A bottle of generic delayed-release Duloxetine (Cymbalta) 30 mg

We have received so many complaints about duloxetine side effects that we have lost count. Far more disturbing are the number of people who tell us how hard it is to discontinue this drug.

Decades ago doctors might have told patients taking a drug like Cymbalta that if they experienced anxiety, irritability or strange sensations after stopping the drug, it was probably their underlying psychological problem returning. Now we know it is withdrawal from the medicine.

The History of Cymbalta:

Cymbalta was originally approved by the FDA in 2004 for the treatment of major depression. It is officially an SNRI-type antidepressant. In doctorspeak that means it is a serotonin-norepinehprine reuptake inhibitor and is somewhat similar to other antidepressants such as Effexor (venlafaxine) and Pristiq (desvenlafaxine).

The FDA also approved Cymbalta to treat nerve pain associated with diabetes in 2004. In 2007 the drug got a green light for anxiety and in 2008 the FDA agreed that it could ease the discomfort associated with fibromyalgia. It was also approved to treat musculoskeletal pain associated with arthritis and lower back pain in 2010.

In other words, here was a drug that could relieve your blues and your aches and pains. And the drug company that makes Cymbalta (Lilly) has been aggressively marketing it as a good way to deal with chronic low back pain and osteoarthritis. Perhaps you have seen the commercials on TV promoting the pain relieving power of the drug with the slogan “Cymbalta can help.” It sounds almost too good to be true.

Ah…and there is the rub. Although there is a long list of serious side effects mentioned during the commercial, the video images seem quite reassuring and trump the scary message the FDA requires for this medication. So, let’s set the record straight. Here, without visual interference, are a list of potential complications associated with this medication.

Cymbalta (Duloxetine) Side Effects

  • Nausea, stomach pain, constipation, diarrhea, decreased appetite, vomiting
  • Dry mouth
  • Insomnia, anxiety, tremor
  • Dizziness, fatigue, sleepiness
  • Sweating, hot flashes
  • Blurred vision
  • Headache
  • Sexual dysfunction, lowered libido, erection difficulties, lack of orgasm
  • Liver damage
  • Serious skin reactions, rash, hives (requires immediate MD assistance!)
  • Glaucoma
  • Irregular heart rhythms
  • Bleeding problems
  • Blood pressure problems
  • Interaction with other drugs (leading to serotonin syndrome among other reactions)
  • Pneumonia
  • Seizures
  • Depressed mood, suicidal thoughts and behavior, suicide

Such a long list of side effects makes your eyes glaze over after the top 3 or 4. That is why we have included stories from real people so you can better understand what these complications feel like.

Stopping Cymbalta:

Even though such side effects are scary, there is another problem with Cymbalta. When people try to stop taking this drug they frequently report unpleasant withdrawal symptoms. An organization (QuarterWatch) that monitors the FDA’s database of serious adverse drug events has noted that:

“We observed a signal for serious drug withdrawal symptoms associated with duloxetine (CYMBALTA), a widely used antidepressant that is also approved to treat arthritis and back pain, anxiety, and fibromyalgia. In the first quarter of 2012 the FDA received 48 case reports of drug withdrawal identifying duloxetine as the suspect drug. They described a wide spectrum of withdrawal effects that began when the patients stopped the drug, including blackouts, suicidal thoughts, tremor, and nausea. Several cases involved hospitalization.

Probing deeper into the scientific record for duloxetine we found that withdrawal symptoms were reported in 44-50% of patients abruptly discontinuing duloxetine at the end of clinical studies for depression, and more than half of this total did not resolve within a week or two. In addition, we identified a serious breakdown at both the FDA and the manufacturer, Eli Lilly and Company, in providing adequate warnings and instructions about how to manage this common adverse effect.”

Doctors have taken to calling this “discontinuation syndrome.” These clinical words do not do justice to what it is like to stop antidepressants like Cymbalta, Effexor (venlafaxine), Paxil (paroxetine), Pristiq (desvenlafaxine) or Zoloft (sertraline) suddenly.

