A bottle of generic delayed-release Duloxetine (Cymbalta) 30 mg

We have received so many complaints about duloxetine side effects that we have lost count. Far more disturbing are the number of people who tell us how hard it is to discontinue this drug.

Decades ago doctors might have told patients taking a drug like Cymbalta that if they experienced anxiety, irritability or strange sensations after stopping the drug, it was probably their underlying psychological problem returning. Now we know it is withdrawal from the medicine.

The History of Cymbalta:

Cymbalta was originally approved by the FDA in 2004 for the treatment of major depression. It is officially an SNRI-type antidepressant. In doctorspeak that means it is a serotonin-norepinehprine reuptake inhibitor and is somewhat similar to other antidepressants such as Effexor (venlafaxine) and Pristiq (desvenlafaxine).

The FDA also approved Cymbalta to treat nerve pain associated with diabetes in 2004. In 2007 the drug got a green light for anxiety and in 2008 the FDA agreed that it could ease the discomfort associated with fibromyalgia. It was also approved to treat musculoskeletal pain associated with arthritis and lower back pain in 2010.

In other words, here was a drug that could relieve your blues and your aches and pains. And the drug company that makes Cymbalta (Lilly) has been aggressively marketing it as a good way to deal with chronic low back pain and osteoarthritis. Perhaps you have seen the commercials on TV promoting the pain relieving power of the drug with the slogan “Cymbalta can help.” It sounds almost too good to be true.

Ah…and there is the rub. Although there is a long list of serious side effects mentioned during the commercial, the video images seem quite reassuring and trump the scary message the FDA requires for this medication. So, let’s set the record straight. Here, without visual interference, are a list of potential complications associated with this medication.

Cymbalta (Duloxetine) Side Effects

  • Nausea, stomach pain, constipation, diarrhea, decreased appetite, vomiting
  • Dry mouth
  • Insomnia, anxiety, tremor
  • Dizziness, fatigue, sleepiness
  • Sweating, hot flashes
  • Blurred vision
  • Headache
  • Sexual dysfunction, lowered libido, erection difficulties, lack of orgasm
  • Liver damage
  • Serious skin reactions, rash, hives (requires immediate MD assistance!)
  • Glaucoma
  • Irregular heart rhythms
  • Bleeding problems
  • Blood pressure problems
  • Interaction with other drugs (leading to serotonin syndrome among other reactions)
  • Pneumonia
  • Seizures
  • Depressed mood, suicidal thoughts and behavior, suicide

Such a long list of side effects makes your eyes glaze over after the top 3 or 4. That is why we have included stories from real people so you can better understand what these complications feel like.

Stopping Cymbalta:

Even though such side effects are scary, there is another problem with Cymbalta. When people try to stop taking this drug they frequently report unpleasant withdrawal symptoms. An organization (QuarterWatch) that monitors the FDA’s database of serious adverse drug events has noted that:

“We observed a signal for serious drug withdrawal symptoms associated with duloxetine (CYMBALTA), a widely used antidepressant that is also approved to treat arthritis and back pain, anxiety, and fibromyalgia. In the first quarter of 2012 the FDA received 48 case reports of drug withdrawal identifying duloxetine as the suspect drug. They described a wide spectrum of withdrawal effects that began when the patients stopped the drug, including blackouts, suicidal thoughts, tremor, and nausea. Several cases involved hospitalization.

Probing deeper into the scientific record for duloxetine we found that withdrawal symptoms were reported in 44-50% of patients abruptly discontinuing duloxetine at the end of clinical studies for depression, and more than half of this total did not resolve within a week or two. In addition, we identified a serious breakdown at both the FDA and the manufacturer, Eli Lilly and Company, in providing adequate warnings and instructions about how to manage this common adverse effect.”

Doctors have taken to calling this “discontinuation syndrome.” These clinical words do not do justice to what it is like to stop antidepressants like Cymbalta, Effexor (venlafaxine), Paxil (paroxetine), Pristiq (desvenlafaxine) or Zoloft (sertraline) suddenly.

