Q. I’m wondering what information you have about SAMe as a treatment for depression. I’ve been taking it for six months along with a daily B vitamin and have gotten great results. I would like to know if it’s really safe.
A. An analysis of S-adenosylmethionine (SAMe) in combination with folate (B vitamin) shows that this regimen reduces symptoms of depression without unpleasant side effects (Canadian Journal of Psychiatry, July, 2012).
Exercise, sun exposure and counseling are also helpful. You can learn more about them in The Depression Cure by Stephen Ilardi, PhD. You will find our interview with Dr. Ilardi on depression on our website. We also offer a number of recommendations on non-drug approaches to depression in our Guide to Dealing with Depression.