The People's Perspective on Medicine

If You’re on Simvastatin, Can You Eat Grapefruit?

If you eat grapefruit the same day you take simvastatin, your blood levels of the drug will be higher.

Do you know whether there are some foods you should avoid while you are taking your medicine? The classic example is grapefruit. When its ability to interact with medications was first discovered, many health professionals were skeptical. Now, some tell patients not to eat grapefruit at all when they are taking certain prescription drugs. Is there a happy medium?

Can You Safely Eat Grapefruit While Taking Simvastatin?

Q. I love grapefruit, the whole fruit. I used to eat grapefruit often, but I have gone without it for several years now. That is because I take simvastatin to lower my cholesterol.

I discussed my cravings with my heart doctor and we reached a happy medium. I can have half a grapefruit in the morning every five or six days. I take my pill in the evening, and he figures 12 hours or so is a safe time spread between medication and fruit.

Is Breakfast to Bedtime Enough Time?

A. Your doctor has it partially correct. Grapefruit contains compounds (furanocoumarins) that inhibit a crucial enzyme in the digestive tract that breaks down many medications, including simvastatin. This means more medicine circulates in the body, increasing the risk for side effects. The enzyme, called CYP3A4, is responsible for the metabolism of numerous medications in addition to simvastatin.

When grapefruit and simvastatin are taken together, blood levels of the drug increase by 260 percent (Lee, Morris & Wald, American Journal of Medicine, Jan. 2016). When taken 12 hours apart, as your doctor recommends, blood levels go up by 90 percent.

Enjoying grapefruit once or twice a week probably won’t have a lasting effect. Daily grapefruit, however, could cause trouble since the grapefruit effect lasts at least 24 hours. Just to complicate the situation, some people react far more strongly when they eat grapefruit than others do. We don’t yet have good ways to tell ahead of time who will get a very noticeable boost in blood levels from this interaction.

Learn More:

To learn more about the interactions of grapefruit and other foods with medicines, you may wish to download our free Guides to Drug and Food Interactions and Grapefruit Interactions.

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About the Author
Terry Graedon, PhD, is a medical anthropologist and co-host of The People’s Pharmacy radio show, co-author of The People’s Pharmacy syndicated newspaper columns and numerous books, and co-founder of The People’s Pharmacy website. Terry taught in the Duke University School of Nursing and was an adjunct assistant professor in the Department of Anthropology. She is a Fellow of the Society of Applied Anthropology. Terry is one of the country's leading authorities on the science behind folk remedies. .
Grapefruit Interactions

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I have seen a lot written about not combining grapefruit and statins, but is it okay to take statins with orange juice, or other juices?

Orange juice does not have the same effect as grapefruit juice. However, orange and apple juice (as well as grapefruit juice) inhibit a transporter protein (OATP) that can interfere with absorption. Better to take the medicine at a different time than the juice. Here’s a link:

Numerous foods and herbs inhibit the P450 enzymes in the liver that metabolize Statins and many other substances. The lists can be found with a little research. Vitamin D is one and Sildenafil (Viagra) is another. The health value of daily Simvastatin is minute in comparison to a daily grapefruit (pink is better). Can the statin and eat the grapefruit.

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