Sudden Withdrawal Symptoms

  • Brain “Zaps” (electric shock-like senstations in the brain)
  • Dizziness, light-headedness, vertigo, feeling faint
  • Headaches
  • Anxiety, irritability, hostility
  • Nausea, diarrhea, digestive upset
  • Tremor, hands shaking, nerve tingles, strange sensations
  • Fatigue, tiredness, lack of energy
  • Visual disturbances

Again, a list of symptoms does not do this problem justice. Below you will read some stories from people who have posted their comments to this website. We would love to hear your story, positive or negative. Share your experience with Cymbalta or any other antidepressant below.

Should you wish to learn more about dealing with depression through some other strategies, we offer our Guide to Dealing with Depression. You will also find a whole chapter on prescribing mistakes doctors make when treating depression and fibromyalgia in our book, Top Screwups Doctors Make and How to Avoid Them.

Cymbalta Withdrawal Stories from Readers

– D.G. shares a tragic story:

“My lovely, young daughter-in law, who was about to celebrate her 29th birthday, was prescribed Cymbalta, Klonopin, and Ambien and has committed suicide.

“She told her physician and her therapist that she’d had thoughts of suicide but no one took her seriously. She suffered from depression, as well as an eating disorder, and had very low body weight. She also used alcohol.

“Please remind your readers of the potentially disastrous effects these chemicals can cause when taken carelessly or in combination with alcohol.”

This from – P.J.:

“I have been on Prozac over the last 20 years off and on and it finally stopped working. The last time I took it about 2 years ago I was taking the generic from Barr – the blue and white capsule. I was feeling as if I were in the deepest dark hole there ever was.

“My doctor put me on Cymbalta from which I had a lot of side effects such as palpitations, feeling constant dread, panic attacks, sweats, lightheadedness and general feeling of not being well.

“She added Abilify which put me over the edge. I was in the worst depression I have ever been in. Finally after living like this for several months, I asked to be put back on Prozac. I was taking the generic from Sandoz. When the prescription ran out I ended up on the big blue and white capsules from Barr.

“Over the last couple of weeks it has been constant crying spells, arguing with everyone and feeling pretty low. I talked to my doctor and she wrote the prescription for Sandoz only generic. The blue and white capsules are like taking a placebo. My doctor said she had had other patients who complained of the same thing and she had to write prescriptions for a certain generic or name brand.”

– R.P. says:

“I took Cymbalta for 3 days and thought I’d go nuts. I’m off it now and refuse to try any other drug like this. My main complaint was extreme hot flashes that estrogen wouldn’t help. I thought I’d be given Prozac, but was given Cymbalta instead. It was a rough 3 days and I stopped it last night. I am extremely tired yet cannot sleep at night. I think I was sweating even worse and my legs started feeling like I had Lyme disease again. And to be honest, within those 3 days of taking it, I didn’t contemplate suicide, but I had this crappy attitude of “who would care?”

– Nancy relates how hard it was to get off Cymbalta:

“It took me 18 months to get off Cymbalta, with no doctor’s help. I can hardly believe that doctors have no exit strategy for this dangerous drug. I had to find this out on my own from reading and as soon as I weaned off that – about a month, the tinnitus that had occurred decreased almost completely. No doctor told me this.”

— J.K. shares a parent perspective:

“My daughter experienced severe side effects when trying to come off Cymbalta – she had nausea, vomiting, lost peripheral vision for 24-48 hours, had shaking, etc. This was while she was doing a clinical in a hospital for college. Had she known she would have stayed on it until after clinical. I called the manufacturer and they acted like there were no such side effects from withdrawal.

“She too took apart the capsules and it took awhile, but finally she is free from that drug. I think it is a crime that the manufacturers don’t publish more detailed information concerning withdrawal. They could even make money selling a one month or two month step down prescription so individuals aren’t taking the capsules apart themselves.”

