bottles of crestor lipitor and simvastatin cholesterol-lowering drugs

The Food and Drug Administration upset the applecart when it announced that statin-type cholesterol-lowering medications like simvastatin (Zocor) could raise blood sugar levels and increase the risk for diabetes. Millions of people with elevated cholesterol are trying desperately to reduce their likelihood of having a heart attack or a stroke. The last thing they need is to have their blood sugar go up, since that can increase the risk of the very complications people are trying to avoid (heart attacks and strokes, not to mention kidney damage, nerve pain and eye problems).

The FDA has worded its warning cautiously:

“A small increased risk of raised blood sugar levels and the development of Type 2 diabetes have been reported with the use of statins.”

We are not so sure this is such a “small increased risk.” Eric Topol, MD, seems to agree with us. He is one of the country’s leading cardiologists. In an op-ed article published in the New York Times (March 4, 2012) titled, “The Diabetic Dilemma for Statin Users,” Dr. Topol points out that the way the data were analyzed could be misleading. The FDA lumped relatively “weak” statins together with more potent statins like atorvastatin (Lipitor), rosuvastatin (Crestor) and simvastatin (Zocor). With this data manipulation the FDA diluted the impact of potent statins on blood sugar increases. According to Dr. Topol, the stronger the statin and the higher the dose the greater the likelihood of diabetes. He states:

“More than 20 million Americans take statins. That would equate to 100,000 new statin-induced diabetics. Not a good thing for the public health and certainly not good for the individual affected with a new serious chronic illness.”

Amidst the statistics we tend to forget that individuals are affected. We have heard from many people who have had significant problems with blood sugar control while taking a statin-type drug. The first case came to our attention almost ten years ago. A husband and wife taking Lipitor had increasing trouble controlling their glucose levels. Why did it take the FDA so long to figure this out?

What other side effects should we be paying more attention to when it comes to statin-type drugs:

  • Altoprev (lovastatin extended-release)
  • Crestor (rosuvastatin)
  • Lescol (fluvastatin)
  • Lipitor (atorvastatin)
  • Livalo (pitavastatin)
  • Mevacor (lovastatin)
  • Pravachol (pravastatin)
  • Zocor (simvastatin).
  • Products containing statins in combination with other drugs include:
    Advicor (lovastatin/niacin extended-release)
  • Simcor (simvastatin/niacin extended-release)
  • Vytorin (simvastatin/ezetimibe)

Potential adverse reactions patients and their families should be aware of include:

  • Muscle pain or spasms (any where in the body, including legs, shoulders, back, arms or neck)
  • Arthritis
  • Blood sugar elevation
  • Memory problems, cognitive dysfunction, confusion, amnesia
  • Nerve pain, peripheral neuropathy, leg cramps
  • Digestive upset, nausea, constipation, diarrhea, flatulence
  • Headache
  • Insomnia
  • Urinary tract infections
  • Skin reactions, hives
  • Pancreatitis
  • Sexual problems, erectile dysfunction

What we do not know is how common some of these side effects may be. Until recently the FDA assumed that memory problems and blood sugar elevation were so rare as to be almost forgettable. The recent alert changes that equation. How common are sexual problems with statins? No one really knows. What about arthritis, nerve pain or peripheral neuropathy? Again we are clueless.

We recognize that some people really do need these medications to prevent a heart attack or a stroke. The data suggest that people who have clearly diagnosed heart disease can benefit. Those who have had one heart attack can reduce the risk of a second by taking a statin. And many individuals never suffer any side effects. Good for them. They are fortunate.

Others are not so lucky. We don’t know what the true incidence of some of the so-called minor side effects really is. That’s why we need your help. Please let us know how you or someone you love has fared on a statin-type drug. You can comment below. Thanks for letting us know about your experience. And one more thing…no one should stop a statin without consulting the prescriber. We do not want anyone to go from the frying pan into the fire. Your doctor needs to know about how you are doing on any medication, especially a statin!

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  1. Carolyn

    Brain fog, depression, borderline diabetic, muscle aches and pains are just a few of the side effects my husband and I are both suffering. It has taken years to figure out that it is coming from the cholesterol meds. Have been on several different ones and can’t tolerate any of them.

    Hair falling out is another one that I have just researched and it is also a side effect. I am once again going to talk to my cardiologist and see about going off the meds. I think the risk of heart attack is smaller than all that is going on with us now. Not to mention the stomach troubles because these meds are so hard on the stomach.

