By: Joe Graedon November 6, 2017 6 Comments
    What To Do When a Miracle Drug for Pain Goes Sou…

    Almost everyone wants a miracle drug for pain relief. Is Lyrica (pregabalin) that medicine? If you watch any television at all you have likely seen commercials for Lyrica. A few years ago there was a …

    By: Joe Graedon October 9, 2017 3 Comments
    Rejecting the Idea of Antidepressants and Suicid…

    There is a common belief that most depressed patients feel helpless and hopeless. The thinking goes that overwhelming sadness and debilitating despair lead to lethargy and immobilization. Health profe…

    By: Joe Graedon September 28, 2017 7 Comments
    Will Sleep Deprivation Improve Your Mood?

    This is a man-bites-dog story that you will probably have a hard time believing. It surprised us, that's for sure. For years, all we have heard is that a good night's sleep is essential for good healt…

    By: Joe Graedon September 25, 2017 7 Comments
    Antidepressants and Suicide: Why Don’t Peo…

    Antidepressants are, by definition, supposed to improve mood. They are prescribed to lift people out of psychological depression. In theory, drugs like fluoxetine (Prozac), paroxetine (Paxil) and sert…

    By: Joe Graedon September 21, 2017 10 Comments
    Will Dangers of Antidepressants Shorten Your Lif…

    Americans love antidepressants. It is estimated that between one in eight and one in ten takes an antidepressant medication. People take SSRIs (selective serotonin reuptake inhibitors) and SNRIs (sero…

    By: Terry Graedon September 10, 2017 6 Comments
    How to Stop an Antidepressant Without Difficulti…

    Have you ever tried to stop an antidepressant abruptly? We have heard from many people who have found that this can trigger an extremely unpleasant experience. They report a discontinuation syndrome t…

    By: Terry Graedon August 24, 2017 6 Comments
    Can Lithium in Water Supply Prevent Dementia?

    The chances are good that you are exposed to some lithium almost every day of your life. That's because this natural element is plentiful in nature. It is found in rocks and soil all over the earth. T…

    By: Joe Graedon August 21, 2017 25 Comments
    Rediscovering Lithium for Mood Disorders

    Lithium is a chemical element that is widespread in nature. You can find it in the earth's crust, in water and even in the food you eat. Depending upon where you live, there is a good chance that ther…

    By: Terry Graedon August 3, 2017 1 Comments
    Veterans Find Yoga Improves Their Moods

    Many people think yoga appeals primarily to women. But a new study from the San Francisco Veterans Affairs Medical Center should put that myth to rest. A group of veterans discovered that yoga improve…

    By: Joe Graedon July 31, 2017 6 Comments
    Can Ketamine Stop Suicidal Thoughts?

    Time magazine has a cover story (August 7, 2017) titled: "THE ANTI ANTIDEPRESSANT Depression afflicts 16 million Americans. One third don't respond to treatment A surprising new drug may change that" …

    By: Joe Graedon July 20, 2017 5 Comments
    Could the Antibiotic Minocycline Ease Depression…

    Minocycline (Minocin) has been prescribed for decades. It belongs in the tetracycline class of antibiotics. Dermatologists have been among the most enthusiastic prescribers of minocycline for the trea…

    By: Joe Graedon July 17, 2017 44 Comments
    Problems with Generic Wellbutrin (Bupropion)? No…

    A decade ago we received a message from J. in Danville, New York. She said: "I have been taking Budeprion XL 300 mg for three months instead of Wellbutrin XL 300 mg. I find that I am easily upset and …

    By: Joe Graedon July 3, 2017 102 Comments
    Are Prescription Drug Ads on TV Driving You Craz…

    Do you watch television? If so, you have almost inevitably seen commercials for medications we hope you will never need. If you are like a lot of our visitors you are sick and tired of prescription dr…

    By: Joe Graedon June 29, 2017 48 Comments
    How To Stop Duloxetine (Cymbalta) Without Withdr…

    From what we hear from readers of our syndicated newspaper column and visitors to this website, most patients are not warned about how to stop duloxetine (Cymbalta). Perhaps the prescriber assumes tha…

    By: Joe Graedon June 12, 2017 17 Comments
    Do Doctors Know How to Help Patients Stop Medica…

    Starting a new prescription is easy. If your doctor tells the pharmacist to write on the label, "take once a day with food," you know exactly what to do. Most people can manage such a simple instructi…

    By: Terry Graedon April 24, 2017 4 Comments
    Balancing the Benefits and Risks of Antidepressa…

    by Amy Beausang, PharmD What Is Depression? What if you could envision no future? If you felt like there were no answers to your problems, which are overwhelming and without end? Perhaps nothing feels…

    By: Terry Graedon April 20, 2017 1 Comments
    Should Women Worry About Antidepressants during …

    When women are pregnant, they frequently worry that something they swallow will harm the developing baby. Previous studies have suggested that mothers who take antidepressants during pregnancy might h…

    By: Joe Graedon March 30, 2017 8 Comments
    Are Men Taking Prostate Drugs More Likely to Be …

    Medications to shrink an enlarged prostate may contribute to depression. Doctors have not previously recognized this possible side effect for men taking prostate drugs. What Do Prostate Drugs Do? Drug…

    By: Joe Graedon January 19, 2017 7 Comments
    Will Antidepressant Medications Increase Your Ri…

    Antidepressants are among the most popular pills in the drugstore. A research letter in JAMA Internal Medicine (Dec. 12, 2016) noted that one in six adults take psychiatric drugs. Antidepressant medic…

    By: Joe Graedon November 28, 2016 13 Comments
    Stopping Duloxetine (Cymbalta) Suddenly Flipped …

