a closeup of a man smoking a dangling cigarette

Q. The story about the person who became depressed on Chantix caught my eye. My husband and I were both on Chantix to quit smoking back in June. Neither of us has a history of depression, but after he was on it he tried (with no warning) to take his own life.

I tell everyone thinking about taking Chantix to make sure they talk to the doctor about ALL of the possible side effects. In rare instances, suicidal ideation and psychotic episodes may happen. That is stated in the prescribing information, which also says that depression and anxiety are frequent side effects.

A. Chantix (varenicline) is a relatively new oral prescription medicine to help people quit smoking. Separating drug side effects from nicotine withdrawal can be tricky.

When people quit smoking it is not unusual to feel angry and irritable. Other symptoms may include anxiety, depression, impatience, and problems concentrating.

Some readers have noted similar experiences to yours, though. One person reported:

“Two weeks after being on Chantix my emotions have been off the scale: from crying to yelling to feeling totally helpless. I have, twice before, quit smoking cold turkey and NEVER felt so depressed.

“After 48 hours without Chantix I am full of energy and ready to fulfill my responsibilities. I think, for me, that the depression must be a side effect and not just the nicotine withdrawal, based on my cold-turkey experiences.”

Get The Graedons' Favorite Home Remedies Health Guide for FREE

Join our daily email newsletter with breaking health news, prescription drug information, home remedies AND you'll get a copy of our brand new full-length health guide — for FREE!

  1. Holly
    Washington State
    Reply

    I am a 29 year old woman who has smoked for 7 or 8 years. I am on my 11th day of Chantix. So far, I have felt slight nausea but only because I’m not a breakfast person, mental fogginess that comes and goes, and sleepiness. I have been diagnosed with anxiety and depression as a result of PTSD and was medical cleared to take this per my MH doctor.

    I have taken it once, and it worked like a charm but I eventually went back to smoking. Now, I am really ready to quit. I decided at about 0800 this morning that today was my quit date. I do not want to end up like my grandparents with COPD, Emphysema, heart disease and the like. I haven’t had a morning cigarette or even a craving today. It is the first day of the rest of my life!

What Do You Think?

We invite you to share your thoughts with others, but remember that our comment section is a public forum. Please do not use your full first and last name if you want to keep details of your medical history anonymous. A first name and last initial or a pseudonym is acceptable. Advice from other commenters on this website is not a substitute for medical attention. Do not stop any medicine without checking with the prescriber. Stopping medication suddenly could result in serious harm. We expect comments to be civil in tone and language. By commenting, you agree to abide by our commenting policy and website terms & conditions. Comments that do not follow these policies will not be posted.

Your cart

Total
USD
Shipping and discount codes are added at checkout.