Ziac combines two different drug ingredients in one tablet. Bisoprolol was approved by the FDA in 1992 and is available by itself as Zebeta, while hydrochlorothiazide has been a mainstay of hypertension treatment for decades. Ziac is prescribed to control high blood pressure

Side Effects and Interactions

Ziac is usually well tolerated with few side effects.

Dizziness and fatigue were reported by some people participating in the tests of the medication. Slowed heart rate, chest pain, muscle aches, and impotence may also occur, but rarely.

Report any suspected reactions to the physician promptly.

Hydrochlorothiazide alone can make the skin more sensitive to the sun. Avoiding sun exposure or using sunscreen and protective clothing are sensible precautions for those taking Ziac.

Ziac may increase the blood-pressure-lowering effect of antihypertensive drugs. It should not be combined with other beta blockers such as atenolol or propranolol.

Patients should be monitored with extra care if they must take Ziac with other heart or blood pressure drugs including Calan, Cardizem CD , Catapres, Dilacor XR, Isoptin, Norpace, or Verelan.

Other medications that may have the potential to interact with Ziac include diabetes medicines, cortisone-like drugs, muscle relaxants, lithium, and arthritis medicines (NSAIDs).

Check with your doctor and pharmacist to make sure Ziac is safe in combination with any other drugs you take.

Special Precautions

People with liver or kidney disease may need lower doses of the drug and should be under close medical supervision.

Ziac, like other medicines that contain beta blockers, is not usually considered appropriate for people with asthma.

A patient who develops breathing difficulty while on Ziac should contact the physician without delay.

Hydrochlorothiazide can aggravate lupus (SLE). Make sure your physician is aware of your health history.

Taking the Medicine

Food does not affect the absorption of Ziac, which is taken once daily.

Do not stop taking Ziac suddenly; it must be phased out gradually over two weeks to avoid dangerous complications.

Learn more about hydrochlorothiazide side effects here.

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  1. Melaine
    North Carolina

    In January 2012, I was diagnosed with mild hypertension and began taking BISOPROLOL-HCTZ 2.5-6.25 MG TB. I suffer no side effects at first and tolerated the medicine well, and my blood pressure stayed within acceptable range. And I felt significantly better taking the med. In July of that same year, I went to the beach for a weekend and discovered that I could not tolerate sitting in the sun for more than thirty minutes without feeling terrible.

    This response was strange because I was a sun lover and had tanned comfortably since since childhood. Anyway, I had to sit under an umbrella while my friends were frolicking on the beach. While I didn’t make the connection between the Bisoprolol and my sensitivity to the sun then, I later read on one of my pharmacy’s prescription inserts that the medicine could cause sun sensitivity.

    After the first year of taking the med (only taking St. John’s Wort and Tramadol at the same time), I began to perspire horribly and have hot flushes, but I assumed that reaction was because of hormonal changes because of menopause. In 2014 I was diagnosed with early stage uterine cancer that was probably a result of taking unopposed Estrogen for ten years. After having a hysterectomy, sweating became a major problem.

    Mild exertion caused me to sweat so badly that my hair would be soaking wet within 30 minutes. Still, I thought it was hormones causing the problem but could not take hormone meds because of the cancer. This past year I have begun to believe that Bisoprolol may be causing the sun sensitivity and the heavy sweating. I started taking taking Losartan recently, but I don’t like the way it makes me feel (surreal, very dizzy, sleepy, hungry). Guess I’ll try another one.

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