Sudden Withdrawal Symptoms

  • Brain “Zaps” (electric shock-like senstations in the brain)
  • Dizziness, light-headedness, vertigo, feeling faint
  • Headaches
  • Anxiety, irritability, hostility
  • Nausea, diarrhea, digestive upset
  • Tremor, hands shaking, nerve tingles, strange sensations
  • Fatigue, tiredness, lack of energy
  • Visual disturbances

Again, a list of symptoms does not do this problem justice. Below you will read some stories from people who have posted their comments to this website. We would love to hear your story, positive or negative. Share your experience with Cymbalta or any other antidepressant below.

Should you wish to learn more about dealing with depression through some other strategies, we offer our Guide to Dealing with Depression. You will also find a whole chapter on prescribing mistakes doctors make when treating depression and fibromyalgia in our book, Top Screwups Doctors Make and How to Avoid Them.

Cymbalta Withdrawal Stories from Readers

– D.G. shares a tragic story:

“My lovely, young daughter-in law, who was about to celebrate her 29th birthday, was prescribed Cymbalta, Klonopin, and Ambien and has committed suicide.

“She told her physician and her therapist that she’d had thoughts of suicide but no one took her seriously. She suffered from depression, as well as an eating disorder, and had very low body weight. She also used alcohol.

“Please remind your readers of the potentially disastrous effects these chemicals can cause when taken carelessly or in combination with alcohol.”

This from – P.J.:

“I have been on Prozac over the last 20 years off and on and it finally stopped working. The last time I took it about 2 years ago I was taking the generic from Barr – the blue and white capsule. I was feeling as if I were in the deepest dark hole there ever was.

“My doctor put me on Cymbalta from which I had a lot of side effects such as palpitations, feeling constant dread, panic attacks, sweats, lightheadedness and general feeling of not being well.

“She added Abilify which put me over the edge. I was in the worst depression I have ever been in. Finally after living like this for several months, I asked to be put back on Prozac. I was taking the generic from Sandoz. When the prescription ran out I ended up on the big blue and white capsules from Barr.

“Over the last couple of weeks it has been constant crying spells, arguing with everyone and feeling pretty low. I talked to my doctor and she wrote the prescription for Sandoz only generic. The blue and white capsules are like taking a placebo. My doctor said she had had other patients who complained of the same thing and she had to write prescriptions for a certain generic or name brand.”

– R.P. says:

“I took Cymbalta for 3 days and thought I’d go nuts. I’m off it now and refuse to try any other drug like this. My main complaint was extreme hot flashes that estrogen wouldn’t help. I thought I’d be given Prozac, but was given Cymbalta instead. It was a rough 3 days and I stopped it last night. I am extremely tired yet cannot sleep at night. I think I was sweating even worse and my legs started feeling like I had Lyme disease again. And to be honest, within those 3 days of taking it, I didn’t contemplate suicide, but I had this crappy attitude of “who would care?”

– Nancy relates how hard it was to get off Cymbalta:

“It took me 18 months to get off Cymbalta, with no doctor’s help. I can hardly believe that doctors have no exit strategy for this dangerous drug. I had to find this out on my own from reading and as soon as I weaned off that – about a month, the tinnitus that had occurred decreased almost completely. No doctor told me this.”

— J.K. shares a parent perspective:

“My daughter experienced severe side effects when trying to come off Cymbalta – she had nausea, vomiting, lost peripheral vision for 24-48 hours, had shaking, etc. This was while she was doing a clinical in a hospital for college. Had she known she would have stayed on it until after clinical. I called the manufacturer and they acted like there were no such side effects from withdrawal.

“She too took apart the capsules and it took awhile, but finally she is free from that drug. I think it is a crime that the manufacturers don’t publish more detailed information concerning withdrawal. They could even make money selling a one month or two month step down prescription so individuals aren’t taking the capsules apart themselves.”

– P.C. Tells what it is like to switch around from one drug to another:

“I just turned 52 today. I went on a very low dose of Zoloft about 8 years ago to treat generalized anxiety disorder. It really did help for a long time. I recently have been pretty depressed (however I can cover it up really well) and my psychiatrist switched me to Effexor which was terrible for me. Now I’m trying Cymbalta which has not done anything either except make me feel more anxious and headachy and weird.”

“I am a registered nurse and I do not understand what the long term effects of these meds are and I am concerned. I really want to get off and see what I can do naturally for myself.”