– P.C. Tells what it is like to switch around from one drug to another:

“I just turned 52 today. I went on a very low dose of Zoloft about 8 years ago to treat generalized anxiety disorder. It really did help for a long time. I recently have been pretty depressed (however I can cover it up really well) and my psychiatrist switched me to Effexor which was terrible for me. Now I’m trying Cymbalta which has not done anything either except make me feel more anxious and headachy and weird.”

“I am a registered nurse and I do not understand what the long term effects of these meds are and I am concerned. I really want to get off and see what I can do naturally for myself.”

– K.T. tells what it is like to try to stop Cymbalta:

“Getting off Cymbalta is challenging but not impossible. I, too, experienced the light-headedness, dizziness, and “brain zaps.” I described it as being able to “hear my eyes move.” It sounded like the light sabers on Star Wars. Very strange and disconcerting.

“The key is to do it very very slowly. Take the capsules apart and begin by removing 5 or 10 of the tiny balls inside. Do this for a week or so, then slowly increase the amount you remove each week or two as you can tolerate it.

“Your doctor will probably be no help at all. Mine wasn’t. He instructed me to wean off over a two to three week period and I almost lost my mind. I did it myself over about a YEAR or more. Be patient. I am completely off now and feeling GOOD.”

– Karen’s story:

“I was prescribed Cymbalta ‘off-label’ to manage fibromyalgia pain When I stopped taking it because it wasn’t delivering on the promised effect of reducing my pain, I became so horribly depressed that I required hospitalization as I had become SUICIDAL!

“I will NEVER take another anti-depressant for an off-label purpose….such as Elavil/amitriptyline as a “sleep aid” which is very commonly prescribed.

“I believe it should be criminal to prescribe ANY drug for a purpose other than the one it was approved to treat.”

– R.H. and Erectile Dysfunction:

“I’m a 76 year old man, my libido was very low. Taking Cymbalta for peripheral neuropathy added ED as a side affect of the drug. I had a testosterone blood test; it was 1/3 what the minimum should be. So I’m taking Androgel to raise testosterone levels and it is magic. I have great libido now and am working on minimizing the Cymbalta pills. In the meantime I have been prescribed Cialis for the ED. Each pill solves the sex problem for a couple of days.”

– M.O. on stopping Cymbalta:

“I have the exact symptoms as everyone else and it’s been a week. I only took Cymbalta for 2 months, but the side effects from stopping it are horrible. My doctor didn’t, nor did anyone else tell me, about any side effects and I did read the insert. Most of the time the listed side effects of meds don’t bother me, so I figured no problem.

“From reading other posts on this website and on other sites, the drug seems to affect every person the same way. I would never have taken it for my neck pain if I had known about the likelihood of side effects. The worst part for me is the dizziness, the brain zings and the sudden burst of tears for no reason. I would never take this drug again. I think the FDA needs to do longer studies on all drugs and be honest with their findings and that doctors should be honest and tell their patients what really happens when you take Cymbalta.”

Please add your own experience below in the comment section.

Revised 1/28/16

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  1. Linda

    I was diagnosed with depression after a back injury which left me with chronic pain for the past 9 years.
    The early days were very hard but I fought Dr, occupational therapists, chronic pain specialists to stay clear of all antidepressants. After being made to feel foolish for my decision I began taking Cymalta. I was told it was very safe and as a positive, great as a pain manager for my back injury as well as for my depression.
    I was one of the lucky ones with no side effects.
    Eight years later! Coming off this medication has proven difficult. I have come off cymbalta very slowly, over five months.
    I amsuffer withdraw symptoms such as.;
    Mood swings
    Heart polpalpitations.
    Aggressive language
    Brain fogged of dissociative feeling, my brain had been in a car crash and I’m unable to concentrate, or stay focused.
    I suffer nausea, Diahourea, blotted stomach.
    I go from being bone deep cold with shivers to the burning
    Passing out
    The feeling of not wanting to be here is definetly overpowering.
    I’m working with my Dr and Phycologest but it’s really really hard. I wish I had stuck to my original instinct and stayed clear of Cymbalta. I would be in a better place today if I have used meditation, yoga, happy moments for a healthier state of mind.

