects BEFORE people start taking such drugs. Here is a list to be aware of:

Fluoroquinolone Side Effects and Complications:

  • Digestive distress, nausea, diarrhea, constipation, stomach pain, heartburn, vomiting
  • Headache, dizziness
  • Agitation, anxiety, irritability, restlessness, confusion
  • Insomnia
  • Tendon problems, tendinitis, tendon rupture
  • Retinal detachment
  • Nerve damage, peripheral neuropathy, nerve tingling, numbness
  • Allergic reactions, skin rash, anaphylaxis (life-threatening reaction requiring immediate medical attention!)
  • Super-infections including C. diff diarrhea
  • Hallucinations, psychosis, seizures
  • Depression, suicidal thoughts or actions
  • Irregular heart rhythms, torsades de pointes, QT prolongation
  • Kidney or liver damage
  • Blood disorders
  • Arthritis, muscle pain, weakness

Share your own experience with FQ antibiotics below. We want to hear the pros and cons of such drugs. Let others know how such medications worked for you and what, if any, side effects you have experienced.

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  1. daveabbadini

    I too took Levaquin 250 mg for 10 days for recurring UTIs, it did get rid of infection, but I continue to have severe vertigo symptoms always stumbling. In addition I hhave post stroke issues such as spasticity which already affects my limb tendons, at times the pam in my left foot is so severe, I cannot walk or stand. I now use a cane for balance, but my infection is gone for now. This med totally screwed me up. I also seem to get very weepy watching sad tv shows

  2. Joanne
    Rhode Island

    Severe Levaquin peripheral neuropathy, swollen joints, difficulty walking.

  3. Sunne
    Grand Prairie, TX.

    I, too, have had complications from elbows to hips. Much less activity due to extreme fatigue and weakness. The pain does jump around but is mostly in the elbows. Very faint, and vision seems to be worse.

    It all started with PCP recommendation for Colonoscopy. Came out of hospital with Aspiration Pneumonia. Thus leading to the Levoquin. That has been 8 months now, and gradually getting worse. I did not want to do that Colonoscopy but after constant recommending, I did. Wrong!

    I wish I had never done it and I tell everyone I know about Levoquin. We all deserve answers and to be warned about from our Physician about medications. In fact, mine said my elbows may hurt, but do not worry it will go away.

  4. Debbie

    On September 21, I went to my Dr for what seemed to be a long cold. Come to find out, I had pneumonia. So I was taking Levofloxacin.

    About 3 days into taking the medicine, my knees started hurting really badly. Then about the 4th day, my upper arms and shoulders started hurting. I have neck problems to begin with. Now, the pain is worse then ever. To be perfectly honest, I hurt so badly that I can’t take the pain.

  5. betty

    I was given Levaquin 250mg for 10 days for a kidney infection caused by too much pain medication after a wreck. I knew within 2 days I didn’t like taking this med and asked my doctor if it was necessary to continue with this one and he said keep taking it. I finished it and was careful not to injure my Achilles tendon in the coming weeks. I thought I was pretty lucky that I didn’t rupture it after reading up on the effects of Levaquin. My feet and ankles really hurt but I thought, well I’m getting old.

    Months later (maybe 9 or 10) I pulled a muscle in my leg and it seemed to take forever to heal. So I stopped drinking diet drinks….(Aspertame, you heard those stories right?) thinking maybe they were having an affect on my joints. It’s been a few months now and I have had an MRI and an XRay for my shoulder that I thought for sure had a torn rotator cuff. Results were nothing needing surgery at this time and had an injection.

    It’s been 6 days now and the pain is excruciating in my bicep muscle area. I read where nerves can mimic torn rotator cuff. Now I am starting to think about that darn Levaquin I took over a year ago. I really just want to be pain free. I’m starting to think I will never be pain free again. Some of the things that have been hurting don’t seem to be bothering me now unless its just being masked by the other pain. (you know let me stomp your toe so you will forget about your hand. or something like that). Is it possible for this drug to really continue to cause additional issues or is this something completely different or am I just going crazy. I will be seeing my doctor again really soon. I intend this time to bring all this up in the hopes that there is something that can be done. I would very much like to return to an active lifestyle. I really miss it. Upside….I will never again take a medication without reading up on it first.

  6. john

    I was prescribed Levaquin for tonsillitis and prednisone for asthma at the same time. Almost immediately I experienced arm pain and headaches.
    3 months later I have ruptured my right bicep distal tendon and underwent surgery last week. I have a long road to recovery.

  7. Melissa Stockman

    I was given this for MRSA (which should not have been used) after 3 days I began with the Pain and shaking and weakness in both my lower legs . Its been nearly a year now and I am still dealing with the pain , its hard to walk and stand for a long (sadly 10 minutes) time . Would never recommend . This was a life altering experience for me . I can no longer do near what I was able to do…..

  8. greg
    Oakland, CA

    I had prostatitis and was prescribed ciprofloxacin for 10 days, then levofloxacin for another 10 days. At the time, I was experiencing side effects of hot lower back pain. It was so bad, I quit the levofloxacin and took ciprofloxacin for the remaining days of the prescription.

    Days later, while sleeping, I started experiencing severe lower leg cramps that I have never had before. The cramping muscles are in front of my shins, the tops of my feet, and sometimes my calf muscles.

    When I get out of bed, I can barely stand as I have lost control of my lower legs. It happens often when my room is below 75 degrees. Those prescriptions were 21 months ago and I still have the side effects. Otherwise, I am a very healthy retired man.

  9. Julie

    My accident happened on Sept 8, 2016. I literally filleted my left knee open down to the bone. The ER prescribed me Levofloxacin 250 mg for 7 days. Only took it for 6 days as Im so anti pill its not funny. Today is Sept 16, 2016 so far all I can say is Im still very sore from how I fell in my accident so I cant say whether or not its side affects from this drug but as I have been reading I see the horror stories and I pray to the good Lord I will be a lucky one. I did visit my doctor for a wound check on Tuesday this past week she saw the drug and explained to me not to do anything strenuous for the next couple weeks as this drug has an affect on the muscles. She told me one of her patients a little older than myself was playing some sport and her achilles tendon ruptured. (my eyes bugged out when she said that) so when I go back to get my stitches out this Monday Im going to ask how long do I have to wait to be able to ride my bike again or go upstairs to bring my vacuum cleaner down etc. If I would have known now what I have seen here posted I would have asked for some other medication. I will say though it has helped my knee to heal but we shall see in the next few months what lies ahead. I pray things will be alright. Best to everyone on here.

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