man with leg cramp

Quinine is one of the oldest drugs in the pharmacy. Even before the Spanish discovered the New World, native healers in Peru were using the bark of the cinchona tree to treat fever, malaria and indigestion. An Augustinian monk wrote about the uses of the “fever tree” back in 1633.
In Europe, this bark proved useful for treating the fever and chills of malaria. Chemists later determined that the active ingredient in this healing bark was quinine, and it was used around the world wherever mosquitoes carried the disease. The British even incorporated it into their “tonic water.”
No one in the United States has worried about malaria for decades. But quinine was popular as a treatment for nighttime leg cramps. For years, people bought this drug in over-the-counter products such as Legatrin, Q-vel and Quinamm to relieve muscle cramps.
In 1994 the FDA banned quinine from over-the-counter sale. The agency decided that quinine was too dangerous for people to take without medical supervision.
Quinine can cause serious side effects, including life-threatening anemia and irregular heartbeats. Other hazards include severe headache, visual disturbances, rash, itching, ringing in the ears, nausea, diarrhea and liver damage. If a pregnant woman took quinine, her baby could be born with a defect.
The FDA maintains that leg cramps are not a serious health problem, while quinine can be lethal. Over the years, more than 90 people have died of quinine complications.
Despite this, nearly two million Americans took quinine to relieve their leg cramps.
Doctors continued to prescribe quinine sulfate for restless legs as well as leg cramps.
Now, however, the FDA is cracking down. Only one brand of quinine will be allowed on the market. Qualaquin is approved only for treating certain types of malaria, and it costs more than $4 per pill.
The more rigorous ban may pose problems for millions. One reader wrote, “It was refreshing that our doctor prescribed quinine sulfate for my husband’s restless leg syndrome. He takes one pill each night before bedtime and gets wonderful results.”
Even people who have used quinine successfully for years won’t have access to it now. The trouble is that there aren’t very many other medications that can relieve leg cramps.
We discuss a number of home remedies and other approaches to this common problem in our Guide to Leg Pain. One reader had good results from an inexpensive remedy:

“After suffering with leg cramps for over 30 years, I heard about putting a bar of soap under the bottom sheet of the bed. Nothing kept me from having to get up and massage my feet and legs until I tried the soap. What a relief to be able to finally get a good night’s sleep!”

Other approaches to leg cramps include drinking low-sodium V-8 juice, consuming extra calcium, magnesium and B vitamins. Some even report that a little yellow mustard can relieve nighttime leg cramps.

Join Over 100,000 Subscribers at The People's Pharmacy

Each week we send two free email newsletters with breaking health news, prescription drug information, home remedies and a preview of our award-winning radio show. Join our mailing list and get the information you need to make confident choices about your health.

  1. Markus

    I have had serious nighttime leg cramping intermittently for a number of years. What I’ve found works to relieve them is eating half a frozen banana. Alternately, using a powerful hand-held massager on the cramping muscle helps stop the cramping. I have not determined any reliable preventive regimen. Maybe the tonic water will be the ticket. I’ll try that. I like to mix it with orange juice, or drink it straight.

  2. Markus
    Northern California

    Big Government steps in again to save all the ignorant little people. So now you can’t get quinine for medicinal purposes, but you can still buy tonic water for cocktails and bitter drinks. Obviously the makers of tonic water aren’t getting their quinine from the pharmacy at $4.00 a pill. So where can I get it to make my own tonic?

  3. Sonny
    Las Vegas, NV

    Dill pickle juice, yes, pickle juice. Leg cramps waking you up? About 2 oz will relax the muscles in under 10 minutes.

  4. Octobyra

    I have posted a number of comments about leg cramps that have been torturing me for the last 12 years. I only get them when I do physical work that involves me bending at the waist, which is most of the work I do. They hamstring cramps had been so brutal at times that I began thinking about checking out altogether. I visited more than 12 different specialists — neurologist, 3 neurosurgeons, acupuncturist, chiropractor, vascular surgeon, etc. Two months ago I decided to have neurosurgery (a foriminotomy at L5) on the chance that my cramps were being caused by a pinched nerve in my lower back.

    Well, it did not work. I continue to get the cramps at night, 12 to 18 hours after a few hours or less of physical work. BUT I JUST DISCOVERED SOMETHING THAT WORKS TO GET RID OF THEM INSTANTLY!!! In all the years I’ve been reading about this horrendous problem, I have never read about this quick solution. HERE IT IS: If I straighten my cramped leg and raise it up and back over my head, so as to stretch my hamstring to the max, the cramp dissipates in one or two seconds !!! It works every single time for me. The hardest part is kicking the blankets out of the way with my right leg so that I can raise my left leg up and back (the cramps are always in my left leg). If only I’d discovered this 12 years ago. Now here is my question: Does this work for any of you folks?

    • Sandy
      S.Windsor, Ct

      I just tried it and it worked imediately. Wow, that is awesome. Thanks for the advice.

  5. Mary B.
    Argyle, TX

    Since quinine tablets are so expensive my doctor suggested that I drink about 4 ozs of tonic water each night to relieve my severe night leg cramps. I mix it with cranberry juice to make it taste better. Since I’ve been drinking this my leg cramps have gone away.

  6. Diane W.

    Easter Sunday 2014 after working several hours I came home around 3:00 p.m. after being home my legs started with restless leg syndrome. I have had it in the past but did not have anymore of my prescription left. I decided to go to Walmart to see if they had anything I could take. I purchased Hyland P.M. for restless legs I took the required dose and do not remember anything after that. Woke my grandaughter up around midnight putting pans of water on the stove saying I was going to work. What happened was I wrecked my car and got arrested for a DUII and I don’t drink. I don’t not remember anything that happened. My doctor said it was possible a reaction. When I can to my senses I took every ingredient in that product and check all the side effects. There were many that mimics being drunk I am just thankful that I did not kill anyone. I will never take an over the counter product without fully researching it. If anyone knows or has had issues with this product please let me know. Thanks

  7. NorthAlta

    Quinine is the only thing that works for my leg cramps! It has improved my quality of life 100% and I have not ever had any side effects.

What Do You Think?

We invite you to share your thoughts with others, but remember that our comment section is a public forum. Please do not use your full first and last name if you want to keep details of your medical history anonymous. A first name and last initial or a pseudonym is acceptable. Advice from other commenters on this website is not a substitute for medical attention. Do not stop any medicine without checking with the prescriber. Stopping medication suddenly could result in serious harm. We expect comments to be civil in tone and language. By commenting, you agree to abide by our commenting policy and website terms & conditions. Comments that do not follow these policies will not be posted.