  2. Carol

    I am in somewhat the same situation as many here. I am female, 65yo, not overweight (BMI 18), high total cholesterol, but also high HDL, which has put my ratio at only 3:2. Doctor put me on Crestor (only 10 mg), and now 3 years later I am pre-diabetic. I took myself off the Crestor when I discovered my A1C had risen.

    I am trying Pravachol, as I read it may not cause diabetes, and hoping my pre-diabetic condition may reverse itself in time. But if it continues to go up, I’ll likely go completely OFF all statins, as I am not considered at high risk for heart disease (no family history, active, healthy diet). I have a male friend younger than I who has had much the same experience using Zocor, and he’s off the meds too. But now he has to take diabetic medication to control his blood sugar.

    • k

      same here…. then I found out the fda was adding a warning to its label…. My blood sugar kept going up when I started losing weight… and im just getting it back to normal… need to lose back 5#’s ….. No more meds for me….

  3. sharon
    las vegas NV

    I am on insulin for diabetes and the doctor put me on simvastation and I am noticing that my insulin is not working or I am using much more insulin, And I am a person who tests all the time my last AIC was 5.4 I know its not gonna be that next time,I dont seem to be able to get my sugar under control now.

  4. peggy

    my ac1 6.0 I take Zocor for 10yr now I have drop foot need help

    • DJ

      If have the same situation. Couldn’t get my BG down. Major discomfort in legs and knees. Constipation and diarrhea. Hair loss. My doctor told me to discontinue Zocor. I am already doing better.

  5. Dawn
    Salem, Oregon

    Wow, My thoughts are I feel like my husband and I have been lied to by the pharmacy and Doctors who we trusted. The pharmacy called my husband about taking Simvastatin. He has diabetes she said it was a new drug and that it would protect him from high blood pressure in the long run. So with question he started taking it. He started having more problems with how he was feeling and his sugar was getting harder to control. Never once did the two different Doctors he had ever said anything about this drug. He has not been able to loose any weight no matter how hard he has tried. He has not felt will for a long time. So far in my research in finding out more about the drugs they are giving him I am not happy with. Plus they have added another blood pressure medication. I thank you very much for your information and have learned to do the research my self. We will be talking to his Doctor about this.

  6. Ray

    I have started vigorous exercise and have lost 10 Lbs in over 6 mos. My idea is to get rid of the statin drug and see if this does not help. If I can get my cholo. levels down, I am hoping to get off of the statin. No one should be on a drug such as this for decades… with the side effects associated with same. One needs to take charge and be proactive with ones health. Let’s try to put the doctors out of so many visits.

  7. Ray

    I’m on Zocor 40mg for many years as a result of high cholesterol. For the past 3 years my A1C has been over 6.5. It’s probably the Zocor.

  8. Bonnie

    I had a family history of heart problems, as such Simvastatin was prescribed for me about 15 years ago. I am 62 y.o. I have never been overweight and always get plenty of exercise, don’t drink much and exercise. My HDL is in the 80s. Because of my familial cardiac history I consulted with a cardiologist. The cardiologist did a blood test which determined that the blood fat was large fluffy particles which do not accumulate along arterial walls. He conducted another test which concluded I have no evidence of inflammation. While these are good things, my glucose and A1C have crept up over the years, so much so that I am pre-diabetic and dangerously close to becoming full blown type 2. I’ve stopped Simvastatin. I’ve begun Metformin.

    Often, like other posters, my legs are a hey, particularly at bed time. I’m hoping this problem can be reversed. I find my circumstances suspicious since I have never been overweight, sedentary and have No family history of diabetes. Does anyone know if blood glucose can trend downwards if Simvastatin is withdrawn from treatment?

  9. JOE

    I’ve taken blood pressure medicine for 18 years along with a statin (simvastatin). I have for last few years taken metformin because I have 130 on test and have become diabetic (type2) I think years of taken statins caused this.

    When I bring this up to my doctor he says stop taking statins and die. Your call Joe!!! I’m scared to stop taking them but I know they have caused me to have type 2 diabetes. I’m 66 and am not sure what to do.

