We used to say that aspirin was the Rodney Dangerfield of drugs...it didn't get much respect. Aspirin as an anticancer agent should!
Can NSAIDs damage the kidneys? If you try to protect your stomach from NSAID damage with a PPI, will you increase kidney damage?
The FDA has a designation for drug reactions it considers especially worrisome: BOXED WARNING. Do prescribers warn patients? Not always!