– K.T. tells what it is like to try to stop Cymbalta:

“Getting off Cymbalta is challenging but not impossible. I, too, experienced the light-headedness, dizziness, and “brain zaps.” I described it as being able to “hear my eyes move.” It sounded like the light sabers on Star Wars. Very strange and disconcerting.

“The key is to do it very very slowly. Take the capsules apart and begin by removing 5 or 10 of the tiny balls inside. Do this for a week or so, then slowly increase the amount you remove each week or two as you can tolerate it.

“Your doctor will probably be no help at all. Mine wasn’t. He instructed me to wean off over a two to three week period and I almost lost my mind. I did it myself over about a YEAR or more. Be patient. I am completely off now and feeling GOOD.”

– Karen’s story:

“I was prescribed Cymbalta ‘off-label’ to manage fibromyalgia pain When I stopped taking it because it wasn’t delivering on the promised effect of reducing my pain, I became so horribly depressed that I required hospitalization as I had become SUICIDAL!

“I will NEVER take another anti-depressant for an off-label purpose….such as Elavil/amitriptyline as a “sleep aid” which is very commonly prescribed.

“I believe it should be criminal to prescribe ANY drug for a purpose other than the one it was approved to treat.”

– R.H. and Erectile Dysfunction:

“I’m a 76 year old man, my libido was very low. Taking Cymbalta for peripheral neuropathy added ED as a side affect of the drug. I had a testosterone blood test; it was 1/3 what the minimum should be. So I’m taking Androgel to raise testosterone levels and it is magic. I have great libido now and am working on minimizing the Cymbalta pills. In the meantime I have been prescribed Cialis for the ED. Each pill solves the sex problem for a couple of days.”

– M.O. on stopping Cymbalta:

“I have the exact symptoms as everyone else and it’s been a week. I only took Cymbalta for 2 months, but the side effects from stopping it are horrible. My doctor didn’t, nor did anyone else tell me, about any side effects and I did read the insert. Most of the time the listed side effects of meds don’t bother me, so I figured no problem.

“From reading other posts on this website and on other sites, the drug seems to affect every person the same way. I would never have taken it for my neck pain if I had known about the likelihood of side effects. The worst part for me is the dizziness, the brain zings and the sudden burst of tears for no reason. I would never take this drug again. I think the FDA needs to do longer studies on all drugs and be honest with their findings and that doctors should be honest and tell their patients what really happens when you take Cymbalta.”

Please add your own experience below in the comment section.

Revised 1/28/16

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  1. Fred
    San Diego

    I have been on Cymbalta/Duloxetene for 8 1/2 years for nerve pain, taking 120 mgs a day. Recently my workers comp insurance refused to cover it anymore even though I have lifetime coverage through a legal settlement. I have been fighting to have it reinstated for 3 months and just ran out of pills last week. For the last 4 days I have been dizzy, lightheaded and had loss of balance. I also have the brain “zaps” and fatigue. I don’t know how long this is going to last but I don’t think I’ll ever take them again.

  2. Nan

    The dr. prescribed it to me for depression. I started out on 30mg, wasnt helping so was put up to 60mg., this was over a 1 year period. I went to my primary recently and told her it’s not working I’m getting worse, I want something else. She told me I had to find a psychiatrist because it wasn’t her specialty and she didn’t know what to give next. So I’ve been weening off and currently have not put any cymbalta in me since 4 days ago. Well all I can say is it has been HELL! I can’t sleep at night and if I do for a few hours it’s nothing but surreal NIGHTMARES!! During the day I have turned into a miserable, nasty person that is completely strung out I hate myself! I have episodes of crying uncontrollably! I have been on numerous antidepressants for over 30 years and have had no side effects while on or coming off as SEVERE as this. I literally pray to God to please take these symptoms, side effects away quickly! The lack of sleep, nightmares, irritability and miserableness are really taking there toll on me. I am starting to cry just from writing this. I wish everyone God speed at getting us off cymbalta and getting us thru it.

