By: Joe Graedon April 1, 2019 6 Comments
    Generic Escitalopram (Lexapro) Bombs Out Against…

    Escitalopram (Lexapro) is an SSRI (selective serotonin reuptake inhibitor). That means it is a lot like fluoxetine (Prozac). We have lost confidence in the FDA’s ability monitor generic drug quality…

    By: Terry Graedon March 20, 2019 6 Comments
    Can You Overcome Depression with Exercise?

    People with heart disease, diabetes and other chronic conditions are more prone to depression. This seems understandable. The problem is that if they do become depressed, their conditions may worsen. …

    By: Joe Graedon March 18, 2019 11 Comments
    How To Stop Venlafaxine: Very, VERY Slowly!

    It has taken the medical profession a very long time to acknowledge that many of the most popular drugs in the pharmacy can cause a kind of dependence. By that we mean such drugs can precipitate serio…

    By: Joe Graedon March 14, 2019 7 Comments
    High Cost of Spravato (Esketamine) For Depressio…

    The first really new antidepressant in decades recently won FDA approval for treatment-resistant depression. Esketamine nasal spray will be sold under the brand name Spravato. Physicians and patients …

    By: Terry Graedon March 7, 2019 7 Comments
    What Should You Know about New Antidepressant Sp…

    The Food and Drug Administration approved a completely new type of antidepressant on March 4, 2019. This ended several weeks of speculation. A nasal spray called esketamine is expected to help people …

    By: Terry Graedon February 14, 2019 6 Comments
    Will FDA Approve Esketamine Nasal Spray for Depr…

    An FDA advisory panel voted this week that a new form of an old compound is sufficiently safe and effective to be considered for approval. The old compound is ketamine, which has been used as an intra…

    By: Joe Graedon December 24, 2018 6 Comments
    Cough Remedy Plus Antidepressant Spark Scary Ser…

    Chances are good that you’ve heard of serotonin. It is a neurotransmitter in the brain that has been linked to mood. Fluoxetine (Prozac) and its antidepressant chemical cousins (citalopram or Celexa…

    By: Joe Graedon December 10, 2018 15 Comments
    Authorized Generic Drugs Offer Quality and Affor…

    Have you ever heard of authorized generic drugs? Most people, including physicians and pharmacists have no idea what they are. That’s largely because the Food and Drug Administration tells the world…

    By: Terry Graedon December 6, 2018 25 Comments
    Show 1145: Are Big Corporations Hacking the Amer…

    The distinction between pleasure and happiness might seem like a philosopher’s quibble. Fat Chance author Dr. Robert Lustig tells us why this difference is vitally important to our national wellbein…

    By: Terry Graedon October 25, 2018 12 Comments
    Why You Can Die of a Broken Heart

    Can you really die of a broken heart? This centuries-old idea may have seemed like an old wives' tale or a romantic fancy powering folk songs like "Barbara Allen." (Here's a link to Joan Baez singing …

    By: Joe Graedon October 22, 2018 9 Comments
    Bupropion Helps With Mood, Sex and Quitting Smok…

    Bupropion (Wellbutrin) was first approved by the FDA in 1985 to treat depression. It remains a totally unique antidepressant. There is no similar antidepressant on the market. Unlike SSRI and SNRI ant…

    By: Terry Graedon October 15, 2018 6 Comments
    Will Vitamin D Boost Your Mood This Winter?

    Vitamin D, sometimes known as the sunshine vitamin, is renowned for its contribution to bone strength. It may also help ward off lung infections, particularly among people who are especially susceptib…

    By: Joe Graedon July 2, 2018 21 Comments
    Which Medicines Can Cause Severe Depression?