    Antidepressants like desvenlafaxine (Pristiq), duloxetine (Cymbalta), sertraline (Zoloft) and venlafaxine (Effexor) have become extremely popular. Millions take such drugs regularly. When such medicat…

    By: Joe Graedon October 24, 2016 10 Comments
    Is Your Blood Pressure Medicine Making You Sad a…

    Do you feel down in the dumps, sad or depressed? Have you ever considered the possibility that your medicine might be responsible for your blue mood? Health professionals rarely mention that many medi…

    By: Terry Graedon October 20, 2016 10 Comments
    Curcumin Eases Both Depression and Anxiety

    Curcumin is the active ingredient in the yellow spice turmeric. Numerous studies have confirmed its antioxidant and anti-inflammatory activity. Could it help against depression and anxiety? Studying…

    By: Joe Graedon October 6, 2016 13 Comments
    Birth Control Hormones Linked to Depression

    For fifty years doctors have been wondering whether hormonal contraception could affect mood. A new study from Denmark suggests that the answer is yes. The researchers reviewed all the records for one…

    By: Joe Graedon October 6, 2016 8 Comments
    Can Psychological Depression Be Triggered By Inf…

    Health professionals have long known that depression can be brought on by challenging life events such as the loss of a loved one, marital difficulties or job loss. Genes can play a role and neuroc…

    By: Joe Graedon August 22, 2016 2 Comments
    Can Ketamine Jump Start Antidepressant Action?

    When people are severely depressed they need immediate help. Sadly, most antidepressant medications take weeks to start working. That's why this reader's question is so very interesting. Q. You've wri…

    By: Joe Graedon August 13, 2016 0 Comments
    Why Did Generic Remeron (Mirtazapine) Disappoint…

    People who are seriously depressed depend upon their medication to get through challenging times. Without a reliable medication they can fall back into a dark depression. This reader shares the frustr…

    By: Joe Graedon August 8, 2016 43 Comments
    Have You Had Problems with Generic Cymbalta (Dul…

    Brand name drugs like Cymbalta have become unaffordable for many patients. That's why most people are dispensed generic Cymbalta (duloxetine). We have received complaints that some generic formulation…

    By: Joe Graedon July 4, 2016 18 Comments
    Abilify Side effects: How Dangerous Are Antipsyc…

    Mental illness has always represented a challenge to the medical community. TV commercials to the contrary, there is no silver bullet to cure anxiety, bipolar disease, major depression or schizophreni…

    By: Joe Graedon June 23, 2016 34 Comments
    Will A Free Lunch Influence Your Doctor’s …

    Ask most physicians whether a free lunch from a drug company would affect their prescribing patterns and the chances are pretty good that they would say no. Some would be highly insulted by the very i…

    By: Terry Graedon April 4, 2016 9 Comments
    How to Fight Depression with a Simple Supplement

    Depression is common, possibly the most common mental illness. According to the CDC, this potentially crippling condition affects almost 8 percent of Americans over 12 years of age (CDC, MMWR, Jan. 6,…

    By: Terry Graedon January 28, 2016 0 Comments
    Pregnant Women Should Be Screened for Depression

    The United States Preventive Services Task Force issues recommendations for screening for a variety of diseases and conditions based on the evidence from studies. Usually these public health messages …

    By: Terry Graedon January 28, 2016 1 Comments
    Teens on Antidepressants Are More Prone to Aggre…

    Questions have been raised in the past about the balance of benefits and risks of antidepressants for youngsters. In fact, a Swedish study published in 2015 showed that people between 15 and 24 were m…

    By: Terry Graedon December 27, 2015 4 Comments
    How to Fight Back Against SAD This Winter

    As the holidays wind down and the weather changes from wet and nasty to cold and icy, many people discover that they are spending more time inside. During short days, they get relatively little sun ex…

    By: Joe Graedon December 21, 2015 14 Comments
    Billion Dollar Drugs Are Dramatically Disappoint…

    How effective is your medicine? This seemingly simple question is surprisingly complex. In many cases a pill's benefits are barely detectable. Before a drug can be approved by the Food and Drug Admini…

    By: Joe Graedon October 29, 2015 51 Comments
    Generic Sertraline (Zoloft) Problems Lead To Anx…

    The FDA insists that all generic drugs sold in the U.S. are "identical" to their brand name counterparts. Visitors to this website disagree. The latest controversy surrounds generic sertraline (Zoloft…

    By: Joe Graedon September 28, 2015 16 Comments
    Antidepressants Linked to Violence: Rape, Robber…

    Q. I am 30 years old and have been taking fluoxetine. I was prescribed this last year because I attempted to take my own life. I have noticed that my behavior, though no longer suicidal, is increasing…

    By: Joe Graedon September 17, 2015 6 Comments
    Is Paxil (Paroxetine) Unsafe for Teens?

    New research suggests that antidepressant medications may pose a serious problem for adolescents. A study from Sweden reveals a relationship between such drugs and violent crimes. More troublesome, a …

    By: Joe Graedon August 19, 2015 2 Comments
    High Glycemic Index Diets Trigger Depression

    What we eat has important effects on our physiology. Should you follow a low-carb or a low-fat diet? The controversy is ongoing. While many nutrition experts maintain firmly that all calories are equa…

    By: Joe Graedon July 16, 2015 3 Comments
    Real World Results Differ from Drug Studies

    People who are recruited to participate in studies of antidepressant medications may not represent typical depressed patients. According to a new study, subjects in clinical trials of antidepressants …

    By: Joe Graedon May 18, 2015 15 Comments
    Doctors Still Doubt Antidepressants Can Trigger …

    Shortly after Prozac was approved for treating depression in 1987 we received a heartbreaking letter from a physician. He was writing as a bereaved father: "My daughter committed suicide in 1988 one m…