  2. Chloe

    I am a psycholigist in Australia and I also have been using Cymbalta for abt 5 yrs for PTSD and to cope with stress from work. Even though I exercise and ‘walk my talk’, I was battling with some past trauma and my doctor started me on Cymbalta. Since then, I’ve privately experienced all of the horiffic side effects mentioned when trying to reduce my dose, inc. dreadful panic attacks and even spatial awareness problems when I try to ride a bike (even though I enjoyed riding in the past).

    I was even experiencing dreadful dizziness when running and yet I’ve done several marathons and have run for 20yrs. I am now very slowly reducing the 60mg, by taking 30mgs one day per week along with Proxan (5htp – makes Serotonin) 2 hrs away from my cymbalta dose – at night. It is important to follow this regime through a good naturopath, but it seems to be working at last! Last year i weaned my self off, over 6mths my unscrewing the capsule and removing 1/2 the beads, but side effects of the discontinuation syndrome were too severe and I foolishly listened to 2 GPs and resumed.. Currently, for me, taking 1× 30mg capsule 1 day per week for seveal weeks then very gradually taking 30mg on 2 days per week seems to work. But, really important to see a good naturopath, to correct the imbalance of the neurotransmitters and to monitor your symptoms..Needs to be done very gradually.

    Also, do watch Dr Charles Gant on utube- he is an expert in this area ( read excellent book: “End Your Addiction” and/or see a Bio Balance Gp who are trained by Dr William Walsh: they are trained in bio molecular medicine and will prescribe supplements to reduce your anxiety/ ptsd /depressive symptions. Also, best to find a good psychologist and /hypnotherapist to resolve underlying emotional issues. Much much cheaper and more beneficial than emotional band aids!! Good luck and best wishes!

  3. Pamela

    My doctor had had me on up to 180mg/day of oxycodone after a car accident that herniated 2 discs and made my hip tilt forward (if it pops into place, it only stays in place for up to two days). My hip tilting pulls on the herniated discs. I asked my doctor to help me wean down on the oxycodone. This doctor wasn’t very helpful all she did was write me a smaller prescription each month, when I complained of bad headaches and depression the only thing she did was lessen the amount I weaned down.

    After changing doctors I found there were several medications the doctor could give me that would/did help with withdrawal symptoms. Having a panic disorder and mild depression anyway, my new doctor put me on clonidine, klonopin, Cymbalta, and Welbutrin all while weaning me off of oxycodone. After I was completely off of the oxycodone, I lost my health insurance and this doctor didn’t know about coupons I could get on goodrx for Cymbalta and I’d never heard of it until later. Since I couldn’t afford almost $300 for a month of Cymbalta, I had to go off of it, coincidentally at the same time I weaned off of oxycodone.

    I had brain zaps, dizziness, no appetite, seeing things out of the corner of my eyes, suicidal thoughts (very strong as I couldn’t live like that!), uncontrollable crying, severe depression, severe anxiety, no interest in ANYTHING. Two things saved my life, my amazing husband that stood by me and wouldn’t budge no matter how hard I pushed him. And the fact that I lost a friend to suicide the same day I took my last dose of both Cymbalta and oxycodone.

    I blamed the oxycodone for what I was going through, but it didn’t make sense that it was so long! I have a B.S., a phenomenal work history, I’m a workaholic, I love to work. I’ve used my anxiety disorder my whole life to better myself, push myself. My anxiety and depression were crippling. I simply couldn’t live that way!

    I saw the aftermath of my friend’s decision to take his own life. I didn’t want my family and friends to go through that because of me. The what ifs the whys etc – I couldn’t do that. My friend taking his own life quite probably saved mine. My horror went on for 3.5 months.

    It wasn’t until my doctor wanted to put me back on Cymbalta that I researched and found my horror was not caused from oxycodone withdrawal, but rather Cymbalta Withdrawal.