    Most people experience sadness or depression sometime during their lives. Divorce, the death of a loved one, work-related problems or financial setbacks can all trigger severe depression. Once the cri…

    By: Joe Graedon June 25, 2018 18 Comments
    Getting Off Venlafaxine Can Be Incredibly Challe…

    Many years ago we heard from a reader who was trying to get off alprazolam (Xanax). It was not commonly recognized that short-acting benzodiazepines (benzos) could pose unbearable withdrawal symptoms …

    By: Joe Graedon June 25, 2018 19 Comments
    Could Suicide Be Prevented with Better Access to…

    Anthony Bourdain, Kate Spade, Robin Williams, Kurt Cobain and Marilyn Monroe are just a few of the celebrities who have taken their own lives. To say their deaths made headlines would be an understate…

    By: Terry Graedon May 31, 2018 14 Comments
    Will You Gain Weight on an Antidepressant?

    People who take antidepressant medications for many years often complain that they gain weight. Is this observation merely anecdotal, or is there evidence to support it? Do People Gain Weight When The…

    By: Joe Graedon April 26, 2018 15 Comments
    Commonly Prescribed Anticholinergic Drugs Linked…

    Alzheimer’s disease is scary. It robs people of their memories and their ability to function. Many people think it’s brought on by bad genes or bad luck. But there is mounting evidence that our en…

    By: Joe Graedon April 23, 2018 27 Comments
    Why Is Antidepressant Withdrawal So Hard?

    It is estimated that one out of every eight Americans takes an antidepressant medication (JAMA Internal Medicine, Feb. 2017). According to the New York Times, roughly 25 million Americans have been ta…

    By: Terry Graedon April 5, 2018 8 Comments
    Why You Should Eat the Mediterranean Way

    The Mediterranean diet has been associated with a number of health benefits. We have written previously about studies showing that a Mediterranean-style eating plan can protect the brain, reduce arthr…

    By: Terry Graedon March 15, 2018 1 Comments
    Will Mindfulness Meditation Reduce the Risk of D…

    Warding off major depression without medication is a big challenge. Mindfulness meditation may help, however. A study found that people with low-level depression who practiced meditation in a group we…

    By: Terry Graedon March 1, 2018 2 Comments
    Enjoy a Vegetable-Rich Diet to Prevent Depressio…

    A vegetable-rich diet is known as DASH, for Dietary Approaches to Stop Hypertension. This eating plan has been shown to help people control their blood pressure. That, in turn, helps reduce their risk…

    By: Terry Graedon February 12, 2018 17 Comments
    Stopping Duloxetine Leads to Terrible Withdrawal…

    Before anyone starts taking an antidepressant, the prescriber should give them some guidance on how to quit. As it turns out, getting off a medication like duloxetine can be extremely difficult becaus…

    By: Joe Graedon January 29, 2018 22 Comments
    How Can I Find Sertraline that Works?

    Sertraline (Zoloft) is one of the most popular antidepressants in the pharmacy. According to our data, over 7 million people take this medicine every day in the United States. That means it beats out …

    By: Terry Graedon January 22, 2018 6 Comments
    How Long Will Dizziness Last After Stopping Lexa…

    It is always smart to have an exit strategy. That is just as true when you begin taking a prescription medication as when you take a new job that might or might not be quite suitable. One reader found…

    By: Terry Graedon January 11, 2018 1 Comments
    Will Magic Mushroom Compound Ease Depression?

    Psilocybin is the psychoactive compound in hallucinogenic mushrooms. Humans have used this magic mushroom compound in rituals for thousands of years. The compound alters sensory perceptions and even t…

    By: Joe Graedon January 8, 2018 4 Comments
    Serotonin Syndrome From Lexapro Plus Robitussin …

    Millions of people take antidepressant medications like escitalopram (Lexapro), citalopram (Celexa), fluoxetine (Prozac), paroxetine (Paxil) or sertraline (Zoloft). These are known as SSRIs (selective…

    By: Joe Graedon January 1, 2018 7 Comments
    Surprising Ketamine Side Effects and Anti-Suicid…

    There is tremendous confusion and controversy surrounding a very old drug called ketamine (Ketalar). The FDA first approved Ketalar in 1970 as an injectable anesthetic. It had advantages over existing…