  3. Susan
    East Coast USA

    I was given Cymbalta to help with chronic pain after breast cancer treatment. During my 7yrs of remission I have been taking several different medications all to assist with pain. A month ago I had a scare: the cancer had spread to my gastro area. Going through my exams and tests I decided I had enough with meds and have been slowly taking myself off opioids and Cymbalta. My last bastion is my Fentanyl patch which I will begin decreasing next month. I,too, have all the withdrawal side effects. I am grateful for the support of my family (and chocolate labradors).

    My goal is to live life without the medications and rely on a holistic approach. After the surgeries, the chemo, radiation, and the biopsies during remission,I hope to take control again. Before cancer I was an athlete, a chef, a healthy person. I want that back for myself and my family. The side effects are brutal, and as I write the brain zaps continue. My sense is that the Fentanyl patch is easing the symptoms because I tried w/d off Fentanyl to 25mg then caved in to the insidiousness of the chemicals.

    Maybe the freeing myself of these meds will help me through the last patch! I send my thoughts and strength for my fellow partners going through this. I truly believe my doctors wanted to help in the immediate present but just did not understand what happened later. I am here in the present and find the days add together if you take one moment at a time. My best in strength and determination: we can do this together .😎

  4. Megan
    New Market, Alabama

    I have been on Cymbalta for 3 year now, started with 60 mgs a day then moved up to 120 mgs a day. I was taking it for fibromyalgia/depression and anxiety. I decided it wasn’t working, and my insurance didn’t want to pay for 120 mg. My doc decided to start me on Savella, he told me to take half of Cymbalta for 4 days and stop it completely. He said it should be ok since I will be taking something else. Wrong! It’s going on 4 days now of the most awful dizziness, shocks, nightmares and crazy dreams. I can’t walk straight, or move my arms right. I feel nauseous and can’t stay out of the bathroom. I can’t hold my eyes open during the day, and can’t close them at night. And I feel like I have the flu on top of it all. It is awful, hopefully it will be over soon. I have a family to take care of, and I can’t do it laying in bed.

  5. Cass
    The Villages, Fl

    I have been on Cymbalta for 20 years. I took it for fybro pain and depression.
    It worked really well until recently. I became dizzy all the time and lost balance sometimes.. My Doctor took me off it and put me on Prozac the next day.. My Fibrom

  6. Ruth

    I have been on antidepressants for many years starting back in the 70’s with amytriptoline and moving on through the array to now being on Cymbalta (duloxetine generic of course). I have been on this for over 10 years now. I was also prescribed Klonopin and in June went through a 5-day in hospital medical detox. After those 5 days, I finished the remainder of the detoxing on my own (no NA, AA, etc). It has been over 90 days off of Klonopin. I am only explaining this part to preface what I am about to report.

    I have tried before to come off of Cymbalta with extreme side effects and by even slowly reducing my dose. My current dose is 60 mg. Almost 3 weeks ago, I abruptly stopped taking my Cymbalta (just tired of being on all the medications that I am on). The only side effect that I have noticed is a significant increase in my heart rate which I am hoping will resolve in the next few weeks. It is amazing to me that I haven’t had any worse problems than this. My BP is even low. The only thing I can even attribute this to is the fact that I went through a living “hell” when I came off of Klonopin. Also, the reason I say my current dose is 60 mg is because I am making perfectly sure I do not have to go back on it again. When I make a good 30 days without it, then I feel that I will no longer take this medication. Don’t know the half-life of this medication or the amount of time that all its medication is out of my system.

  7. Barbara

    I was placed on duloxetine for minor depression and nerve pain. Started at 30 mgs and it was increased to 60 mgs. I forgot to take my 60 mg dose for a few days and paid dearly for it. I realized at that time that this medication is not worth taking. I asked to be decreased to 30 mgs and then down to 20 mgs. I made it clear I wanted to come off the medication. It was recommended to take it every other day, and then withdraw and deal with the symptoms. It did not work and was not acceptable to me.The docs have no easy solution for coming off the medication. I started taking the capsules apart and dividing the dose.

    It took a very long time for me to come off the medication. I have been off of it for 2 weeks and am still experiencing minor side effects. I am sleeping very well and experience minor brain zaps in the morning. Feeling kind of lousy in general but I will maintain the course. I will never take another antidepressant every again. The side effects of this medication are worse than the problems I had before I started.

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