    I’ll deal with the chronic pain, the depression and the anxiety before I take Cymbalta again. I was lucky enough to be fine while on Cymbalta. But the only way I’ll ever take it again is if it’s for the rest of my life. I’m 46, that should potentially be a long while – so I’m staying away from it.

  4. Terrance

    I was diagnosed with Bi-Polar years ago and have been on all kinds of medications. I am now on Cymbalta 60mg. twice a day. I am shocked at some of the comments made about the drug. In fact I am frightened and mad at what I am going through. To think that my PA would increase the dosage makes me angry.

    Now, I understand the drug epidemic that is going on in this county. We have professional drug pushers making good money from Insurance Companies and continue to do so with no regard to the patient. I know I am going to stop two a day to only one. Then I am going to have a nice little talk with my Physician’s Assistant. Where do I go to for help?

  5. AutumnRose

    My son been taken med I’n guessing about a year and half. Oh my gosh he was not my son after a while. The finally blow was he go so violent he was taken to jail. Now he is off this med and pretty much back to his old self. He have a lot more energy and tell me he love me a lot , The only side effect by stopping them is the brain zaps

  6. Nicole

    I am currently withdrawing from Cymbalta due to not being able to pick it up from the pharmacy until tomorrow afternoon. This is day 3, and I feel like I am going to die. My resting heart rate is over 90. I am extremely nausea. The anxiety is so intense that I want to scream and run out of work. I am sweating and having low grade fevers. I have blurry vision. I don’t know what to do. I don’t know if I am going to make it through the day.

  7. Tracy
    United Kingdom

    I’ve been on Duloxetine for about 8 months for Anxiety/Panic Attacks, eventually on 120mg per day, 60mg in the morning and 60mg at dinner time. I was vacant, moody, argumentative and generally on a different plant. I went to the Doctors as I wanted to come off and was advised to do a weaning off phase. I’m halfway through week 3 and down to 30mg in the morning, but seriously the dizzy spells are awful, my head goes fuzzy as if I’m going to faint, I ache from head to toe, I’m exhausted all the time, I get hot flushes and an awful dry mouth and the mood swings are a nightmare.

    I can’t seem to find the right words or think for myself properly and the negativity in my head some days is awful, that it gives me a pounding headache trying to concentrate on not being negative or low. I’m argumentative, cry a lot, moody, emotional and have caused no end of rows over the past few weeks. My partner deserves a medal for what he has had to put up with from me.

    Don’t get me wrong, I have been more positive some of the days and they have been good apart from the dizzy spells, lethargy and aching. It’s almost like having the flu without some of the symptoms. If I’d of known about the side effects from this drug before being put on it by the Doctor, I would of definitely declined from being prescribed it. So, if anyone has any ideas on how to cope with any of the symptoms, then please let me know.

  8. Alica
    Gilbert, AZ

    First, I want to say that there are many helpful antidepressants out there. I have taken several of them. The problem is they don’t help forever. After a while, our bodies become resistant to them it seems. I have taken Elovil, Flexor, Paxil, Cymbalta, and a couple of others I can’t think of. Paxil was difficult to get off of because of the shooting neuropathy in feet and nerve pain in my body but nothing has prepared me for trying to get off of Cymbalta.

    I am 56 and have experienced regular pain since my childhood. I was diagnosed with fibromyalgia by a neurologist years before it became in “vogue.” I went on Cymbalta for fibromyalgia pain. I was on it for a year or so. I was excited when I realized that I could finally eat chocolate (which I have always been allergic too) without getting a 5 day migraine. (woohoo) I decided to go off of it because I started a “natural supplement” regimen. While on both, I felt pretty good. Then the weaning- nightmare began.