    By: Joe Graedon December 21, 2017 4 Comments
    Ketamine Zaps Suicidal Thoughts Within Hours

    An old anesthetic medication is getting new attention as a fast-acting way to reverse suicidal thoughts. That's the news from a high-powered study published in The American Journal of Psychiatry, onli…

    By: Joe Graedon November 27, 2017 6 Comments
    Tramadol Plus Sertraline Could be Deadly Cocktai…

    Serotonin is a crucial neurotransmitter. It is found in the brain as well as the digestive tract. Serotonin is also found in blood cells called platelets. It plays a crucial role in regulating mood. T…

    By: Joe Graedon November 6, 2017 8 Comments
    What To Do When a Miracle Drug for Pain Goes Sou…

    Almost everyone wants a miracle drug for pain relief. Is Lyrica (pregabalin) that medicine? If you watch any television at all you have likely seen commercials for Lyrica. A few years ago there was a …

    By: Joe Graedon October 9, 2017 4 Comments
    Rejecting the Idea of Antidepressants and Suicid…

    There is a common belief that most depressed patients feel helpless and hopeless. The thinking goes that overwhelming sadness and debilitating despair lead to lethargy and immobilization. Health profe…

    By: Joe Graedon September 28, 2017 7 Comments
    Will Sleep Deprivation Improve Your Mood?

    This is a man-bites-dog story that you will probably have a hard time believing. It surprised us, that's for sure. For years, all we have heard is that a good night's sleep is essential for good healt…

    By: Joe Graedon September 25, 2017 8 Comments
    Antidepressants and Suicide: Why Don’t Peo…

    Antidepressants are, by definition, supposed to improve mood. They are prescribed to lift people out of psychological depression. In theory, drugs like fluoxetine (Prozac), paroxetine (Paxil) and sert…

    By: Joe Graedon September 21, 2017 13 Comments
    Will Dangers of Antidepressants Shorten Your Lif…

    Americans love antidepressants. It is estimated that between one in eight and one in ten takes an antidepressant medication. People take SSRIs (selective serotonin reuptake inhibitors) and SNRIs (sero…

    By: Terry Graedon September 10, 2017 9 Comments
    How to Stop an Antidepressant Without Difficulti…

    Have you ever tried to stop an antidepressant abruptly? We have heard from many people who have found that this can trigger an extremely unpleasant experience. They report a discontinuation syndrome t…

    By: Terry Graedon August 24, 2017 6 Comments
    Can Lithium in Water Supply Prevent Dementia?

    The chances are good that you are exposed to some lithium almost every day of your life. That's because this natural element is plentiful in nature. It is found in rocks and soil all over the earth. T…

    By: Joe Graedon August 21, 2017 39 Comments
    Rediscovering Lithium for Mood Disorders

    Lithium is a chemical element that is widespread in nature. You can find it in the earth's crust, in water and even in the food you eat. Depending upon where you live, there is a good chance that ther…

    By: Terry Graedon August 3, 2017 1 Comments
    Veterans Find Yoga Improves Their Moods

    Many people think yoga appeals primarily to women. But a new study from the San Francisco Veterans Affairs Medical Center should put that myth to rest. A group of veterans discovered that yoga improve…

    By: Joe Graedon July 31, 2017 8 Comments
    Can Ketamine Stop Suicidal Thoughts?

    Time magazine has a cover story (August 7, 2017) titled: "THE ANTI ANTIDEPRESSANT Depression afflicts 16 million Americans. One third don't respond to treatment A surprising new drug may change that" …

    By: Joe Graedon July 20, 2017 6 Comments
    Could the Antibiotic Minocycline Ease Depression…

    Minocycline (Minocin) has been prescribed for decades. It belongs in the tetracycline class of antibiotics. Dermatologists have been among the most enthusiastic prescribers of minocycline for the trea…