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Can GI Problems Interfere With Thyroid Medication?

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Q. I have suffered with stomach pain and reflux for a long time. I have tried Zantac and Pepcid without much success. I am now taking Prevacid that my doctor prescribed to control excess acid. Even after an increase in dose I am still experiencing gastrointestinal upset. Any ideas?

I also have a thyroid problem. My endocrinologist started me on Synthroid and recently switched me to Levoxyl. Now I am noticing side effects. It seems as if the drug isn’t working the way it used to. I know these drugs are supposed to be equivalent but my body says something different. Should I ask my doctor to put me back on Synthroid?


A. Substituting one brand of levothyroxine (Levoxyl) for another (Synthroid) may require an adjustment in dose. But first, you and your doctor need to consider your stomach problems.

An article in The New England Journal of Medicine (April 27, 2006) shows that people with low stomach acidity do not absorb levothyroxine well and may need a higher dose. The Prevacid you are taking reduces stomach acid.

People infected with stomach bacteria called Helicobacter pylori also seem to have trouble absorbing thyroid hormone. This bug may also be contributing to your GI problems. We discuss the treatment of this infection in our Guide to Digestive Disorders. Our Guide to Thyroid Hormones has more information on levothyroxine and other drugs that may interact with it.

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I took Prevacid for years due to severe reflux. Remembered my father took 1/4 - 1/2 teaspoon of baking soda twice a day and I tried this also. It worked after several days, so stopped taking Prevacid and have not taken since. Told my Dr., and he grinned and wanted to know how I knew to do this. Asked him why he never told me this since he knew this remedy! Also lost a few pounds which also helped. With a flare-up of reflux, I take some baking soda, which always works.

You have three major symptoms of celiac disease or gluten intolerance--acid reflux, stomach pain, and thyroid problems. Doctors rarely check for this genetically common intolerance. Do yourself a favor and go to www.enterolab.com and get yourself checked for stool antibodies to gluten. Your doctor can test for antibodies in your blood, but the antibodies can be detected earlier in stool samples.

There is quite a bit of negative info recently about acid reducers. Another old time remedy is apple cider vinegar (about one tablespoon a day). I suggest organic unfiltered. There are many ways to take it such as mixed with honey in warm water or stirred into pineapple juice, etc.

Forgot to add in the baking soda remedy to mix this in a glass of water and then drink.

I'd been on the same dose of levoxyl for 10 years and levels were fine. After taking Prilosec for a year, the levels began changing and found I had to change the levoxyl dose. My Dr. said not to take them together or the Prilosec would absorb the thyroid med. I now take levoxyl in am (as directed) and wait an hour or so and then take the acid reducer. Seems OK now.

I take Synthroid early morning and take the Prilosec about 3-4 hrs later. I haven't noticed any issues with it. My biggest issue is trying to lose the 30 pounds I gained in two years before I found out I had a thyroid problem.

I have been taking both levoxyl and prevacid for the past 5 1/2 years since I had my thyroid removed because it was 3 times larger than normal but not diseased. I have found that for both medications to be effective, I take my levoxyl in the morning and my prevacid in the evening.

i also take throyid and nexium together and have had a lot o problems.Going to try spliting them up and see what happens.

I have been taking Synthroid for over a decade and was just recently diagnosed with IBS and stomach acid issues. I was told to take Prilosec in the morning before my first meal. This is also when I take my Synthroid, so I didn't think anything of taking them together. After one week I felt so tired I could barely get out of bed, realized the Prilosec must be interfering with the Synthroid's ability to work, and am now switching to Synthroid first thing in the a.m., Prilosec with second meal (luch) of the day. Hopefully this will work (and I hope it helps).

I have many issues with my health, and recently I've been picking up more information on Prilosec and how it may be affecting my health. I have optic neuropathy, I've lost my peripheral vision. I also have Pernicious Anemia which is a lack of B12. Did you know you could go blind with Anemia? Me neither, but you can.