    Oh my goodness, I am glad I got on my laptop today and began reading the withdrawl symptoms for Cymbalta. I thought I was going crazy. I have been so sick and in so much pain and discomfort. This list of complaints doesn’t reflect order or levels of discomfort. Some days I experience some of the discomforts more intense than the other. I have found the evenings to be so painful that I dread when the afternoons come. I have been off completely for a week and this morning I gave in again and took one because I couldn’t handle it anymore. I just thought it would make it easier to see what I am experiencing and see if you can relate.Thanks so much for the idea to take the capsules apart. I will try that.

    1. Crying, angry, suicidal, sadness, anxiety- I became pretty creatively scary while contemplating how to off myself, I hate myself sometimes, then I feel good at other times (I am sure due to the supplements)
    2. Gut, teeth, eye pain and pressure
    3. An over all feeling of flu like symptoms.
    4. My head, hurts, feels off balance, I can’t focus, I couldn’t drive and find where I was going, my eyesight is horrible.
    5. Nauseousness, stomach cramps
    6. Electrical zaps but they are throughout my entire body like I stuck my finger in a light socket. This is off and on every few minutes sometimes and lasts for hours the first couple of days off of it.
    7. Incredible Fatigue- I slept one day until 3:30 in the afternoon. I had never done that. Unbelievable weakness
    8. Hot flashes, chills, shaking, through out the day, worse in the evenings.
    9. Soaking sweats,
    10. Loss of motivation
    11. Racing heart rate when I try even smallest exercise which causes more nausea.
    12. Intestinal distress, diahreah
    13. Lack of appetite
    14. nightmares, crazy dreams, and more chaotic nightmares
    15. Can’t fall asleep, inability to stay asleep, sleep and wake every few minutes for hours on end. Very tiresome.
    16. painful shooting neuropathy in my feet
    17. Colitis

    while I was on Cymbalta, I couldn’t stop eating, now I can’t hardly eat at all. I gained almost twenty pounds in a year and in the last week, I have lost 3 pounds. I wouldn’t suggest this method of weight loss. I feel like I have been living in hell. I can’t tell anyone and have them understand. My husband just thinks I am overly emotionally sensitive. I am way beyond just emotionally sensitive, my body hurts in new ways, I never experienced with my severe fibromyalgia pain, and that had me confined to bed half of the time, for nearly a decade.

    Here is what I did to help with my fibromyalgia before Cymbalta. I got out of bed after ten years and began jogging. It was horrible and not fun. I went on a weight loss program and lost 65 pounds. I gave up sugar. Let me tell you a secret about sugar. It is something we all love to hate and it is full of inflammatory properties. I loved sugar so much I was willing to hurt for it. I finally recognized that I could be having a good pain free day and then I ate ice cream or cookies for example. Within only a few minutes. Before I got up from a restaurant table, I could hardly walk with my arthritis pain in my hips.

    My shoulder fibromyalgia pain would begin to scream at me. I had been told about sugar and its dangers and could not make myself quit it. Then I did the experiment over and over again on my good days. I am talking about doing this at least 10-20 times. Fully aware of what I was trying to do. I successfully turned my good days into bad days after a simple dessert.
    So why go on Cymbalta at all if I had figured out how to prevent the pain? Because as amazing the difference I felt after exercise and the removal of sugar, I did not experience 100 percent good days. I got greedy. I still had hard days on occasion. And I still got “stupid” on occasion and wanted my sugar. I wanted a pill that would take away all my pain and I could do, eat what ever I wanted. I wanted my cake and to eat it too. I am going to continue to try and get myself out of this nightmare.

    For me. . . The best way to achieve being pain free (This includes emotional/physical) is to exercise when I don’t feel like it, resist sugar when I don’t want to, continue the vitamin mineral supplement regimen I have started. Have annual check-ups. Get occasional blood work done to make sure the hormones are where they need to be. If this doesn’t work for you, find something that does. Don’t just give up and believe you are expected to live in pain. AND don’t think that every day must be 100 percent pain free either. We experience the pain so that we may appreciate the time we have without it. We appreciate sorrow so we may appreciate when we feel happy.