  10. Harmony1

    Well I noticed you added and “…what else” … at 59 I was exercising like crazy not least of all to get into great shape for knee replacement surgery. 3 hours swimming, 1/2 hr – 1 ha, biking 6 days a week, weightlifting, spinning, group dancing and yoga, long walks with my dogs…. biked to/from work up steep hills.

    Then WHAM…. I just couldn’t use my muscles… I would leave my exercise groups in tears … out of nowhere I lost the ability to use my leg muscles, I couldn’t even use the foot brakes on my bike going downhill. It was horrific.

    I would get debilitating cramps and electric muscle spasms at night etc. etc. I screamed in agony. I got tested for everything under the sun over a 2 year period, some neurological tests were conducted several times… I was just super healthy… except for this one HUGE problem that finally sent me to a wheelchair. I can hardly walk at all. I keep moving as best I can, I use a stationary bike (4 minutes 4 times a day) and I swim about 15 minutes at a stretch a couple of times a week… any more exertion and I am awake all night for many nights in agony. I can hardly walk to the meeting rooms from my office at work.

    Finally the experts concluded that my muscle neuropathy was drug induced from statin usage over a period of 10 years. As long as I didn’t exercise, it seemed I somewhat tolerated the 5 – 20 mg dose of Simvastatin or 10mg dose of Lipitor (though I did get ad hoc cramping after some years). But once I started robust exercising, it seems I just destroyed my leg muscles.

    I also had several trigger- finger operations and carpel tunnel operations and at a very young age contracted cataracts. I have been off the medication for 2 years with minor improvements, but still near-zero tolerance for movement and exercise. It is so sad, so sad. I am now 62. Nobody is paying the bills I have to pay for all the services I need to get by. Unbelievable. The has given me much useful information and emotional support. Well done.

    • Sam

      Hey I was reading about your situation. So what did you do about it, did you go after the doc that did this stuff to you?

      You got to know that was your life they messed up, don’t let them get away with that, they took your money and put you in the situation that you are in

  11. MICK

    I am on 220 units of insulin a day was told I was eating to much and I was fat 17 stone. Put back on liptor and metformin and my glucose levels have now doubled!

  12. rosemary

    When I was put on Zocor, I noticed a lot of leg cramps. Close to a year later, I was told I was diabetic. Do you think taking this medication could have triggered type 2 diabetes?

    • Sam

      Yes it did studies has shown that this drug does a lot to a person body. Go to FDA. Org and read there report

  13. DH

    I am totally convinced Lipitor is the cause of me being borderline diabetic, as no one in my family ever had it. I have been on Lipitor for 10-15 years, and diagnosed as borderline for at least 10. However, I am on NO medication and control it by diet and exercise. My weight is normal, 129, so that is not the cause. For that matter, even tho my husband’s mother was diabetic, he was on Zocor, and was no doubt diagnosed diabetic because of that.
    It’s a shame that I, as well as others, have been diagnosed because of a miserable statin. What is this prescription helping? Something should be done!

  14. Linda S

    I am a 65 yr old female diagnosed with type 2 diabetes 3 years ago. Two weeks ago my Dr. prescribed Simvastatin 20 mg. once a day. The next day my blood sugar was elevated while taking my normal meds. Two days later it was over 200. I watched my diet more closely and increased my metformin. My blood sugar continued to remain elevated. I have nueropathy, but for the last few nights the pain has kept me awake. I started to look at what changes I might have made in my diet lately. Nothing. Then I remembered the new medication. Simvastatin. I looked online and this is the first article I read. It is scarey to think that something that should help can also be so detrimental.

  15. wtl

    had genetic heart valve problem. had valve replaced. doctor put me on simvasatin 40mg. in two and a half years my glucose level went from 100 to 150. have had two cardio caths in six years and they are clear. I had no heart attacks. my doctor refused to take me off satin. after last blood test my levels other than glucose have been extremely low. cholesterol 123 and hdl 21. I have had some of other side effects an have demanded to stop satin for 6 months till next blood test with reluctance from doctor. I feel that I was put on this because I was in cardiac icu and this is protocol. I have been also told by a cardiac nutritionist to get off due to my cholesterol/hdl ratio being high and the satin could cause unwanted problems.

  16. VLA

    My doctor knows I am not a pharma fan so he suggested Amla (Indian Gooseberry).
    Here are some links that might be of interest:
    Take this in to your physician and ask, this may be a natural alternative that does not carry the type nasty side effects and damage to you and does have a study on it.

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