Also, I have chronic gastritis and Graves Disease which is thyroid disease. I also have Graves Eye Disease, where my eyes bulge out of my head, they are extremely dry and my eye lids barely cover my eyes. I have taken Prilosec for about ten years, prescribed by various drs. for chronic stomach pain and GERD. I've had three endoscopies.

Why didn't they just fix the sphincter where my stomach meets my esphophagus? Because Prilosec suppresses the acid in the stomach, it also messes with the flora and fauna that should be working. It has left me with no Intrinsic Factor, hence I cannot absorb B12. I have to give myself shots of B12 bi-weekly. Recently I came upon an article about Prilosec causing thyroid disease, which I also have.

To sum this up, I think Prilosec made me go blind from lack of B12 and also has destroyed my thyroid, I take 200 mcgs of Levothyroxin everyday which is a very high dose. I've been told my vision will not get better. I have lost my driver license. Where do I go from here?

I am taking Synthroid and have just been prescribed Avapro for High Blood Pressure, Crestor for High Cholesterol and also CoQ10 vitamin for high blood pressure and Selenium for my thyroid condition (these two last pills are vitamins/minerals. I am now experiencing terrible heartburn and I am not sure what pill(s) are doing this. I do not want to take any more meds (for heartburn) I was told by a friend to take 1/2 tsp. baking soda. If I did this, when would I take it as not interfere with my thyroid pill? I take the synthroid in the morning.
Please, I am suffering with this heartburn and cannot get answers from my doctor.

I too was taking all the meds and vitamins you described.
I also take Prevacid for Acid Reflux. Did not know what pill was giving me so much heartburn. Researched, researched, went off Crestor first, heartburn disappeared, went off vitamins, until my heartburn really clears up.

Currently taking Avapro for high blood pressure, Prevacid, Synthroid and Omega 3 for hair loss and nails. Doctor now wants me on Vitamin D, because I'm so cold all the time. My daily regime:-
As soon as I wake up, anytime, I take my Synthroid, wait at least 3 hrs, take my Prevacid, wait about an hour then take my high fibre drink and then my Omega 3. I take my Avapro at dinner time. My research revealed that a high fibre drink can interfere with the thyroid absorption, that is why I wait at least 3 hrs.

The Avapro when I took in the morning, made me extremely fatigued, again researched, this is one of the side-effects, even tho doctor disagrees, I read it on different web sites. After taking it at supper the fatigue has disappeared. My suggestion anytime you have doubts what to mix with your thyroid med., go to goggle type in (example: thyroid pill and prevacid) and you will get more than enough info. Doctor's do not know how YOUR body works, they are going on general data. Hope this helps

I have been taking Synthroid for 30 years after having a thyroidectomy due to Graves disease. Recently I went to a naturopath for the first time regarding some digestive and hormonal issues. The slippery elm powder and probiotics she recommended have worked better than any antacid medication I've ever taken.

In addition, I've learned that raw cruciferous vegetables and non-fermented soy products should be avoided by people with thyroid problems as they are goitrogens. Glad I found this out as I'd been increasing my soy intake to combat perimenopausal symptoms.

I've been taking Levathroid now for 15 years after partial removal of my thyroid. I just recently learned I've been taking it at the wrong time. I was taking it along with breakfast & all my other meds. & vitamins (Prevacid, Hydro. Lopressor, Klonopin, Estrace, multi vit., Acedophilus, Citrucil & fish oil) Now I learned I should take the Levathroid 1st thing in the AM 4 hours before the Previcid & maybe other meds. They also told me to take the Previcid 1st thing in the morning!!!!! Help!!! I'm totally confused!!! Also I can't wait 4 hours before I eat breakfast & the Prevacid is to be taken before I eat. Can anyone help me coordinate my med schedule!!?? Thank you

I can certainly relate. I gained 80 lbs before they determined that was my problem. Haven't been able to take it off in 8 years. Now I have celiac on top of that.

Try taking your thyroid medication at night 3 hours after your last meal and see if it helps, but I would consult your doctor first ... I did this and it helped a great deal. I am on levoxyl ... that way the levoxyl will be diluted in your system and not interfere with other meds. Hope this helps ...

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