  9. E

    Have been on this drug, 60 mg, for several years. Not feeling well – have had many tests – all neg. Feel that Cymbalta is causing symptoms. Tired, out of breath on exertion, extreme sweating, no desire to go or do anything, gastrointestinal upsets every few weeks. Just don’t feel well. Has anyone JUST STOPPED this med ??? I would like to get off of it, NOW. Feel like it’s the pill that’s making me sick. Comments appreciated from those who just STOPPED TAKING.

    • scott
      raleigh, nc

      I am currently on this medication right now and am considering stopping it as well. But not cold turkey. I have done this before in the past with other drugs but I have been off this for 2 days and am so tired and miserable I am going to take them again just to stop the horrible feeling I have inside.

      I am on 60mg and feel like my energy and life has been taken from me. I am going to try and ween myself off it. Be careful. I have read alot of bad stuff.

  10. CD
    Springfield, MO

    I have been on Cymbalta for several years to help with depression and fibromyalgia pain. I tolerated the medication well. A few weeks ago my physician was going to change my medication and had me stop Cymbalta suddenly. I had horrible withdrawal symptoms. To put it mildly, I had a week from hell. I had very strange headaches, nausea and digestive upset, irritability and anxiety, chest pain, shakes, and one evening it felt like my “insides” were shaking, and I couldn’t get it to stop. I am still having (2 weeks later) terrible muscle pain.

    • Fran

      Omg the brain zaps I am trying so hard to get off this medicine so Hard . I can go a few days maybe 4 or 5 then the brain zaps start the only thing that helps is taking one again !!!!!

    • Cheryl

      I have been on Cymbalta about 2 years now my doctor told me to stop taking it just like that not to wean off it nothing I thought I was going to die the crying spells the chills my blood pressure was sky-high my stomach hurts so bad I was killed over when I had to walk wanted to be dead real bad tremors my head felt like there was like cotton balls in it I could not function at all all I wanted to do was commit suicide I am now back on it after only 5 days of being off of it and I feel 100% better I will never stop taking it like that again it was hell

  11. Claudia
    Winston ga.

    I was on 60 mg for , 2/3 yrs. I was having all these withdrawal symptoms I am reading about before coming off Duloxetine. Had the worst flare up of my fibro and depression symptoms,(so my dr. Said ) in June, July & and August of 2017 since diagnosed 18 yrs. ago, while still on Duloxetine! In the first yr. Duloxetine seemed to help with fibro. Symptoms after that went progressively down hill. It took me awhile to realize what was going on. Started coming off 1 week ago. I am taking a few grains from the capsule each day. Down to less than 1capsule in a week.

  12. Sue

    I have been taking Cymbalta (120 mg) for a number of years because of chronic shoulder pain. In the last year I have felt that it was not helping since it was supposed to last for 24 hours and was only lasting 4 hours. I finally got a new doctor and advised her that I would like to stop taking this medication since I was recently diagnosed with a several non-alcoholic fatty liver. So far I have only been taking 60mg for a couple of weeks and already am having light headless, dizziness and feeling very tired.

    I’m not sure how long to stay on the 60mg but my doctor did give me a prescription for 30mg tablets so I can decrease again when I am ready. I was hoping to do it sooner than later but in reading comments from others am thinking that I should still stay on the 60mg for a little longer before reducing to the lower 30 mg. dose. I could not figure out why I was feeling so tired after recently losing weight and feeling so energetic and now I feel like I need naps again. Hopefully I will be able to get off this medication as soon as possible.

    • John

      I was on 120 mg. for two years (PTSD) than I told my doctor I wanted to start to come off. He prescribed me 30 mg and I decreased to 90mg. Took 90 for several months and than went down to 60. I started to feel a small change in my mood (anger) but stayed on 60 for about a year. Well a couple of months ago I went down to 30 mg. and now seem to have a worse problem now than I did when I started it. I have gone back up to 60mg. I guess that’s how they get you. I would really like to stop taking them but I am afraid I would lose my wife and family. No joke

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